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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:platelet-derived growth factor receptor-alpha signaling pathway
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Accession:GO:0035790 term browser browse the term
Definition:A series of molecular signals initiated by the binding of a ligand to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: PDGF receptor-alpha signaling pathway;   alphaPDGF receptor signaling pathway;   platelet-derived growth factor receptor-alpha signalling pathway
 related_synonym: PDGFR-alpha signaling pathway


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platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfra platelet derived growth factor receptor alpha involved_in ISO
IEA		 (PMID:2554309)
(MGI:5294530|PMID:20110689)
GO_REF:0000107		 RGD
Ensembl		 PMID:2554309 PMID:20110689 GO_REF:0000107 MGI:5294530 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISS
ISO		 GO_REF:0000024
(MGI:4943654|PMID:19460854)		 UniProt
RGD		 PMID:19460854 GO_REF:0000024 MGI:4943654 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Phf14 PHD finger protein 14 acts_upstream_of_or_within ISO MGI:5426539 (MGI:5426441|PMID:22730381) RGD PMID:22730381 MGI:5426441 NCBI chr 4:40,009,691...40,195,870
Ensembl chr 4:40,009,264...40,195,885 		JBrowse link
regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in ISO (MGI:6108066|PMID:29237719) RGD PMID:29237719 MGI:6108066 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cblb Cbl proto-oncogene B involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:6108066|PMID:29237719)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:29237719 GO_REF:0000024 GO_REF:0000107 MGI:6108066 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839 		JBrowse link
G Ift20 intraflagellar transport 20 involved_in ISO (MGI:6108066|PMID:29237719) RGD PMID:29237719 MGI:6108066 NCBI chr10:63,432,597...63,438,125
Ensembl chr10:63,432,633...63,438,124 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    signaling 7439
      signal transduction 6859
        cell surface receptor signaling pathway 2772
          enzyme linked receptor protein signaling pathway 978
            transmembrane receptor protein tyrosine kinase signaling pathway 613
              platelet-derived growth factor receptor signaling pathway 63
                platelet-derived growth factor receptor-alpha signaling pathway 6
                  VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway 0
                  negative regulation of platelet-derived growth factor receptor-alpha signaling pathway 2
                  positive regulation of platelet-derived growth factor receptor-alpha signaling pathway 0
                  regulation of platelet-derived growth factor receptor-alpha signaling pathway + 5
Path 2
Term Annotations click to browse term
  biological_process 19390
    biological regulation 13476
      regulation of biological process 12735
        regulation of cellular process 12196
          signal transduction 6859
            cell surface receptor signaling pathway 2772
              enzyme linked receptor protein signaling pathway 978
                transmembrane receptor protein tyrosine kinase signaling pathway 613
                  platelet-derived growth factor receptor signaling pathway 63
                    platelet-derived growth factor receptor-alpha signaling pathway 6
                      VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway 0
                      negative regulation of platelet-derived growth factor receptor-alpha signaling pathway 2
                      positive regulation of platelet-derived growth factor receptor-alpha signaling pathway 0
                      regulation of platelet-derived growth factor receptor-alpha signaling pathway + 5
paths to the root