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ONTOLOGY REPORT - ANNOTATIONS


Term:platelet-derived growth factor receptor-alpha signaling pathway
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Accession:GO:0035790 term browser browse the term
Definition:The series of molecular signals initiated a ligand binding to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: PDGF receptor-alpha signaling pathway;   alphaPDGF receptor signaling pathway;   platelet-derived growth factor receptor-alpha signalling pathway
 related_synonym: PDGFR-alpha signaling pathway



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platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alk ALK receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 6:28,631,431...29,351,321 JBrowse link
G Axl Axl receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:90,392,864...90,424,123 JBrowse link
G Csf1r colony stimulating factor 1 receptor involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr18:56,834,152...56,860,804 JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr20:3,047,269...3,069,277 JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr13:84,726,412...84,851,032 JBrowse link
G Egfr epidermal growth factor receptor involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:95,378,626...95,551,358 JBrowse link
G Epha1 Eph receptor A1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:72,213,022...72,227,543 JBrowse link
G Epha2 Eph receptor A2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:158,888,629...158,917,100 JBrowse link
G Epha3 Eph receptor A3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr11:14,585,041...14,920,721 JBrowse link
G Epha4 Eph receptor A4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 9:86,263,982...86,406,744 JBrowse link
G Epha5 EPH receptor A5 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:24,007,400...24,374,854 JBrowse link
G Epha6 Eph receptor A6 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr11:53,226,784...54,178,120 JBrowse link
G Epha7 Eph receptor A7 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:47,771,776...47,925,189 JBrowse link
G Epha8 Eph receptor A8 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:154,449,566...154,476,966 JBrowse link
G Ephb1 Eph receptor B1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:111,386,432...111,823,759 JBrowse link
G Ephb2 Eph receptor B2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:154,179,065...154,360,459 JBrowse link
G Ephb3 Eph receptor B3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr11:93,345,098...93,363,775 JBrowse link
G Ephb4 EPH receptor B4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr12:24,963,174...24,988,473 JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:83,907,491...83,931,365 JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:1,579,079...1,600,379 JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 9:76,973,386...78,045,633 JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr16:73,194,631...73,249,855 JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:194,175,703...194,280,914 JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:81,211,800...81,227,215 JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr17:9,466,686...9,481,423 JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr12:12,333,050...12,504,750 JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr12:12,660,035...12,735,584 JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:34,414,834...34,455,878 JBrowse link
G Igf1r insulin-like growth factor 1 receptor involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:130,959,787...131,248,664 JBrowse link
G Insr insulin receptor involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr12:5,991,135...6,129,275 JBrowse link
G Insrr insulin receptor-related receptor involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:175,553,244...175,572,676 JBrowse link
G Kdr kinase insert domain receptor involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:32,572,031...32,615,204 JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:32,901,615...32,978,895 JBrowse link
G Ltk leukocyte receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:127,188,479...127,195,356 JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:136,391,936...136,498,366 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:46,756,823...46,864,041 JBrowse link
G Mst1r macrophage stimulating 1 receptor involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:117,471,928...117,491,059 JBrowse link
G Musk muscle associated receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:77,853,560...77,967,653 JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:175,534,844...175,551,664 JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr17:5,560,558...5,875,899 JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:141,526,192...141,913,575 JBrowse link
G Pdgfra platelet derived growth factor receptor alpha involved_in ISO
IEA
(PMID:2554309)
GO_REF:0000107
(PMID:20110689)
RGD
Ensembl
PMID:2554309 PMID:20110689 GO_REF:0000107 NCBI chr14:33,360,027...33,408,604 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr18:56,770,348...56,809,228 JBrowse link
G Ret ret proto-oncogene involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:152,998,344...153,040,556 JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr20:31,975,328...32,126,675 JBrowse link
G Tek TEK receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:114,722,815...114,849,535 JBrowse link
G Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:137,285,408...137,305,047 JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:127,231,468...127,254,806 JBrowse link
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISS
ISO
GO_REF:0000024
(PMID:19460854)
UniProt
RGD
PMID:19460854 GO_REF:0000024 NCBI chr11:91,226,524...91,240,244 JBrowse link
G Phf14 PHD finger protein 14 acts_upstream_of_or_within ISO MGI:5426539 (PMID:22730381) RGD PMID:22730381 NCBI chr 4:40,975,897...41,162,043 JBrowse link
regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in ISO (PMID:29237719) RGD PMID:29237719 NCBI chr 8:53,384,656...53,468,067 JBrowse link
G Cblb Cbl proto-oncogene B involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:29237719)
Ensembl
UniProt
RGD
PMID:29237719 GO_REF:0000024 GO_REF:0000107 NCBI chr11:62,058,829...62,225,904 JBrowse link
G Ift20 intraflagellar transport 20 involved_in ISO (PMID:29237719) RGD PMID:29237719 NCBI chr10:63,930,629...63,936,174 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      signal transduction 7250
        cell surface receptor signaling pathway 2882
          enzyme-linked receptor protein signaling pathway 1062
            cell surface receptor protein tyrosine kinase signaling pathway 671
              platelet-derived growth factor receptor signaling pathway 116
                platelet-derived growth factor receptor-alpha signaling pathway 53
                  VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway 0
                  negative regulation of platelet-derived growth factor receptor-alpha signaling pathway 2
                  positive regulation of platelet-derived growth factor receptor-alpha signaling pathway 0
                  regulation of platelet-derived growth factor receptor-alpha signaling pathway + 5
Path 2
Term Annotations click to browse term
  biological_process 20534
    biological regulation 13821
      regulation of biological process 13375
        signaling 7808
          signal transduction 7250
            cell surface receptor signaling pathway 2882
              enzyme-linked receptor protein signaling pathway 1062
                cell surface receptor protein tyrosine kinase signaling pathway 671
                  platelet-derived growth factor receptor signaling pathway 116
                    platelet-derived growth factor receptor-alpha signaling pathway 53
                      VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway 0
                      negative regulation of platelet-derived growth factor receptor-alpha signaling pathway 2
                      positive regulation of platelet-derived growth factor receptor-alpha signaling pathway 0
                      regulation of platelet-derived growth factor receptor-alpha signaling pathway + 5
paths to the root