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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:platelet-derived growth factor receptor-alpha signaling pathway
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Accession:GO:0035790 term browser browse the term
Definition:The series of molecular signals initiated a ligand binding to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: PDGF receptor-alpha signaling pathway;   alphaPDGF receptor signaling pathway;   platelet-derived growth factor receptor-alpha signalling pathway
 related_synonym: PDGFR-alpha signaling pathway


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platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfra platelet derived growth factor receptor alpha involved_in ISO
IEA		 (PMID:2554309)
(MGI:5294530|PMID:20110689)
GO_REF:0000107		 RGD
Ensembl		 PMID:2554309 PMID:20110689 GO_REF:0000107 MGI:5294530 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISS
ISO		 GO_REF:0000024
(MGI:4943654|PMID:19460854)		 UniProt
RGD		 PMID:19460854 GO_REF:0000024 MGI:4943654 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Phf14 PHD finger protein 14 acts_upstream_of_or_within ISO MGI:5426539 (MGI:5426441|PMID:22730381) RGD PMID:22730381 MGI:5426441 NCBI chr 4:40,009,691...40,195,870
Ensembl chr 4:40,009,264...40,195,885 		JBrowse link
regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in ISO (MGI:6108066|PMID:29237719) RGD PMID:29237719 MGI:6108066 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cblb Cbl proto-oncogene B involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:6108066|PMID:29237719)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:29237719 GO_REF:0000024 GO_REF:0000107 MGI:6108066 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839 		JBrowse link
G Ift20 intraflagellar transport 20 involved_in ISO (MGI:6108066|PMID:29237719) RGD PMID:29237719 MGI:6108066 NCBI chr10:63,432,597...63,438,125
Ensembl chr10:63,432,633...63,438,124 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18737
    signaling 7370
      signal transduction 6808
        cell surface receptor signaling pathway 2778
          enzyme-linked receptor protein signaling pathway 1015
            transmembrane receptor protein tyrosine kinase signaling pathway 644
              platelet-derived growth factor receptor signaling pathway 67
                platelet-derived growth factor receptor-alpha signaling pathway 6
                  VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway 0
                  negative regulation of platelet-derived growth factor receptor-alpha signaling pathway 2
                  positive regulation of platelet-derived growth factor receptor-alpha signaling pathway 0
                  regulation of platelet-derived growth factor receptor-alpha signaling pathway + 5
Path 2
Term Annotations click to browse term
  biological_process 18737
    biological regulation 13318
      regulation of biological process 12598
        regulation of cellular process 11911
          signal transduction 6808
            cell surface receptor signaling pathway 2778
              enzyme-linked receptor protein signaling pathway 1015
                transmembrane receptor protein tyrosine kinase signaling pathway 644
                  platelet-derived growth factor receptor signaling pathway 67
                    platelet-derived growth factor receptor-alpha signaling pathway 6
                      VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway 0
                      negative regulation of platelet-derived growth factor receptor-alpha signaling pathway 2
                      positive regulation of platelet-derived growth factor receptor-alpha signaling pathway 0
                      regulation of platelet-derived growth factor receptor-alpha signaling pathway + 5
paths to the root