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ONTOLOGY REPORT - ANNOTATIONS

Term:CD4-positive, alpha-beta T cell costimulation
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Accession:GO:0035783 term browser browse the term
Definition:The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation.

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CD4-positive, alpha-beta T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 CD81 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936794:664,089...670,294
Ensembl chrNW_004936794:664,115...669,800 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4819294|PMID:20639485) BHF-UCL PMID:20639485 MGI:4819294 NCBI chrNW_004936481:14,391,359...14,409,514 JBrowse link
negative regulation of CD4-positive, alpha-beta T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd160 CD160 molecule involved_in ISO (PMID:18193050) UniProt PMID:18193050 NCBI chrNW_004936867:478,625...485,905 JBrowse link
positive regulation of CD4-positive, alpha-beta T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4819294|PMID:20639485) BHF-UCL PMID:20639485 MGI:4819294 NCBI chrNW_004936481:14,391,359...14,409,514 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15969
    immune system process 2209
      lymphocyte costimulation 33
        T cell costimulation 31
          CD4-positive, alpha-beta T cell costimulation 3
            negative regulation of CD4-positive, alpha-beta T cell costimulation 1
            positive regulation of CD4-positive, alpha-beta T cell costimulation 1
            regulation of CD4-positive, alpha-beta T cell costimulation + 2
Path 2
Term Annotations click to browse term
  biological_process 15969
    biological regulation 11154
      regulation of biological process 10818
        regulation of cellular process 10346
          regulation of cell activation 582
            regulation of leukocyte activation 529
              regulation of lymphocyte activation 463
                regulation of T cell activation 334
                  regulation of alpha-beta T cell activation 108
                    positive regulation of alpha-beta T cell activation 69
                      positive regulation of CD4-positive, alpha-beta T cell activation 42
                        CD4-positive, alpha-beta T cell costimulation 3
                          negative regulation of CD4-positive, alpha-beta T cell costimulation 1
                          positive regulation of CD4-positive, alpha-beta T cell costimulation 1
                          regulation of CD4-positive, alpha-beta T cell costimulation + 2
paths to the root