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ONTOLOGY REPORT - ANNOTATIONS

Term:mitophagy by internal vacuole formation
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Accession:GO:0035695 term browser browse the term
Definition:The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes.
Comment:In this mechanism of mitochondrion degradation, the mitochondrion is directly engulfed by a lysosome-like vacuole. It is therefore distinct from canonical autophagy, which is mediated by a double-membrane autophagosome.
Synonyms:narrow_synonym: MIV-mediated mitophagy

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mitophagy by internal vacuole formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spata18 spermatogenesis associated 18 involved_in ISO (PMID:21264228) UniProt PMID:21264228 NCBI chrNW_004955447:18,401,881...18,437,878 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12563
    cellular process 12002
      process utilizing autophagic mechanism 460
        autophagy 460
          autophagy of mitochondrion 82
            mitophagy by internal vacuole formation 1
Path 2
Term Annotations click to browse term
  biological_process 12563
    cellular process 12002
      metabolic process 7932
        catabolic process 1982
          autophagy 460
            autophagy of mitochondrion 82
              mitophagy by internal vacuole formation 1
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