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ONTOLOGY REPORT - ANNOTATIONS


Term:maintenance of blood-brain barrier
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Accession:GO:0035633 term browser browse the term
Definition:Maintaining the structure and function of the blood-brain barrier, thus ensuring specific regulated transport of substances (e.g. macromolecules, small molecules, ions) into the brain, and out of the brain into the blood circulation.
Comment:Homeostasis and maintenance processes are regulatory processes, therefore, regulation child terms, such as: regulation of maintenance of blood-brain barrier, should not exist for these terms. \nInstead, for capturing regulation at the blood-brain barrier, consider using the part_of child term: regulation of blood-brain barrier permeability.
Synonyms:related_synonym: maintenance of BBB
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa



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maintenance of blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IMP RGD PMID:26830080 RGD:11041002 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Bdkrb2 bradykinin receptor B2 IDA RGD PMID:20080302 RGD:4891047 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Cd2ap CD2-associated protein involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2664945 (PMID:26358779)
Ensembl
RGD
PMID:26358779 GO_REF:0000107 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199
JBrowse link
G Cdc45 cell division cycle 45 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619
JBrowse link
G Cldn5 claudin 5 involved_in ISO (PMID:28961379) RGD PMID:28961379 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
JBrowse link
G Mbp myelin basic protein involved_in ISO
IEA
(PMID:22524708)
GO_REF:0000107
RGD
Ensembl
PMID:22524708 GO_REF:0000107 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid acts_upstream_of_or_within ISO (MGI:6196220|PMID:30074985) RGD PMID:30074985 MGI:6196220 NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690
JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase acts_upstream_of_or_within ISO MGI:1934018 (PMID:21408219) RGD PMID:21408219 NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 IMP RGD PMID:17704356 RGD:2325928 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP RGD PMID:17704356 RGD:2325928 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Slc12a2 solute carrier family 12 member 2 acts_upstream_of_or_within ISO (MGI:6392927|PMID:28577991) RGD PMID:28577991 MGI:6392927 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
JBrowse link
G Slc1a1 solute carrier family 1 member 1 acts_upstream_of_or_within ISO (MGI:6393184|PMID:25350110) RGD PMID:25350110 MGI:6393184 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Tspan12 tetraspanin 12 acts_upstream_of_or_within ISO MGI:6105927 (PMID:30478038) RGD PMID:30478038 NCBI chr 4:50,313,768...50,389,246
Ensembl chr 4:50,313,772...50,389,246
JBrowse link
G Wnk3 WNK lysine deficient protein kinase 3 acts_upstream_of_or_within ISO (MGI:6221361|PMID:27782176) RGD PMID:27782176 MGI:6221361 NCBI chr  X:20,156,260...20,299,252
Ensembl chr  X:20,157,041...20,296,821
JBrowse link
negative regulation of blood-brain barrier permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 IMP RGD PMID:18854840 RGD:2325137 NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
JBrowse link
G Ifnb1 interferon beta 1 IDA RGD PMID:12973019 PMID:12973022 RGD:401851924, RGD:401851925 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Sh3gl2 SH3 domain containing GRB2 like 2, endophilin A1 involved_in ISO
IEA
(PMID:24854121)
GO_REF:0000107
RGD
Ensembl
PMID:24854121 GO_REF:0000107 NCBI chr 5:99,653,189...99,827,500
Ensembl chr 5:99,653,152...100,113,843
JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO
IEA
(PMID:19148554)
GO_REF:0000107
RGD
Ensembl
PMID:19148554 GO_REF:0000107 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
positive regulation of blood-brain barrier permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:19148554)
Ensembl
RGD
PMID:19148554 GO_REF:0000107 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
JBrowse link
G Ocln occludin involved_in ISO (PMID:24854121) RGD PMID:24854121 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Tjp1 tight junction protein 1 involved_in ISO
IBA
(PMID:24854121)
GO_REF:0000033
RGD
GO_Central
PMID:24854121 GO_REF:0000033 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tjp2 tight junction protein 2 involved_in ISO
IBA
(PMID:19148554)
GO_REF:0000033
RGD
GO_Central
PMID:19148554 GO_REF:0000033 NCBI chr 1:221,709,745...221,838,291
Ensembl chr 1:221,709,745...221,838,295
JBrowse link
G Tjp3 tight junction protein 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:8,427,650...8,446,279
Ensembl chr 7:8,432,811...8,446,279
JBrowse link
regulation of blood-brain barrier permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zeb2 zinc finger E-box binding homeobox 2 IMP RGD PMID:34334113 RGD:155882538 NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19872
    multicellular organismal process 8843
      multicellular organismal-level homeostasis 947
        tissue homeostasis 287
          maintenance of blood-brain barrier 24
            regulation of blood-brain barrier permeability + 10
Path 2
Term Annotations click to browse term
  biological_process 19872
    multicellular organismal process 8843
      multicellular organismal-level homeostasis 947
        anatomical structure homeostasis 287
          tissue homeostasis 287
            maintenance of blood-brain barrier 24
              regulation of blood-brain barrier permeability + 10
paths to the root