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ONTOLOGY REPORT - ANNOTATIONS

Term:maintenance of blood-brain barrier
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Accession:GO:0035633 term browser browse the term
Definition:Maintaining the structure and function of the blood-brain barrier, thus ensuring specific regulated transport of substances (e.g. macromolecules, small molecules, ions) into the brain, and out of the brain into the blood circulation.
Comment:Homeostasis and maintenance processes are regulatory processes, therefore, regulation child terms, such as: regulation of maintenance of blood-brain barrier, should not exist for these terms. \nInstead, for capturing regulation at the blood-brain barrier, consider using the part_of child term: regulation of blood-brain barrier permeability.
Synonyms:related_synonym: maintenance of BBB
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa


show annotations for term's descendants           Sort by:
maintenance of blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IMP RGD PMID:26830080 RGD:11041002 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Bdkrb2 bradykinin receptor B2 IDA RGD PMID:20080302 RGD:4891047 NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:130,237,255...130,267,209 		JBrowse link
G Cd2ap CD2-associated protein acts_upstream_of_or_within ISO MGI:2664945 (PMID:26358779) RGD PMID:26358779 NCBI chr 9:25,580,071...25,679,968
Ensembl chr 9:25,583,975...25,679,968 		JBrowse link
G Cldn5 claudin 5 involved_in ISO
IEA 		(PMID:28961379)
GO_REF:0000107 		RGD
Ensembl		 PMID:28961379 GO_REF:0000107 NCBI chr11:95,717,172...95,718,598
Ensembl chr11:95,717,176...95,719,322 		JBrowse link
G Mbp myelin basic protein involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174 		JBrowse link
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:30074985) 		Ensembl
RGD		 PMID:30074985 GO_REF:0000107 NCBI chr 5:140,510,933...140,525,828
Ensembl chr 5:140,510,953...140,525,916 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:1934018 (PMID:21408219) 		Ensembl
RGD		 PMID:21408219 GO_REF:0000107 NCBI chr10:86,501,864...86,509,333
Ensembl chr10:86,501,836...86,509,315 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 involved_in IMP
IEA 		GO_REF:0000117 UniProt
RGD		 PMID:17704356 GO_REF:0000117, RGD:2325928 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in IMP
IEA 		GO_REF:0000117 UniProt
RGD		 PMID:17704356 GO_REF:0000117, RGD:2325928 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 acts_upstream_of_or_within ISO (PMID:28577991) RGD PMID:28577991 NCBI chr18:53,546,263...53,614,478
Ensembl chr18:53,546,333...53,614,470 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:25350110) 		Ensembl
RGD		 PMID:25350110 GO_REF:0000107 NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:235,963,437...236,045,469 		JBrowse link
G Tspan12 tetraspanin 12 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:6105927 (PMID:30478038) 		Ensembl
RGD		 PMID:30478038 GO_REF:0000107 NCBI chr 4:51,279,562...51,355,030
Ensembl chr 4:51,279,563...51,355,030 		JBrowse link
G Wnk3 WNK lysine deficient protein kinase 3 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:27782176) 		Ensembl
RGD		 PMID:27782176 GO_REF:0000107 NCBI chr  X:23,599,278...23,742,290
Ensembl chr  X:23,599,305...23,742,290 		JBrowse link
negative regulation of blood-brain barrier permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 IMP RGD PMID:18854840 RGD:2325137 NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:105,734,992...105,815,982 		JBrowse link
G Ifnb1 interferon beta 1 IDA RGD PMID:12973019 PMID:12973022 RGD:401851924, RGD:401851925 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487 		JBrowse link
G Sh3gl2 SH3 domain containing GRB2 like 2, endophilin A1 involved_in ISO
IEA 		(PMID:24854121)
GO_REF:0000107 		RGD
Ensembl		 PMID:24854121 GO_REF:0000107 NCBI chr 5:104,699,270...104,874,724
Ensembl chr 5:104,698,929...105,159,896 		JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO
IEA 		(PMID:19148554)
GO_REF:0000107 		RGD
Ensembl		 PMID:19148554 GO_REF:0000107 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
positive regulation of blood-brain barrier permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:19148554) 		Ensembl
RGD		 PMID:19148554 GO_REF:0000107 NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696 		JBrowse link
G Ocln occludin involved_in ISO (PMID:24854121) RGD PMID:24854121 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411 		JBrowse link
G Tjp1 tight junction protein 1 involved_in ISO
IBA 		(PMID:24854121)
GO_REF:0000033 		RGD
GO_Central		 PMID:24854121 GO_REF:0000033 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158 		JBrowse link
G Tjp2 tight junction protein 2 involved_in ISO
IBA 		(PMID:19148554)
GO_REF:0000033 		RGD
GO_Central		 PMID:19148554 GO_REF:0000033 NCBI chr 1:231,136,218...231,264,750
Ensembl chr 1:231,136,243...231,264,750 		JBrowse link
regulation of blood-brain barrier permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zeb2 zinc finger E-box binding homeobox 2 IMP RGD PMID:34334113 RGD:155882538 NCBI chr 3:49,624,028...49,754,323
Ensembl chr 3:49,624,028...49,754,323 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    multicellular organismal process 9018
      multicellular organismal-level homeostasis 1009
        tissue homeostasis 304
          maintenance of blood-brain barrier 22
            regulation of blood-brain barrier permeability + 9
Path 2
Term Annotations click to browse term
  biological_process 19315
    multicellular organismal process 9018
      multicellular organismal-level homeostasis 1009
        anatomical structure homeostasis 304
          tissue homeostasis 304
            maintenance of blood-brain barrier 22
              regulation of blood-brain barrier permeability + 9
paths to the root