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ONTOLOGY REPORT - ANNOTATIONS


Term:sequestering of TGFbeta in extracellular matrix
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Accession:GO:0035583 term browser browse the term
Definition:Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins.
Synonyms:exact_synonym: negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta;   negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta;   sequestering of TGFbeta LLC in extracellular matrix;   sequestering of TGFbeta large latency complex in extracellular matrix



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sequestering of TGFbeta in extracellular matrix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBN1 fibrillin 1 involved_in ISO (MGI:4836762|PMID:20855508) BHF-UCL PMID:20855508 MGI:4836762 NCBI chr15:27,358,780...27,593,539
Ensembl chr15:45,682,450...45,918,111
JBrowse link
G FBN2 fibrillin 2 involved_in ISO (MGI:4836762|PMID:20855508) BHF-UCL PMID:20855508 MGI:4836762 NCBI chr 5:123,673,209...123,953,741
Ensembl chr 5:129,435,248...129,715,711
JBrowse link
G LTBP1 latent transforming growth factor beta binding protein 1 involved_in ISO (PMID:2022183), (PMID:8617200) UniProt PMID:2022183 PMID:8617200 NCBI chr2A:32,956,937...33,409,286
Ensembl chr2A:33,667,191...34,120,602
JBrowse link
G NRROS negative regulator of reactive oxygen species involved_in ISO (MGI:6192878|PMID:29909984) UniProt PMID:29909984 MGI:6192878 NCBI chr 3:193,984,797...194,007,173
Ensembl chr 3:203,920,334...203,948,506
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12658
    localization 5016
      maintenance of location 300
        maintenance of protein location 85
          maintenance of protein location in extracellular region 6
            sequestering of TGFbeta in extracellular matrix 4
Path 2
Term Annotations click to browse term
  biological_process 12658
    biological regulation 9214
      regulation of biological process 8708
        regulation of cellular process 8228
          signal transduction 3927
            cell surface receptor signaling pathway 2106
              enzyme linked receptor protein signaling pathway 825
                transmembrane receptor protein serine/threonine kinase signaling pathway 342
                  transforming growth factor beta receptor signaling pathway 180
                    regulation of transforming growth factor beta receptor signaling pathway 122
                      negative regulation of transforming growth factor beta receptor signaling pathway 76
                        sequestering of TGFbeta in extracellular matrix 4
paths to the root