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ONTOLOGY REPORT - ANNOTATIONS


Term:sequestering of TGFbeta in extracellular matrix
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Accession:GO:0035583 term browser browse the term
Definition:Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins.
Synonyms:exact_synonym: negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta;   negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta;   sequestering of TGFbeta LLC in extracellular matrix;   sequestering of TGFbeta large latency complex in extracellular matrix



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sequestering of TGFbeta in extracellular matrix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbn1 fibrillin 1 involved_in ISO (MGI:4836762|PMID:20855508) RGD PMID:20855508 MGI:4836762 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fbn2 fibrillin 2 involved_in ISO (MGI:4836762|PMID:20855508) RGD PMID:20855508 MGI:4836762 NCBI chr18:51,499,737...51,703,976
Ensembl chr18:51,499,737...51,703,976
JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 involved_in ISO
ISS
(PMID:2022183), (PMID:8617200)
GO_REF:0000024
RGD
UniProt
PMID:2022183 PMID:8617200 GO_REF:0000024 NCBI chr 6:20,029,629...20,425,339
Ensembl chr 6:20,029,629...20,425,349
JBrowse link
G Nrros negative regulator of reactive oxygen species involved_in ISS
ISO
GO_REF:0000024
(MGI:6192878|PMID:29909984)
UniProt
RGD
PMID:29909984 GO_REF:0000024 MGI:6192878 NCBI chr11:68,628,641...68,646,152
Ensembl chr11:68,628,712...68,646,142
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    localization 6437
      maintenance of location 364
        maintenance of protein location 104
          maintenance of protein location in extracellular region 7
            sequestering of TGFbeta in extracellular matrix 4
Path 2
Term Annotations click to browse term
  biological_process 19390
    biological regulation 13476
      regulation of biological process 12735
        regulation of cellular process 12196
          signal transduction 6859
            cell surface receptor signaling pathway 2772
              enzyme linked receptor protein signaling pathway 978
                transmembrane receptor protein serine/threonine kinase signaling pathway 391
                  transforming growth factor beta receptor signaling pathway 193
                    regulation of transforming growth factor beta receptor signaling pathway 127
                      negative regulation of transforming growth factor beta receptor signaling pathway 79
                        sequestering of TGFbeta in extracellular matrix 4
paths to the root