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ONTOLOGY REPORT - ANNOTATIONS

Term:sequestering of BMP in extracellular matrix
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Accession:GO:0035582 term browser browse the term
Definition:Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.
Comment:Confining BMP in the extracellular matrix may be achieved by binding BMP directly, or by binding to members of a BMP-containing complex.
Synonyms:exact_synonym: BMP sequestration in the ECM;   negative regulation of BMP signaling pathway by extracellular sequestering of BMP;   negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP;   negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein


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sequestering of BMP in extracellular matrix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cer1 cerberus 1, DAN family BMP antagonist involved_in ISO
IEA 		(PMID:9660951)
(PMID:10748465)
GO_REF:0000107 		RGD
Ensembl		 PMID:9660951 PMID:10748465 GO_REF:0000107 NCBI chr 5:97,306,427...97,309,783
Ensembl chr 5:97,306,431...97,309,783 		JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:23,330,917...23,340,486
Ensembl chr19:23,334,164...23,339,589 		JBrowse link
G Fbn1 fibrillin 1 involved_in ISO
IEA 		(PMID:20855508)
GO_REF:0000107 		RGD
Ensembl		 PMID:20855508 GO_REF:0000107 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889 		JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist involved_in ISO
IEA 		(PMID:9660951)
GO_REF:0000107 		RGD
Ensembl		 PMID:9660951 GO_REF:0000107 NCBI chr 5:151,318,752...151,329,948
Ensembl chr 5:151,318,754...151,338,719 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    negative regulation of biological process 5844
      negative regulation of response to stimulus 1947
        negative regulation of cellular response to growth factor stimulus 139
          negative regulation of BMP signaling pathway 72
            sequestering of BMP in extracellular matrix 4
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        regulation of cellular process 13032
          signal transduction 7313
            cell surface receptor signaling pathway 2915
              enzyme-linked receptor protein signaling pathway 1073
                cell surface receptor protein serine/threonine kinase signaling pathway 433
                  transforming growth factor beta receptor superfamily signaling pathway 396
                    BMP signaling pathway 181
                      regulation of BMP signaling pathway 121
                        negative regulation of BMP signaling pathway 72
                          sequestering of BMP in extracellular matrix 4
paths to the root