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ONTOLOGY REPORT - ANNOTATIONS


Term:sequestering of BMP in extracellular matrix
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Accession:GO:0035582 term browser browse the term
Definition:Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.
Comment:Confining BMP in the extracellular matrix may be achieved by binding BMP directly, or by binding to members of a BMP-containing complex.
Synonyms:exact_synonym: BMP sequestration in the ECM;   negative regulation of BMP signaling pathway by extracellular sequestering of BMP;   negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP;   negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein


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sequestering of BMP in extracellular matrix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CER1 cerberus 1, DAN family BMP antagonist involved_in ISO (PMID:9660951)
(MGI:1858315|PMID:10748465)
BHF-UCL PMID:9660951 PMID:10748465 MGI:1858315 NCBI chr 9:14,552,062...14,559,632
Ensembl chr 9:15,063,766...15,066,776
JBrowse link
G FBN1 fibrillin 1 involved_in ISO (MGI:4836762|PMID:20855508) BHF-UCL PMID:20855508 MGI:4836762 NCBI chr15:27,358,780...27,593,539
Ensembl chr15:45,682,450...45,918,111
JBrowse link
G NBL1 NBL1, DAN family BMP antagonist involved_in ISO (MGI:1203284|PMID:9660951) BHF-UCL PMID:9660951 MGI:1203284 NCBI chr 1:18,599,121...18,613,305
Ensembl chr 1:19,641,279...19,656,431
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12650
    cellular process 11785
      negative regulation of cellular process 4422
        negative regulation of cellular response to growth factor stimulus 95
          negative regulation of BMP signaling pathway 51
            sequestering of BMP in extracellular matrix 3
Path 2
Term Annotations click to browse term
  biological_process 12650
    biological regulation 9216
      regulation of biological process 8710
        regulation of cellular process 8237
          signal transduction 3925
            cell surface receptor signaling pathway 2101
              enzyme linked receptor protein signaling pathway 825
                transmembrane receptor protein serine/threonine kinase signaling pathway 342
                  BMP signaling pathway 139
                    regulation of BMP signaling pathway 94
                      negative regulation of BMP signaling pathway 51
                        sequestering of BMP in extracellular matrix 3
paths to the root