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ONTOLOGY REPORT - ANNOTATIONS


Term:sequestering of BMP in extracellular matrix
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Accession:GO:0035582 term browser browse the term
Definition:Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.
Comment:Confining BMP in the extracellular matrix may be achieved by binding BMP directly, or by binding to members of a BMP-containing complex.
Synonyms:exact_synonym: BMP sequestration in the ECM;   negative regulation of BMP signaling pathway by extracellular sequestering of BMP;   negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP;   negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein


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sequestering of BMP in extracellular matrix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cer1 cerberus 1, DAN family BMP antagonist involved_in ISO
IBA
(PMID:9660951)
(MGI:1858315|PMID:10748465)
PMID:21873635
RGD PMID:9660951 PMID:10748465 PMID:21873635 MGI:1858315, RGD:13792537 NCBI chr 5:97,306,427...97,309,783
Ensembl chr 5:97,306,431...97,309,783
JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:23,330,917...23,340,486
Ensembl chr19:23,334,164...23,339,589
JBrowse link
G Fbn1 fibrillin 1 involved_in ISO (MGI:4836762|PMID:20855508) RGD PMID:20855508 MGI:4836762 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist involved_in IEA
ISO
GO_REF:0000107
(MGI:1203284|PMID:9660951)
Ensembl
RGD
PMID:9660951 GO_REF:0000107 MGI:1203284 NCBI chr 5:151,318,752...151,329,948
Ensembl chr 5:151,318,754...151,338,719
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18340
      negative regulation of cellular process 5060
        negative regulation of cellular response to growth factor stimulus 104
          negative regulation of BMP signaling pathway 56
            sequestering of BMP in extracellular matrix 4
Path 2
Term Annotations click to browse term
  biological_process 19492
    biological regulation 13513
      regulation of biological process 12769
        regulation of cellular process 12228
          signal transduction 6882
            cell surface receptor signaling pathway 2779
              enzyme linked receptor protein signaling pathway 978
                transmembrane receptor protein serine/threonine kinase signaling pathway 391
                  BMP signaling pathway 172
                    regulation of BMP signaling pathway 102
                      negative regulation of BMP signaling pathway 56
                        sequestering of BMP in extracellular matrix 4
paths to the root