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ONTOLOGY REPORT - ANNOTATIONS

Term:sequestering of extracellular ligand from receptor
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Accession:GO:0035581 term browser browse the term
Definition:The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor.
Comment:Preventing a ligand from binding to its cell surface receptor be achieved by binding to the ligand directly, or by binding to members of a ligand-containing complex.
Synonyms:exact_synonym: extracellular sequestering of receptor ligand
 related_synonym: negative regulation of protein bioavailability


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sequestering of extracellular ligand from receptor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:23086448) RGD PMID:23086448 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
sequestering of BMP from receptor via BMP binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grem1 gremlin 1, DAN family BMP antagonist involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082 		JBrowse link
G Grem2 gremlin 2, DAN family BMP antagonist involved_in ISO
IBA		 (MGI:5507937|PMID:23063586)
GO_REF:0000033		 RGD
GO_Central		 PMID:23063586 GO_REF:0000033 MGI:5507937 NCBI chr13:86,778,543...86,871,509
Ensembl chr13:86,778,500...86,871,615 		JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist involved_in ISO
IEA
IBA		 (PMID:23063586)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000118		 RGD
Ensembl
GO_Central
TreeGrafter		 PMID:23063586 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:151,318,752...151,329,948
Ensembl chr 5:151,318,754...151,338,719 		JBrowse link
sequestering of BMP in extracellular matrix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cer1 cerberus 1, DAN family BMP antagonist involved_in ISO
IBA		 (PMID:9660951)
GO_REF:0000033
(MGI:1858315|PMID:10748465)		 RGD
GO_Central		 PMID:9660951 PMID:10748465 GO_REF:0000033 MGI:1858315 NCBI chr 5:97,306,427...97,309,783
Ensembl chr 5:97,306,431...97,309,783 		JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:23,330,917...23,340,486
Ensembl chr19:23,334,164...23,339,589 		JBrowse link
G Fbn1 fibrillin 1 involved_in ISO (MGI:4836762|PMID:20855508) RGD PMID:20855508 MGI:4836762 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889 		JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist involved_in ISO (MGI:1203284|PMID:9660951) RGD PMID:9660951 MGI:1203284 NCBI chr 5:151,318,752...151,329,948
Ensembl chr 5:151,318,754...151,338,719 		JBrowse link
sequestering of nodal from receptor via nodal binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dand5 DAN domain BMP antagonist family member 5 involved_in ISO (MGI:3055649|PMID:15466485) RGD PMID:15466485 MGI:3055649 NCBI chr19:23,330,917...23,340,486
Ensembl chr19:23,334,164...23,339,589 		JBrowse link
sequestering of TGFbeta in extracellular matrix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbn1 fibrillin 1 involved_in ISO (MGI:4836762|PMID:20855508) RGD PMID:20855508 MGI:4836762 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889 		JBrowse link
G Fbn2 fibrillin 2 involved_in ISO (MGI:4836762|PMID:20855508) RGD PMID:20855508 MGI:4836762 NCBI chr18:51,499,670...51,703,976
Ensembl chr18:51,499,737...51,703,976 		JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 involved_in ISO
IEA
ISS		 (PMID:2022183), (PMID:8617200)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:2022183 PMID:8617200 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:20,029,629...20,425,339
Ensembl chr 6:20,029,629...20,425,349 		JBrowse link
G Nrros negative regulator of reactive oxygen species involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:6192878|PMID:29909984)		 UniProt
Ensembl
RGD		 PMID:29909984 GO_REF:0000024 GO_REF:0000107 MGI:6192878 NCBI chr11:68,628,641...68,646,152
Ensembl chr11:68,628,712...68,646,142 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    cellular process 18812
      signal transduction 7209
        negative regulation of signal transduction 1466
          extracellular negative regulation of signal transduction 11
            sequestering of extracellular ligand from receptor 10
              sequestering of BMP from receptor via BMP binding 3
              sequestering of BMP in extracellular matrix 4
              sequestering of TGFbeta from receptor via TGFbeta binding 0
              sequestering of TGFbeta in extracellular matrix 4
              sequestering of nodal from receptor via nodal binding 1
Path 2
Term Annotations click to browse term
  biological_process 20413
    biological regulation 13755
      regulation of biological process 13322
        signaling 7775
          signal transduction 7209
            regulation of signal transduction 3220
              extracellular regulation of signal transduction 11
                extracellular negative regulation of signal transduction 11
                  sequestering of extracellular ligand from receptor 10
                    sequestering of BMP from receptor via BMP binding 3
                    sequestering of BMP in extracellular matrix 4
                    sequestering of TGFbeta from receptor via TGFbeta binding 0
                    sequestering of TGFbeta in extracellular matrix 4
                    sequestering of nodal from receptor via nodal binding 1
paths to the root