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ONTOLOGY REPORT - ANNOTATIONS


Term:sequestering of extracellular ligand from receptor
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Accession:GO:0035581 term browser browse the term
Definition:The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor.
Comment:Preventing a ligand from binding to its cell surface receptor be achieved by binding to the ligand directly, or by binding to members of a ligand-containing complex.
Synonyms:exact_synonym: extracellular sequestering of receptor ligand
 related_synonym: negative regulation of protein bioavailability


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sequestering of extracellular ligand from receptor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD46 CD46 molecule involved_in ISO (PMID:23086448) UniProt PMID:23086448 NCBI chr 1:183,330,423...183,373,916
Ensembl chr 1:188,031,758...188,182,046
JBrowse link
sequestering of BMP from receptor via BMP binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GREM2 gremlin 2, DAN family BMP antagonist involved_in ISO (MGI:5507937|PMID:23063586) UniProt PMID:23063586 MGI:5507937 NCBI chr 1:216,037,977...216,163,020
Ensembl chr 1:221,026,605...221,027,111
JBrowse link
G NBL1 NBL1, DAN family BMP antagonist involved_in ISO (PMID:23063586) UniProt PMID:23063586 NCBI chr 1:18,599,121...18,613,305
Ensembl chr 1:19,641,279...19,656,431
JBrowse link
sequestering of BMP in extracellular matrix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CER1 cerberus 1, DAN family BMP antagonist involved_in ISO (PMID:9660951)
(MGI:1858315|PMID:10748465)
BHF-UCL PMID:9660951 PMID:10748465 MGI:1858315 NCBI chr 9:14,552,062...14,559,632
Ensembl chr 9:15,063,766...15,066,776
JBrowse link
G FBN1 fibrillin 1 involved_in ISO (MGI:4836762|PMID:20855508) BHF-UCL PMID:20855508 MGI:4836762 NCBI chr15:27,358,780...27,593,539
Ensembl chr15:45,682,450...45,918,111
JBrowse link
G NBL1 NBL1, DAN family BMP antagonist involved_in ISO (MGI:1203284|PMID:9660951) BHF-UCL PMID:9660951 MGI:1203284 NCBI chr 1:18,599,121...18,613,305
Ensembl chr 1:19,641,279...19,656,431
JBrowse link
sequestering of nodal from receptor via nodal binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAND5 DAN domain BMP antagonist family member 5 involved_in ISO (MGI:3055649|PMID:15466485) BHF-UCL PMID:15466485 MGI:3055649 NCBI chr19:12,529,830...12,536,052 JBrowse link
sequestering of TGFbeta in extracellular matrix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBN1 fibrillin 1 involved_in ISO (MGI:4836762|PMID:20855508) BHF-UCL PMID:20855508 MGI:4836762 NCBI chr15:27,358,780...27,593,539
Ensembl chr15:45,682,450...45,918,111
JBrowse link
G FBN2 fibrillin 2 involved_in ISO (MGI:4836762|PMID:20855508) BHF-UCL PMID:20855508 MGI:4836762 NCBI chr 5:123,673,209...123,953,741
Ensembl chr 5:129,435,248...129,715,711
JBrowse link
G LTBP1 latent transforming growth factor beta binding protein 1 involved_in ISO (PMID:2022183), (PMID:8617200) UniProt PMID:2022183 PMID:8617200 NCBI chr2A:32,956,937...33,409,286
Ensembl chr2A:33,667,191...34,120,602
JBrowse link
G NRROS negative regulator of reactive oxygen species involved_in ISO (MGI:6192878|PMID:29909984) UniProt PMID:29909984 MGI:6192878 NCBI chr 3:193,984,797...194,007,173
Ensembl chr 3:203,920,334...203,948,506
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12650
    cellular process 11785
      signal transduction 3925
        negative regulation of signal transduction 1183
          extracellular negative regulation of signal transduction 10
            sequestering of extracellular ligand from receptor 9
              sequestering of BMP from receptor via BMP binding 2
              sequestering of BMP in extracellular matrix 3
              sequestering of TGFbeta from receptor via TGFbeta binding 0
              sequestering of TGFbeta in extracellular matrix 4
              sequestering of nodal from receptor via nodal binding 1
Path 2
Term Annotations click to browse term
  biological_process 12650
    biological regulation 9216
      regulation of biological process 8710
        regulation of cellular process 8237
          signal transduction 3925
            regulation of signal transduction 2618
              extracellular regulation of signal transduction 10
                extracellular negative regulation of signal transduction 10
                  sequestering of extracellular ligand from receptor 9
                    sequestering of BMP from receptor via BMP binding 2
                    sequestering of BMP in extracellular matrix 3
                    sequestering of TGFbeta from receptor via TGFbeta binding 0
                    sequestering of TGFbeta in extracellular matrix 4
                    sequestering of nodal from receptor via nodal binding 1
paths to the root