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ONTOLOGY REPORT - ANNOTATIONS


Term:intracellular signal transduction
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Accession:GO:0035556 term browser browse the term
Definition:The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
Synonyms:exact_synonym: intracellular signaling chain
 narrow_synonym: intracellular protein kinase cascade;   intracellular signal transduction pathway;   protein kinase cascade;   signal transmission via intracellular cascade
 related_synonym: intracellular signaling cascade;   intracellular signaling pathway;   signal transduction via intracellular signaling cascade
 alt_id: GO:0007242;   GO:0007243;   GO:0023013;   GO:0023034


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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 130258
    signaling 46546
      signal transduction 42136
        intracellular signal transduction 18985
          I-kappaB kinase/NF-kappaB signaling + 2080
          MAPK cascade + 6387
          NIK/NF-kappaB signaling + 1024
          PKR-mediated signaling 0
          RAM/MOR signaling pathway 0
          TOR signaling + 974
          TRAF-mediated signal transduction 8
          cytoplasmic pattern recognition receptor signaling pathway + 395
          endosomal signal transduction 0
          hippo signaling + 272
          inositol lipid-mediated signaling + 1309
          intracellular signal transduction involved in positive regulation of cell growth 0
          intrinsic apoptotic signaling pathway + 2375
          negative regulation of intracellular signal transduction + 4193
          phosphorelay signal transduction system + 1
          positive regulation of intracellular signal transduction + 8085
          protein kinase A signaling + 298
          protein kinase B signaling + 1639
          protein kinase C signaling + 306
          protein kinase D signaling + 29
          regulation of intracellular signal transduction + 12947
          second-messenger-mediated signaling + 3441
          signal transduction by p53 class mediator + 1252
          signal transduction downstream of smoothened + 32
          signal transduction in response to DNA damage + 786
          signal transduction involved in cell cycle checkpoint + 290
          signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle 0
          small GTPase mediated signal transduction + 3057
          stress-activated protein kinase signaling cascade + 2203
Path 2
Term Annotations click to browse term
  biological_process 130258
    biological regulation 89360
      regulation of biological process 84937
        regulation of cellular process 81044
          signal transduction 42136
            intracellular signal transduction 18985
              I-kappaB kinase/NF-kappaB signaling + 2080
              MAPK cascade + 6387
              NIK/NF-kappaB signaling + 1024
              PKR-mediated signaling 0
              RAM/MOR signaling pathway 0
              TOR signaling + 974
              TRAF-mediated signal transduction 8
              cytoplasmic pattern recognition receptor signaling pathway + 395
              endosomal signal transduction 0
              hippo signaling + 272
              inositol lipid-mediated signaling + 1309
              intracellular signal transduction involved in positive regulation of cell growth 0
              intrinsic apoptotic signaling pathway + 2375
              negative regulation of intracellular signal transduction + 4193
              phosphorelay signal transduction system + 1
              positive regulation of intracellular signal transduction + 8085
              protein kinase A signaling + 298
              protein kinase B signaling + 1639
              protein kinase C signaling + 306
              protein kinase D signaling + 29
              regulation of intracellular signal transduction + 12947
              second-messenger-mediated signaling + 3441
              signal transduction by p53 class mediator + 1252
              signal transduction downstream of smoothened + 32
              signal transduction in response to DNA damage + 786
              signal transduction involved in cell cycle checkpoint + 290
              signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle 0
              small GTPase mediated signal transduction + 3057
              stress-activated protein kinase signaling cascade + 2203
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.