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ONTOLOGY REPORT - ANNOTATIONS

Term:broad specificity oxidative DNA demethylase activity
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Accession:GO:0035516 term browser browse the term
Definition:Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA.
Comment:This reaction directly reverses the alkylation on a nucleotide within DNA. Do not confuse with 5-methylcytosine dioxygenase activity ; GO:0070579, which removes the methyl group from position 5 of cytosine in DNA via oxidation of the 5-methylcytosine, followed by removal of the oxidated base by the base excision repair system.
Synonyms:exact_synonym: 2-oxoglutarate-dependent DNA demethylase
 narrow_synonym: 1-ethyladenine demethylase activity;   5-formylcytosine dioxygenase activity;   5-hydroxymethylcytosine dioxygenase activity;   5fC dioxygenase;   5hmC dioxygenase;   N1-methyladenine demethylase activity;   N3-methylcytosine demethylase activity
 broad_synonym: oxidative DNA demethylase activity
 alt_id: GO:0103051;   GO:0103052;   GO:0103053
 xref: EC:1.14.11.33;   MetaCyc:RXN-12353;   RHEA:30299;   Reactome:R-HSA-112118 "Oxidative demethylation of 1-meA damaged DNA by ALKBH2";   Reactome:R-HSA-112123 "Oxidative demethylation of 1-meA damaged DNA By ALKBH3"


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broad specificity oxidative DNA demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh1 alkB homolog 1, histone H2A dioxygenase enables ISO
IBA		 (PMID:18603530), (PMID:30017583), (PMID:30392959)
GO_REF:0000033
(PMID:27027282)		 RGD
GO_Central		 PMID:18603530 PMID:27027282 PMID:30017583 PMID:30392959 GO_REF:0000033 NCBI chr 6:107,068,301...107,088,784
Ensembl chr 6:107,068,475...107,088,759 		JBrowse link
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase enables ISO
IBA		 (PMID:12486230), (PMID:16174769), (PMID:18432238), (PMID:20714506)
GO_REF:0000033
(PMID:16174769), (PMID:18519673)		 RGD
GO_Central		 PMID:12486230 PMID:16174769 PMID:18432238 PMID:18519673 PMID:20714506 GO_REF:0000033 NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914 		JBrowse link
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase enables ISS
ISO		 GO_REF:0000024
(PMID:12486230), (PMID:16174769), (PMID:16858410), (PMID:20714506), (PMID:22055184)
(PMID:16174769)		 UniProt
RGD		 PMID:12486230 PMID:16174769 PMID:16858410 PMID:20714506 PMID:22055184 GO_REF:0000024 NCBI chr 3:79,939,515...79,972,820
Ensembl chr 3:79,939,600...79,972,000 		JBrowse link
G Alkbh4 alkB homolog 4, lysine demethylase enables ISO (PMID:30982744) RGD PMID:30982744 NCBI chr12:20,524,030...20,529,947
Ensembl chr12:20,524,030...20,529,947 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase enables ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:18775698), (PMID:20376003)
GO_REF:0000107
GO_REF:0000033		 UniProt
RGD
Ensembl
GO_Central		 PMID:18775698 PMID:20376003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      demethylase activity 42
        DNA demethylase activity 5
          broad specificity oxidative DNA demethylase activity 5
Path 2
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 238
          2-oxoglutarate-dependent dioxygenase activity 63
            broad specificity oxidative DNA demethylase activity 5
paths to the root