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ONTOLOGY REPORT - ANNOTATIONS

Term:oxidative RNA demethylase activity
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Accession:GO:0035515 term browser browse the term
Definition:Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
Synonyms:exact_synonym: 2-oxoglutarate-dependent RNA demethylase
 xref: reactome:R-HSA-8857692 "RNA demethylases demethylate N6-methyladenosine RNA"


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oxidative RNA demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh1 alkB homolog 1, histone H2A dioxygenase enables IBA
ISO		 GO_REF:0000033
(PMID:18603530), (PMID:31188562)		 GO_Central
RGD		 PMID:18603530 PMID:31188562 GO_REF:0000033 NCBI chr 6:107,068,301...107,088,784
Ensembl chr 6:107,068,475...107,088,759 		JBrowse link
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase enables ISO (PMID:16174769)
(MGI:3611146|PMID:16174769)		 RGD PMID:16174769 MGI:3611146 NCBI chr 3:79,939,515...79,972,820
Ensembl chr 3:79,939,600...79,972,000 		JBrowse link
G Alkbh5 alkB homolog 5, RNA demethylase enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:45,344,888...45,366,331
Ensembl chr10:45,343,395...45,366,331 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase enables ISS
ISO		 GO_REF:0000024
(MGI:3817348|PMID:18775698)
(PMID:18775698), (PMID:22002720), (PMID:28002401), (PMID:30197295)		 UniProt
RGD		 PMID:18775698 PMID:22002720 PMID:28002401 PMID:30197295 GO_REF:0000024 MGI:3817348 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:24360279)		 UniProt
Ensembl
RGD		 PMID:24360279 GO_REF:0000024 GO_REF:0000107 NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182 		JBrowse link
mRNA N1-methyladenosine dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase enables ISS
ISO		 GO_REF:0000024
(PMID:26863196), (PMID:26863410)		 UniProt
RGD		 PMID:26863196 PMID:26863410 GO_REF:0000024 NCBI chr 3:79,939,515...79,972,820
Ensembl chr 3:79,939,600...79,972,000 		JBrowse link
mRNA N6-methyladenosine dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh5 alkB homolog 5, RNA demethylase enables ISS
ISO		 GO_REF:0000024
(MGI:6111276|PMID:29279410), (MGI:7437433|PMID:35939687), (MGI:7441422|PMID:36859428)
(PMID:23177736), (PMID:24616105), (PMID:34048572), (PMID:35333330), (PMID:36944332), (PMID:37257451), (PMID:37369679), (PMID:37474102)		 UniProt
RGD		 PMID:23177736 PMID:24616105 PMID:29279410 PMID:34048572 PMID:35333330 More... GO_REF:0000024 MGI:6111276 MGI:7437433 MGI:7441422 NCBI chr10:45,344,888...45,366,331
Ensembl chr10:45,343,395...45,366,331 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase enables ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000003
(PMID:25452335), (PMID:26457839), (PMID:26458103), (PMID:30197295)		 UniProt
GO_Central
RGD		 PMID:25452335 PMID:26457839 PMID:26458103 PMID:30197295 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
tRNA demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh1 alkB homolog 1, histone H2A dioxygenase enables ISO (PMID:27745969) RGD PMID:27745969 NCBI chr 6:107,068,301...107,088,784
Ensembl chr 6:107,068,475...107,088,759 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase enables ISO
ISS
IEA		 (PMID:30197295)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:30197295 GO_REF:0000024 GO_REF:0000107 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20733
    catalytic activity 6109
      demethylase activity 42
        oxidative RNA demethylase activity 5
          mRNA N1-methyladenosine dioxygenase activity 1
          mRNA N6-methyladenosine dioxygenase activity 2
          tRNA demethylase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 20733
    catalytic activity 6109
      oxidoreductase activity 859
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 241
          2-oxoglutarate-dependent dioxygenase activity 63
            oxidative RNA demethylase activity 5
              mRNA N1-methyladenosine dioxygenase activity 1
              mRNA N6-methyladenosine dioxygenase activity 2
              tRNA demethylase activity 2
paths to the root