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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:Roundabout signaling pathway
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Accession:GO:0035385 term browser browse the term
Definition:The series of molecular signals initiated by a SLIT protein binding to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: ROBO signaling pathway;   ROBO/SLIT signaling pathway;   Roundabout signalling pathway


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Roundabout signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir218-2 microRNA 218-2 acts_upstream_of_or_within ISO (PMID:20947829) RGD PMID:20947829 NCBI chr10:20,068,451...20,068,560
Ensembl chr10:20,068,451...20,068,560 		JBrowse link
G Myo9b myosin IXb involved_in ISO
ISS
IEA		 (PMID:26529257)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:26529257 GO_REF:0000024 GO_REF:0000107 NCBI chr16:17,945,379...18,030,114
Ensembl chr16:17,945,448...18,030,126 		JBrowse link
G Rhoa ras homolog family member A involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:26529257)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:26529257 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Robo1 roundabout guidance receptor 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:18829537), (PMID:26529257)
GO_REF:0000002		 UniProt
RGD
InterPro		 PMID:18829537 PMID:26529257 GO_REF:0000002 GO_REF:0000024 NCBI chr11:10,580,863...11,621,675
Ensembl chr11:10,580,908...11,620,203 		JBrowse link
G Slit2 slit guidance ligand 2 involved_in ISO
IEA		 (PMID:18829537)
GO_REF:0000107		 RGD
Ensembl		 PMID:18829537 GO_REF:0000107 NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948 		JBrowse link
G Slit3 slit guidance ligand 3 involved_in ISO
IEA		 (PMID:18829537)
GO_REF:0000107		 RGD
Ensembl		 PMID:18829537 GO_REF:0000107 NCBI chr10:19,571,798...20,156,634
Ensembl chr10:19,571,684...20,156,634 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    cellular process 18812
      signal transduction 7209
        cell surface receptor signaling pathway 2886
          Roundabout signaling pathway 6
            Roundabout signaling pathway involved in axon guidance 0
            Roundabout signaling pathway involved in muscle cell chemotaxis toward tendon cell 0
            negative regulation of Roundabout signaling pathway + 0
            positive regulation of Roundabout signaling pathway 0
            regulation of Roundabout signaling pathway + 0
            termination of Roundabout signal transduction 0
Path 2
Term Annotations click to browse term
  biological_process 20413
    biological regulation 13755
      regulation of biological process 13322
        signaling 7775
          signal transduction 7209
            cell surface receptor signaling pathway 2886
              Roundabout signaling pathway 6
                Roundabout signaling pathway involved in axon guidance 0
                Roundabout signaling pathway involved in muscle cell chemotaxis toward tendon cell 0
                negative regulation of Roundabout signaling pathway + 0
                positive regulation of Roundabout signaling pathway 0
                regulation of Roundabout signaling pathway + 0
                termination of Roundabout signal transduction 0
paths to the root