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ONTOLOGY REPORT - ANNOTATIONS

Term:thioester biosynthetic process
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Accession:GO:0035384 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol.
Synonyms:exact_synonym: thioester anabolism;   thioester biosynthesis;   thioester formation;   thioester synthesis


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acetyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAT1 acetyl-CoA acetyltransferase 1 involved_in IDA (PMID:17371050) BHF-UCL PMID:17371050 NCBI chr11:108,116,705...108,147,603
Ensembl chr11:108,116,695...108,148,957 		JBrowse link
G ACLY ATP citrate lyase involved_in IDA
IBA
IEA		 (PMID:1371749) BHF-UCL
GO_Central
InterPro		 PMID:1371749 GO_REF:0000002 GO_REF:0000033 NCBI chr17:41,866,917...41,930,545
Ensembl chr17:41,866,917...41,930,542 		JBrowse link
G ACSS1 acyl-CoA synthetase short chain family member 1 involved_in
acts_upstream_of_or_within		 IDA
ISO
IBA
IEA		 (PMID:16788062)
(PMID:11150295)		 UniProt
MGI
GO_Central
Ensembl		 PMID:11150295 PMID:16788062 GO_REF:0000033 GO_REF:0000107 NCBI chr20:25,006,237...25,058,139
Ensembl chr20:25,006,230...25,058,980 		JBrowse link
G ACSS2 acyl-CoA synthetase short chain family member 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:11150295) GO_Central
MGI		 PMID:11150295 GO_REF:0000033 NCBI chr20:34,874,989...34,927,959
Ensembl chr20:34,872,146...34,927,962 		JBrowse link
G DIP2A disco interacting protein 2 homolog A involved_in ISS UniProt GO_REF:0000024 NCBI chr21:46,458,891...46,583,871
Ensembl chr21:46,458,891...46,572,743 		JBrowse link
G MLYCD malonyl-CoA decarboxylase involved_in ISO
IBA
IDA
IEA		 (PMID:10417274), (PMID:10455107), (PMID:9869665) RGD
GO_Central
UniProt
Ensembl		 PMID:9869665 PMID:10417274 PMID:10455107 PMID:17316539 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 RGD:1600790 NCBI chr16:83,899,115...83,927,031
Ensembl chr16:83,899,115...83,951,445 		JBrowse link
G PPCS phosphopantothenoylcysteine synthetase involved_in IMP (PMID:29754768) UniProt PMID:29754768 NCBI chr 1:42,456,341...42,473,417
Ensembl chr 1:42,456,117...42,473,385 		JBrowse link
acetyl-CoA biosynthetic process from acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACSS1 acyl-CoA synthetase short chain family member 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr20:25,006,237...25,058,139
Ensembl chr20:25,006,230...25,058,980 		JBrowse link
G ACSS2 acyl-CoA synthetase short chain family member 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr20:34,874,989...34,927,959
Ensembl chr20:34,872,146...34,927,962 		JBrowse link
acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DLAT dihydrolipoamide S-acetyltransferase involved_in ISO
TAS
IBA
IEA
ISS
IDA		 (PMID:24534072) RGD
Reactome
GO_Central
Ensembl
ComplexPortal
InterPro		 PMID:7487891 PMID:24534072 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000114 RGD:1599112 Reactome:R-HSA-9861559 NCBI chr11:112,025,408...112,064,404
Ensembl chr11:112,025,033...112,064,404 		JBrowse link
G DLD dihydrolipoamide dehydrogenase involved_in
acts_upstream_of_or_within		 ISO
IEA
ISS
IC
IDA		 (PMID:9242632)
(PMID:24534072)		 RGD
Ensembl
ComplexPortal
MGI		 PMID:7487891 PMID:9242632 PMID:24534072 GO_REF:0000107 GO_REF:0000114 RGD:1599112 NCBI chr 7:107,891,107...107,921,198
Ensembl chr 7:107,891,162...107,931,730 		JBrowse link
G MPC1 mitochondrial pyruvate carrier 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:22628558) MGI PMID:22628558 NCBI chr 6:166,364,919...166,382,940
Ensembl chr 6:166,364,919...166,383,013 		JBrowse link
G MPC2 mitochondrial pyruvate carrier 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24910426)
(PMID:22628558)		 Ensembl
MGI		 PMID:22628558 PMID:24910426 GO_REF:0000107 NCBI chr 1:167,916,675...167,937,072
Ensembl chr 1:167,916,675...167,937,072 		JBrowse link
G PDHA1 pyruvate dehydrogenase E1 subunit alpha 1 acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA
IDA		 (PMID:18586888)
(PMID:19081061), (PMID:24534072)		 RGD
MGI
GO_Central
Ensembl
InterPro
UniProt		 PMID:7487891 PMID:18586888 PMID:19081061 PMID:24534072 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:1599112 NCBI chr  X:19,343,927...19,361,718
Ensembl chr  X:19,343,893...19,361,718 		JBrowse link
G PDHA2 pyruvate dehydrogenase E1 subunit alpha 2 acts_upstream_of_or_within
involved_in		 ISO
IC
IBA
ISS
IEA		 (PMID:16436377) RGD
MGI
GO_Central
ComplexPortal
InterPro		 PMID:7487891 PMID:16436377 GO_REF:0000002 GO_REF:0000033 GO_REF:0000114 RGD:1599112 NCBI chr 4:95,840,093...95,841,464
Ensembl chr 4:95,840,093...95,841,464 		JBrowse link
G PDHB pyruvate dehydrogenase E1 subunit beta involved_in
acts_upstream_of_or_within		 ISO
IBA
ISS
IC
IEA
IDA		 (PMID:18164639)
(PMID:19081061), (PMID:24534072)		 RGD
GO_Central
ComplexPortal
MGI
InterPro
UniProt		 PMID:7487891 PMID:18164639 PMID:19081061 PMID:24534072 GO_REF:0000002 GO_REF:0000033 GO_REF:0000114 RGD:1599112 NCBI chr 3:58,427,630...58,433,832
Ensembl chr 3:58,427,630...58,433,857 		JBrowse link
G PDHX pyruvate dehydrogenase complex component X involved_in
acts_upstream_of_or_within		 IDA
ISS
IC
IEA		 (PMID:24534072)
(PMID:9242632)		 ComplexPortal
MGI
InterPro		 PMID:9242632 PMID:24534072 GO_REF:0000002 GO_REF:0000114 NCBI chr11:34,915,920...34,996,128
Ensembl chr11:34,915,829...35,020,591 		JBrowse link
fatty-acyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACACA acetyl-CoA carboxylase alpha involved_in TAS Reactome Reactome:R-HSA-75105 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G CBR4 carbonyl reductase 4 involved_in TAS Reactome Reactome:R-HSA-75105 NCBI chr 4:168,894,486...169,010,255
Ensembl chr 4:168,863,770...169,010,275 		JBrowse link
G FASN fatty acid synthase involved_in TAS Reactome Reactome:R-HSA-75105 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G GCDH glutaryl-CoA dehydrogenase involved_in ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:6895440 GO_REF:0000033 GO_REF:0000107 RGD:1598697 NCBI chr19:12,891,129...12,899,999
Ensembl chr19:12,891,128...12,915,126 		JBrowse link
G HTD2 hydroxyacyl-thioester dehydratase type 2 involved_in TAS Reactome Reactome:R-HSA-75105 NCBI chr 3:58,306,245...58,320,193
Ensembl chr 3:58,306,262...58,320,193 		JBrowse link
G PPT1 palmitoyl-protein thioesterase 1 involved_in TAS Reactome Reactome:R-HSA-75105 NCBI chr 1:40,071,461...40,097,252
Ensembl chr 1:40,072,710...40,097,260 		JBrowse link
G PPT2 palmitoyl-protein thioesterase 2 involved_in TAS Reactome Reactome:R-HSA-75105 NCBI chr 6:32,153,528...32,163,675
Ensembl chr 6:32,153,441...32,163,678 		JBrowse link
G SLC27A2 solute carrier family 27 member 2 involved_in TAS Reactome Reactome:R-HSA-75105 NCBI chr15:50,182,196...50,236,385
Ensembl chr15:50,182,196...50,236,385 		JBrowse link
long-chain fatty-acyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACSBG1 acyl-CoA synthetase bubblegum family member 1 involved_in TAS Reactome Reactome:R-HSA-75876 NCBI chr15:78,167,468...78,234,565
Ensembl chr15:78,167,468...78,245,688 		JBrowse link
G ACSBG2 acyl-CoA synthetase bubblegum family member 2 involved_in TAS Reactome Reactome:R-HSA-75876 NCBI chr19:6,135,633...6,193,091
Ensembl chr19:6,135,247...6,193,094 		JBrowse link
G ACSF3 acyl-CoA synthetase family member 3 involved_in TAS Reactome Reactome:R-HSA-75876 NCBI chr16:89,093,852...89,156,233
Ensembl chr16:89,088,375...89,164,121 		JBrowse link
G ACSL1 acyl-CoA synthetase long chain family member 1 involved_in ISO
IBA
IEA
TAS		 RGD
GO_Central
Ensembl
Reactome		 PMID:16466685 GO_REF:0000033 GO_REF:0000107 RGD:2312800 Reactome:R-HSA-75876 NCBI chr 4:184,755,595...184,826,594
Ensembl chr 4:184,755,595...184,826,818 		JBrowse link
G ACSL3 acyl-CoA synthetase long chain family member 3 involved_in TAS Reactome Reactome:R-HSA-75876 NCBI chr 2:222,861,036...222,944,639
Ensembl chr 2:222,860,942...222,944,639 		JBrowse link
G ACSL4 acyl-CoA synthetase long chain family member 4 involved_in ISO
TAS		 RGD
Reactome		 PMID:16466685 RGD:2312800 Reactome:R-HSA-75876 NCBI chr  X:109,641,335...109,733,257
Ensembl chr  X:109,624,244...109,733,403 		JBrowse link
G ACSL5 acyl-CoA synthetase long chain family member 5 involved_in ISO
IBA
TAS		 RGD
GO_Central
Reactome		 PMID:16466685 GO_REF:0000033 RGD:2312800 Reactome:R-HSA-75876 NCBI chr10:112,374,116...112,428,376
Ensembl chr10:112,374,116...112,428,379 		JBrowse link
G ACSL6 acyl-CoA synthetase long chain family member 6 involved_in ISO
IBA
TAS		 RGD
GO_Central
Reactome		 PMID:16466685 GO_REF:0000033 RGD:2312800 Reactome:R-HSA-75876 NCBI chr 5:131,949,973...132,012,213
Ensembl chr 5:131,949,973...132,012,243 		JBrowse link
G ELOVL1 ELOVL fatty acid elongase 1 involved_in IEA
TAS		 UniProt
Reactome		 GO_REF:0000104 Reactome:R-HSA-75876 NCBI chr 1:43,363,401...43,368,011
Ensembl chr 1:43,363,398...43,368,074 		JBrowse link
G ELOVL2 ELOVL fatty acid elongase 2 involved_in TAS Reactome Reactome:R-HSA-75876 NCBI chr 6:10,980,759...11,044,305
Ensembl chr 6:10,980,759...11,044,305 		JBrowse link
G ELOVL3 ELOVL fatty acid elongase 3 involved_in TAS
IEA		 Reactome
UniProt		 GO_REF:0000104 Reactome:R-HSA-75876 NCBI chr10:102,224,767...102,229,589
Ensembl chr10:102,226,299...102,229,589 		JBrowse link
G ELOVL4 ELOVL fatty acid elongase 4 involved_in IEA UniProt GO_REF:0000104 NCBI chr 6:79,914,814...79,947,553
Ensembl chr 6:79,914,814...79,947,553 		JBrowse link
G ELOVL5 ELOVL fatty acid elongase 5 involved_in TAS
IEA		 Reactome
UniProt		 GO_REF:0000104 Reactome:R-HSA-75876 NCBI chr 6:53,267,404...53,348,950
Ensembl chr 6:53,267,398...53,349,179 		JBrowse link
G ELOVL6 ELOVL fatty acid elongase 6 involved_in IEA
TAS		 UniProt
Reactome		 GO_REF:0000104 Reactome:R-HSA-75876 NCBI chr 4:110,045,846...110,199,202
Ensembl chr 4:110,045,846...110,199,199 		JBrowse link
G ELOVL7 ELOVL fatty acid elongase 7 involved_in IEA
TAS		 UniProt
Reactome		 GO_REF:0000104 Reactome:R-HSA-75876 NCBI chr 5:60,751,791...60,844,269
Ensembl chr 5:60,751,791...60,844,274 		JBrowse link
G HACD1 3-hydroxyacyl-CoA dehydratase 1 involved_in TAS Reactome Reactome:R-HSA-75876 NCBI chr10:17,589,032...17,617,374
Ensembl chr10:17,589,032...17,617,374 		JBrowse link
G HACD2 3-hydroxyacyl-CoA dehydratase 2 involved_in TAS Reactome Reactome:R-HSA-75876 NCBI chr 3:123,491,554...123,585,053
Ensembl chr 3:123,490,820...123,585,053 		JBrowse link
G HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 involved_in TAS Reactome Reactome:R-HSA-75876 NCBI chr11:43,556,721...43,856,615
Ensembl chr11:43,680,680...43,856,617 		JBrowse link
G TECR trans-2,3-enoyl-CoA reductase involved_in TAS Reactome Reactome:R-HSA-75876 NCBI chr19:14,527,726...14,565,980
Ensembl chr19:14,517,085...14,565,980 		JBrowse link
malonyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACACA acetyl-CoA carboxylase alpha involved_in IEA UniProt GO_REF:0000041 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G ACACB acetyl-CoA carboxylase beta involved_in IEA UniProt
Ensembl		 GO_REF:0000041 GO_REF:0000107 NCBI chr12:109,111,189...109,268,226
Ensembl chr12:109,116,587...109,268,226 		JBrowse link
negative regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PGK1 phosphoglycerate kinase 1 involved_in IDA (PMID:26942675) UniProt PMID:26942675 NCBI chr  X:78,104,248...78,129,295
Ensembl chr  X:77,910,739...78,129,295 		JBrowse link
propionyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAT1 acetyl-CoA acetyltransferase 1 involved_in IDA (PMID:17371050) BHF-UCL PMID:17371050 NCBI chr11:108,116,705...108,147,603
Ensembl chr11:108,116,695...108,148,957 		JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCKDK branched chain keto acid dehydrogenase kinase involved_in IBA GO_Central GO_REF:0000033 NCBI chr16:31,108,386...31,117,640
Ensembl chr16:31,106,107...31,112,791 		JBrowse link
G PDK1 pyruvate dehydrogenase kinase 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:172,555,373...172,724,312
Ensembl chr 2:172,555,373...172,608,669 		JBrowse link
G PDK2 pyruvate dehydrogenase kinase 2 involved_in IEA
IBA
ISS		 Ensembl
GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr17:50,094,737...50,112,152
Ensembl chr17:50,094,737...50,112,152 		JBrowse link
G PDK3 pyruvate dehydrogenase kinase 3 involved_in IMP
IBA		 (PMID:22865452) UniProt
GO_Central		 PMID:22865452 GO_REF:0000033 NCBI chr  X:24,465,286...24,550,466
Ensembl chr  X:24,465,244...24,550,466 		JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 involved_in IEA
IBA
IMP		 (PMID:21852536) Ensembl
GO_Central
UniProt		 PMID:21852536 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516 		JBrowse link
G TPK1 thiamin pyrophosphokinase 1 involved_in IMP (PMID:38547260) UniProt PMID:38547260 NCBI chr 7:144,451,941...144,836,437
Ensembl chr 7:144,451,941...144,836,395 		JBrowse link
regulation of acyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNCA synuclein alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16636270)
(PMID:16734431)		 Ensembl
MGI		 PMID:16636270 PMID:16734431 GO_REF:0000107 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315 		JBrowse link
succinyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MMUT methylmalonyl-CoA mutase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:49,430,360...49,463,253
Ensembl chr 6:49,430,360...49,463,253 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19688
    cellular process 18940
      metabolic process 12898
        sulfur compound metabolic process 374
          thioester metabolic process 107
            thioester biosynthetic process 52
              acyl-CoA biosynthetic process + 52
paths to the root