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ONTOLOGY REPORT - ANNOTATIONS


Term:thioester biosynthetic process
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Accession:GO:0035384 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol.
Synonyms:exact_synonym: thioester anabolism;   thioester biosynthesis;   thioester formation;   thioester synthesis


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acetyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 ISO (PMID:17371050) RGD PMID:17371050 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
G Acly ATP citrate lyase NAS
IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(PMID:1371749)
GO_REF:0000002
Ensembl
RGD
InterPro
PMID:1371749, PMID:2295639, PMID:21873635 GO_REF:0000002, GO_REF:0000107, RGD:631761, RGD:13792537 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 ISO (MGI:MGI:2151932|PMID:11150295)
(PMID:16788062)
RGD PMID:11150295, PMID:16788062 MGI:MGI:2151932 NCBI chr 3:146,420,346...146,470,293
Ensembl chr 3:146,420,346...146,470,293
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 ISO (MGI:MGI:2151932|PMID:11150295) RGD PMID:11150295 MGI:MGI:2151932 NCBI chr 3:151,032,925...151,075,856
Ensembl chr 3:151,032,952...151,075,856
JBrowse link
G Mlycd malonyl-CoA decarboxylase IDA
IBA
ISO
IEA
PMID:21873635
(PMID:10417274), (PMID:10455107), (PMID:9869665)
GO_REF:0000041
RGD
UniProt
PMID:9869665, PMID:10417274, PMID:10455107, PMID:17316539, PMID:21873635 GO_REF:0000041, RGD:1600790, RGD:13792537 NCBI chr19:52,032,950...52,048,773
Ensembl chr19:52,032,886...52,048,753
JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase ISO (PMID:29754768) RGD PMID:29754768 NCBI chr 5:138,466,298...138,470,108
Ensembl chr 5:138,466,293...138,470,096
JBrowse link
acetyl-CoA biosynthetic process from acetate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acss1 acyl-CoA synthetase short-chain family member 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:146,420,346...146,470,293
Ensembl chr 3:146,420,346...146,470,293
JBrowse link
acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:7487891, PMID:21873635 RGD:1599112, RGD:13792537 NCBI chr 8:55,062,549...55,087,832
Ensembl chr 8:55,062,551...55,087,832
JBrowse link
G Dld dihydrolipoamide dehydrogenase IDA RGD PMID:7487891 RGD:1599112 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 IDA
IBA
ISO
IEA
PMID:21873635
(PMID:19081061)
GO_REF:0000002
RGD
InterPro
PMID:19081061, PMID:7487891, PMID:21873635 GO_REF:0000002, RGD:1599112, RGD:13792537 NCBI chr  X:37,329,779...37,343,410
Ensembl chr  X:37,329,779...37,343,410
JBrowse link
G Pdha1l1 pyruvate dehydrogenase (lipoamide) alpha 1-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:88,344,440...88,347,335
Ensembl chr16:88,345,247...88,347,369
JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:7487891, PMID:21873635 RGD:1599112, RGD:13792537 NCBI chr 2:246,736,449...246,737,997
Ensembl chr 2:246,736,459...246,737,997
JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta IDA
IBA
ISO
IEA
PMID:21873635
(PMID:19081061)
GO_REF:0000107
RGD
Ensembl
PMID:19081061, PMID:7487891, PMID:21873635 GO_REF:0000107, RGD:1599112, RGD:13792537 NCBI chr15:18,540,826...18,546,855
Ensembl chr15:18,539,210...18,546,854
JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:92,910,300...92,933,725
Ensembl chr 3:92,909,725...92,969,050
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 TAS RGD PMID:12435272 RGD:729541 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
fatty-acyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gcdh glutaryl-CoA dehydrogenase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:6895440, PMID:21873635 RGD:1598697, RGD:13792537 NCBI chr19:26,000,497...26,006,970
Ensembl chr19:26,000,497...26,006,970
JBrowse link
long-chain fatty-acyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl1 acyl-CoA synthetase long-chain family member 1 IGI
IBA
PMID:21873635 RGD
GO_Central
PMID:16466685, PMID:21873635 RGD:2312800, RGD:13792537 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 IGI RGD PMID:16466685 RGD:2312800 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 IGI
IBA
PMID:21873635 RGD
GO_Central
PMID:16466685, PMID:21873635 RGD:2312800, RGD:13792537 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008
JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 IGI
IBA
PMID:21873635 RGD
GO_Central
PMID:16466685, PMID:21873635 RGD:2312800, RGD:13792537 NCBI chr10:39,654,771...39,717,592
Ensembl chr10:39,655,455...39,719,312
JBrowse link
G Elovl1 ELOVL fatty acid elongase 1 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 5:137,255,868...137,260,486
Ensembl chr 5:137,255,908...137,260,483
JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:265,883,353...265,887,181
Ensembl chr 1:265,883,355...265,887,226
JBrowse link
G Elovl4 ELOVL fatty acid elongase 4 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 8:91,310,690...91,338,625
Ensembl chr 8:91,310,630...91,338,843
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 8:85,220,941...85,287,449
Ensembl chr 8:85,259,982...85,285,983
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 2:234,187,490...234,296,124
Ensembl chr 2:234,189,105...234,296,145
Ensembl chr 2:234,189,105...234,296,145
JBrowse link
G Elovl7 ELOVL fatty acid elongase 7 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 2:40,373,211...40,386,643
Ensembl chr 2:40,373,211...40,386,669
JBrowse link
G LOC102549542 elongation of very long chain fatty acids protein 6-like IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 2:234,375,172...234,486,639
Ensembl chr 2:234,375,315...234,483,149
JBrowse link
malonyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acacb acetyl-CoA carboxylase beta ISO
IEA
(MGI:MGI:3804564|PMID:18487439)
GO_REF:0000041
RGD
UniProt
PMID:18487439 GO_REF:0000041, MGI:MGI:3804564 NCBI chr12:48,127,149...48,238,969
Ensembl chr12:48,127,149...48,238,887
JBrowse link
mitochondrial acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpc1 mitochondrial pyruvate carrier 1 ISO (MGI:MGI:5428352|PMID:22628558) RGD PMID:22628558 MGI:MGI:5428352 NCBI chr 1:53,026,608...53,038,229
Ensembl chr 1:53,026,608...53,038,229
JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 ISO MGI:MGI:5635078 (MGI:MGI:5428352|PMID:22628558), (MGI:MGI:5576400|PMID:24910426) RGD PMID:22628558, PMID:24910426 MGI:MGI:5428352, MGI:MGI:5576400 NCBI chr13:83,680,527...83,700,491
Ensembl chr13:83,681,322...83,700,213
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 ISO MGI:MGI:2182095|MGI:MGI:2386703 (MGI:MGI:3817854|PMID:18586888) RGD PMID:18586888 MGI:MGI:3817854 NCBI chr  X:37,329,779...37,343,410
Ensembl chr  X:37,329,779...37,343,410
JBrowse link
propionyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 ISO (PMID:17371050) RGD PMID:17371050 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdk1 pyruvate dehydrogenase kinase 1 IEA
ISO
GO_REF:0000107
(MGI:MGI:5487511|PMID:22195962)
Ensembl
RGD
PMID:22195962 GO_REF:0000107, MGI:MGI:5487511 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5428826|PMID:22360721)
Ensembl
UniProt
RGD
PMID:22360721 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5428826 NCBI chr10:82,838,270...82,852,758
Ensembl chr10:82,839,153...82,852,660
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 ISO (PMID:22865452) RGD PMID:22865452 NCBI chr  X:62,836,131...62,904,114
Ensembl chr  X:62,836,131...62,903,554
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:3692363|PMID:16606348)
(PMID:21852536)
Ensembl
UniProt
RGD
PMID:16606348, PMID:21852536 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3692363 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
regulation of acyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snca synuclein alpha ISO MGI:MGI:2389489 (MGI:MGI:3628986|PMID:16636270), (MGI:MGI:3629421|PMID:16734431) RGD PMID:16636270, PMID:16734431 MGI:MGI:3628986, MGI:MGI:3629421 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    metabolic process 12259
      biosynthetic process 6218
        organic substance biosynthetic process 6116
          thioester biosynthetic process 34
            acyl-CoA biosynthetic process + 34
Path 2
Term Annotations click to browse term
  biological_process 20015
    metabolic process 12259
      cellular metabolic process 11067
        sulfur compound metabolic process 307
          thioester metabolic process 89
            thioester biosynthetic process 34
              acyl-CoA biosynthetic process + 34
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.