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ONTOLOGY REPORT - ANNOTATIONS


Term:thioester metabolic process
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Accession:GO:0035383 term browser browse the term
Definition:The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol.
Synonyms:exact_synonym: thioester metabolism


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acetyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 ISO (PMID:17371050) BHF-UCL PMID:17371050 NCBI chrNW_004936551:594,647...626,016 JBrowse link
G Acly ATP citrate lyase ISO (PMID:1371749) BHF-UCL PMID:1371749 NCBI chrNW_004936490:16,758,001...16,798,152 JBrowse link
G Acss1 acyl-CoA synthetase short chain family member 1 ISO (PMID:16788062)
(MGI:MGI:2151932|PMID:11150295)
UniProtKB
MGI
PMID:11150295, PMID:16788062 MGI:MGI:2151932 NCBI chrNW_004936620:739,633...800,472 JBrowse link
G Acss2 acyl-CoA synthetase short chain family member 2 ISO (MGI:MGI:2151932|PMID:11150295) MGI PMID:11150295 MGI:MGI:2151932 NCBI chrNW_004936561:5,794,685...5,842,619 JBrowse link
G Mlycd malonyl-CoA decarboxylase ISO (PMID:10417274), (PMID:10455107), (PMID:9869665) RGD
UniProtKB
PMID:9869665, PMID:10417274, PMID:10455107, PMID:17316539 RGD:1600790 NCBI chrNW_004936641:3,836,418...3,846,485 JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase ISO (PMID:29754768) UniProt PMID:29754768 NCBI chrNW_004936474:23,867,117...23,870,832 JBrowse link
acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase ISO RGD PMID:7487891 RGD:1599112 NCBI chrNW_004936612:2,395,452...2,437,592 JBrowse link
G Dld dihydrolipoamide dehydrogenase ISO RGD PMID:7487891 RGD:1599112 NCBI chrNW_004936479:16,247,230...16,271,597 JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 ISO (PMID:19081061) UniProtKB
RGD
PMID:7487891, PMID:19081061 RGD:1599112 NCBI chrNW_004936844:889,720...906,631 JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 ISO RGD PMID:7487891 RGD:1599112 NCBI chrNW_004936717:2,377,982...2,379,137 JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta ISO (PMID:19081061) RGD
UniProtKB
PMID:7487891, PMID:19081061 RGD:1599112 NCBI chrNW_004936473:2,580,642...2,586,266 JBrowse link
acetyl-CoA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 ISO (PMID:17371050) BHF-UCL PMID:17371050 NCBI chrNW_004936551:594,647...626,016 JBrowse link
G Nudt7 nudix hydrolase 7 ISO (MGI:MGI:2137102|PMID:11415433), (MGI:MGI:6450264|PMID:18799520) UniProt PMID:11415433, PMID:18799520 MGI:MGI:2137102, MGI:MGI:6450264 NCBI chrNW_004936475:26,079,298...26,095,466 JBrowse link
acetyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 ISO RGD PMID:16476568 RGD:2317620 NCBI chrNW_004936497:13,242,644...13,269,007 JBrowse link
G Acaca acetyl-CoA carboxylase alpha ISO (MGI:MGI:4840155|PMID:20952656) UniProtKB PMID:20952656 MGI:MGI:4840155 NCBI chrNW_004936490:927,769...1,191,483 JBrowse link
G Acacb acetyl-CoA carboxylase beta ISO (PMID:20952656) UniProtKB PMID:20952656 NCBI chrNW_004936769:950,970...1,053,671 JBrowse link
G Acly ATP citrate lyase ISO RGD PMID:18062843 RGD:2317315 NCBI chrNW_004936490:16,758,001...16,798,152 JBrowse link
G Acot12 acyl-CoA thioesterase 12 ISO (MGI:MGI:2450440|PMID:12545200) MGI PMID:12545200 MGI:MGI:2450440 NCBI chrNW_004936469:635,663...681,373 JBrowse link
G Cs citrate synthase ISO RGD PMID:818082, PMID:938457, PMID:5820645 RGD:2306824, RGD:2306825, RGD:2306828 NCBI chrNW_004936646:676,926...704,988 JBrowse link
G Fasn fatty acid synthase ISO RGD PMID:18062843 RGD:2317315 NCBI chrNW_004936594:5,591,785...5,609,886 JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 ISO (PMID:23751782) UniProt PMID:23751782 NCBI chrNW_004936627:4,451,847...4,473,163 JBrowse link
acyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadsb acyl-CoA dehydrogenase short/branched chain ISO PMID:8660691 MGI PMID:8660691 RGD:631739 NCBI chrNW_004936486:11,668,099...11,707,946 JBrowse link
G Acot12 acyl-CoA thioesterase 12 ISO PMID:11322891 HGNC PMID:11322891 RGD:633789 NCBI chrNW_004936469:635,663...681,373 JBrowse link
G Acot4 acyl-CoA thioesterase 4 ISO (PMID:16940157)
(MGI:MGI:3663233|PMID:16940157)
HGNC PMID:16940157 MGI:MGI:3663233 NCBI chrNW_004936488:2,912,016...2,914,995 JBrowse link
G Acot8 acyl-CoA thioesterase 8 ISO PMID:11785945
(MGI:MGI:2156286|PMID:11673457)
(PMID:9153233), (PMID:9299485)
UniProt
MGI
UniProtKB
PMID:9153233, PMID:9299485, PMID:11673457, PMID:11785945 MGI:MGI:2156286, RGD:70235 NCBI chrNW_004936514:7,166,392...7,180,537 JBrowse link
G Acot9 acyl-CoA thioesterase 9 ISO (MGI:MGI:1928308|PMID:10383425) HGNC PMID:10383425 MGI:MGI:1928308 NCBI chrNW_004936624:795,272...834,441 JBrowse link
G Gcdh glutaryl-CoA dehydrogenase ISO RGD PMID:6895440 RGD:1598697 NCBI chrNW_004936659:1,955,601...1,961,925 JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial ISO (MGI:MGI:3619815|PMID:15878874) MGI PMID:15878874 MGI:MGI:3619815 NCBI chrNW_004936486:2,754,753...2,823,600 JBrowse link
G Gpat4 glycerol-3-phosphate acyltransferase 4 ISO (PMID:18238778) UniProtKB PMID:18238778 NCBI chrNW_004936785:967,871...1,007,761 JBrowse link
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase ISO RGD PMID:2573547 RGD:1599519 NCBI chrNW_004936474:8,955,216...8,971,078 JBrowse link
G Hnf4a hepatocyte nuclear factor 4 alpha ISO RGD PMID:15870076 RGD:1625002 NCBI chrNW_004936530:2,401,053...2,425,989 JBrowse link
G Oxsm 3-oxoacyl-ACP synthase, mitochondrial ISO (PMID:15668256) HGNC PMID:15668256 NCBI chrNW_004936473:17,298,641...17,302,954 JBrowse link
butyryl-CoA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nudt7 nudix hydrolase 7 ISO (MGI:MGI:6450264|PMID:18799520) UniProt PMID:18799520 MGI:MGI:6450264 NCBI chrNW_004936475:26,079,298...26,095,466 JBrowse link
fatty-acyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gcdh glutaryl-CoA dehydrogenase ISO RGD PMID:6895440 RGD:1598697 NCBI chrNW_004936659:1,955,601...1,961,925 JBrowse link
isopentenyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mvd mevalonate diphosphate decarboxylase ISO RGD PMID:197206 RGD:2316852 NCBI chrNW_004936641:1,030,465...1,035,967 JBrowse link
G Mvk mevalonate kinase ISO RGD PMID:197206 RGD:2316852 NCBI chrNW_004936769:1,274,595...1,295,186 JBrowse link
G Pmvk phosphomevalonate kinase ISO RGD PMID:197206 RGD:2316852 NCBI chrNW_004936580:4,473,554...4,482,396 JBrowse link
L-lysine catabolic process to acetyl-CoA via L-pipecolate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pipox pipecolic acid and sarcosine oxidase ISO (PMID:10642506) UniProtKB PMID:10642506 NCBI chrNW_004936538:5,218,097...5,252,579 JBrowse link
L-methylmalonyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcee methylmalonyl-CoA epimerase ISO (PMID:11481338) UniProtKB PMID:11481338 NCBI chrNW_004936483:971,148...990,634 JBrowse link
long-chain fatty-acyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl1 acyl-CoA synthetase long chain family member 1 ISO RGD PMID:16466685 RGD:2312800 NCBI chrNW_004936554:4,425,518...4,484,853 JBrowse link
G Acsl4 acyl-CoA synthetase long chain family member 4 ISO RGD PMID:16466685 RGD:2312800 NCBI chrNW_004936499:5,456,985...5,540,115 JBrowse link
G Acsl5 acyl-CoA synthetase long chain family member 5 ISO RGD PMID:16466685 RGD:2312800 NCBI chrNW_004936486:2,952,379...2,992,148 JBrowse link
G Acsl6 acyl-CoA synthetase long chain family member 6 ISO RGD PMID:16466685 RGD:2312800 NCBI chrNW_004936647:3,153,586...3,208,935 JBrowse link
long-chain fatty-acyl-CoA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot7 acyl-CoA thioesterase 7 ISO (PMID:10578051) BHF-UCL PMID:10578051 NCBI chrNW_004936623:1,112,021...1,191,190 JBrowse link
long-chain fatty-acyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgat1 diacylglycerol O-acyltransferase 1 ISO (MGI:MGI:2151970|PMID:11481335) BHF-UCL PMID:11481335 MGI:MGI:2151970 NCBI chrNW_004936470:7,916,438...7,926,089 JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 ISO (MGI:MGI:2151970|PMID:11481335)
(PMID:11481335)
BHF-UCL PMID:11481335 MGI:MGI:2151970 NCBI chrNW_004936498:4,514,212...4,544,523 JBrowse link
G Far1 fatty acyl-CoA reductase 1 ISO (PMID:15220348) UniProtKB PMID:15220348 NCBI chrNW_004936528:4,898,920...4,956,417 JBrowse link
G Far2 fatty acyl-CoA reductase 2 ISO (PMID:15220348) UniProtKB PMID:15220348 NCBI chrNW_004936760:1,265,803...1,406,405 JBrowse link
G Them5 thioesterase superfamily member 5 ISO (PMID:22586271) UniProtKB PMID:22586271 NCBI chrNW_004936580:2,036,595...2,044,053 JBrowse link
malonyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acacb acetyl-CoA carboxylase beta ISO (MGI:MGI:3804564|PMID:18487439) UniProtKB PMID:18487439 MGI:MGI:3804564 NCBI chrNW_004936769:950,970...1,053,671 JBrowse link
malonyl-CoA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlycd malonyl-CoA decarboxylase ISO (PMID:10417274), (PMID:10455107), (PMID:15003260)
(MGI:MGI:5501374|PMID:23746352)
UniProtKB PMID:10417274, PMID:10455107, PMID:15003260, PMID:23746352 MGI:MGI:5501374 NCBI chrNW_004936641:3,836,418...3,846,485 JBrowse link
medium-chain fatty-acyl-CoA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot7 acyl-CoA thioesterase 7 ISO (PMID:10578051) BHF-UCL PMID:10578051 NCBI chrNW_004936623:1,112,021...1,191,190 JBrowse link
G Nudt7 nudix hydrolase 7 ISO (MGI:MGI:6450264|PMID:18799520) UniProt PMID:18799520 MGI:MGI:6450264 NCBI chrNW_004936475:26,079,298...26,095,466 JBrowse link
medium-chain fatty-acyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b4 hydroxysteroid 17-beta dehydrogenase 4 ISO (PMID:9089413) UniProtKB PMID:9089413 NCBI chrNW_004936715:2,357,215...2,446,601 JBrowse link
mitochondrial acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpc1 mitochondrial pyruvate carrier 1 ISO (MGI:MGI:5428352|PMID:22628558) MGI PMID:22628558 MGI:MGI:5428352 NCBI chrNW_004936489:16,179,321...16,181,991 JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 ISO (MGI:MGI:5428352|PMID:22628558)
(MGI:MGI:5576400|PMID:24910426)
MGI PMID:22628558, PMID:24910426 MGI:MGI:5428352, MGI:MGI:5576400 NCBI chrNW_004936481:18,253,929...18,259,738 JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 ISO (MGI:MGI:3817854|PMID:18586888) MGI PMID:18586888 MGI:MGI:3817854 NCBI chrNW_004936844:889,720...906,631 JBrowse link
propionyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 ISO (PMID:17371050) BHF-UCL PMID:17371050 NCBI chrNW_004936551:594,647...626,016 JBrowse link
propionyl-CoA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nudt7 nudix hydrolase 7 ISO (MGI:MGI:6450264|PMID:18799520) UniProt PMID:18799520 MGI:MGI:6450264 NCBI chrNW_004936475:26,079,298...26,095,466 JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdk1 pyruvate dehydrogenase kinase 1 ISO (MGI:MGI:5487511|PMID:22195962) UniProtKB PMID:22195962 MGI:MGI:5487511 NCBI chrNW_004936509:2,597,593...2,633,780 JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 ISO (MGI:MGI:5428826|PMID:22360721) UniProtKB PMID:22360721 MGI:MGI:5428826 NCBI chrNW_004936490:11,534,412...11,549,128 JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 ISO (PMID:22865452) UniProtKB PMID:22865452 NCBI chrNW_004936624:141,745...213,495 JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 ISO (MGI:MGI:3692363|PMID:16606348)
(PMID:21852536)
UniProtKB PMID:16606348, PMID:21852536 MGI:MGI:3692363 NCBI chrNW_004936585:4,701,012...4,713,421 JBrowse link
regulation of acyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snca synuclein alpha ISO (MGI:MGI:3629421|PMID:16734431)
(MGI:MGI:3628986|PMID:16636270)
MGI PMID:16636270, PMID:16734431 MGI:MGI:3628986, MGI:MGI:3629421 NCBI chrNW_004936685:2,077,017...2,175,298 JBrowse link
succinyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot4 acyl-CoA thioesterase 4 ISO (PMID:16940157)
(MGI:MGI:3663233|PMID:16940157)
HGNC PMID:16940157 MGI:MGI:3663233 NCBI chrNW_004936488:2,912,016...2,914,995 JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase ISO (PMID:10806400) UniProt PMID:10806400 NCBI chrNW_004936488:4,038,985...4,061,071 JBrowse link
G Ogdh oxoglutarate dehydrogenase ISO (PMID:24495017), (PMID:29211711) UniProtKB
RGD
PMID:9712727, PMID:24495017, PMID:29211711 RGD:2306877 NCBI chrNW_004936478:19,506,845...19,584,411 JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta ISO RGD PMID:17403370 RGD:2306915 NCBI chrNW_004936565:1,313,150...1,355,693 JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha ISO RGD PMID:7430155, PMID:17403370 RGD:2306879, RGD:2306915 NCBI chrNW_004936650:3,278,769...3,313,537 JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta ISO RGD PMID:7430155, PMID:17403370 RGD:2306879, RGD:2306915 NCBI chrNW_004936603:243,113...378,526 JBrowse link
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kynu kynureninase ISO RGD PMID:7236232 RGD:2303721 NCBI chrNW_004936469:33,632,885...33,805,158 JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase ISO RGD PMID:7236232 RGD:2303721 NCBI chrNW_004936576:2,537,702...2,555,790 JBrowse link
very long-chain fatty-acyl-CoA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 ISO (PMID:23671276) UniProtKB PMID:23671276 NCBI chrNW_004936809:615,133...634,618 JBrowse link
very long-chain fatty-acyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b4 hydroxysteroid 17-beta dehydrogenase 4 ISO (PMID:9482850) UniProtKB PMID:9482850 NCBI chrNW_004936715:2,357,215...2,446,601 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11962
    metabolic process 7653
      organic substance metabolic process 7353
        thioester metabolic process 60
          acyl-CoA metabolic process + 60
          thioester biosynthetic process + 24
Path 2
Term Annotations click to browse term
  biological_process 11962
    metabolic process 7653
      cellular metabolic process 7051
        sulfur compound metabolic process 201
          thioester metabolic process 60
            acyl-CoA metabolic process + 60
            thioester biosynthetic process + 24
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.