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ONTOLOGY REPORT - ANNOTATIONS


Term:thioester metabolic process
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Accession:GO:0035383 term browser browse the term
Definition:The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol.
Synonyms:exact_synonym: thioester metabolism


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acetyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 ISO (PMID:17371050) BHF-UCL PMID:17371050 NCBI chrNW_004955412:10,350,088...10,369,806 JBrowse link
G Acly ATP citrate lyase ISO (PMID:1371749) BHF-UCL PMID:1371749 NCBI chrNW_004955451:16,058,916...16,091,831 JBrowse link
G Acss1 acyl-CoA synthetase short chain family member 1 ISO (MGI:MGI:2151932|PMID:11150295)
(PMID:16788062)
MGI
UniProtKB
PMID:11150295, PMID:16788062 MGI:MGI:2151932 NCBI chrNW_004955415:31,117,542...31,154,654 JBrowse link
G Acss2 acyl-CoA synthetase short chain family member 2 ISO (MGI:MGI:2151932|PMID:11150295) MGI PMID:11150295 MGI:MGI:2151932 NCBI chrNW_004955422:26,450,899...26,500,336 JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase ISO (PMID:29754768) UniProt PMID:29754768 NCBI chrNW_004955537:2,080,865...2,084,199 JBrowse link
acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase ISO RGD PMID:7487891 RGD:1599112 NCBI chrNW_004955412:13,718,091...13,746,220 JBrowse link
G Dld dihydrolipoamide dehydrogenase ISO RGD PMID:7487891 RGD:1599112 NCBI chrNW_004955410:12,212,981...12,238,561 JBrowse link
G Pdha1 pyruvate dehydrogenase E1 alpha 1 subunit ISO (PMID:19081061) RGD
UniProtKB
PMID:7487891, PMID:19081061 RGD:1599112 NCBI chrNW_004955586:98,492...114,927 JBrowse link
G Pdha2 pyruvate dehydrogenase E1 alpha 2 subunit ISO RGD PMID:7487891 RGD:1599112 NCBI chrNW_004955405:6,383,088...6,383,946 JBrowse link
G Pdhb pyruvate dehydrogenase E1 beta subunit ISO (PMID:19081061) UniProtKB
RGD
PMID:7487891, PMID:19081061 RGD:1599112 NCBI chrNW_004955430:1,707,615...1,713,541 JBrowse link
acetyl-CoA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 ISO (PMID:17371050) BHF-UCL PMID:17371050 NCBI chrNW_004955412:10,350,088...10,369,806 JBrowse link
G Nudt7 nudix hydrolase 7 ISO (MGI:MGI:2137102|PMID:11415433), (MGI:MGI:6450264|PMID:18799520) UniProt PMID:11415433, PMID:18799520 MGI:MGI:2137102, MGI:MGI:6450264 NCBI chrNW_004955522:945,186...960,094 JBrowse link
acetyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 ISO RGD PMID:16476568 RGD:2317620 NCBI chrNW_004955402:34,857,317...34,885,169 JBrowse link
G Acaca acetyl-CoA carboxylase alpha ISO (MGI:MGI:4840155|PMID:20952656) UniProtKB PMID:20952656 MGI:MGI:4840155 NCBI chrNW_004955451:679,033...909,892 JBrowse link
G Acacb acetyl-CoA carboxylase beta ISO (PMID:20952656) UniProtKB PMID:20952656 NCBI chrNW_004955455:10,282,308...10,427,439 JBrowse link
G Acly ATP citrate lyase ISO RGD PMID:18062843 RGD:2317315 NCBI chrNW_004955451:16,058,916...16,091,831 JBrowse link
G Acot12 acyl-CoA thioesterase 12 ISO (MGI:MGI:2450440|PMID:12545200) MGI PMID:12545200 MGI:MGI:2450440 NCBI chrNW_004955418:28,829,316...28,872,629 JBrowse link
G Cs citrate synthase ISO RGD PMID:818082, PMID:938457, PMID:5820645 RGD:2306824, RGD:2306825, RGD:2306828 NCBI chrNW_004955458:3,881,798...3,913,044 JBrowse link
G Fasn fatty acid synthase ISO RGD PMID:18062843 RGD:2317315 NCBI chrNW_004955506:1,063,002...1,079,939 JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 ISO (PMID:23751782) UniProt PMID:23751782 NCBI chrNW_004955435:22,804,484...22,820,807 JBrowse link
acyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadsb acyl-CoA dehydrogenase short/branched chain ISO PMID:8660691 MGI PMID:8660691 RGD:631739 NCBI chrNW_004955477:1,177,704...1,213,347 JBrowse link
G Acot12 acyl-CoA thioesterase 12 ISO PMID:11322891 HGNC PMID:11322891 RGD:633789 NCBI chrNW_004955418:28,829,316...28,872,629 JBrowse link
G Acot8 acyl-CoA thioesterase 8 ISO (PMID:9153233), (PMID:9299485)
(MGI:MGI:2156286|PMID:11673457)
PMID:11785945
UniProtKB
MGI
UniProt
PMID:9153233, PMID:9299485, PMID:11673457, PMID:11785945 MGI:MGI:2156286, RGD:70235 NCBI chrNW_004955445:11,434,649...11,454,806 JBrowse link
G Acot9 acyl-CoA thioesterase 9 ISO (MGI:MGI:1928308|PMID:10383425) HGNC PMID:10383425 MGI:MGI:1928308 NCBI chrNW_004955509:4,143,246...4,167,129 JBrowse link
G Acsm4 acyl-CoA synthetase medium chain family member 4 ISO RGD PMID:12709059 RGD:1299602 NCBI chrNW_004955493:6,023...31,418 JBrowse link
G Baat bile acid-CoA:amino acid N-acyltransferase ISO (PMID:12810727) UniProtKB PMID:12810727 NCBI chrNW_004955419:24,469,213...24,521,728 JBrowse link
G Gcdh glutaryl-CoA dehydrogenase ISO RGD PMID:6895440 RGD:1598697 NCBI chrNW_004955415:31,952,400...31,958,067 JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial ISO (MGI:MGI:3619815|PMID:15878874) MGI PMID:15878874 MGI:MGI:3619815 NCBI chrNW_004955431:17,291,890...17,363,611 JBrowse link
G Gpat4 glycerol-3-phosphate acyltransferase 4 ISO (PMID:18238778) UniProtKB PMID:18238778 NCBI chrNW_004955536:1,266,920...1,313,765 JBrowse link
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase ISO RGD PMID:2573547 RGD:1599519 NCBI chrNW_004955452:3,720,103...3,734,730 JBrowse link
G Hnf4a hepatocyte nuclear factor 4 alpha ISO RGD PMID:15870076 RGD:1625002 NCBI chrNW_004955445:12,925,248...12,962,501 JBrowse link
G Oxsm 3-oxoacyl-ACP synthase, mitochondrial ISO (PMID:15668256) HGNC PMID:15668256 NCBI chrNW_004955430:17,644,800...17,661,097 JBrowse link
benzoyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glyat glycine-N-acyltransferase ISO (PMID:22475485) UniProtKB PMID:22475485 NCBI chrNW_004955511:3,670,736...3,683,751 JBrowse link
butyryl-CoA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nudt7 nudix hydrolase 7 ISO (MGI:MGI:6450264|PMID:18799520) UniProt PMID:18799520 MGI:MGI:6450264 NCBI chrNW_004955522:945,186...960,094 JBrowse link
fatty-acyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gcdh glutaryl-CoA dehydrogenase ISO RGD PMID:6895440 RGD:1598697 NCBI chrNW_004955415:31,952,400...31,958,067 JBrowse link
isopentenyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mvd mevalonate diphosphate decarboxylase ISO RGD PMID:197206 RGD:2316852 NCBI chrNW_004955541:2,578,584...2,581,823 JBrowse link
G Mvk mevalonate kinase ISO RGD PMID:197206 RGD:2316852 NCBI chrNW_004955455:8,933,250...8,953,883 JBrowse link
G Pmvk phosphomevalonate kinase ISO RGD PMID:197206 RGD:2316852 NCBI chrNW_004955545:1,421,562...1,440,038 JBrowse link
L-lysine catabolic process to acetyl-CoA via L-pipecolate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pipox pipecolic acid and sarcosine oxidase ISO (PMID:10642506) UniProtKB PMID:10642506 NCBI chrNW_004955481:4,128,503...4,225,027 JBrowse link
L-methylmalonyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcee methylmalonyl-CoA epimerase ISO (PMID:11481338) UniProtKB PMID:11481338 NCBI chrNW_004955416:29,684,557...29,703,495 JBrowse link
long-chain fatty-acyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl1 acyl-CoA synthetase long chain family member 1 ISO RGD PMID:16466685 RGD:2312800 NCBI chrNW_004955403:24,190,674...24,235,354 JBrowse link
G Acsl4 acyl-CoA synthetase long chain family member 4 ISO RGD PMID:16466685 RGD:2312800 NCBI chrNW_004955490:6,143,833...6,228,395 JBrowse link
G Acsl5 acyl-CoA synthetase long chain family member 5 ISO RGD PMID:16466685 RGD:2312800 NCBI chrNW_004955431:17,477,113...17,524,539 JBrowse link
G Acsl6 acyl-CoA synthetase long chain family member 6 ISO RGD PMID:16466685 RGD:2312800 NCBI chrNW_004955408:3,336,214...3,391,117 JBrowse link
long-chain fatty-acyl-CoA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot7 acyl-CoA thioesterase 7 ISO (PMID:10578051) BHF-UCL PMID:10578051 NCBI chrNW_004955486:6,188,102...6,258,230 JBrowse link
long-chain fatty-acyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgat1 diacylglycerol O-acyltransferase 1 ISO (MGI:MGI:2151970|PMID:11481335) BHF-UCL PMID:11481335 MGI:MGI:2151970 NCBI chrNW_004955454:2,933,904...2,944,675 JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 ISO (PMID:11481335)
(MGI:MGI:2151970|PMID:11481335)
BHF-UCL PMID:11481335 MGI:MGI:2151970 NCBI chrNW_004955414:16,059,781...16,089,727 JBrowse link
G Far1 fatty acyl-CoA reductase 1 ISO (PMID:15220348) UniProtKB PMID:15220348 NCBI chrNW_004955414:28,938,535...28,996,622 JBrowse link
G Far2 fatty acyl-CoA reductase 2 ISO (PMID:15220348) UniProtKB PMID:15220348 NCBI chrNW_004955505:5,585,846...5,724,234 JBrowse link
G Them5 thioesterase superfamily member 5 ISO (PMID:22586271) UniProtKB PMID:22586271 NCBI chrNW_004955589:546,592...571,844 JBrowse link
malonyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acacb acetyl-CoA carboxylase beta ISO (MGI:MGI:3804564|PMID:18487439) UniProtKB PMID:18487439 MGI:MGI:3804564 NCBI chrNW_004955455:10,282,308...10,427,439 JBrowse link
medium-chain fatty-acyl-CoA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot7 acyl-CoA thioesterase 7 ISO (PMID:10578051) BHF-UCL PMID:10578051 NCBI chrNW_004955486:6,188,102...6,258,230 JBrowse link
G Nudt7 nudix hydrolase 7 ISO (MGI:MGI:6450264|PMID:18799520) UniProt PMID:18799520 MGI:MGI:6450264 NCBI chrNW_004955522:945,186...960,094 JBrowse link
medium-chain fatty-acyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b4 hydroxysteroid 17-beta dehydrogenase 4 ISO (PMID:9089413) UniProtKB PMID:9089413 NCBI chrNW_004955408:39,041,028...39,136,867 JBrowse link
mitochondrial acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpc1 mitochondrial pyruvate carrier 1 ISO (MGI:MGI:5428352|PMID:22628558) MGI PMID:22628558 MGI:MGI:5428352 NCBI chrNW_004955439:15,515,966...15,531,618 JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 ISO (MGI:MGI:5428352|PMID:22628558)
(MGI:MGI:5576400|PMID:24910426)
MGI PMID:22628558, PMID:24910426 MGI:MGI:5428352, MGI:MGI:5576400 NCBI chrNW_004955462:9,177,484...9,193,646 JBrowse link
G Pdha1 pyruvate dehydrogenase E1 alpha 1 subunit ISO (MGI:MGI:3817854|PMID:18586888) MGI PMID:18586888 MGI:MGI:3817854 NCBI chrNW_004955586:98,492...114,927 JBrowse link
propionyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 ISO (PMID:17371050) BHF-UCL PMID:17371050 NCBI chrNW_004955412:10,350,088...10,369,806 JBrowse link
propionyl-CoA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nudt7 nudix hydrolase 7 ISO (MGI:MGI:6450264|PMID:18799520) UniProt PMID:18799520 MGI:MGI:6450264 NCBI chrNW_004955522:945,186...960,094 JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdk1 pyruvate dehydrogenase kinase 1 ISO (MGI:MGI:5487511|PMID:22195962) UniProtKB PMID:22195962 MGI:MGI:5487511 NCBI chrNW_004955449:2,546,790...2,582,402 JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 ISO (MGI:MGI:5428826|PMID:22360721) UniProtKB PMID:22360721 MGI:MGI:5428826 NCBI chrNW_004955451:11,547,660...11,559,266 JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 ISO (PMID:22865452) UniProtKB PMID:22865452 NCBI chrNW_004955509:4,809,422...4,888,802 JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 ISO (MGI:MGI:3692363|PMID:16606348)
(PMID:21852536)
UniProtKB PMID:16606348, PMID:21852536 MGI:MGI:3692363 NCBI chrNW_004955432:12,169,548...12,182,064 JBrowse link
regulation of acyl-CoA biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snca synuclein alpha ISO (MGI:MGI:3629421|PMID:16734431)
(MGI:MGI:3628986|PMID:16636270)
MGI PMID:16636270, PMID:16734431 MGI:MGI:3628986, MGI:MGI:3629421 NCBI chrNW_004955405:854,011...962,741 JBrowse link
succinyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlst dihydrolipoamide S-succinyltransferase ISO (PMID:10806400) UniProt PMID:10806400 NCBI chrNW_004955523:660,413...680,878 JBrowse link
G Ogdh oxoglutarate dehydrogenase ISO (PMID:24495017), (PMID:29211711) RGD
UniProtKB
PMID:9712727, PMID:24495017, PMID:29211711 RGD:2306877 NCBI chrNW_004955456:7,416,343...7,484,889 JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming beta subunit ISO RGD PMID:17403370 RGD:2306915 NCBI chrNW_004955431:1,678,720...1,737,234 JBrowse link
G Suclg1 succinate-CoA ligase alpha subunit ISO RGD PMID:7430155, PMID:17403370 RGD:2306879, RGD:2306915 NCBI chrNW_004955424:2,810,557...2,838,827 JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming beta subunit ISO RGD PMID:7430155, PMID:17403370 RGD:2306879, RGD:2306915 NCBI chrNW_004955421:20,089,471...20,350,334 JBrowse link
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kynu kynureninase ISO RGD PMID:7236232 RGD:2303721 NCBI chrNW_004955440:9,420,141...9,536,767 JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase ISO RGD PMID:7236232 RGD:2303721 NCBI chrNW_004955471:11,229,795...11,245,255 JBrowse link
very long-chain fatty-acyl-CoA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 ISO (PMID:23671276) UniProtKB PMID:23671276 NCBI chrNW_004955580:459,715...475,363 JBrowse link
very long-chain fatty-acyl-CoA metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b4 hydroxysteroid 17-beta dehydrogenase 4 ISO (PMID:9482850) UniProtKB PMID:9482850 NCBI chrNW_004955408:39,041,028...39,136,867 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11857
    metabolic process 7593
      organic substance metabolic process 7299
        thioester metabolic process 61
          acyl-CoA metabolic process + 61
          thioester biosynthetic process + 23
Path 2
Term Annotations click to browse term
  biological_process 11857
    metabolic process 7593
      cellular metabolic process 7005
        sulfur compound metabolic process 203
          thioester metabolic process 61
            acyl-CoA metabolic process + 61
            thioester biosynthetic process + 23
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.