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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:peroxisome proliferator activated receptor signaling pathway
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Accession:GO:0035357 term browser browse the term
Definition:The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes.
Synonyms:exact_synonym: PPAR signaling pathway;   peroxisome proliferator activated receptor signalling pathway


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peroxisome proliferator activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn4 actinin alpha 4 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:28,592,673...28,661,799
Ensembl chr 7:28,592,673...28,661,765 		JBrowse link
G Aloxe3 arachidonate lipoxygenase 3 involved_in IMP (MGI:4819891|PMID:20530198) UniProt PMID:20530198 MGI:4819891 NCBI chr11:69,016,243...69,039,941
Ensembl chr11:69,016,722...69,039,941 		JBrowse link
G Fam120b family with sequence similarity 120, member B acts_upstream_of_or_within
involved_in		 IPI
IBA		 (PMID:17595322) MGI
GO_Central		 PMID:17595322 GO_REF:0000033 NCBI chr17:15,616,464...15,653,843
Ensembl chr17:15,616,464...15,653,845 		JBrowse link
G Hmga1 high mobility group AT-hook 1 acts_upstream_of_or_within IMP (PMID:22207709) MGI PMID:22207709 NCBI chr17:27,774,798...27,782,649
Ensembl chr17:27,775,471...27,782,648 		JBrowse link
G Med1 mediator complex subunit 1 acts_upstream_of_or_within IMP (PMID:15150259) MGI PMID:15150259 NCBI chr11:98,042,980...98,084,121
Ensembl chr11:98,042,980...98,084,119 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 involved_in NAS (MGI:6867153|PMID:16373399) ComplexPortal PMID:16373399 MGI:6867153 NCBI chr12:4,297,362...4,569,452
Ensembl chr12:4,297,362...4,527,182 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 involved_in NAS (MGI:6867153|PMID:16373399) ComplexPortal PMID:16373399 MGI:6867153 NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307 		JBrowse link
G Pdk3 pyruvate dehydrogenase kinase, isoenzyme 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr  X:92,798,923...92,875,756
Ensembl chr  X:92,808,213...92,875,807 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma involved_in
acts_upstream_of_or_within		 NAS
IPI
ISO		 (MGI:6867153|PMID:16373399)
(PMID:17595322)		 ComplexPortal
MGI		 PMID:16373399 PMID:17595322 GO_REF:0000119 MGI:4834177 MGI:6867153 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Rxra retinoid X receptor alpha involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969 		JBrowse link
negative regulation of peroxisome proliferator activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asxl1 ASXL transcriptional regulator 1 involved_in IDA (MGI:5318011|PMID:21047783) UniProt PMID:21047783 MGI:5318011 NCBI chr 2:153,187,750...153,245,927
Ensembl chr 2:153,187,749...153,245,927 		JBrowse link
G Cyp2j6 cytochrome P450, family 2, subfamily j, polypeptide 6 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 4:96,404,375...96,449,835
Ensembl chr 4:96,404,375...96,441,898 		JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 ISO RGD PMID:25840911 RGD:12904676 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815 		JBrowse link
G Mir34a microRNA 34a involved_in ISO (PMID:26330104) ARUK-UCL PMID:26330104 NCBI chr 4:150,152,911...150,153,012
Ensembl chr 4:150,152,911...150,153,012 		JBrowse link
G Plin5 perilipin 5 involved_in IDA (MGI:5559662|PMID:22675471) UniProt PMID:22675471 MGI:5559662 NCBI chr17:56,418,601...56,424,606
Ensembl chr17:56,418,601...56,424,596 		JBrowse link
G Twist1 twist basic helix-loop-helix transcription factor 1 involved_in IDA (MGI:3843109|PMID:19345188) BHF-UCL PMID:19345188 MGI:3843109 NCBI chr12:34,007,670...34,009,830
Ensembl chr12:34,007,670...34,009,828 		JBrowse link
positive regulation of peroxisome proliferator activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox8 arachidonate 8-lipoxygenase involved_in IMP (MGI:3784332|PMID:10965849) UniProt PMID:10965849 MGI:3784332 NCBI chr11:69,074,711...69,088,669
Ensembl chr11:69,074,758...69,088,669 		JBrowse link
G Asxl2 ASXL transcriptional regulator 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:3,476,892...3,560,811
Ensembl chr12:3,476,857...3,556,852 		JBrowse link
G Bmp2 bone morphogenetic protein 2 acts_upstream_of_or_within ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:17,598,452...17,601,422
Ensembl chr10:17,598,966...17,601,422 		JBrowse link
G Fabp5 fatty acid binding protein 5, epidermal involved_in IMP (MGI:6158690|PMID:17512406) UniProt PMID:17512406 MGI:6158690 NCBI chr 3:10,077,645...10,081,670
Ensembl chr 3:10,077,608...10,081,667 		JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in IDA (MGI:6148392|PMID:24953653) UniProt PMID:24953653 MGI:6148392 NCBI chr11:69,804,805...69,807,882
Ensembl chr11:69,804,714...69,807,417 		JBrowse link
G Jund jun D proto-oncogene involved_in ISO RGD
MGI		 PMID:30629164 GO_REF:0000096 MGI:4417868 RGD:401900736 NCBI chr 8:71,150,389...71,153,265
Ensembl chr 8:71,151,599...71,153,265 		JBrowse link
G Lep leptin involved_in ISO RGD
MGI		 PMID:20738325 GO_REF:0000096 MGI:4417868 RGD:8693628 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lmo3 LIM domain only 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 6:138,339,916...138,559,204
Ensembl chr 6:138,339,916...138,558,966 		JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524 		JBrowse link
G Stard10 StAR related lipid transfer domain containing 10 acts_upstream_of_or_within IMP (PMID:23200860) MGI PMID:23200860 NCBI chr 7:100,966,293...100,995,833
Ensembl chr 7:100,966,293...100,995,833 		JBrowse link
regulation of peroxisome proliferator activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15 arachidonate 15-lipoxygenase involved_in IMP (MGI:5508298|PMID:10432118) UniProt PMID:10432118 MGI:5508298 NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857 		JBrowse link
G Sirt1 sirtuin 1 involved_in IMP (MGI:3045940|PMID:15175761) BHF-UCL PMID:15175761 MGI:3045940 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    cellular process 17545
      signal transduction 6675
        intracellular receptor signaling pathway 373
          peroxisome proliferator activated receptor signaling pathway 29
            negative regulation of peroxisome proliferator activated receptor signaling pathway 6
            positive regulation of peroxisome proliferator activated receptor signaling pathway 11
            regulation of peroxisome proliferator activated receptor signaling pathway + 19
Path 2
Term Annotations click to browse term
  biological_process 28573
    biological regulation 13118
      regulation of biological process 12727
        signaling 7288
          signal transduction 6675
            intracellular receptor signaling pathway 373
              peroxisome proliferator activated receptor signaling pathway 29
                negative regulation of peroxisome proliferator activated receptor signaling pathway 6
                positive regulation of peroxisome proliferator activated receptor signaling pathway 11
                regulation of peroxisome proliferator activated receptor signaling pathway + 19
paths to the root