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ONTOLOGY REPORT - ANNOTATIONS


Term:peroxisome proliferator activated receptor signaling pathway
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Accession:GO:0035357 term browser browse the term
Definition:The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes.
Synonyms:exact_synonym: PPAR signaling pathway;   peroxisome proliferator activated receptor signalling pathway



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peroxisome proliferator activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn4 actinin alpha 4 involved_in ISO
ISS
(PMID:22351778)
GO_REF:0000024
RGD
UniProt
PMID:22351778 GO_REF:0000024 NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847
JBrowse link
G Aloxe3 arachidonate lipoxygenase 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:4819891|PMID:20530198)
UniProt
RGD
PMID:20530198 GO_REF:0000024 MGI:4819891 NCBI chr10:53,830,219...53,854,328
Ensembl chr10:53,831,264...53,854,328
JBrowse link
G Fam120b family with sequence similarity 120B involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
PR:P37238 (MGI:3758409|PMID:17595322)
RGD PMID:17595322 PMID:21873635 MGI:3758409, RGD:13792537 NCBI chr 1:56,320,015...56,385,064
Ensembl chr 1:56,339,129...56,385,061
JBrowse link
G Med1 mediator complex subunit 1 acts_upstream_of_or_within ISO MGI:2176946|MGI:3511276 (MGI:3511247|PMID:15150259) RGD PMID:15150259 MGI:3511247 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 involved_in ISO (PMID:17669420) RGD PMID:17669420 NCBI chr  X:58,477,471...58,553,932
Ensembl chr  X:58,486,554...58,553,557
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma acts_upstream_of_or_within
involved_in
ISO PR:Q6RI63 (MGI:3758409|PMID:17595322)
UniProtKB:P01137|UniProtKB:P12643 (PMID:20622039), (PMID:28467929)
RGD PMID:17595322 PMID:20622039 PMID:28467929 MGI:3758409 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Rxra retinoid X receptor alpha involved_in IEA
ISO
GO_REF:0000107
(PMID:10195690)
Ensembl
RGD
PMID:10195690 GO_REF:0000107 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
negative regulation of peroxisome proliferator activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asxl1 ASXL transcriptional regulator 1 involved_in ISO (MGI:5318011|PMID:21047783) RGD PMID:21047783 MGI:5318011 NCBI chr 3:141,814,012...141,881,526
Ensembl chr 3:141,813,433...141,881,538
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 IMP RGD PMID:25840911 RGD:12904676 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Plin5 perilipin 5 involved_in ISS
ISO
GO_REF:0000024
(MGI:5559662|PMID:22675471)
UniProt
RGD
PMID:22675471 GO_REF:0000024 MGI:5559662 NCBI chr 9:939,745...946,188
Ensembl chr 9:939,747...946,120
JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (MGI:3843109|PMID:19345188) RGD PMID:19345188 MGI:3843109 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
positive regulation of peroxisome proliferator activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15b arachidonate 15-lipoxygenase, type B involved_in IEA
ISO
GO_REF:0000107
(MGI:3784332|PMID:10965849)
Ensembl
RGD
PMID:10965849 GO_REF:0000107 MGI:3784332 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812
JBrowse link
G Asxl2 ASXL transcriptional regulator 2 involved_in ISO (PMID:21047783) RGD PMID:21047783 NCBI chr 6:26,425,017...26,514,899
Ensembl chr 6:26,425,954...26,507,477
JBrowse link
G Bmp2 bone morphogenetic protein 2 acts_upstream_of_or_within
involved_in
ISO
IEA
UniProtKB:P01137|UniProtKB:P37231 (PMID:28467929)
GO_REF:0000107
RGD
Ensembl
PMID:28467929 GO_REF:0000107 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 involved_in ISO (PMID:15051727) RGD PMID:15051727 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Fabp5 fatty acid binding protein 5 involved_in ISO (MGI:6158690|PMID:17512406) RGD PMID:17512406 MGI:6158690 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (MGI:6148392|PMID:24953653) RGD PMID:24953653 MGI:6148392 NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650
JBrowse link
G Lep leptin IDA RGD PMID:20738325 RGD:8693628 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lmo3 LIM domain only 3 involved_in ISO (PMID:23823477) RGD PMID:23823477 NCBI chr 4:171,234,686...171,297,677
Ensembl chr 4:171,234,696...171,292,222
JBrowse link
G Ptgis prostaglandin I2 synthase involved_in ISS
ISO
GO_REF:0000024
(PMID:11551955)
UniProt
RGD
PMID:11551955 GO_REF:0000024 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
JBrowse link
G Stard10 StAR-related lipid transfer domain containing 10 acts_upstream_of_or_within ISO (MGI:5499673|PMID:23200860) RGD PMID:23200860 MGI:5499673 NCBI chr 1:155,722,637...155,748,007
Ensembl chr 1:155,718,389...155,747,094
JBrowse link
regulation of peroxisome proliferator activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15 arachidonate 15-lipoxygenase involved_in ISS
ISO
GO_REF:0000024
(MGI:5508298|PMID:10432118)
UniProt
RGD
PMID:10432118 GO_REF:0000024 MGI:5508298 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (MGI:3045940|PMID:15175761) RGD PMID:15175761 MGI:3045940 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19812
    signaling 7578
      signal transduction 6989
        intracellular receptor signaling pathway 259
          peroxisome proliferator activated receptor signaling pathway 23
            negative regulation of peroxisome proliferator activated receptor signaling pathway 4
            positive regulation of peroxisome proliferator activated receptor signaling pathway 10
            regulation of peroxisome proliferator activated receptor signaling pathway + 16
Path 2
Term Annotations click to browse term
  biological_process 19812
    biological regulation 13762
      regulation of biological process 13019
        regulation of cellular process 12485
          signal transduction 6989
            intracellular receptor signaling pathway 259
              peroxisome proliferator activated receptor signaling pathway 23
                negative regulation of peroxisome proliferator activated receptor signaling pathway 4
                positive regulation of peroxisome proliferator activated receptor signaling pathway 10
                regulation of peroxisome proliferator activated receptor signaling pathway + 16
paths to the root