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ONTOLOGY REPORT - ANNOTATIONS


Term:SPOTS complex
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Accession:GO:0035339 term browser browse the term
Definition:A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis.
Synonyms:narrow_synonym: serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex


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SPOTS complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:48,243,365...48,253,316
Ensembl chr 9:48,237,572...48,253,211
JBrowse link
G Ormdl2 ORMDL sphingolipid biosynthesis regulator 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:1,247,869...1,250,999
Ensembl chr 7:1,246,479...1,250,907
JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 part_of ISS
ISO
IEA
IBA
GO_REF:0000024
(PMID:20182505), (PMID:25691431)
GO_REF:0000107
PMID:21873635
UniProt
RGD
Ensembl
PMID:20182505 PMID:25691431 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr10:83,590,052...83,598,620
Ensembl chr10:83,590,071...83,598,620
JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 part_of ISO (PMID:20182505), (PMID:25691431) RGD PMID:20182505 PMID:25691431 NCBI chr17:11,877,249...11,916,295
Ensembl chr17:11,877,249...11,916,295
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20010
    protein-containing complex 6011
      endoplasmic reticulum protein-containing complex 139
        endoplasmic reticulum palmitoyltransferase complex 8
          serine C-palmitoyltransferase complex 8
            SPOTS complex 4
Path 2
Term Annotations click to browse term
  cellular_component 20010
    cellular anatomical entity 19714
      intracellular anatomical structure 14388
        intracellular organelle 12741
          intracellular membrane-bounded organelle 11186
            endoplasmic reticulum 1754
              endoplasmic reticulum subcompartment 959
                endoplasmic reticulum membrane 949
                  endoplasmic reticulum palmitoyltransferase complex 8
                    serine C-palmitoyltransferase complex 8
                      SPOTS complex 4
paths to the root