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ONTOLOGY REPORT - ANNOTATIONS


Term:SPOTS complex
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Accession:GO:0035339 term browser browse the term
Definition:A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis.
Synonyms:narrow_synonym: serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex



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SPOTS complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 part_of ISO (PMID:20182505), (PMID:25691431) MGI PMID:20182505 PMID:25691431 NCBI chr17:17,361,624...17,368,194
Ensembl chr17:17,581,612...17,587,741
JBrowse link
G SPTLC1 serine palmitoyltransferase long chain base subunit 1 part_of ISO (PMID:20182505), (PMID:25691431) UniProt PMID:20182505 PMID:25691431 NCBI chr 9:63,087,798...63,174,977 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 12813
    protein-containing complex 3982
      endoplasmic reticulum protein-containing complex 102
        endoplasmic reticulum palmitoyltransferase complex 5
          serine C-palmitoyltransferase complex 5
            SPOTS complex 2
Path 2
Term Annotations click to browse term
  cellular_component 12813
    cellular anatomical entity 12661
      intracellular anatomical structure 10801
        intracellular organelle 9569
          intracellular membrane-bounded organelle 8699
            endoplasmic reticulum 1266
              endoplasmic reticulum subcompartment 466
                endoplasmic reticulum membrane 453
                  endoplasmic reticulum palmitoyltransferase complex 5
                    serine C-palmitoyltransferase complex 5
                      SPOTS complex 2
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