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ONTOLOGY REPORT - ANNOTATIONS

Term:Notch receptor processing, ligand-dependent
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Accession:GO:0035333 term browser browse the term
Definition:The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD).
Synonyms:narrow_synonym: Notch S2 cleavage;   Notch S3 cleavage


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  biological_process 20076
    cellular process 19155
      signal transduction 7183
        cell surface receptor signaling pathway 2842
          Notch signaling pathway 194
            Notch receptor processing, ligand-dependent 0
Path 2
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        macromolecule metabolic process 9812
          protein metabolic process 5297
            proteolysis 1766
              membrane protein proteolysis 64
                membrane protein intracellular domain proteolysis 14
                  Notch receptor processing, ligand-dependent 0
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