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ONTOLOGY REPORT - ANNOTATIONS


Term:hippo signaling
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Accession:GO:0035329 term browser browse the term
Definition:The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.
Synonyms:exact_synonym: hippo signal transduction;   hippo signaling pathway
 narrow_synonym: SWH pathway;   Salvador-Warts-Hippo signaling pathway
 related_synonym: hippo signaling cascade;   hippo signalling cascade



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hippo signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amot angiomotin acts_upstream_of_or_within ISO UniProtKB:P46937 (PMID:21205866) RGD PMID:21205866 NCBI chr  X:108,982,399...109,041,265
Ensembl chr  X:108,984,022...109,041,272
JBrowse link
G Amotl2 angiomotin like 2 acts_upstream_of_or_within ISO (PMID:21205866) RGD PMID:21205866 NCBI chr 8:103,303,368...103,319,161
Ensembl chr 8:103,302,992...103,318,910
JBrowse link
G Dchs1 dachsous cadherin-related 1 involved_in ISO
ISS
(MGI:5544531|PMID:24056717)
GO_REF:0000024
RGD
UniProt
PMID:24056717 GO_REF:0000024 MGI:5544531 NCBI chr 1:160,104,931...160,138,958
Ensembl chr 1:160,104,931...160,124,808
JBrowse link
G Fat4 FAT atypical cadherin 4 involved_in ISO (MGI:5544531|PMID:24056717) RGD PMID:24056717 MGI:5544531 NCBI chr 2:121,928,188...122,056,711
Ensembl chr 2:121,927,942...122,056,707
JBrowse link
G Lats1 large tumor suppressor kinase 1 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:20412773)
MGI:103262|MGI:1927144|MGI:1929004 (MGI:3785211|PMID:18369314)
PMID:21873635
RGD PMID:18369314 PMID:20412773 PMID:21873635 MGI:3785211, RGD:13792537 NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640
JBrowse link
G Lats2 large tumor suppressor kinase 2 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:20412773)
MGI:103262|MGI:1927144|MGI:1929004 (MGI:3785211|PMID:18369314)
PMID:21873635
RGD PMID:18369314 PMID:20412773 PMID:21873635 MGI:3785211, RGD:13792537 NCBI chr15:31,825,068...31,877,193
Ensembl chr15:31,825,092...31,877,220
JBrowse link
G Mob1a MOB kinase activator 1A involved_in ISO
IBA
(PMID:19739119)
PMID:21873635
RGD PMID:19739119 PMID:21873635 RGD:13792537 NCBI chr 4:115,831,581...115,848,561
Ensembl chr 4:115,831,551...115,848,561
JBrowse link
G Mob1b MOB kinase activator 1B involved_in ISO
IBA
(PMID:19739119)
PMID:21873635
RGD PMID:19739119 PMID:21873635 RGD:13792537 NCBI chr14:19,333,058...19,365,845
Ensembl chr14:19,332,459...19,365,845
JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783
JBrowse link
G Sav1 salvador family WW domain containing protein 1 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:103262|MGI:1333883|MGI:1354386|MGI:1929004|MGI:2654594|MGI:4430538 (MGI:3785211|PMID:18369314), (MGI:4948149|PMID:21512031)
(MGI:4420842|PMID:20080689)
UniProt
RGD
PMID:18369314 PMID:20080689 PMID:21512031 GO_REF:0000024 MGI:3785211 MGI:4420842 MGI:4948149 NCBI chr 6:88,478,536...88,500,121
Ensembl chr 6:88,478,539...88,499,968
JBrowse link
G Stk3 serine/threonine kinase 3 involved_in ISO
IEA
ISS
(PMID:20412773)
GO_REF:0000107
(MGI:4420842|PMID:20080689)
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:20080689 PMID:20412773 GO_REF:0000024 GO_REF:0000107 MGI:4420842 NCBI chr 7:66,053,209...66,323,292
Ensembl chr 7:66,052,345...66,323,233
JBrowse link
G Stk4 serine/threonine kinase 4 involved_in
acts_upstream_of_or_within
ISO (PMID:20412773)
(MGI:4420842|PMID:20080689)
MGI:103262|MGI:1333883|MGI:1354386|MGI:1927144|MGI:1929004 (MGI:3785211|PMID:18369314)
RGD PMID:18369314 PMID:20080689 PMID:20412773 MGI:3785211 MGI:4420842 NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744
JBrowse link
G Tead1 TEA domain transcription factor 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1354386 (MGI:3821642|PMID:19004856)
(PMID:18579750), (PMID:19324877)
RGD PMID:18579750 PMID:19004856 PMID:19324877 PMID:21873635 MGI:3821642, RGD:13792537 NCBI chr 1:166,791,900...167,010,591
Ensembl chr 1:166,792,628...167,003,369
JBrowse link
G Tead2 TEA domain transcription factor 2 involved_in ISO
IBA
(PMID:18579750), (PMID:19324877)
PMID:21873635
RGD PMID:18579750 PMID:19324877 PMID:21873635 RGD:13792537 NCBI chr 1:95,702,366...95,719,186
Ensembl chr 1:95,703,005...95,719,186
JBrowse link
G Tead3 TEA domain transcription factor 3 involved_in ISO
IBA
(PMID:18579750), (PMID:19324877)
PMID:21873635
RGD PMID:18579750 PMID:19324877 PMID:21873635 RGD:13792537 NCBI chr20:6,392,053...6,411,446
Ensembl chr20:6,392,053...6,411,446
JBrowse link
G Tead4 TEA domain transcription factor 4 involved_in ISO
IBA
(PMID:18579750), (PMID:19324877)
PMID:21873635
RGD PMID:18579750 PMID:19324877 PMID:21873635 RGD:13792537 NCBI chr 4:161,474,122...161,572,837
Ensembl chr 4:161,497,851...161,572,323
JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 involved_in IBA
ISO
PMID:21873635
(PMID:18227151), (PMID:20412773)
RGD PMID:18227151 PMID:20412773 PMID:21873635 RGD:13792537 NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968
JBrowse link
G Yap1 Yes1 associated transcriptional regulator involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1333883|MGI:1354386|MGI:1927144|MGI:1929004 (MGI:3785211|PMID:18369314)
RGD PMID:18369314 PMID:21873635 MGI:3785211, RGD:13792537 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
JBrowse link
negative regulation of hippo signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ajuba ajuba LIM protein involved_in ISO
IBA
ISS
(PMID:20303269)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:20303269 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr15:28,019,775...28,031,537
Ensembl chr15:28,019,778...28,030,021
JBrowse link
G Cit citron rho-interacting serine/threonine kinase involved_in ISO (PMID:30865227) RGD PMID:30865227 NCBI chr12:40,603,073...40,764,846
Ensembl chr12:40,605,563...40,763,860
JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 involved_in ISO
IBA
(PMID:28087714)
PMID:21873635
(MGI:5823491|PMID:28087714)
RGD PMID:28087714 PMID:21873635 MGI:5823491, RGD:13792537 NCBI chr15:75,786...209,735
Ensembl chr15:75,786...187,837
JBrowse link
G Limd1 LIM domain containing 1 involved_in ISO
IBA
ISS
(PMID:20303269)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:20303269 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 8:123,121,363...123,168,476
Ensembl chr 8:123,122,460...123,167,714
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 involved_in ISO (PMID:27402810) RGD PMID:27402810 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
JBrowse link
G Mapk14 mitogen activated protein kinase 14 involved_in ISO
IEA
(PMID:27402810)
GO_REF:0000107
RGD
Ensembl
PMID:27402810 GO_REF:0000107 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mark3 microtubule affinity regulating kinase 3 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:28087714)
UniProt
Ensembl
RGD
PMID:28087714 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:130,626,612...130,716,245
Ensembl chr 6:130,627,482...130,716,647
JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 involved_in ISO (PMID:32661924) RGD PMID:32661924 NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394
JBrowse link
G Vgll4 vestigial-like family member 4 involved_in ISO (PMID:28051067)
(MGI:6120600|PMID:27720608)
RGD PMID:27720608 PMID:28051067 MGI:6120600 NCBI chr 4:147,925,630...148,038,514
Ensembl chr 4:147,927,034...148,038,471
JBrowse link
G Wtip WT1 interacting protein involved_in ISO
IBA
(PMID:20303269)
PMID:21873635
RGD PMID:20303269 PMID:21873635 RGD:13792537 NCBI chr 1:86,731,214...86,764,939
Ensembl chr 1:86,731,265...86,765,014
JBrowse link
G Wwc1 WW and C2 domain containing 1 involved_in ISO (PMID:24682284) RGD PMID:24682284 NCBI chr10:20,300,735...20,454,393
Ensembl chr10:20,300,833...20,454,497
JBrowse link
G Wwc2 WW and C2 domain containing 2 involved_in ISO (PMID:24682284) RGD PMID:24682284 NCBI chr16:44,258,372...44,421,815
Ensembl chr16:44,258,372...44,421,812
JBrowse link
G Wwc3 WWC family member 3 involved_in ISO (PMID:24682284) RGD PMID:24682284 NCBI chr  X:23,584,204...23,701,864
Ensembl chr  X:23,584,424...23,700,513
JBrowse link
positive regulation of hippo signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coro7 coronin 7 involved_in IEA
ISO
GO_REF:0000107
(PMID:33162394)
Ensembl
RGD
PMID:33162394 GO_REF:0000107 NCBI chr10:10,880,299...10,941,001
Ensembl chr10:10,885,196...10,941,001
JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 involved_in ISO (PMID:28169360) RGD PMID:28169360 NCBI chr15:75,786...209,735
Ensembl chr15:75,786...187,837
JBrowse link
G Schip1 schwannomin interacting protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585
JBrowse link
G Sox11 SRY-box transcription factor 11 involved_in ISS
ISO
GO_REF:0000024
(MGI:5285157|PMID:20596238)
UniProt
RGD
PMID:20596238 GO_REF:0000024 MGI:5285157 NCBI chr 6:44,008,333...44,010,354
Ensembl chr 6:44,008,340...44,010,354
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in IEA
ISO
GO_REF:0000107
(PMID:33162394)
Ensembl
RGD
PMID:33162394 GO_REF:0000107 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tial1 Tia1 cytotoxic granule-associated RNA binding protein-like 1 involved_in ISO (PMID:33203680) RGD PMID:33203680 NCBI chr 1:183,008,358...183,045,092
Ensembl chr 1:183,009,253...183,031,637
JBrowse link
regulation of hippo signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mob3b MOB kinase activator 3B involved_in ISO (PMID:28792927) RGD PMID:28792927 NCBI chr 5:49,541,804...49,737,934
Ensembl chr 5:49,545,815...49,737,934
JBrowse link
G Nek8 NIMA-related kinase 8 involved_in ISO (PMID:23418306) RGD PMID:23418306 NCBI chr10:63,060,868...63,073,546
Ensembl chr10:63,061,253...63,072,416
JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor involved_in ISO
IBA
(PMID:20159598)
PMID:21873635
RGD PMID:20159598 PMID:21873635 RGD:13792537 NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667
JBrowse link
G Nuak2 NUAK family kinase 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:32845958)
UniProt
RGD
PMID:32845958 GO_REF:0000024 NCBI chr13:43,753,454...43,770,604
Ensembl chr13:43,753,832...43,770,604
JBrowse link
G Wwc1 WW and C2 domain containing 1 involved_in ISO
IBA
(PMID:20159598)
PMID:21873635
RGD PMID:20159598 PMID:21873635 RGD:13792537 NCBI chr10:20,300,735...20,454,393
Ensembl chr10:20,300,833...20,454,497
JBrowse link
G Wwc2 WW and C2 domain containing 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:44,258,372...44,421,815
Ensembl chr16:44,258,372...44,421,812
JBrowse link
G Wwc3 WWC family member 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:23,584,204...23,701,864
Ensembl chr  X:23,584,424...23,700,513
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18872
    signaling 7397
      signal transduction 6836
        intracellular signal transduction 2675
          hippo signaling 40
            negative regulation of hippo signaling 13
            positive regulation of hippo signaling 6
            regulation of hippo signaling + 22
Path 2
Term Annotations click to browse term
  biological_process 18872
    biological regulation 13378
      regulation of biological process 12642
        regulation of cellular process 11957
          signal transduction 6836
            intracellular signal transduction 2675
              hippo signaling 40
                negative regulation of hippo signaling 13
                positive regulation of hippo signaling 6
                regulation of hippo signaling + 22
paths to the root