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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of dephosphorylation
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Accession:GO:0035305 term browser browse the term
Definition:Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule.
Synonyms:exact_synonym: down regulation of dephosphorylation;   downregulation of dephosphorylation
 narrow_synonym: inhibition of dephosphorylation


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negative regulation of dephosphorylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epm2a EPM2A glucan phosphatase, laforin ISO (PMID:18617530) UniProtKB PMID:18617530 NCBI chrNW_004955436:14,925,452...14,982,357 JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K ISO (MGI:MGI:5294535|PMID:19250614) UniProtKB PMID:19250614 MGI:MGI:5294535 NCBI chrNW_004955481:1,651,422...1,674,402 JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 ISO (MGI:MGI:5085959|PMID:21709260) MGI PMID:21709260 MGI:MGI:5085959 NCBI chrNW_004955416:14,558,628...14,652,031 JBrowse link
negative regulation of alkaline phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor ISO RGD PMID:12193573 RGD:625678 NCBI chrNW_004955410:20,428,531...20,459,482 JBrowse link
G Hpn hepsin ISO (MGI:MGI:5437809|PMID:22912808) MGI PMID:22912808 MGI:MGI:5437809 NCBI chrNW_004955468:4,384,630...4,399,881 JBrowse link
G Sema4d semaphorin 4D ISO (MGI:MGI:5297297|PMID:22019888)
(PMID:22019888)
BHF-UCL PMID:22019888 MGI:MGI:5297297 NCBI chrNW_004955515:2,573,816...2,676,387 JBrowse link
G Tgfb2 transforming growth factor beta 2 ISO (PMID:18358889) BHF-UCL PMID:18358889 NCBI chrNW_004955406:174,949...249,248 JBrowse link
G Tnf tumor necrosis factor ISO (MGI:MGI:5285024|PMID:21689636) BHF-UCL PMID:21689636 MGI:MGI:5285024 NCBI chrNW_004955437:117,267...119,899 JBrowse link
negative regulation of myosin-light-chain-phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO (PMID:25816133) UniProtKB PMID:25816133 NCBI chrNW_004955536:611,965...658,647 JBrowse link
G Mprip myosin phosphatase Rho interacting protein ISO RGD PMID:17661354 RGD:9685557 NCBI chrNW_004955577:705,435...838,948 JBrowse link
G Nckap1l NCK associated protein 1 like ISO (PMID:16417406) UniProtKB PMID:16417406 NCBI chrNW_004955458:1,733,799...1,785,591 JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 ISO (PMID:25816133) UniProtKB PMID:25816133 NCBI chrNW_004955402:9,752,101...9,864,317 JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 ISO (PMID:25816133) UniProtKB PMID:25816133 NCBI chrNW_004955487:5,856,190...5,972,408 JBrowse link
G Tnf tumor necrosis factor ISO (PMID:25816133) UniProtKB PMID:25816133 NCBI chrNW_004955437:117,267...119,899 JBrowse link
negative regulation of peptidyl-serine dephosphorylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r16b protein phosphatase 1 regulatory subunit 16B ISO (PMID:25007873) GO_Central PMID:25007873 NCBI chrNW_004955445:17,864,103...17,961,295 JBrowse link
G Swap70 switching B cell complex subunit SWAP70 ISO (MGI:MGI:5554982|PMID:23921380) CACAO PMID:23921380 MGI:MGI:5554982 NCBI chrNW_004955414:25,385,648...25,444,743 JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon ISO (PMID:11953308) BHF-UCL PMID:11953308 NCBI chrNW_004955481:1,752,778...1,805,700 JBrowse link
negative regulation of phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arfgef3 ARFGEF family member 3 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955436:21,220,743...21,366,477 JBrowse link
G Camsap3 calmodulin regulated spectrin associated protein family member 3 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955563:1,639,369...1,648,826 JBrowse link
G Ccdc8 coiled-coil domain containing 8 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955574:551,582...553,829 JBrowse link
G Cd2bp2 CD2 cytoplasmic tail binding protein 2 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955493:7,281,073...7,283,879 JBrowse link
G Cep192 centrosomal protein 192 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955402:604,605...675,179 JBrowse link
G Chp1 calcineurin like EF-hand protein 1 ISO (PMID:10593895) UniProtKB PMID:10593895 NCBI chrNW_004955416:8,090,034...8,131,605 JBrowse link
G Cnst consortin, connexin sorting protein ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955406:9,441,441...9,531,792 JBrowse link
G Csrnp2 cysteine and serine rich nuclear protein 2 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955547:1,584,061...1,601,556 JBrowse link
G Csrnp3 cysteine and serine rich nuclear protein 3 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955449:8,450,292...8,635,393 JBrowse link
G Dlg2 discs large MAGUK scaffold protein 2 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955414:7,247,248...9,171,664 JBrowse link
G Dlg3 discs large MAGUK scaffold protein 3 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955475:9,992,888...10,056,197 JBrowse link
G Elfn1 extracellular leucine rich repeat and fibronectin type III domain containing 1 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955460:9,250,522...9,305,895 JBrowse link
G Elfn2 extracellular leucine rich repeat and fibronectin type III domain containing 2 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955413:23,805,494...23,862,067 JBrowse link
G Ell elongation factor for RNA polymerase II ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955524:3,054,296...3,094,125 JBrowse link
G Epm2a EPM2A glucan phosphatase, laforin ISO (PMID:18617530) UniProtKB PMID:18617530 NCBI chrNW_004955436:14,925,452...14,982,357 JBrowse link
G Farp1 FERM, ARH/RhoGEF and pleckstrin domain protein 1 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955404:12,050,225...12,316,842 JBrowse link
G Fkbp15 FKBP prolyl isomerase 15 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955419:14,264,488...14,329,890 JBrowse link
G Gpatch2 G-patch domain containing 2 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955406:800,496...963,004 JBrowse link
G Grxcr1 glutaredoxin and cysteine rich domain containing 1 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955443:4,799,056...4,908,749 JBrowse link
G Knl1 kinetochore scaffold 1 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955416:7,498,983...7,561,620 JBrowse link
G Lmtk3 lemur tyrosine kinase 3 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955559:1,994,851...2,011,578 JBrowse link
G Marf1 meiosis regulator and mRNA stability factor 1 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955442:442,512...490,784 JBrowse link
G Mphosph10 M-phase phosphoprotein 10 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955416:29,703,596...29,719,226 JBrowse link
G Myo1d myosin ID ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955481:7,413,211...7,752,198 JBrowse link
G Pcdh11x protocadherin 11 X-linked ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955525:2,982,220...3,919,729 JBrowse link
G Pcif1 phosphorylated CTD interacting factor 1 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955445:11,355,227...11,368,392 JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955442:14,368,110...14,372,365 JBrowse link
G Ppp1r26 protein phosphatase 1 regulatory subunit 26 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955513:4,039,819...4,046,482 JBrowse link
G Ppp1r27 protein phosphatase 1 regulatory subunit 27 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955506:1,327,073...1,328,187 JBrowse link
G Ppp1r35 protein phosphatase 1 regulatory subunit 35 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955573:523,512...524,979 JBrowse link
G Ppp1r36 protein phosphatase 1 regulatory subunit 36 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955466:5,312,602...5,339,402 JBrowse link
G Rbm26 RNA binding motif protein 26 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955404:28,116,009...28,198,878 JBrowse link
G Rimbp2 RIMS binding protein 2 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955482:1,326,628...1,431,358 JBrowse link
G Rrp1b ribosomal RNA processing 1B ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955407:38,553,866...38,577,547 JBrowse link
G Sfi1 SFI1 centrin binding protein ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955455:5,667,105...5,744,878 JBrowse link
G Sh2d4a SH2 domain containing 4A ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955403:43,111,804...43,170,344 JBrowse link
G Sh3rf2 SH3 domain containing ring finger 2 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955415:8,024,984...8,148,970 JBrowse link
G Slc7a14 solute carrier family 7 member 14 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955420:624,929...732,108 JBrowse link
G Spocd1 SPOC domain containing 1 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955452:10,192,076...10,214,914 JBrowse link
G Spred1 sprouty related EVH1 domain containing 1 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955416:5,288,779...5,376,861 JBrowse link
G Sytl2 synaptotagmin like 2 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955414:7,104,239...7,172,791 JBrowse link
G Tmem132d transmembrane protein 132D ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955482:1,672,267...2,165,302 JBrowse link
G Tmem225 transmembrane protein 225 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955412:24,544,669...24,547,471 JBrowse link
G Tsks testis specific serine kinase substrate ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955559:1,151,247...1,162,856 JBrowse link
G Uri1 URI1 prefoldin like chaperone ISO (PMID:17936702) UniProtKB PMID:17936702 NCBI chrNW_004955468:7,651,061...7,718,968 JBrowse link
G Wdr81 WD repeat domain 81 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955481:1,450,127...1,462,564 JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955454:6,228,492...6,358,690 JBrowse link
G Zcchc9 zinc finger CCHC-type containing 9 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955418:28,886,738...28,896,012 JBrowse link
G Zfyve1 zinc finger FYVE-type containing 1 ISO (PMID:19389623) UniProtKB PMID:19389623 NCBI chrNW_004955523:2,334,175...2,388,612 JBrowse link
negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag4 BAG cochaperone 4 ISO (MGI:MGI:5292318|PMID:21712384) UniProtKB PMID:21712384 MGI:MGI:5292318 NCBI chrNW_004955463:13,788,852...13,824,135 JBrowse link
negative regulation of phosphoprotein phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bod1 biorientation of chromosomes in cell division 1 ISO (PMID:24157919) UniProtKB PMID:24157919 NCBI chrNW_004955408:26,235,229...26,242,576 JBrowse link
G Cmya5 cardiomyopathy associated 5 ISO (MGI:MGI:5056263|PMID:21427212) MGI PMID:21427212 MGI:MGI:5056263 NCBI chrNW_004955425:21,410,396...21,517,307 JBrowse link
G Cry2 cryptochrome circadian regulator 2 ISO (PMID:9383998) UniProtKB PMID:9383998 NCBI chrNW_004955422:2,084,020...2,114,980 JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO (PMID:7592869) BHF-UCL PMID:7592869 NCBI chrNW_004955596:580,106...606,210 JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B ISO (PMID:7592869) BHF-UCL PMID:7592869 NCBI chrNW_004955469:6,263,271...6,274,823 JBrowse link
G Mastl microtubule associated serine/threonine kinase like ISO (PMID:20538976) UniProtKB PMID:20538976 NCBI chrNW_004955429:2,591,173...2,617,084 JBrowse link
G Ppia peptidylprolyl isomerase A ISO RGD PMID:19832699 RGD:7247324 NCBI chrNW_004955456:7,381,923...7,383,203 JBrowse link
G Ppp1r15a protein phosphatase 1 regulatory subunit 15A ISO (PMID:11564868) ParkinsonsUK-UCL PMID:11564868 NCBI chrNW_004955559:1,750,227...1,753,607 JBrowse link
G Ppp1r1b protein phosphatase 1 regulatory inhibitor subunit 1B ISO (PMID:10807923) CAFA PMID:10807923 NCBI chrNW_004955451:14,378,186...14,394,910 JBrowse link
G Ppp1r9b protein phosphatase 1 regulatory subunit 9B ISO RGD PMID:10585469, PMID:12016225 RGD:625568, RGD:9999389 NCBI chrNW_004955451:11,516,548...11,530,263 JBrowse link
G Ppp4r4 protein phosphatase 4 regulatory subunit 4 ISO (PMID:18715871) MGI PMID:18715871 NCBI chrNW_004955438:16,237,472...16,332,542 JBrowse link
G Ptpa protein phosphatase 2 phosphatase activator ISO (PMID:16916641) HGNC PMID:16916641 NCBI chrNW_004955570:1,429,316...1,454,820 JBrowse link
G Rgn regucalcin ISO RGD PMID:10922512 RGD:9590172 NCBI chrNW_004955516:958,416...978,829 JBrowse link
G Styxl1 serine/threonine/tyrosine interacting like 1 ISO (PMID:24709986) UniProtKB PMID:24709986 NCBI chrNW_004955456:14,755,516...14,819,326 JBrowse link
G Tiprl TOR signaling pathway regulator ISO (PMID:17384681) UniProtKB PMID:17384681 NCBI chrNW_004955462:8,921,678...8,939,785 JBrowse link
negative regulation of protein dephosphorylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap1 A-kinase anchoring protein 1 ISO NFATc3 RGD PMID:19358331 RGD:2312604 NCBI chrNW_004955451:5,756,648...5,787,617 JBrowse link
G Igbp1 immunoglobulin binding protein 1 ISO (MGI:MGI:4457251|PMID:17438131), (MGI:MGI:4457259|PMID:9792806) UniProtKB PMID:9792806, PMID:17438131 MGI:MGI:4457251, MGI:MGI:4457259 NCBI chrNW_004955475:9,671,162...9,694,926 JBrowse link
G Mfhas1 malignant fibrous histiocytoma amplified sequence 1 ISO (PMID:28609714) UniProtKB PMID:28609714 NCBI chrNW_004955463:4,900,115...4,993,793 JBrowse link
G Ppp1r15a protein phosphatase 1 regulatory subunit 15A ISO (PMID:11564868) ParkinsonsUK-UCL PMID:11564868 NCBI chrNW_004955559:1,750,227...1,753,607 JBrowse link
G Ppp1r16b protein phosphatase 1 regulatory subunit 16B ISO (PMID:21466834) GO_Central PMID:21466834 NCBI chrNW_004955445:17,864,103...17,961,295 JBrowse link
G Ptpa protein phosphatase 2 phosphatase activator ISO (PMID:16916641) HGNC PMID:16916641 NCBI chrNW_004955570:1,429,316...1,454,820 JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta ISO (PMID:17255105) BHF-UCL PMID:17255105 NCBI chrNW_004955445:12,451,644...12,474,251 JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon ISO (MGI:MGI:2665158|PMID:12796778) MGI PMID:12796778 MGI:MGI:2665158 NCBI chrNW_004955481:1,752,778...1,805,700 JBrowse link
negative regulation of protein serine/threonine phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r14d protein phosphatase 1 regulatory inhibitor subunit 14D ISO (PMID:12974676) UniProtKB PMID:12974676 NCBI chrNW_004955416:7,681,138...7,693,644 JBrowse link
negative regulation of protein tyrosine phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:11500506 RGD:13508599 NCBI chrNW_004955532:2,059,038...2,079,120 JBrowse link
G Mgat5 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase ISO (PMID:24846175) ARUK-UCL PMID:24846175 NCBI chrNW_004955440:1,705,018...2,004,838 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11862
    metabolic process 7593
      cellular metabolic process 7005
        phosphorus metabolic process 2371
          phosphate-containing compound metabolic process 2360
            dephosphorylation 296
              negative regulation of dephosphorylation 87
                negative regulation of phosphatase activity + 78
                negative regulation of protein dephosphorylation + 31
Path 2
Term Annotations click to browse term
  biological_process 11862
    biological regulation 8697
      regulation of biological process 8250
        regulation of metabolic process 5047
          regulation of cellular metabolic process 4516
            regulation of phosphorus metabolic process 1540
              regulation of phosphate metabolic process 1539
                regulation of dephosphorylation 156
                  negative regulation of dephosphorylation 87
                    negative regulation of phosphatase activity + 78
                    negative regulation of protein dephosphorylation + 31
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.