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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:ionotropic glutamate receptor signaling pathway
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Accession:GO:0035235 term browser browse the term
Definition:The series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: ionotropic glutamate receptor signalling pathway


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ionotropic glutamate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in
acts_upstream_of_or_within		 ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
MGI:2652346 (PMID:16025111)		 UniProt
Ensembl
RGD		 PMID:16025111 GO_REF:0000024 GO_REF:0000107 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 acts_upstream_of_or_within ISO MGI:3696954 (PMID:17234593) RGD PMID:17234593 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha involved_in IDA PMID:12223541 UniProt PMID:12223541 RGD:8554161 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 involved_in IDA PMID:12223541 UniProt PMID:12223541 RGD:8554161 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin acts_upstream_of_or_within ISO MGI:1933976 (PMID:16483786) RGD PMID:16483786 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434 		JBrowse link
G Cpeb4 cytoplasmic polyadenylation element binding protein 4 involved_in IDA PMID:20937770 UniProt PMID:20937770 RGD:8553637 NCBI chr10:15,717,794...15,780,482
Ensembl chr10:15,717,794...15,780,603 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase TAS RGD PMID:12736333 RGD:1358550 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 involved_in IEA
ISS
ISO		 GO_REF:0000108
GO_REF:0000107
GO_REF:0000024
(PMID:20614889)		 GOC
Ensembl
UniProt
RGD		 PMID:20614889 GO_REF:0000024 GO_REF:0000107 GO_REF:0000108 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096 		JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within IDA
ISO		 (MGI:3629813|PMID:15483117) RGD PMID:15483117 PMID:17395219 MGI:3629813, RGD:1642466 NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645 		JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375 		JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:137,767,865...137,989,617
Ensembl chr 5:137,767,865...137,984,307 		JBrowse link
G Grik4 glutamate ionotropic receptor kainate type subunit 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:42,903,043...43,331,990
Ensembl chr 8:42,905,056...43,193,751 		JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 acts_upstream_of_or_within
involved_in		 IDA
ISO
IBA
IEA
ISS		 (PMID:16025111)
GO_REF:0000033
GO_REF:0000108
GO_REF:0000114
PMID:19793963
(PMID:28228639)		 RGD
GO_Central
GOC
ComplexPortal		 PMID:16025111 PMID:28228639 PMID:16477151 PMID:19793963 GO_REF:0000033 GO_REF:0000108 GO_REF:0000114, RGD:1642190, RGD:150521643 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A involved_in IDA
ISS
IEA		 GO_REF:0000114
PMID:19793963
GO_REF:0000108		 ComplexPortal
GOC
RGD		 PMID:16477151 PMID:19793963 GO_REF:0000108 GO_REF:0000114, RGD:1642190, RGD:150521643 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B involved_in IDA
ISS
IEA		 GO_REF:0000114
GO_REF:0000108
PMID:19793963		 ComplexPortal
GOC
RGD		 PMID:16477151 PMID:19793963 GO_REF:0000108 GO_REF:0000114, RGD:1642190, RGD:150521643 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C involved_in IEA
IDA		 GO_REF:0000108
PMID:19793963		 GOC PMID:19793963 GO_REF:0000108, RGD:150521643 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D involved_in IDA PMID:19793963 ComplexPortal PMID:19793963 RGD:150521643 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793 		JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A involved_in IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000117		 GO_Central
UniProt
RGD		 PMID:16477151 GO_REF:0000033 GO_REF:0000117, RGD:1642190 NCBI chr 5:64,006,847...64,206,408
Ensembl chr 5:64,009,980...64,206,085 		JBrowse link
G Grin3b glutamate ionotropic receptor NMDA type subunit 3B involved_in IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000117		 GO_Central
UniProt
RGD		 PMID:11823786 GO_REF:0000033 GO_REF:0000117, RGD:632842 NCBI chr 7:9,730,861...9,737,183
Ensembl chr 7:9,730,862...9,737,183 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in IMP PMID:15814199 Alzheimers_University_of_Toronto PMID:15814199 RGD:8655534 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
AMPA selective glutamate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mef2c myocyte enhancer factor 2C acts_upstream_of_negative_effect ISS
ISO		 GO_REF:0000024
(MGI:3804504|PMID:18599438)		 UniProt
RGD		 PMID:18599438 GO_REF:0000024 MGI:3804504 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Plp1 proteolipid protein 1 IMP RGD PMID:16510724 RGD:30296668 NCBI chr  X:100,184,039...100,201,035
Ensembl chr  X:100,185,767...100,201,032 		JBrowse link
NMDA selective glutamate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2a calcium/calmodulin-dependent protein kinase II alpha involved_in IMP PMID:20670832 SynGO PMID:20670832 RGD:12050125 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B involved_in IMP PMID:15987933 SynGO PMID:15987933 RGD:12050132 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Kalrn kalirin, RhoGEF kinase involved_in IMP PMID:18031682 SynGO PMID:18031682 RGD:12050112 NCBI chr11:66,198,155...66,803,166
Ensembl chr11:66,198,173...66,797,610 		JBrowse link
G Mef2c myocyte enhancer factor 2C acts_upstream_of_negative_effect ISS
ISO		 GO_REF:0000024
(MGI:3804504|PMID:18599438)		 Alzheimers_University_of_Toronto
RGD		 PMID:18599438 GO_REF:0000024 MGI:3804504 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 involved_in IMP PMID:15721239 SynGO PMID:15721239 RGD:12050147 NCBI chr11:29,031,347...29,380,153
Ensembl chr11:29,031,348...29,159,901 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    cellular process 18769
      signal transduction 7163
        ligand-gated ion channel signaling pathway 40
          ionotropic glutamate receptor signaling pathway 28
            AMPA selective glutamate receptor signaling pathway 2
            NMDA selective glutamate receptor signaling pathway 5
            kainate selective glutamate receptor signaling pathway + 0
Path 2
Term Annotations click to browse term
  biological_process 20292
    biological regulation 13633
      regulation of biological process 13220
        regulation of cellular process 12685
          signal transduction 7163
            cell surface receptor signaling pathway 2879
              glutamate receptor signaling pathway 57
                ionotropic glutamate receptor signaling pathway 28
                  AMPA selective glutamate receptor signaling pathway 2
                  NMDA selective glutamate receptor signaling pathway 5
                  kainate selective glutamate receptor signaling pathway + 0
paths to the root