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ONTOLOGY REPORT - ANNOTATIONS


Term:sterol regulatory element binding protein cleavage
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Accession:GO:0035103 term browser browse the term
Definition:The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids.
Synonyms:exact_synonym: SREBP cleavage;   sterol depletion response, SREBP cleavage
 narrow_synonym: sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway
 alt_id: GO:0006992


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positive regulation of sterol regulatory element binding protein cleavage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpcat3 lysophosphatidylcholine acyltransferase 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:5927299|PMID:28846071)
UniProt
RGD
PMID:28846071 GO_REF:0000024 MGI:5927299 NCBI chr 4:157,181,722...157,222,997
Ensembl chr 4:157,181,795...157,222,996
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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      cellular metabolic process 10755
        cellular macromolecule metabolic process 8243
          cellular protein metabolic process 5230
            sterol regulatory element binding protein cleavage 1
              negative regulation of sterol regulatory element binding protein cleavage 0
              positive regulation of sterol regulatory element binding protein cleavage 1
              regulation of sterol regulatory element binding protein cleavage + 1
Path 2
Term Annotations click to browse term
  biological_process 19491
    biological regulation 13514
      regulation of biological process 12772
        regulation of cellular process 12273
          signal transduction 6881
            ER-nucleus signaling pathway 44
              SREBP signaling pathway 16
                sterol regulatory element binding protein cleavage 1
                  negative regulation of sterol regulatory element binding protein cleavage 0
                  positive regulation of sterol regulatory element binding protein cleavage 1
                  regulation of sterol regulatory element binding protein cleavage + 1
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