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ONTOLOGY REPORT - ANNOTATIONS

Term:PRC1 complex
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Accession:GO:0035102 term browser browse the term
Definition:A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.
Comment:In Drosophila the core subunits are Pc (Polycomb), Psc (Posterior sex combs), Ph (Polyhomeotic) and Sce (Sex comb extra). In mammals, which have several orthologs for each of the Drosophila core proteins, a family of distinct PRC1-like complexes seem to exist which contain at least some PcG proteins in mutually exclusive manner.
Synonyms:exact_synonym: Polycomb repressive complex 1

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PRC1 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmi1 BMI1 proto-oncogene, polycomb ring finger part_of ISO (PMID:12167701), (PMID:19636380)
(PMID:16359901)		 UniProt
MGI		 PMID:12167701 PMID:16359901 PMID:19636380 NCBI chrNW_004955429:6,548,586...6,553,730
Ensembl chrNW_004955429:6,547,731...6,558,105 		JBrowse link
G Cbx2 chromobox 2 part_of ISO (PMID:12167701), (PMID:19636380) UniProt PMID:12167701 PMID:19636380 NCBI chrNW_004955506:3,045,395...3,053,003
Ensembl chrNW_004955506:3,046,607...3,053,001 		JBrowse link
G Cbx4 chromobox 4 part_of ISO (PMID:12167701), (PMID:19636380) UniProt PMID:12167701 PMID:19636380 NCBI chrNW_004955506:2,998,241...3,002,788
Ensembl chrNW_004955506:2,998,237...3,002,788 		JBrowse link
G Cbx7 chromobox 7 part_of ISO (MGI:4353923|PMID:19636380) UniProt PMID:19636380 MGI:4353923 NCBI chrNW_004955413:25,079,627...25,100,039
Ensembl chrNW_004955413:25,086,186...25,100,039 		JBrowse link
G Cbx8 chromobox 8 part_of ISO (PMID:12167701), (PMID:19636380)
(PMID:16359901)		 UniProt
MGI		 PMID:12167701 PMID:16359901 PMID:19636380 NCBI chrNW_004955506:3,035,510...3,038,204
Ensembl chrNW_004955506:3,035,621...3,040,354 		JBrowse link
G Pcgf2 polycomb group ring finger 2 part_of ISO (PMID:19636380)
(PMID:16359901)		 UniProt
MGI		 PMID:16359901 PMID:19636380 NCBI chrNW_004955451:13,817,559...13,822,342
Ensembl chrNW_004955451:13,817,559...13,832,653 		JBrowse link
G Pcgf6 polycomb group ring finger 6 part_of ISO (PMID:19636380) UniProt PMID:19636380 NCBI chrNW_004955485:7,196,626...7,228,918
Ensembl chrNW_004955485:7,196,626...7,227,536 		JBrowse link
G Phc1 polyhomeotic homolog 1 part_of ISO (PMID:12167701), (PMID:19636380) UniProt PMID:12167701 PMID:19636380 NCBI chrNW_004955413:6,156,934...6,176,460 JBrowse link
G Phc2 polyhomeotic homolog 2 part_of ISO (PMID:12167701), (PMID:19636380)
(PMID:16359901)		 UniProt
MGI		 PMID:12167701 PMID:16359901 PMID:19636380 NCBI chrNW_004955452:11,490,336...11,538,618
Ensembl chrNW_004955452:11,491,573...11,538,618 		JBrowse link
G Phc3 polyhomeotic homolog 3 part_of ISO (PMID:12167701), (PMID:19636380) UniProt PMID:12167701 PMID:19636380 NCBI chrNW_004955420:329,215...403,191
Ensembl chrNW_004955420:329,215...403,168 		JBrowse link
G Ring1 ring finger protein 1 part_of ISO (PMID:12167701), (PMID:19636380)
(PMID:16359901)		 UniProt
MGI		 PMID:12167701 PMID:16359901 PMID:19636380 NCBI chrNW_004955437:1,782,156...1,785,811
Ensembl chrNW_004955437:1,782,115...1,788,842 		JBrowse link
G Rnf2 ring finger protein 2 part_of ISO (PMID:12167701), (PMID:19636380)
(PMID:16359901)		 UniProt
MGI		 PMID:12167701 PMID:16359901 PMID:19636380 NCBI chrNW_004955406:23,672,947...23,725,253 JBrowse link
G Samd11 sterile alpha motif domain containing 11 part_of ISO (MGI:6512737|PMID:33603070) UniProt PMID:33603070 MGI:6512737 NCBI chrNW_004955486:9,763,704...9,781,132
Ensembl chrNW_004955486:9,763,725...9,779,197 		JBrowse link
G Samd7 sterile alpha motif domain containing 7 part_of ISO (MGI:6095048|PMID:28900001), (MGI:6512737|PMID:33603070) UniProt PMID:28900001 PMID:33603070 MGI:6095048 MGI:6512737 NCBI chrNW_004955420:161,353...178,768
Ensembl chrNW_004955420:161,353...177,936 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 12554
    protein-containing complex 4416
      nuclear protein-containing complex 976
        PcG protein complex 44
          PRC1 complex 14
Path 2
Term Annotations click to browse term
  cellular_component 12554
    cellular anatomical entity 12397
      organelle 9788
        intracellular organelle 9421
          intracellular membrane-bounded organelle 8477
            nucleus 5235
              nuclear protein-containing complex 976
                nuclear ubiquitin ligase complex 38
                  PRC1 complex 14
paths to the root