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ONTOLOGY REPORT - ANNOTATIONS

Term:protein folding in endoplasmic reticulum
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Accession:GO:0034975 term browser browse the term
Definition:A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).
Synonyms:exact_synonym: oxidative protein folding;   protein folding in ER


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protein folding in endoplasmic reticulum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALR calreticulin involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489 		JBrowse link
G CANX calnexin involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 5:179,678,656...179,731,641
Ensembl chr 5:179,678,628...179,731,641 		JBrowse link
G DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 involved_in IEA
IDA		 (PMID:23769672) InterPro
UniProt		 PMID:23769672 GO_REF:0000002 NCBI chr 2:182,716,257...182,794,464
Ensembl chr 2:182,716,255...182,794,464 		JBrowse link
G DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr13:95,677,139...95,794,988
Ensembl chr13:95,677,139...95,794,988 		JBrowse link
G EMC1 ER membrane protein complex subunit 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:19,215,660...19,251,524
Ensembl chr 1:19,215,660...19,251,552 		JBrowse link
G EMC2 ER membrane protein complex subunit 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:108,443,624...108,489,196
Ensembl chr 8:108,443,601...108,489,196 		JBrowse link
G EMC3 ER membrane protein complex subunit 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:9,962,682...10,011,118
Ensembl chr 3:9,962,682...10,011,202 		JBrowse link
G EMC4 ER membrane protein complex subunit 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:34,225,016...34,230,156
Ensembl chr15:34,225,013...34,230,156 		JBrowse link
G EMC6 ER membrane protein complex subunit 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:3,668,812...3,669,665
Ensembl chr17:3,668,812...3,669,668 		JBrowse link
G ERO1A endoplasmic reticulum oxidoreductase 1 alpha involved_in IEA
IBA		 InterPro
TreeGrafter
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr14:52,639,915...52,695,558
Ensembl chr14:52,639,915...52,695,900 		JBrowse link
G ERO1B endoplasmic reticulum oxidoreductase 1 beta involved_in IDA
IEA
IBA		 (PMID:21091435) FlyBase
TreeGrafter
GO_Central
InterPro		 PMID:21091435 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:236,215,101...236,281,958
Ensembl chr 1:236,214,681...236,282,019 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr12:103,930,410...103,947,926
Ensembl chr12:103,930,107...103,953,931 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G P4HB prolyl 4-hydroxylase subunit beta involved_in IDA (PMID:21091435) FlyBase PMID:21091435 NCBI chr17:81,843,166...81,860,535
Ensembl chr17:81,843,159...81,860,856 		JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr16:283,164...287,215
Ensembl chr16:283,164...287,215 		JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr15:43,746,438...43,773,278
Ensembl chr15:43,746,394...43,773,279 		JBrowse link
G SUCO SUN domain containing ossification factor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:172,532,349...172,611,833
Ensembl chr 1:172,532,349...172,611,833 		JBrowse link
G VAPA VAMP associated protein A NOT|involved_in IMP (PMID:18713837) UniProt PMID:18713837 NCBI chr18:9,914,016...9,960,021
Ensembl chr18:9,914,016...9,960,021 		JBrowse link
regulation of protein folding in endoplasmic reticulum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in TAS (PMID:19816510) BHF-UCL PMID:19816510 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19770
    cellular process 18460
      protein folding 248
        protein folding in endoplasmic reticulum 18
          regulation of protein folding in endoplasmic reticulum 1
Path 2
Term Annotations click to browse term
  biological_process 19770
    cellular process 18460
      cellular metabolic process 11168
        cellular biosynthetic process 9160
          macromolecule biosynthetic process 8233
            gene expression 7781
              protein maturation 586
                protein folding 248
                  protein folding in endoplasmic reticulum 18
                    regulation of protein folding in endoplasmic reticulum 1
paths to the root