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ONTOLOGY REPORT - ANNOTATIONS


Term:cortisol biosynthetic process
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Accession:GO:0034651 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.
Synonyms:exact_synonym: cortisol biosynthesis;   cortisol formation;   cortisol synthesis
 narrow_synonym: cortisol anabolism


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cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1H calcium voltage-gated channel subunit alpha1 H involved_in IMP (PMID:19342457) UniProt PMID:19342457 NCBI chr16:1,153,106...1,221,769
Ensembl chr16:1,153,106...1,221,771
JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 involved_in IMP
IDA
(PMID:19342457), (PMID:2022736)
(PMID:8506298)
UniProt
BHF-UCL
PMID:2022736 PMID:8506298 PMID:19342457 NCBI chr 8:142,872,357...142,879,825
Ensembl chr 8:142,872,356...142,879,846
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 NOT|involved_in IMP (PMID:9703385)
(PMID:19342457)
BHF-UCL
UniProt
PMID:9703385 PMID:19342457 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843
JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr 6:55,753,653...55,875,590
Ensembl chr 6:55,753,653...55,875,590
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IDA (PMID:16981135) UniProt PMID:16981135 NCBI chr11:11,963,036...12,009,827
Ensembl chr11:11,956,207...12,009,769
JBrowse link
G REST RE1 silencing transcription factor involved_in IMP (PMID:19342457) UniProt PMID:19342457 NCBI chr 4:56,907,900...56,935,847
Ensembl chr 4:56,907,876...56,966,808
JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT4 Wnt family member 4 involved_in IDA (PMID:16981135) UniProt PMID:16981135 NCBI chr 1:22,117,308...22,143,981
Ensembl chr 1:22,117,313...22,143,969
JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DGKQ diacylglycerol kinase theta involved_in IMP (PMID:24369117) ParkinsonsUK-UCL PMID:24369117 NCBI chr 4:958,887...973,569
Ensembl chr 4:958,887...986,895
JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in IMP (PMID:18628520), (PMID:23132696) UniProt PMID:18628520 PMID:23132696 NCBI chr 1:9,234,767...9,271,337
Ensembl chr 1:9,234,774...9,271,337
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18536
    metabolic process 11863
      biosynthetic process 6242
        olefinic compound biosynthetic process 32
          cortisol biosynthetic process 10
            negative regulation of cortisol biosynthetic process 4
            positive regulation of cortisol biosynthetic process 1
            regulation of cortisol biosynthetic process + 7
Path 2
Term Annotations click to browse term
  biological_process 18536
    metabolic process 11863
      organic substance metabolic process 11369
        organic hydroxy compound metabolic process 591
          alcohol metabolic process 383
            tertiary alcohol metabolic process 21
              cortisol metabolic process 11
                cortisol biosynthetic process 10
                  negative regulation of cortisol biosynthetic process 4
                  positive regulation of cortisol biosynthetic process 1
                  regulation of cortisol biosynthetic process + 7
paths to the root