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ONTOLOGY REPORT - ANNOTATIONS

Term:cellular response to unfolded protein
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Accession:GO:0034620 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
Comment:Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to the signaling pathways that respond to the presence of unfolded proteins in the ER.
Synonyms:related_synonym: heat shock protein activity


show annotations for term's descendants           Sort by:
cellular response to unfolded protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAG3 BAG cochaperone 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:129,510,240...129,533,998
Ensembl chr14:129,466,905...129,533,987 		JBrowse link
G DAXX death domain associated protein involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:29,676,854...29,681,145
Ensembl chr 7:29,676,856...29,681,110 		JBrowse link
G DERL1 derlin 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:4361100|PMID:19509052) MGI
Ensembl		 PMID:19509052 GO_REF:0000107 MGI:4361100 NCBI chr 4:16,310,407...16,341,405
Ensembl chr 4:16,310,314...16,341,433 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284 		JBrowse link
G HSF1 heat shock transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:463,531...486,483
Ensembl chr 4:463,393...486,473 		JBrowse link
G HSP70.2 heat shock protein 70.2 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 7:23,925,929...23,927,854 JBrowse link
G HSPA13 heat shock protein family A (Hsp70) member 13 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr13:179,309,746...179,321,297
Ensembl chr13:179,310,727...179,321,491 		JBrowse link
G HSPA14 heat shock protein family A (Hsp70) member 14 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr10:46,908,161...46,935,323
Ensembl chr10:46,904,311...46,935,280 		JBrowse link
G HSPA1L heat shock protein family A (Hsp70) member 1 like involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 7:23,909,960...23,938,678
Ensembl chr 7:23,909,960...23,914,629 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 4:88,970,592...88,973,109
Ensembl chr 4:88,970,599...88,973,918 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 9:49,982,278...49,986,760
Ensembl chr 9:49,982,284...49,990,508 		JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 2:140,515,239...140,532,164
Ensembl chr 2:140,515,253...140,531,857 		JBrowse link
G HSPB8 heat shock protein family B (small) member 8 involved_in IEA
IBA		 (PMID:21873635) InterPro
GO_Central
InterPro
GO_Central		 PMID:21873635 GO_REF:0000002 NCBI chr14:33,626,125...33,639,824
Ensembl chr14:33,626,120...33,640,792 		JBrowse link
G OPTN optineurin involved_in IEA
ISS		 Ensembl
UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr10:48,532,029...48,582,952
Ensembl chr10:48,530,843...48,582,860 		JBrowse link
G PMP22 peripheral myelin protein 22 acts_upstream_of_or_within ISO (MGI:5517729|PMID:23847051) MGI PMID:23847051 MGI:5517729 NCBI chr12:58,679,773...58,734,195
Ensembl chr12:58,679,775...58,707,925 		JBrowse link
G RHBDD1 rhomboid domain containing 1 involved_in IBA
IEA		 (PMID:21873635) GO_Central
GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr15:128,346,315...128,499,151
Ensembl chr15:128,346,373...128,469,213 		JBrowse link
G TM7SF3 transmembrane 7 superfamily member 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 5:46,740,936...46,784,195
Ensembl chr 5:46,740,949...46,784,194 		JBrowse link
G TMBIM6 transmembrane BAX inhibitor motif containing 6 involved_in IEA
IBA		 (PMID:21873635) Ensembl
GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 5:15,674,028...15,692,944
Ensembl chr 5:15,674,057...15,692,936 		JBrowse link
G UMOD uromodulin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5916257|PMID:28437467) Ensembl
Ensembl
MGI		 PMID:28437467 GO_REF:0000107 MGI:5916257 NCBI chr 3:25,473,048...25,492,286
Ensembl chr 3:25,473,162...25,492,278 		JBrowse link
endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMFR autocrine motility factor receptor involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 6:29,366,812...29,417,800
Ensembl chr 6:29,366,936...29,413,697 		JBrowse link
G ATF3 activating transcription factor 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:130,772,259...130,829,678
Ensembl chr 9:130,772,262...130,785,506 		JBrowse link
G ATF4 activating transcription factor 4 involved_in ISO (MGI:5496937|PMID:23624402) UniProt PMID:23624402 MGI:5496937 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368 		JBrowse link
G ATF6 activating transcription factor 6 involved_in IBA
IEA		 (PMID:21873635) GO_Central
GO_Central
InterPro		 PMID:21873635 GO_REF:0000002 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304 		JBrowse link
G ATF6B activating transcription factor 6 beta involved_in IEA
IBA		 (PMID:21873635) InterPro
GO_Central
GO_Central		 PMID:21873635 GO_REF:0000002 NCBI chr 7:24,153,551...24,171,743
Ensembl chr 7:24,161,061...24,171,709 		JBrowse link
G BHLHA15 basic helix-loop-helix family member a15 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:5,410,467...5,414,074
Ensembl chr 3:5,410,518...5,414,072 		JBrowse link
G CCND1 cyclin D1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3620306|PMID:16176978) Ensembl
Ensembl
MGI		 PMID:16176978 GO_REF:0000107 MGI:3620306 NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296 		JBrowse link
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:24,224,262...24,234,468
Ensembl chr12:24,224,263...24,234,467 		JBrowse link
G CREB3 cAMP responsive element binding protein 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:236,450,573...236,456,381
Ensembl chr 1:236,450,573...236,456,375 		JBrowse link
G CREB3L1 cAMP responsive element binding protein 3 like 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 2:16,186,206...16,220,948
Ensembl chr 2:16,186,206...16,220,940 		JBrowse link
G CREB3L2 cAMP responsive element binding protein 3 like 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr18:11,533,184...11,666,132
Ensembl chr18:11,533,183...11,666,113 		JBrowse link
G CREB3L3 cAMP responsive element binding protein 3 like 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr 2:74,578,471...74,588,269
Ensembl chr 2:74,578,483...74,601,784 		JBrowse link
G CREB3L4 cAMP responsive element binding protein 3 like 4 involved_in IEA InterPro GO_REF:0000002 NCBI chr 4:95,716,530...95,723,959
Ensembl chr 4:95,716,537...95,722,947 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:6270315|PMID:30188326)
(MGI:3525819|PMID:15601821)		 Ensembl
Ensembl
MGI		 PMID:15601821 PMID:30188326 GO_REF:0000107 MGI:3525819 MGI:6270315 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829 		JBrowse link
G DERL1 derlin 1 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr 4:16,310,407...16,341,405
Ensembl chr 4:16,310,314...16,341,433 		JBrowse link
G DERL2 derlin 2 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr12:51,508,138...51,524,799
Ensembl chr12:51,507,996...51,524,793 		JBrowse link
G DERL3 derlin 3 involved_in IBA
IEA		 (PMID:21873635) GO_Central
GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr14:49,871,077...49,875,022
Ensembl chr14:49,871,218...49,877,672 		JBrowse link
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3511630|PMID:15542627) Ensembl
Ensembl
MGI		 PMID:15542627 GO_REF:0000107 MGI:3511630 NCBI chr 3:103,041,029...103,096,741
Ensembl chr 3:103,041,221...103,096,738 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:1333015|PMID:9930704), (MGI:2677605|PMID:14517290)
(MGI:1858648|PMID:10882126), (MGI:2136067|PMID:11430819), (MGI:3511630|PMID:15542627), (MGI:3583403|PMID:15911877), (MGI:3620306|PMID:16176978)		 Ensembl
Ensembl
MGI		 PMID:9930704 PMID:10882126 PMID:11430819 PMID:14517290 PMID:15542627 More... GO_REF:0000107 MGI:1333015 MGI:1858648 MGI:2136067 MGI:2677605 MGI:3511630 MGI:3583403 MGI:3620306 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245 		JBrowse link
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 acts_upstream_of_or_within ISO (MGI:3620306|PMID:16176978) MGI PMID:16176978 MGI:3620306 NCBI chr 1:131,244,818...131,355,240
Ensembl chr 1:131,245,466...131,355,226 		JBrowse link
G ERLEC1 endoplasmic reticulum lectin 1 involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr 3:87,362,166...87,389,814
Ensembl chr 3:87,355,904...87,389,814 		JBrowse link
G ERMP1 endoplasmic reticulum metallopeptidase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27566589) Ensembl
Ensembl
FlyBase		 PMID:27566589 GO_REF:0000107 NCBI chr 1:216,312,827...216,382,063
Ensembl chr 1:216,312,615...216,396,296 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1858648|PMID:10882126), (MGI:2136067|PMID:11430819), (MGI:3525819|PMID:15601821) MGI
InterPro
Ensembl
InterPro		 PMID:10882126 PMID:11430819 PMID:15601821 GO_REF:0000002 GO_REF:0000107 MGI:1858648 MGI:2136067 MGI:3525819 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284 		JBrowse link
G ERN2 endoplasmic reticulum to nucleus signaling 2 involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr 3:22,510,067...22,537,872
Ensembl chr 3:22,510,558...22,537,868 		JBrowse link
G ERO1A endoplasmic reticulum oxidoreductase 1 alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3525819|PMID:15601821) Ensembl
MGI		 PMID:15601821 GO_REF:0000107 MGI:3525819 NCBI chr 1:182,268,651...182,318,147
Ensembl chr 1:182,265,261...182,318,195 		JBrowse link
G FGF21 fibroblast growth factor 21 ISO RGD PMID:23123503 RGD:10401883 NCBI chr 6:54,082,653...54,084,532
Ensembl chr 6:54,080,739...54,084,601 		JBrowse link
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 (PMID:21873635)
(MGI:1913176|PMID:10922362)		 GO_Central
GO_Central
Ensembl
MGI
RGD		 PMID:10922362 PMID:15102845 PMID:21873635 GO_REF:0000107 MGI:1913176 RGD:1304324 NCBI chr 6:18,901,171...18,913,427
Ensembl chr 6:18,901,297...18,913,424 		JBrowse link
G HERPUD2 HERPUD family member 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr18:38,284,520...38,326,323
Ensembl chr18:38,284,520...38,326,311 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G ICAM2 intercellular adhesion molecule 2 involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr12:14,986,636...14,991,639
Ensembl chr12:14,972,852...14,997,428 		JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (MGI:3583403|PMID:15911877) MGI PMID:15911877 MGI:3583403 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2677605|PMID:14517290) MGI
Ensembl		 PMID:14517290 GO_REF:0000107 MGI:2677605 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
G OS9 OS9 endoplasmic reticulum lectin involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr 5:22,957,903...23,004,464
Ensembl chr 5:22,957,875...23,004,458 		JBrowse link
G PARP16 poly(ADP-ribose) polymerase family member 16 involved_in IBA
IEA		 (PMID:21873635) GO_Central
GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 1:163,292,778...163,320,047
Ensembl chr 1:163,292,784...163,320,021 		JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A acts_upstream_of_or_within ISO (MGI:3525819|PMID:15601821) RGD
MGI		 PMID:15601821 PMID:18266951 PMID:22154936 MGI:3525819 RGD:9999171 RGD:9999413 NCBI chr 6:54,172,038...54,175,461
Ensembl chr 6:54,172,050...54,175,463 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:52,017,100...52,086,747
Ensembl chr17:52,017,130...52,086,736 		JBrowse link
G QRICH1 glutamine rich 1 involved_in ISO (PMID:33384352) UniProt PMID:33384352 NCBI chr13:31,663,812...31,714,523
Ensembl chr13:31,658,642...31,714,455 		JBrowse link
G RHBDD2 rhomboid domain containing 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 3:10,299,201...10,329,638
Ensembl chr 3:10,299,209...10,309,622 		JBrowse link
G SELENOS selenoprotein S involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr 1:139,829,002...139,836,923
Ensembl chr 1:139,828,791...139,836,914 		JBrowse link
G SERP1 stress associated endoplasmic reticulum protein 1 involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 (PMID:21873635)
(MGI:3619104|PMID:16415102)		 GO_Central
GO_Central
Ensembl
MGI		 PMID:16415102 PMID:21873635 GO_REF:0000107 MGI:3619104 NCBI chr13:90,756,845...90,761,400
Ensembl chr13:90,756,855...90,761,560 		JBrowse link
G SERP2 stress associated endoplasmic reticulum protein family member 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr11:22,672,235...22,700,895
Ensembl chr11:22,672,240...22,700,675 		JBrowse link
G STC2 stanniocalcin 2 acts_upstream_of_or_within ISO (MGI:3511371|PMID:15485913) MGI PMID:15485913 MGI:3511371 NCBI chr16:50,989,676...51,001,412
Ensembl chr16:50,989,433...51,004,481 		JBrowse link
G STUB1 STIP1 homology and U-box containing protein 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:41,092,514...41,095,181
Ensembl chr 3:41,092,449...41,095,136 		JBrowse link
G TBL2 transducin beta like 2 involved_in IEA
IBA		 (PMID:21873635) Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr 3:10,850,347...10,892,441
Ensembl chr 3:10,876,973...10,892,404 		JBrowse link
G TMTC4 transmembrane O-mannosyltransferase targeting cadherins 4 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:21873635)
(MGI:6270315|PMID:30188326)		 Ensembl
GO_Central
Ensembl
MGI		 PMID:21873635 PMID:30188326 GO_REF:0000107 MGI:6270315 NCBI chr11:69,361,219...69,442,769
Ensembl chr11:69,361,229...69,443,039 		JBrowse link
G VAPB VAMP associated protein B and C involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:58,594,749...58,644,925
Ensembl chr17:58,594,749...58,644,914 		JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 8:4,362,678...4,405,185
Ensembl chr 8:4,362,680...4,385,273 		JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO (MGI:5573106|PMID:24753614), (MGI:5607242|PMID:17612490) RGD
UniProt		 PMID:15171721 PMID:17612490 PMID:24753614 MGI:5573106 MGI:5607242 RGD:1304536 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526 		JBrowse link
G YOD1 YOD1 deubiquitinase involved_in IBA
IEA		 (PMID:21873635) GO_Central
GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 9:67,672,640...67,681,889
Ensembl chr 9:67,672,651...67,681,826 		JBrowse link
IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:88,198,751...88,256,396
Ensembl chr15:88,198,794...88,259,002 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284 		JBrowse link
G ERN2 endoplasmic reticulum to nucleus signaling 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 3:22,510,067...22,537,872
Ensembl chr 3:22,510,558...22,537,868 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in ISO (MGI:5571560|PMID:24508390) WB PMID:24508390 MGI:5571560 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G ICAM2 intercellular adhesion molecule 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr12:14,986,636...14,991,639
Ensembl chr12:14,972,852...14,997,428 		JBrowse link
G PARP16 poly(ADP-ribose) polymerase family member 16 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 1:163,292,778...163,320,047
Ensembl chr 1:163,292,784...163,320,021 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr17:52,017,100...52,086,747
Ensembl chr17:52,017,130...52,086,736 		JBrowse link
G VAPB VAMP associated protein B and C involved_in IEA
ISS		 Ensembl
UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:58,594,749...58,644,925
Ensembl chr17:58,594,749...58,644,914 		JBrowse link
mitochondrial unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB10 ATP binding cassette subfamily B member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:60,309,893...60,346,283
Ensembl chr14:60,309,931...60,346,280 		JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6B activating transcription factor 6 beta involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:24,153,551...24,171,743
Ensembl chr 7:24,161,061...24,171,709 		JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 8:4,362,678...4,405,185
Ensembl chr 8:4,362,680...4,385,273 		JBrowse link
negative regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREBRF CREB3 regulatory factor involved_in ISO (PMID:18391022) UniProt PMID:18391022 NCBI chr16:51,146,015...51,210,806
Ensembl chr16:51,150,560...51,226,212 		JBrowse link
G MIR199A-1 microRNA mir-199a-1 acts_upstream_of ISO (PMID:24299514) BHF-UCL PMID:24299514 NCBI chr 9:114,533,783...114,533,858
Ensembl chr 9:114,533,777...114,533,880 		JBrowse link
G MIR199A-2 microRNA mir-199a-2 acts_upstream_of ISO (PMID:24299514) BHF-UCL PMID:24299514 NCBI chr 2:69,558,051...69,558,130
Ensembl chr 2:69,558,050...69,558,131 		JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO (PMID:25239945) UniProt PMID:25239945 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526 		JBrowse link
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BFAR bifunctional apoptosis regulator involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:28,572,789...28,612,659
Ensembl chr 3:28,573,393...28,612,217 		JBrowse link
G DDRGK1 DDRGK domain containing 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr17:32,479,981...32,491,401
Ensembl chr17:32,479,977...32,491,396 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in ISS UniProt
UniProt		 GO_REF:0000024 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 involved_in ISO (MGI:5571560|PMID:24508390) WB PMID:24508390 MGI:5571560 NCBI chr 3:125,752,079...125,774,225
Ensembl chr 3:125,751,978...125,776,077 		JBrowse link
G UFL1 UFM1 specific ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:63,638,589...63,698,931
Ensembl chr 1:63,638,596...63,700,476 		JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) ARUK-UCL PMID:27030769 MGI:5774886 NCBI chr 2:77,357,161...77,375,349
Ensembl chr 2:77,357,218...77,375,180 		JBrowse link
G NCK1 NCK adaptor protein 1 involved_in IEA
IBA		 (PMID:21873635) Ensembl
Ensembl
GO_Central
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr13:77,863,655...77,940,944
Ensembl chr13:77,863,701...77,945,468 		JBrowse link
G NCK2 NCK adaptor protein 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:49,063,813...49,222,274
Ensembl chr 3:49,063,991...49,198,664 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IEA
IBA		 (PMID:21873635) Ensembl
GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr17:52,017,100...52,086,747
Ensembl chr17:52,017,130...52,086,736 		JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:3722921|PMID:14729979), (MGI:6467680|PMID:17707796) UniProt PMID:14729979 PMID:17707796 MGI:3722921 MGI:6467680 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha involved_in IEA
ISS		 Ensembl
UniProt
Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
G QRICH1 glutamine rich 1 involved_in ISO (PMID:33384352) UniProt PMID:33384352 NCBI chr13:31,663,812...31,714,523
Ensembl chr13:31,658,642...31,714,455 		JBrowse link
G TMED2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO (MGI:5914333|PMID:28797121) MGI PMID:28797121 MGI:5914333 NCBI chr14:29,390,903...29,400,454
Ensembl chr14:29,390,335...29,400,437 		JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304 		JBrowse link
positive regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAK1 BCL2 antagonist/killer 1 involved_in ISO (PMID:16645094) UniProt PMID:16645094 NCBI chr 7:29,808,849...29,815,345 JBrowse link
G BAX BCL2 associated X, apoptosis regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284 		JBrowse link
G ICAM2 intercellular adhesion molecule 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:14,986,636...14,991,639
Ensembl chr12:14,972,852...14,997,428 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609 		JBrowse link
G XBP1 X-box binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526 		JBrowse link
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:86,042,070...86,053,893
Ensembl chr 9:86,041,369...86,053,857 		JBrowse link
G TMEM33 transmembrane protein 33 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 8:33,012,540...33,036,448
Ensembl chr 8:33,012,390...33,036,993 		JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:86,042,070...86,053,893
Ensembl chr 9:86,041,369...86,053,857 		JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr15:140,171,134...140,184,126
Ensembl chr15:140,171,143...140,184,121 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:96,769,862...96,847,136
Ensembl chr 6:96,770,253...96,847,125 		JBrowse link
G TMEM33 transmembrane protein 33 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 8:33,012,540...33,036,448
Ensembl chr 8:33,012,390...33,036,993 		JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein NOT|involved_in ISO (PMID:21803450) ARUK-UCL PMID:21803450 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,435,094...189,716,056 		JBrowse link
G CREB3 cAMP responsive element binding protein 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 1:236,450,573...236,456,381
Ensembl chr 1:236,450,573...236,456,375 		JBrowse link
G EP300 E1A binding protein p300 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760 		JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO (PMID:25239945)
(MGI:5607243|PMID:16332684)
(MGI:5605954|PMID:14559994)		 UniProt
ParkinsonsUK-UCL		 PMID:14559994 PMID:16332684 PMID:25239945 MGI:5605954 MGI:5607243 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526 		JBrowse link
regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIGBOS1 PIGB opposite strand 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:116,519,834...116,522,515
Ensembl chr 1:116,522,226...116,522,390 		JBrowse link
regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COPS5 COP9 signalosome subunit 5 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 4:67,740,528...67,758,153
Ensembl chr 4:67,739,251...67,758,150 		JBrowse link
G FICD FIC domain protein adenylyltransferase involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr14:42,261,505...42,269,184
Ensembl chr14:42,260,069...42,266,858 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17484
    response to stimulus 9732
      response to stress 4032
        response to topologically incorrect protein 128
          response to unfolded protein 105
            cellular response to unfolded protein 92
              endoplasmic reticulum unfolded protein response + 74
              mitochondrial unfolded protein response 1
Path 2
Term Annotations click to browse term
  biological_process 17484
    cellular process 16257
      cellular response to stimulus 8281
        cellular response to chemical stimulus 3098
          cellular response to organic substance 2426
            cellular response to topologically incorrect protein 113
              cellular response to unfolded protein 92
                endoplasmic reticulum unfolded protein response + 74
                mitochondrial unfolded protein response 1
paths to the root