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ONTOLOGY REPORT - ANNOTATIONS


Term:cellular response to unfolded protein
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Accession:GO:0034620 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
Comment:Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to the signaling pathways that respond to the presence of unfolded proteins in the ER.
Synonyms:related_synonym: heat shock protein activity



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cellular response to unfolded protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag3 BCL2-associated athanogene 3 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 7:128,523,583...128,546,981
Ensembl chr 7:128,523,616...128,546,981
JBrowse link
G Daxx Fas death domain-associated protein involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr17:33,909,404...33,915,590
Ensembl chr17:33,909,414...33,915,590
JBrowse link
G Derl1 Der1-like domain family, member 1 acts_upstream_of_or_within IMP (MGI:4361100|PMID:19509052) MGI PMID:19509052 MGI:4361100 NCBI chr15:57,869,502...57,892,418
Ensembl chr15:57,869,502...57,892,448
JBrowse link
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852
JBrowse link
G Hsf1 heat shock factor 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr15:76,477,362...76,501,155
Ensembl chr15:76,477,422...76,501,913
JBrowse link
G Hspa13 heat shock protein 70 family, member 13 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr16:75,755,190...75,767,276
Ensembl chr16:75,745,431...75,767,104
JBrowse link
G Hspa14 heat shock protein 14 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 2:3,488,854...3,512,814
Ensembl chr 2:3,504,527...3,512,790
Ensembl chr 2:3,504,527...3,512,790
JBrowse link
G Hspa1a heat shock protein 1A involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr17:34,969,359...34,972,156
Ensembl chr17:34,969,190...34,972,156
JBrowse link
G Hspa1b heat shock protein 1B involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr17:34,956,429...34,959,238
Ensembl chr17:34,956,436...34,959,238
JBrowse link
G Hspa1l heat shock protein 1-like involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr17:34,972,703...34,979,228
Ensembl chr17:34,972,703...34,979,285
JBrowse link
G Hspa2 heat shock protein 2 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr12:76,403,812...76,406,938
Ensembl chr12:76,404,176...76,406,938
JBrowse link
G Hspa5 heat shock protein 5 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Hspa8 heat shock protein 8 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 9:40,801,276...40,805,202
Ensembl chr 9:40,800,984...40,810,087
JBrowse link
G Hspa9 heat shock protein 9 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr18:34,937,414...34,954,351
Ensembl chr18:34,937,414...34,954,357
JBrowse link
G Hspb8 heat shock protein 8 involved_in IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr 5:116,408,491...116,422,864
Ensembl chr 5:116,408,491...116,422,864
JBrowse link
G Optn optineurin involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:5,020,521...5,064,399
Ensembl chr 2:5,020,642...5,064,051
JBrowse link
G Pacrg PARK2 co-regulated involved_in TAS (MGI:5586802|PMID:14532270) ParkinsonsUK-UCL PMID:14532270 MGI:5586802 NCBI chr17:10,403,009...10,840,191
Ensembl chr17:10,403,012...10,840,311
JBrowse link
G Pmp22 peripheral myelin protein 22 acts_upstream_of_or_within IMP (MGI:5517729|PMID:23847051) MGI PMID:23847051 MGI:5517729 NCBI chr11:63,128,982...63,159,547
Ensembl chr11:63,128,982...63,159,547
JBrowse link
G Rhbdd1 rhomboid domain containing 1 involved_in IBA
IDA
(MGI:6201960|PMID:21873635)
(MGI:5437551|PMID:22795130)
GO_Central
UniProt
PMID:21873635 PMID:22795130 MGI:5437551 MGI:6201960 NCBI chr 1:82,316,457...82,445,366
Ensembl chr 1:82,316,452...82,445,366
JBrowse link
G Tm7sf3 transmembrane 7 superfamily member 3 involved_in IMP
ISO
(MGI:5909200|PMID:27740623) UniProt
MGI
PMID:27740623 GO_REF:0000096 MGI:4834177 MGI:5909200 NCBI chr 6:146,602,276...146,634,605
Ensembl chr 6:146,602,352...146,642,824
JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 involved_in ISO
IMP
(MGI:3840374|PMID:19328063) MGI
ParkinsonsUK-UCL
PMID:19328063 GO_REF:0000096 MGI:3840374 MGI:4834177 NCBI chr15:99,392,947...99,410,049
Ensembl chr15:99,392,882...99,410,049
JBrowse link
G Umod uromodulin acts_upstream_of_or_within IMP (MGI:5916257|PMID:28437467) MGI PMID:28437467 MGI:5916257 NCBI chr 7:119,462,708...119,479,262
Ensembl chr 7:119,462,711...119,479,282
JBrowse link
endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor involved_in ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr 8:93,971,588...94,012,640
Ensembl chr 8:93,971,588...94,012,842
JBrowse link
G Atf3 activating transcription factor 3 involved_in IMP (MGI:3722921|PMID:14729979) ParkinsonsUK-UCL PMID:14729979 MGI:3722921 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G Atf4 activating transcription factor 4 involved_in IDA (MGI:5496937|PMID:23624402) UniProt PMID:23624402 MGI:5496937 NCBI chr15:80,255,184...80,257,545
Ensembl chr15:80,255,184...80,257,541
JBrowse link
G Atf6 activating transcription factor 6 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 1:170,704,457...170,868,585
Ensembl chr 1:170,704,674...170,867,771
JBrowse link
G Atf6b activating transcription factor 6 beta involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr17:34,647,146...34,655,074
Ensembl chr17:34,647,146...34,655,074
JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 involved_in IDA (MGI:5607242|PMID:17612490) UniProt PMID:17612490 MGI:5607242 NCBI chr 5:144,190,286...144,194,441
Ensembl chr 5:144,190,286...144,194,441
JBrowse link
G Casp12 caspase 12 acts_upstream_of_or_within IDA (MGI:1858648|PMID:10882126) MGI PMID:10882126 MGI:1858648 NCBI chr 9:5,345,442...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Ccnd1 cyclin D1 acts_upstream_of_or_within IDA (MGI:3620306|PMID:16176978) MGI PMID:16176978 MGI:3620306 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr11:96,907,425...96,916,531
Ensembl chr11:96,907,426...96,916,496
JBrowse link
G Creb3 cAMP responsive element binding protein 3 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 4:43,562,658...43,567,061
Ensembl chr 4:43,562,332...43,567,060
JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 involved_in IDA (MGI:4438316|PMID:19767743) UniProt PMID:19767743 MGI:4438316 NCBI chr 2:91,982,328...92,024,170
Ensembl chr 2:91,982,328...92,024,502
JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 6:37,327,255...37,442,276
Ensembl chr 6:37,327,255...37,442,146
JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr10:81,084,329...81,098,872
Ensembl chr10:81,084,324...81,098,874
JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 3:90,237,498...90,244,582
Ensembl chr 3:90,237,500...90,243,512
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 acts_upstream_of_or_within
involved_in
IMP
IDA
(MGI:6270315|PMID:30188326)
(MGI:3525819|PMID:15601821)
(MGI:5496937|PMID:23624402)
MGI
UniProt
PMID:15601821 PMID:23624402 PMID:30188326 MGI:3525819 MGI:5496937 MGI:6270315 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Derl1 Der1-like domain family, member 1 involved_in IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr15:57,869,502...57,892,418
Ensembl chr15:57,869,502...57,892,448
JBrowse link
G Derl2 Der1-like domain family, member 2 involved_in ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr11:71,007,440...71,019,841
Ensembl chr11:71,007,164...71,019,841
JBrowse link
G Derl3 Der1-like domain family, member 3 involved_in IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr10:75,893,398...75,895,941
Ensembl chr10:75,893,413...75,895,941
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 involved_in IC (MGI:4418606|PMID:18923430) BHF-UCL PMID:18923430 MGI:4418606 NCBI chr14:118,937,932...118,981,702
Ensembl chr14:118,937,976...118,981,697
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A involved_in TAS (MGI:4999711|PMID:19911006) MGI PMID:19911006 MGI:4999711 NCBI chr 3:58,525,821...58,557,501
Ensembl chr 3:58,525,821...58,557,501
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 acts_upstream_of_or_within IDA (MGI:3511630|PMID:15542627) MGI PMID:15542627 MGI:3511630 NCBI chr17:78,850,504...78,882,572
Ensembl chr17:78,852,564...78,882,573
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in
acts_upstream_of_or_within
ISO
IMP
TAS
IDA
(MGI:1858648|PMID:10882126), (MGI:2136067|PMID:11430819), (MGI:3511630|PMID:15542627), (MGI:3583403|PMID:15911877), (MGI:3620306|PMID:16176978)
(MGI:4999711|PMID:19911006)
(MGI:1333015|PMID:9930704), (MGI:2677605|PMID:14517290)
MGI PMID:9930704 PMID:10882126 PMID:11430819 PMID:14517290 PMID:15542627 More... GO_REF:0000096 MGI:1333015 MGI:1858648 MGI:2136067 MGI:2677605 MGI:3511630 MGI:3583403 MGI:3620306 MGI:4834177 MGI:4999711 NCBI chr 6:70,844,484...70,905,241
Ensembl chr 6:70,844,515...70,905,245
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 acts_upstream_of_or_within IMP (MGI:3620306|PMID:16176978) MGI PMID:16176978 MGI:3620306 NCBI chr 2:118,388,583...118,475,234
Ensembl chr 2:118,388,618...118,475,234
JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 acts_upstream_of_or_within ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr19:29,609,876...29,648,415
Ensembl chr19:29,608,214...29,648,415
JBrowse link
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 acts_upstream_of_or_within
involved_in
IDA
TAS
(MGI:1858648|PMID:10882126), (MGI:2136067|PMID:11430819), (MGI:3525819|PMID:15601821)
(MGI:4999711|PMID:19911006)
MGI PMID:10882126 PMID:11430819 PMID:15601821 PMID:19911006 MGI:1858648 MGI:2136067 MGI:3525819 MGI:4999711 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha acts_upstream_of_or_within IDA (MGI:3525819|PMID:15601821) MGI PMID:15601821 MGI:3525819 NCBI chr14:45,283,087...45,318,572
Ensembl chr14:45,283,087...45,318,771
JBrowse link
G Fgf21 fibroblast growth factor 21 ISO RGD PMID:23123503 RGD:10401883 NCBI chr 7:45,613,890...45,615,490
Ensembl chr 7:45,613,886...45,615,490
JBrowse link
G Herpud1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 involved_in
acts_upstream_of_or_within
IBA
ISO
IDA
(MGI:6201960|PMID:21873635)
(MGI:1913176|PMID:10922362)
GO_Central
MGI
RGD
PMID:10922362 PMID:15102845 PMID:21873635 GO_REF:0000096 MGI:1913176 MGI:4417868 MGI:6201960 RGD:1304324 NCBI chr 8:94,386,429...94,395,371
Ensembl chr 8:94,386,438...94,395,377
JBrowse link
G Herpud2 HERPUD family member 2 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 9:25,108,126...25,151,813
Ensembl chr 9:25,108,132...25,151,820
JBrowse link
G Hspa5 heat shock protein 5 involved_in IBA
IMP
(MGI:6201960|PMID:21873635)
(MGI:4437543|PMID:19816510)
GO_Central
BHF-UCL
PMID:19816510 PMID:21873635 MGI:4437543 MGI:6201960 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within IDA (MGI:3583403|PMID:15911877) MGI PMID:15911877 MGI:3583403 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 acts_upstream_of_or_within IDA (MGI:2677605|PMID:14517290) MGI PMID:14517290 MGI:2677605 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Parp16 poly (ADP-ribose) polymerase family, member 16 involved_in IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr 9:65,214,652...65,239,220
Ensembl chr 9:65,195,353...65,239,224
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A acts_upstream_of_or_within IMP
ISO
(MGI:3525819|PMID:15601821) MGI
RGD
PMID:15601821 PMID:18266951 PMID:22154936 MGI:3525819 RGD:9999171 RGD:9999413 NCBI chr 7:45,522,917...45,526,268
Ensembl chr 7:45,522,916...45,526,268
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:167,930,750...167,979,385
Ensembl chr 2:167,932,057...167,979,385
JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 9:108,516,982...108,560,167
Ensembl chr 9:108,516,806...108,560,163
JBrowse link
G Selenos selenoprotein S involved_in IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr 7:66,079,649...66,089,405
Ensembl chr 7:66,079,649...66,089,405
JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 acts_upstream_of_or_within
involved_in
IMP
IBA
(MGI:3619104|PMID:16415102)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:16415102 PMID:21873635 MGI:3619104 MGI:6201960 NCBI chr 3:58,521,969...58,525,884
Ensembl chr 3:58,519,817...58,525,892
JBrowse link
G Serp2 stress-associated endoplasmic reticulum protein family member 2 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr14:76,532,812...76,557,074
Ensembl chr14:76,532,814...76,556,889
JBrowse link
G Stc2 stanniocalcin 2 acts_upstream_of_or_within IMP (MGI:3511371|PMID:15485913) MGI PMID:15485913 MGI:3511371 NCBI chr11:31,359,441...31,370,061
Ensembl chr11:31,357,307...31,370,074
JBrowse link
G Stub1 STIP1 homology and U-Box containing protein 1 involved_in IDA (MGI:5582182|PMID:12150907) ParkinsonsUK-UCL PMID:12150907 MGI:5582182 NCBI chr17:25,830,634...25,832,919
Ensembl chr17:25,830,505...25,833,404
JBrowse link
G Tbl2 transducin (beta)-like 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 5:135,149,429...135,163,873
Ensembl chr 5:135,149,657...135,165,760
JBrowse link
G Tmtc4 transmembrane and tetratricopeptide repeat containing 4 acts_upstream_of_or_within IMP (MGI:6270315|PMID:30188326) MGI PMID:30188326 MGI:6270315 NCBI chr14:122,918,971...122,983,285
Ensembl chr14:122,918,971...122,984,035
JBrowse link
G Vapb vesicle-associated membrane protein, associated protein B and C involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:173,737,571...173,784,336
Ensembl chr 2:173,737,511...173,784,339
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in IBA
IMP
(MGI:6201960|PMID:21873635)
(MGI:3629256|PMID:16571599), (MGI:4999711|PMID:19911006)
GO_Central
MGI
PMID:16571599 PMID:19911006 PMID:21873635 MGI:3629256 MGI:4999711 MGI:6201960 NCBI chr 5:36,966,104...36,988,982
Ensembl chr 5:36,966,104...36,989,205
JBrowse link
G Xbp1 X-box binding protein 1 involved_in IDA
ISO
(MGI:5573106|PMID:24753614), (MGI:5607242|PMID:17612490) UniProt
MGI
RGD
PMID:15171721 PMID:17612490 PMID:24753614 GO_REF:0000096 MGI:4417868 MGI:5573106 MGI:5607242 RGD:1304536 NCBI chr11:5,520,641...5,525,993
Ensembl chr11:5,520,659...5,525,893
JBrowse link
G Yod1 YOD1 deubiquitinase involved_in ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr 1:130,717,327...130,722,073
Ensembl chr 1:130,717,327...130,724,358
JBrowse link
IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 involved_in ISO
IBA
IDA
(MGI:6201960|PMID:21873635)
(MGI:5571560|PMID:24508390), (MGI:6114871|PMID:25164867)
MGI
GO_Central
WB
PMID:21873635 PMID:24508390 PMID:25164867 GO_REF:0000096 MGI:4834177 MGI:5571560 MGI:6114871 MGI:6201960 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852
JBrowse link
G Ern2 endoplasmic reticulum (ER) to nucleus signalling 2 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 7:122,169,893...122,186,239
Ensembl chr 7:122,169,893...122,186,207
JBrowse link
G Hspa5 heat shock protein 5 involved_in IEP (MGI:5571560|PMID:24508390) WB PMID:24508390 MGI:5571560 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Parp16 poly (ADP-ribose) polymerase family, member 16 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 9:65,214,652...65,239,220
Ensembl chr 9:65,195,353...65,239,224
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in IMP (MGI:5616322|PMID:15465829) ParkinsonsUK-UCL PMID:15465829 MGI:5616322 NCBI chr 2:167,930,750...167,979,385
Ensembl chr 2:167,932,057...167,979,385
JBrowse link
G Vapb vesicle-associated membrane protein, associated protein B and C involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:173,737,571...173,784,336
Ensembl chr 2:173,737,511...173,784,339
JBrowse link
mitochondrial unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 8:123,952,459...123,983,122
Ensembl chr 8:123,952,459...123,983,122
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 1:55,077,833...55,088,243
Ensembl chr 1:55,077,835...55,088,243
JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6b activating transcription factor 6 beta involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr17:34,647,146...34,655,074
Ensembl chr17:34,647,146...34,655,074
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO MGI GO_REF:0000096 MGI:4417868 MGI:4834177 NCBI chr 5:36,966,104...36,988,982
Ensembl chr 5:36,966,104...36,989,205
JBrowse link
negative regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crebrf CREB3 regulatory factor involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr17:26,715,594...26,776,637
Ensembl chr17:26,715,650...26,776,635
JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr11:5,520,641...5,525,993
Ensembl chr11:5,520,659...5,525,893
JBrowse link
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bfar bifunctional apoptosis regulator involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr16:13,671,858...13,703,612
Ensembl chr16:13,671,858...13,703,612
Ensembl chr16:13,671,858...13,703,612
JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in IMP
ISO
(MGI:5912977|PMID:28128204) UniProt
MGI
PMID:28128204 GO_REF:0000096 MGI:4834177 MGI:5912977 NCBI chr 2:130,654,033...130,664,654
Ensembl chr 2:130,653,960...130,664,659
JBrowse link
G Pdia6 protein disulfide isomerase associated 6 involved_in IMP (MGI:5571560|PMID:24508390) WB PMID:24508390 MGI:5571560 NCBI chr12:17,266,589...17,284,785
Ensembl chr12:17,266,545...17,284,770
JBrowse link
G Ufl1 UFM1 specific ligase 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 4:25,247,149...25,281,821
Ensembl chr 4:25,248,600...25,281,821
JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP-binding cassette, sub-family A (ABC1), member 7 involved_in IMP (MGI:5774886|PMID:27030769) ARUK-UCL PMID:27030769 MGI:5774886 NCBI chr10:79,996,453...80,015,572
Ensembl chr10:79,996,494...80,015,572
JBrowse link
G Nck1 non-catalytic region of tyrosine kinase adaptor protein 1 involved_in ISO
IBA
IGI
(MGI:6201960|PMID:21873635)
(MGI:5613478|PMID:14676213)
MGI
GO_Central
ParkinsonsUK-UCL
PMID:14676213 PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:5613478 MGI:6201960 NCBI chr 9:100,494,302...100,546,134
Ensembl chr 9:100,492,293...100,546,134
JBrowse link
G Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 involved_in IGI
IBA
(MGI:5613478|PMID:14676213)
(MGI:6201960|PMID:21873635)
ParkinsonsUK-UCL
GO_Central
PMID:14676213 PMID:21873635 MGI:5613478 MGI:6201960 NCBI chr 1:43,445,483...43,570,518
Ensembl chr 1:43,444,579...43,570,515
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in IMP
ISO
(MGI:5619464|PMID:21216966) ParkinsonsUK-UCL
MGI
PMID:21216966 GO_REF:0000096 MGI:4834177 MGI:5619464 NCBI chr 2:167,930,750...167,979,385
Ensembl chr 2:167,932,057...167,979,385
JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in IDA
IMP
(MGI:3798818|PMID:12667446)
(MGI:3722921|PMID:14729979)
UniProt
ParkinsonsUK-UCL
PMID:12667446 PMID:14729979 MGI:3722921 MGI:3798818 NCBI chr15:80,255,184...80,257,545
Ensembl chr15:80,255,184...80,257,541
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in IMP (MGI:3722921|PMID:14729979), (MGI:6467680|PMID:17707796) UniProt PMID:14729979 PMID:17707796 MGI:3722921 MGI:6467680 NCBI chr 6:70,844,484...70,905,241
Ensembl chr 6:70,844,515...70,905,245
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr12:78,862,072...78,887,010
Ensembl chr12:78,861,819...78,887,010
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 involved_in IDA (MGI:2677605|PMID:14517290) ParkinsonsUK-UCL PMID:14517290 MGI:2677605 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 9:108,516,982...108,560,167
Ensembl chr 9:108,516,806...108,560,163
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within IMP (MGI:5914333|PMID:28797121) MGI PMID:28797121 MGI:5914333 NCBI chr 5:124,540,791...124,550,503
Ensembl chr 5:124,540,695...124,550,506
JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 1:170,704,457...170,868,585
Ensembl chr 1:170,704,674...170,867,771
JBrowse link
positive regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr17:27,019,812...27,028,627
Ensembl chr17:27,019,810...27,029,009
JBrowse link
G Bax BCL2-associated X protein involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr13:101,680,761...101,768,217
Ensembl chr13:101,680,563...101,768,217
JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr11:5,520,641...5,525,993
Ensembl chr11:5,520,659...5,525,893
JBrowse link
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr12:35,992,925...36,004,081
Ensembl chr12:35,992,907...36,004,087
JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 5:67,260,565...67,291,461
Ensembl chr 5:67,260,565...67,291,461
JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr12:35,992,925...36,004,081
Ensembl chr12:35,992,907...36,004,087
JBrowse link
G Bok BCL2-related ovarian killer involved_in IMP (MGI:5648772|PMID:26015568) UniProt PMID:26015568 MGI:5648772 NCBI chr 1:93,685,575...93,695,770
Ensembl chr 1:93,685,660...93,695,764
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in IMP (MGI:5619464|PMID:21216966) ParkinsonsUK-UCL PMID:21216966 MGI:5619464 NCBI chr18:67,665,501...67,724,632
Ensembl chr18:67,665,511...67,724,595
JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 5:67,260,565...67,291,461
Ensembl chr 5:67,260,565...67,291,461
JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta (A4) precursor protein NOT|involved_in ISO (PMID:21803450) ARUK-UCL PMID:21803450 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Creb3 cAMP responsive element binding protein 3 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 4:43,562,658...43,567,061
Ensembl chr 4:43,562,332...43,567,060
JBrowse link
G Ep300 E1A binding protein p300 involved_in IDA (MGI:5607229|PMID:20955178) UniProt PMID:20955178 MGI:5607229 NCBI chr15:81,586,209...81,652,077
Ensembl chr15:81,585,351...81,652,077
JBrowse link
G Xbp1 X-box binding protein 1 involved_in IBA
IDA
ISO
IMP
(MGI:6201960|PMID:21873635)
(MGI:5607229|PMID:20955178), (MGI:5607243|PMID:16332684)
(MGI:5605954|PMID:14559994)
GO_Central
MGI
ParkinsonsUK-UCL
PMID:14559994 PMID:16332684 PMID:20955178 PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:5605954 MGI:5607229 MGI:5607243 MGI:6201960 NCBI chr11:5,520,641...5,525,993
Ensembl chr11:5,520,659...5,525,893
JBrowse link
regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pigbos1 Pigb opposite strand 1 involved_in ISO (PMID:31653868) UniProt PMID:31653868 NCBI chr 9:73,039,718...73,042,782
Ensembl chr 9:73,039,718...73,042,779
JBrowse link
regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 1:10,024,600...10,038,159
Ensembl chr 1:10,024,601...10,038,168
JBrowse link
G Ficd FIC domain containing involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 5:113,735,758...113,740,607
Ensembl chr 5:113,735,803...113,740,600
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 29905
    response to stimulus 10529
      response to stress 4237
        response to topologically incorrect protein 143
          response to unfolded protein 121
            cellular response to unfolded protein 91
              endoplasmic reticulum unfolded protein response + 70
              mitochondrial unfolded protein response + 2
Path 2
Term Annotations click to browse term
  biological_process 29905
    cellular process 17662
      cellular response to stimulus 8605
        cellular response to chemical stimulus 3704
          cellular response to organic substance 3019
            cellular response to topologically incorrect protein 111
              cellular response to unfolded protein 91
                endoplasmic reticulum unfolded protein response + 70
                mitochondrial unfolded protein response + 2
paths to the root