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ONTOLOGY REPORT - ANNOTATIONS

Term:cellular response to unfolded protein
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Accession:GO:0034620 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
Comment:Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to the signaling pathways that respond to the presence of unfolded proteins in the ER.
Synonyms:related_synonym: heat shock protein activity


show annotations for term's descendants           Sort by:
cellular response to unfolded protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAG3 BAG cochaperone 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:29,792,612...29,815,466
Ensembl chr28:29,792,777...29,815,138 		JBrowse link
G DAXX death domain associated protein involved_in ISS
IEA		 UniProt
UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:2,755,960...2,760,687
Ensembl chr12:2,755,960...2,761,340 		JBrowse link
G DERL1 derlin 1 acts_upstream_of_or_within ISO (MGI:4361100|PMID:19509052) MGI PMID:19509052 MGI:4361100 NCBI chr13:21,423,501...21,452,594
Ensembl chr13:21,419,352...21,482,133 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:11,930,614...12,006,724
Ensembl chr 9:11,934,965...12,006,814 		JBrowse link
G HSF1 heat shock transcription factor 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr13:37,724,741...37,745,259
Ensembl chr13:37,724,759...37,745,252 		JBrowse link
G HSP70 heat shock protein 70 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr12:1,285,282...1,287,670 JBrowse link
G HSPA13 heat shock protein family A (Hsp70) member 13 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr31:11,365,374...11,377,896
Ensembl chr31:11,367,788...11,377,828 		JBrowse link
G HSPA14 heat shock protein family A (Hsp70) member 14 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:21,757,326...21,795,445
Ensembl chr 2:21,757,289...21,853,468 		JBrowse link
G HSPA2 heat shock protein family A (Hsp70) member 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:38,967,104...38,969,806
Ensembl chr 8:38,967,400...38,969,313 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:11,292,219...11,296,851
Ensembl chr 5:11,292,262...11,296,797 		JBrowse link
G HSPB8 heat shock protein family B (small) member 8 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central
InterPro
InterPro		 PMID:21873635 GO_REF:0000002 GO_REF:0000107 NCBI chr26:15,337,718...15,349,993
Ensembl chr26:15,336,864...15,355,757 		JBrowse link
G LOC474850 heat shock 70 kDa protein 1-like involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:1,281,164...1,285,010
Ensembl chr12:1,281,472...1,285,440 		JBrowse link
G OPTN optineurin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:23,356,471...23,390,569
Ensembl chr 2:23,357,237...23,392,511 		JBrowse link
G PMP22 peripheral myelin protein 22 acts_upstream_of_or_within ISO (MGI:5517729|PMID:23847051) MGI PMID:23847051 MGI:5517729 NCBI chr 5:38,806,731...38,839,002
Ensembl chr 5:38,807,826...38,838,971 		JBrowse link
G RHBDD1 rhomboid domain containing 1 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr25:39,719,474...39,844,634
Ensembl chr25:39,719,872...39,842,289 		JBrowse link
G TM7SF3 transmembrane 7 superfamily member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:20,615,054...20,665,596
Ensembl chr27:20,627,120...20,664,089 		JBrowse link
G TMBIM6 transmembrane BAX inhibitor motif containing 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:4,921,606...4,944,830
Ensembl chr27:4,921,606...4,944,783 		JBrowse link
G UMOD uromodulin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5916257|PMID:28437467) MGI
Ensembl
Ensembl		 PMID:28437467 GO_REF:0000107 MGI:5916257 NCBI chr 6:24,991,459...25,006,735
Ensembl chr 6:24,991,459...25,006,735 		JBrowse link
endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMFR autocrine motility factor receptor involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 2:59,766,910...59,803,292
Ensembl chr 2:59,767,324...59,801,883 		JBrowse link
G ATF3 activating transcription factor 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:10,784,445...10,795,285
Ensembl chr 7:10,782,064...10,794,163 		JBrowse link
G ATF4 activating transcription factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:25,528,880...25,531,018
Ensembl chr10:25,528,874...25,530,993 		JBrowse link
G ATF6 activating transcription factor 6 involved_in IBA
IEA		 (PMID:21873635) GO_Central
InterPro		 PMID:21873635 GO_REF:0000002 NCBI chr38:20,705,167...20,903,852
Ensembl chr38:20,709,038...20,903,814 		JBrowse link
G ATF6B activating transcription factor 6 beta involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:1,515,186...1,525,165
Ensembl chr12:1,515,503...1,525,110 		JBrowse link
G BHLHA15 basic helix-loop-helix family member a15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:11,112,233...11,115,776
Ensembl chr 6:11,114,694...11,115,257 		JBrowse link
G CASP12 caspase 12 acts_upstream_of_or_within ISO (MGI:1858648|PMID:10882126) MGI PMID:10882126 MGI:1858648 NCBI chr 5:27,162,840...27,176,964
Ensembl chr 5:27,161,700...27,177,683 		JBrowse link
G CCND1 cyclin D1 acts_upstream_of_or_within ISO (MGI:3620306|PMID:16176978) MGI PMID:16176978 MGI:3620306 NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005 		JBrowse link
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:24,276,660...24,286,273
Ensembl chr 9:24,276,768...24,286,272 		JBrowse link
G CILP cartilage intermediate layer protein involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr30:29,626,675...29,649,992
Ensembl chr30:29,573,184...29,650,883 		JBrowse link
G CREB3 cAMP responsive element binding protein 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr11:52,260,340...52,265,085
Ensembl chr11:52,260,420...52,266,515 		JBrowse link
G CREB3L1 cAMP responsive element binding protein 3 like 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr18:43,138,779...43,173,535
Ensembl chr18:43,139,453...43,173,420 		JBrowse link
G CREB3L2 cAMP responsive element binding protein 3 like 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr16:10,683,169...10,803,071
Ensembl chr16:10,682,935...11,248,029 		JBrowse link
G CREB3L3 cAMP responsive element binding protein 3 like 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr20:55,426,406...55,439,070
Ensembl chr20:55,426,813...55,436,882 		JBrowse link
G CREB3L4 cAMP responsive element binding protein 3 like 4 involved_in IEA InterPro GO_REF:0000002 NCBI chr 7:43,161,814...43,166,149
Ensembl chr 7:43,161,816...43,165,641 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3525819|PMID:15601821)
(MGI:6270315|PMID:30188326)		 MGI
Ensembl
Ensembl		 PMID:15601821 PMID:30188326 GO_REF:0000107 MGI:3525819 MGI:6270315 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303 		JBrowse link
G DERL1 derlin 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:21,423,501...21,452,594
Ensembl chr13:21,419,352...21,482,133 		JBrowse link
G DERL2 derlin 2 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 5:31,319,660...31,330,846
Ensembl chr 5:31,319,717...31,330,841 		JBrowse link
G DERL3 derlin 3 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr26:28,688,307...28,690,400
Ensembl chr26:28,688,106...28,690,400 		JBrowse link
G DGKI diacylglycerol kinase iota involved_in IEA InterPro GO_REF:0000002 NCBI chr16:10,975,394...11,250,430
Ensembl chr16:10,682,935...11,248,029 		JBrowse link
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3511630|PMID:15542627) MGI
Ensembl
Ensembl		 PMID:15542627 GO_REF:0000107 MGI:3511630 NCBI chr17:29,494,641...29,537,933
Ensembl chr17:29,496,128...29,537,933 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1333015|PMID:9930704), (MGI:2677605|PMID:14517290)
(MGI:1858648|PMID:10882126), (MGI:2136067|PMID:11430819), (MGI:3511630|PMID:15542627), (MGI:3583403|PMID:15911877), (MGI:3620306|PMID:16176978)		 MGI
Ensembl
Ensembl		 PMID:9930704 PMID:10882126 PMID:11430819 PMID:14517290 PMID:15542627 More... GO_REF:0000107 MGI:1333015 MGI:1858648 MGI:2136067 MGI:2677605 MGI:3511630 MGI:3583403 MGI:3620306 NCBI chr17:37,886,397...37,950,671
Ensembl chr17:37,886,601...37,949,812 		JBrowse link
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 acts_upstream_of_or_within ISO (MGI:3620306|PMID:16176978) MGI PMID:16176978 MGI:3620306 NCBI chr30:7,144,727...7,248,014
Ensembl chr30:7,144,570...7,248,000 		JBrowse link
G ERLEC1 endoplasmic reticulum lectin 1 involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr10:54,815,592...54,845,776
Ensembl chr10:54,815,638...54,845,080 		JBrowse link
G ERMP1 endoplasmic reticulum metallopeptidase 1 acts_upstream_of_or_within ISO (PMID:27566589) FlyBase PMID:27566589 NCBI chr 1:93,845,874...94,008,266
Ensembl chr 1:93,846,269...93,957,359 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:1858648|PMID:10882126), (MGI:2136067|PMID:11430819), (MGI:3525819|PMID:15601821) InterPro
Ensembl
MGI		 PMID:10882126 PMID:11430819 PMID:15601821 GO_REF:0000002 GO_REF:0000107 MGI:1858648 MGI:2136067 MGI:3525819 NCBI chr 9:11,930,614...12,006,724
Ensembl chr 9:11,934,965...12,006,814 		JBrowse link
G ERN2 endoplasmic reticulum to nucleus signaling 2 involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr 6:22,150,275...22,165,382
Ensembl chr 6:22,150,307...22,165,614 		JBrowse link
G ERO1A endoplasmic reticulum oxidoreductase 1 alpha acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3525819|PMID:15601821) MGI
Ensembl		 PMID:15601821 GO_REF:0000107 MGI:3525819 NCBI chr 8:28,864,642...28,913,864
Ensembl chr 8:28,864,925...28,914,368 		JBrowse link
G FGF21 fibroblast growth factor 21 ISO RGD PMID:23123503 RGD:10401883 NCBI chr 1:107,571,449...107,576,630
Ensembl chr 1:107,571,446...107,573,281 		JBrowse link
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 (PMID:21873635)
(MGI:1913176|PMID:10922362)		 RGD
Ensembl
GO_Central
MGI		 PMID:10922362 PMID:15102845 PMID:21873635 GO_REF:0000107 MGI:1913176 RGD:1304324 NCBI chr 2:59,388,492...59,400,028
Ensembl chr 2:59,388,494...59,400,003 		JBrowse link
G HERPUD2 HERPUD family member 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:47,251,733...47,284,519
Ensembl chr14:47,210,672...47,284,529 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257 		JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (MGI:3583403|PMID:15911877) MGI PMID:15911877 MGI:3583403 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2677605|PMID:14517290) MGI
Ensembl		 PMID:14517290 GO_REF:0000107 MGI:2677605 NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524 		JBrowse link
G OS9 OS9 endoplasmic reticulum lectin involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr10:1,757,070...1,787,822
Ensembl chr10:1,757,103...1,787,203 		JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A acts_upstream_of_or_within ISO (MGI:3525819|PMID:15601821) RGD
MGI		 PMID:15601821 PMID:18266951 PMID:22154936 MGI:3525819 RGD:9999171 RGD:9999413 NCBI chr 1:107,486,399...107,490,151
Ensembl chr 1:107,486,438...107,489,222 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:36,936,469...37,010,929
Ensembl chr24:36,936,298...37,003,720 		JBrowse link
G QRICH1 glutamine rich 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:40,086,141...40,135,810
Ensembl chr20:40,097,149...40,135,140 		JBrowse link
G RHBDD2 rhomboid domain containing 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:7,218,796...7,230,949
Ensembl chr 6:7,218,853...7,232,321 		JBrowse link
G SELENOS selenoprotein S involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 3:39,796,711...39,805,654
Ensembl chr 3:39,796,711...39,805,591 		JBrowse link
G SERP1 stress associated endoplasmic reticulum protein 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3619104|PMID:16415102) MGI
Ensembl		 PMID:16415102 GO_REF:0000107 MGI:3619104
G SERP2 stress associated endoplasmic reticulum protein family member 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr22:6,540,055...6,560,980
Ensembl chr22:6,540,050...6,561,034 		JBrowse link
G STC2 stanniocalcin 2 acts_upstream_of_or_within ISO (MGI:3511371|PMID:15485913) MGI PMID:15485913 MGI:3511371 NCBI chr 4:39,151,951...39,165,514
Ensembl chr 4:39,152,503...39,162,343 		JBrowse link
G STUB1 STIP1 homology and U-box containing protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:39,893,492...39,895,385
Ensembl chr 6:39,893,670...39,897,573 		JBrowse link
G TBL2 transducin beta like 2 involved_in ISO (PMID:25393282) ParkinsonsUK-UCL PMID:25393282 NCBI chr 6:6,656,158...6,664,900
Ensembl chr 6:6,656,035...6,660,963 		JBrowse link
G TMTC4 transmembrane O-mannosyltransferase targeting cadherins 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:6270315|PMID:30188326) MGI
Ensembl		 PMID:30188326 GO_REF:0000107 MGI:6270315 NCBI chr22:50,483,799...50,554,421
Ensembl chr22:50,485,190...50,555,587 		JBrowse link
G VAPB VAMP associated protein B and C involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:43,182,158...43,238,019
Ensembl chr24:43,182,196...43,231,336 		JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:38,451,722...38,466,481
Ensembl chr13:38,451,710...38,475,827 		JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO (MGI:5573106|PMID:24753614), (MGI:5607242|PMID:17612490) RGD
UniProt		 PMID:15171721 PMID:17612490 PMID:24753614 MGI:5573106 MGI:5607242 RGD:1304536 NCBI chr26:22,162,675...22,168,149
Ensembl chr26:22,163,222...22,168,105 		JBrowse link
G YOD1 YOD1 deubiquitinase involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 7:6,185,650...6,194,005
Ensembl chr 7:6,190,752...6,193,284 		JBrowse link
IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CILP cartilage intermediate layer protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:29,626,675...29,649,992
Ensembl chr30:29,573,184...29,650,883 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 involved_in IEA
IBA		 (PMID:21873635) Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr 9:11,930,614...12,006,724
Ensembl chr 9:11,934,965...12,006,814 		JBrowse link
G ERN2 endoplasmic reticulum to nucleus signaling 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:22,150,275...22,165,382
Ensembl chr 6:22,150,307...22,165,614 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in ISO (MGI:5571560|PMID:24508390) WB PMID:24508390 MGI:5571560 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:36,936,469...37,010,929
Ensembl chr24:36,936,298...37,003,720 		JBrowse link
G VAPB VAMP associated protein B and C involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr24:43,182,158...43,238,019
Ensembl chr24:43,182,196...43,231,336 		JBrowse link
mitochondrial unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB10 ATP binding cassette subfamily B member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:9,711,509...9,746,785
Ensembl chr 4:9,711,100...9,745,106 		JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6B activating transcription factor 6 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:1,515,186...1,525,165
Ensembl chr12:1,515,503...1,525,110 		JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein involved_in ISO (PMID:20160352) ParkinsonsUK-UCL PMID:20160352 RGD:10047363 NCBI chr13:38,451,722...38,466,481
Ensembl chr13:38,451,710...38,475,827 		JBrowse link
negative regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREBRF CREB3 regulatory factor involved_in ISO (PMID:18391022) UniProt PMID:18391022 NCBI chr 4:39,308,429...39,366,031
Ensembl chr 4:39,313,512...39,365,953 		JBrowse link
G MIR199-1 microRNA mir-199-1 acts_upstream_of ISO (PMID:24299514) BHF-UCL PMID:24299514 NCBI chr20:50,410,924...50,410,984
Ensembl chr20:50,410,913...50,410,994 		JBrowse link
G MIR199-2 microRNA mir-199-2 acts_upstream_of ISO (PMID:24299514) BHF-UCL PMID:24299514 NCBI chr 7:26,812,766...26,812,824
Ensembl chr 7:26,812,735...26,812,838 		JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO (PMID:25239945) UniProt PMID:25239945 NCBI chr26:22,162,675...22,168,149
Ensembl chr26:22,163,222...22,168,105 		JBrowse link
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BFAR bifunctional apoptosis regulator involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:28,593,931...28,624,867
Ensembl chr 6:28,594,709...28,624,759 		JBrowse link
G DDRGK1 DDRGK domain containing 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr24:18,085,865...18,098,868
Ensembl chr24:18,084,725...18,097,157 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 involved_in ISO (MGI:5571560|PMID:24508390) WB PMID:24508390 MGI:5571560 NCBI chr17:7,653,834...7,674,136
Ensembl chr17:7,654,175...7,685,999 		JBrowse link
G UFL1 UFM1 specific ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:54,988,200...55,023,414
Ensembl chr12:54,988,264...55,021,626 		JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) ARUK-UCL PMID:27030769 MGI:5774886 NCBI chr20:57,668,371...57,684,111
Ensembl chr20:57,667,706...57,677,342 		JBrowse link
G NCK1 NCK adaptor protein 1 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr23:33,297,660...33,374,025
Ensembl chr23:33,297,756...33,372,534 		JBrowse link
G NCK2 NCK adaptor protein 2 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr10:37,584,351...37,734,388
Ensembl chr10:37,585,565...37,732,994 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:36,936,469...37,010,929
Ensembl chr24:36,936,298...37,003,720 		JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr10:25,528,880...25,531,018
Ensembl chr10:25,528,874...25,530,993 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:3722921|PMID:14729979), (MGI:6467680|PMID:17707796) UniProt PMID:14729979 PMID:17707796 MGI:3722921 MGI:6467680 NCBI chr17:37,886,397...37,950,671
Ensembl chr17:37,886,601...37,949,812 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 8:41,354,400...41,371,676
Ensembl chr 8:41,351,244...41,371,056 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524 		JBrowse link
G QRICH1 glutamine rich 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr20:40,086,141...40,135,810
Ensembl chr20:40,097,149...40,135,140 		JBrowse link
G TMED2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO (MGI:5914333|PMID:28797121) MGI PMID:28797121 MGI:5914333 NCBI chr26:6,039,046...6,047,490
Ensembl chr26:6,039,405...6,047,459 		JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:20,705,167...20,903,852
Ensembl chr38:20,709,038...20,903,814 		JBrowse link
positive regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAK1 BCL2 antagonist/killer 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr12:2,950,359...2,957,604
Ensembl chr12:2,948,364...2,957,018 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:11,930,614...12,006,724
Ensembl chr 9:11,934,965...12,006,814 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970 		JBrowse link
G XBP1 X-box binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:22,162,675...22,168,149
Ensembl chr26:22,163,222...22,168,105 		JBrowse link
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr14:31,303,784...31,316,752
Ensembl chr14:31,305,567...31,316,686 		JBrowse link
G TMEM33 transmembrane protein 33 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr13:39,013,799...39,039,059
Ensembl chr13:39,013,855...39,052,547 		JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr14:31,303,784...31,316,752
Ensembl chr14:31,305,567...31,316,686 		JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5648772|PMID:26015568) UniProt PMID:26015568 MGI:5648772 NCBI chr25:51,449,700...51,450,967 JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:78,160,564...78,252,382
Ensembl chr 7:78,160,589...78,252,719 		JBrowse link
G TMEM33 transmembrane protein 33 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr13:39,013,799...39,039,059
Ensembl chr13:39,013,855...39,052,547 		JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein NOT|involved_in ISO (PMID:21803450) ARUK-UCL PMID:21803450 NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337 		JBrowse link
G CREB3 cAMP responsive element binding protein 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr11:52,260,340...52,265,085
Ensembl chr11:52,260,420...52,266,515 		JBrowse link
G XBP1 X-box binding protein 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr26:22,162,675...22,168,149
Ensembl chr26:22,163,222...22,168,105 		JBrowse link
regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIGBOS1 PIGB opposite strand 1 involved_in ISO (PMID:31653868) UniProt PMID:31653868 NCBI chr30:20,716,509...20,718,608 JBrowse link
regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COPS5 COP9 signalosome subunit 5 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr29:16,562,234...16,579,082
Ensembl chr29:16,562,234...16,578,847 		JBrowse link
G FICD FIC domain protein adenylyltransferase involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr26:18,347,393...18,353,081
Ensembl chr26:18,348,526...18,353,665 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17437
    response to stimulus 9286
      response to stress 4049
        response to topologically incorrect protein 127
          response to unfolded protein 103
            cellular response to unfolded protein 90
              endoplasmic reticulum unfolded protein response + 73
              mitochondrial unfolded protein response 1
Path 2
Term Annotations click to browse term
  biological_process 17437
    cellular process 16172
      cellular response to stimulus 7834
        cellular response to chemical stimulus 3161
          cellular response to organic substance 2474
            cellular response to topologically incorrect protein 112
              cellular response to unfolded protein 90
                endoplasmic reticulum unfolded protein response + 73
                mitochondrial unfolded protein response 1
paths to the root