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ONTOLOGY REPORT - ANNOTATIONS

Term:cellular response to unfolded protein
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Accession:GO:0034620 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
Comment:Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to the signaling pathways that respond to the presence of unfolded proteins in the ER.
Synonyms:related_synonym: heat shock protein activity

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cellular response to unfolded protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag3 BAG cochaperone 3 involved_in ISO (PMID:18006506) ARUK-UCL PMID:18006506 NCBI chrNW_004955551:446,322...468,329
Ensembl chrNW_004955551:446,605...469,207 		JBrowse link
G Daxx death domain associated protein involved_in ISO (PMID:15016915) UniProt PMID:15016915 NCBI chrNW_004955437:1,869,692...1,874,041
Ensembl chrNW_004955437:1,869,572...1,873,050 		JBrowse link
G Derl1 derlin 1 acts_upstream_of_or_within ISO (MGI:4361100|PMID:19509052) MGI PMID:19509052 MGI:4361100 NCBI chrNW_004955540:1,918,230...1,944,186
Ensembl chrNW_004955540:1,917,655...1,944,214 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO (PMID:19328063)
(PMID:20625543)		 ParkinsonsUK-UCL PMID:19328063 PMID:20625543 NCBI chrNW_004955478:7,720,664...7,803,662
Ensembl chrNW_004955478:7,751,830...7,799,460 		JBrowse link
G Hsf1 heat shock transcription factor 1 involved_in ISO (PMID:15016915) UniProt PMID:15016915 NCBI chrNW_004955454:2,907,265...2,932,352
Ensembl chrNW_004955454:2,907,265...2,932,351 		JBrowse link
G Hspb8 heat shock protein family B (small) member 8 involved_in ISO (PMID:18006506) ARUK-UCL PMID:18006506 NCBI chrNW_004955455:12,290,884...12,304,588
Ensembl chrNW_004955455:12,290,587...12,304,656 		JBrowse link
G Optn optineurin involved_in ISO (PMID:27534431) UniProt PMID:27534431 NCBI chrNW_004955462:1,098,118...1,150,291
Ensembl chrNW_004955462:1,107,510...1,151,269 		JBrowse link
G Pmp22 peripheral myelin protein 22 acts_upstream_of_or_within ISO (MGI:5517729|PMID:23847051) MGI PMID:23847051 MGI:5517729 NCBI chrNW_004955467:2,422,181...2,456,925
Ensembl chrNW_004955467:2,423,659...2,457,307 		JBrowse link
G Rhbdd1 rhomboid domain containing 1 involved_in ISO (PMID:22795130)
(MGI:5437551|PMID:22795130)		 ParkinsonsUK-UCL
UniProt		 PMID:22795130 MGI:5437551 NCBI chrNW_004955453:7,527,090...7,656,689
Ensembl chrNW_004955453:7,528,916...7,644,477 		JBrowse link
G Tm7sf3 transmembrane 7 superfamily member 3 involved_in ISO (PMID:27740623)
(MGI:5909200|PMID:27740623)		 UniProt PMID:27740623 MGI:5909200 NCBI chrNW_004955413:21,847,695...21,890,449
Ensembl chrNW_004955413:21,844,333...21,890,449 		JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 involved_in ISO (PMID:19328063)
(MGI:3840374|PMID:19328063)		 ParkinsonsUK-UCL PMID:19328063 MGI:3840374 NCBI chrNW_004955547:335,344...358,503
Ensembl chrNW_004955547:335,275...358,503 		JBrowse link
G Umod uromodulin acts_upstream_of_or_within ISO (MGI:5916257|PMID:28437467) MGI PMID:28437467 MGI:5916257 NCBI chrNW_004955442:3,986,936...4,001,155
Ensembl chrNW_004955442:3,985,308...3,999,598 		JBrowse link
endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor involved_in ISO (PMID:17157811) UniProt PMID:17157811 NCBI chrNW_004955433:14,172,871...14,205,484
Ensembl chrNW_004955433:14,172,808...14,212,110 		JBrowse link
G Atf3 activating transcription factor 3 involved_in ISO (MGI:3722921|PMID:14729979) ParkinsonsUK-UCL PMID:14729979 MGI:3722921 NCBI chrNW_004955406:4,875,672...4,889,173
Ensembl chrNW_004955406:4,875,613...4,889,242 		JBrowse link
G Atf4 activating transcription factor 4 involved_in ISO (MGI:5496937|PMID:23624402) UniProt PMID:23624402 MGI:5496937 NCBI chrNW_004955413:25,406,589...25,408,727
Ensembl chrNW_004955413:25,406,589...25,412,218 		JBrowse link
G Bhlha15 basic helix-loop-helix family member a15 involved_in ISO (MGI:5607242|PMID:17612490) UniProt PMID:17612490 MGI:5607242 NCBI chrNW_004955460:14,103,053...14,106,714
Ensembl chrNW_004955460:14,103,053...14,106,714 		JBrowse link
G Ccnd1 cyclin D1 acts_upstream_of_or_within ISO (MGI:3620306|PMID:16176978) MGI PMID:16176978 MGI:3620306 NCBI chrNW_004955422:16,449,921...16,462,676
Ensembl chrNW_004955422:16,448,770...16,463,300 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISO (PMID:23152784) UniProt PMID:23152784 NCBI chrNW_004955451:13,160,811...13,170,012
Ensembl chrNW_004955451:13,120,761...13,170,073 		JBrowse link
G Creb3l1 cAMP responsive element binding protein 3 like 1 involved_in ISO (MGI:4438316|PMID:19767743) UniProt PMID:19767743 MGI:4438316 NCBI chrNW_004955422:1,702,131...1,734,603
Ensembl chrNW_004955422:1,700,692...1,734,773 		JBrowse link
G Ddit3 DNA damage inducible transcript 3 acts_upstream_of_or_within
involved_in		 ISO (MGI:3525819|PMID:15601821)
(MGI:5496937|PMID:23624402)
(MGI:6270315|PMID:30188326)		 MGI
UniProt		 PMID:15601821 PMID:23624402 PMID:30188326 MGI:3525819 MGI:5496937 MGI:6270315 NCBI chrNW_004955458:5,232,979...5,238,513
Ensembl chrNW_004955458:5,232,979...5,238,513 		JBrowse link
G Derl1 derlin 1 involved_in ISO (PMID:15215856) UniProt PMID:15215856 NCBI chrNW_004955540:1,918,230...1,944,186
Ensembl chrNW_004955540:1,917,655...1,944,214 		JBrowse link
G Derl2 derlin 2 involved_in ISO (PMID:16449189) UniProt PMID:16449189 NCBI chrNW_004955467:10,824,922...10,837,408
Ensembl chrNW_004955467:10,825,341...10,837,328 		JBrowse link
G Derl3 derlin 3 involved_in ISO (PMID:16449189) UniProt PMID:16449189 NCBI chrNW_004955455:8,415,868...8,418,753
Ensembl chrNW_004955455:8,415,839...8,421,762 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2 alpha kinase 2 acts_upstream_of_or_within ISO (MGI:3511630|PMID:15542627) MGI PMID:15542627 MGI:3511630 NCBI chrNW_004955441:4,908,318...4,944,343 JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:10677345), (PMID:11907036), (PMID:22169477)
(MGI:1333015|PMID:9930704), (MGI:2677605|PMID:14517290)
(MGI:1858648|PMID:10882126), (MGI:2136067|PMID:11430819), (MGI:3511630|PMID:15542627), (MGI:3583403|PMID:15911877), (MGI:3620306|PMID:16176978)		 UniProt
MGI		 PMID:9930704 PMID:10677345 PMID:10882126 PMID:11430819 PMID:11907036 More... MGI:1333015 MGI:1858648 MGI:2136067 MGI:2677605 MGI:3511630 MGI:3583403 MGI:3620306 NCBI chrNW_004955424:210,867...279,267
Ensembl chrNW_004955424:226,038...280,593 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 acts_upstream_of_or_within ISO (MGI:3620306|PMID:16176978) MGI PMID:16176978 MGI:3620306 NCBI chrNW_004955416:6,897,897...7,005,602
Ensembl chrNW_004955416:6,897,848...7,009,965 		JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 acts_upstream_of_or_within ISO (PMID:27566589) FlyBase PMID:27566589 NCBI chrNW_004955434:9,772,667...9,825,048
Ensembl chrNW_004955434:9,778,465...9,824,973 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 acts_upstream_of_or_within ISO (MGI:1858648|PMID:10882126), (MGI:2136067|PMID:11430819), (MGI:3525819|PMID:15601821) MGI PMID:10882126 PMID:11430819 PMID:15601821 MGI:1858648 MGI:2136067 MGI:3525819 NCBI chrNW_004955478:7,720,664...7,803,662
Ensembl chrNW_004955478:7,751,830...7,799,460 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha acts_upstream_of_or_within ISO (MGI:3525819|PMID:15601821) MGI PMID:15601821 MGI:3525819 NCBI chrNW_004955409:10,495,892...10,533,383
Ensembl chrNW_004955409:10,502,554...10,530,376 		JBrowse link
G Fgf21 fibroblast growth factor 21 ISO RGD PMID:23123503 RGD:10401883 NCBI chrNW_004955559:1,818,400...1,821,423
Ensembl chrNW_004955559:1,817,110...1,820,417 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 acts_upstream_of_or_within ISO (MGI:1913176|PMID:10922362) RGD
MGI		 PMID:10922362 PMID:15102845 MGI:1913176 RGD:1304324 NCBI chrNW_004955433:14,609,275...14,621,774
Ensembl chrNW_004955433:14,608,375...14,621,839 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISO (MGI:4437543|PMID:19816510) BHF-UCL PMID:19816510 MGI:4437543 NCBI chrNW_004955419:3,055,420...3,060,208
Ensembl chrNW_004955419:3,055,420...3,062,131 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (MGI:3583403|PMID:15911877) MGI PMID:15911877 MGI:3583403 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 acts_upstream_of_or_within ISO (MGI:2677605|PMID:14517290) MGI PMID:14517290 MGI:2677605 NCBI chrNW_004955403:19,510,122...19,536,428
Ensembl chrNW_004955403:19,532,103...19,535,944 		JBrowse link
G Parp16 poly(ADP-ribose) polymerase family member 16 involved_in ISO (PMID:23103912) UniProt PMID:23103912 NCBI chrNW_004955450:10,157,731...10,177,939
Ensembl chrNW_004955450:10,157,731...10,178,803 		JBrowse link
G Ppp1r15a protein phosphatase 1 regulatory subunit 15A acts_upstream_of_or_within ISO (MGI:3525819|PMID:15601821) RGD
MGI		 PMID:15601821 PMID:18266951 PMID:22154936 MGI:3525819 RGD:9999171 RGD:9999413 NCBI chrNW_004955559:1,750,227...1,753,607
Ensembl chrNW_004955559:1,750,168...1,753,629 		JBrowse link
G Ptpn1 protein tyrosine phosphatase non-receptor type 1 involved_in ISO (PMID:22169477) UniProt PMID:22169477 NCBI chrNW_004955445:7,754,313...7,819,229
Ensembl chrNW_004955445:7,754,319...7,819,275 		JBrowse link
G Qrich1 glutamine rich 1 involved_in ISO (PMID:33384352) UniProt PMID:33384352 NCBI chrNW_004955532:1,052,174...1,092,211
Ensembl chrNW_004955532:1,052,174...1,091,449 		JBrowse link
G Selenos selenoprotein S involved_in ISO (PMID:15215856) UniProt PMID:15215856 NCBI chrNW_004955416:28,152,984...28,162,173
Ensembl chrNW_004955416:28,153,460...28,162,095 		JBrowse link
G Serp1 stress associated endoplasmic reticulum protein 1 acts_upstream_of_or_within ISO (MGI:3619104|PMID:16415102) MGI PMID:16415102 MGI:3619104 NCBI chrNW_004955448:1,738,242...1,742,807
Ensembl chrNW_004955448:1,738,242...1,743,107 		JBrowse link
G Stc2 stanniocalcin 2 acts_upstream_of_or_within ISO (MGI:3511371|PMID:15485913) MGI PMID:15485913 MGI:3511371 NCBI chrNW_004955408:25,937,174...25,950,221
Ensembl chrNW_004955408:25,934,932...25,949,399 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO (MGI:5582182|PMID:12150907) ParkinsonsUK-UCL PMID:12150907 MGI:5582182 NCBI chrNW_004955442:16,521,130...16,523,733
Ensembl chrNW_004955442:16,521,130...16,523,468 		JBrowse link
G Tbl2 transducin beta like 2 involved_in ISO (PMID:25393282) ParkinsonsUK-UCL PMID:25393282 NCBI chrNW_004955456:14,128,847...14,134,314
Ensembl chrNW_004955456:14,128,188...14,134,314 		JBrowse link
G Tmtc4 transmembrane O-mannosyltransferase targeting cadherins 4 acts_upstream_of_or_within ISO (MGI:6270315|PMID:30188326) MGI PMID:30188326 MGI:6270315 NCBI chrNW_004955404:10,213,186...10,266,581
Ensembl chrNW_004955404:10,213,186...10,266,116 		JBrowse link
G Vapb VAMP associated protein B and C involved_in ISO (PMID:16891305) UniProt PMID:16891305 NCBI chrNW_004955445:1,098,454...1,122,879
Ensembl chrNW_004955445:1,098,454...1,120,823 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO (MGI:3629256|PMID:16571599), (MGI:4999711|PMID:19911006) MGI PMID:16571599 PMID:19911006 MGI:3629256 MGI:4999711 NCBI chrNW_004955514:3,902,508...3,924,281
Ensembl chrNW_004955514:3,902,454...3,924,610 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (MGI:5573106|PMID:24753614), (MGI:5607242|PMID:17612490) RGD
UniProt		 PMID:15171721 PMID:17612490 PMID:24753614 MGI:5573106 MGI:5607242 RGD:1304536 NCBI chrNW_004955455:3,037,885...3,041,827 JBrowse link
IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO (PMID:11779465), (PMID:19328063), (PMID:29198525), (PMID:9637683)
(MGI:5571560|PMID:24508390), (MGI:6114871|PMID:25164867)
(PMID:28128204)		 ParkinsonsUK-UCL
WB
UniProt		 PMID:9637683 PMID:11779465 PMID:19328063 PMID:24508390 PMID:25164867 More... MGI:5571560 MGI:6114871 NCBI chrNW_004955478:7,720,664...7,803,662
Ensembl chrNW_004955478:7,751,830...7,799,460 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISO (MGI:5571560|PMID:24508390) WB PMID:24508390 MGI:5571560 NCBI chrNW_004955419:3,055,420...3,060,208
Ensembl chrNW_004955419:3,055,420...3,062,131 		JBrowse link
G Parp16 poly(ADP-ribose) polymerase family member 16 involved_in ISO (PMID:23103912) UniProt PMID:23103912 NCBI chrNW_004955450:10,157,731...10,177,939
Ensembl chrNW_004955450:10,157,731...10,178,803 		JBrowse link
G Ptpn1 protein tyrosine phosphatase non-receptor type 1 involved_in ISO (MGI:5616322|PMID:15465829) ParkinsonsUK-UCL PMID:15465829 MGI:5616322 NCBI chrNW_004955445:7,754,313...7,819,229
Ensembl chrNW_004955445:7,754,319...7,819,275 		JBrowse link
G Vapb VAMP associated protein B and C involved_in ISO (PMID:20940299) UniProt PMID:20940299 NCBI chrNW_004955445:1,098,454...1,122,879
Ensembl chrNW_004955445:1,098,454...1,120,823 		JBrowse link
mitochondrial unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb10 ATP binding cassette subfamily B member 10 involved_in ISO (PMID:28315685) UniProt PMID:28315685 NCBI chrNW_004955492:8,532,240...8,573,211
Ensembl chrNW_004955492:8,532,240...8,577,041 		JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6b activating transcription factor 6 beta involved_in ISO (PMID:9837962) UniProt PMID:9837962 NCBI chrNW_004955437:582,083...592,026
Ensembl chrNW_004955437:582,431...591,810 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO (PMID:20160352) ParkinsonsUK-UCL PMID:20160352 RGD:10047363 NCBI chrNW_004955514:3,902,508...3,924,281
Ensembl chrNW_004955514:3,902,454...3,924,610 		JBrowse link
negative regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crebrf CREB3 regulatory factor involved_in ISO (PMID:18391022) UniProt PMID:18391022 NCBI chrNW_004955408:25,718,523...25,769,551
Ensembl chrNW_004955408:25,719,187...25,774,555 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:25239945) UniProt PMID:25239945 NCBI chrNW_004955455:3,037,885...3,041,827 JBrowse link
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bfar bifunctional apoptosis regulator involved_in ISO (PMID:21068390) ParkinsonsUK-UCL PMID:21068390 NCBI chrNW_004955442:4,229,236...4,255,623
Ensembl chrNW_004955442:4,226,756...4,255,623 		JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in ISO (PMID:28128204), (PMID:32160526)
(MGI:5912977|PMID:28128204)		 UniProt PMID:28128204 PMID:32160526 MGI:5912977 NCBI chrNW_004955415:14,085,404...14,098,220
Ensembl chrNW_004955415:14,085,404...14,098,856 		JBrowse link
G Pdia6 protein disulfide isomerase family A member 6 involved_in ISO (MGI:5571560|PMID:24508390) WB PMID:24508390 MGI:5571560 NCBI chrNW_004955487:5,735,698...5,744,601
Ensembl chrNW_004955487:5,735,698...5,748,015 		JBrowse link
G Ufl1 UFM1 specific ligase 1 involved_in ISO (PMID:32160526) UniProt PMID:32160526 NCBI chrNW_004955411:22,548,139...22,577,287
Ensembl chrNW_004955411:22,548,219...22,580,903 		JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) ARUK-UCL PMID:27030769 MGI:5774886 NCBI chrNW_004955495:6,818,002...6,838,177
Ensembl chrNW_004955495:6,815,562...6,836,772 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO (PMID:14676213)
(MGI:5613478|PMID:14676213)		 ParkinsonsUK-UCL PMID:14676213 MGI:5613478 NCBI chrNW_004955501:1,867,956...1,963,091 JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO (MGI:5613478|PMID:14676213) ParkinsonsUK-UCL PMID:14676213 MGI:5613478 NCBI chrNW_004955470:10,487,962...10,593,046
Ensembl chrNW_004955470:10,487,481...10,593,046 		JBrowse link
G Ptpn1 protein tyrosine phosphatase non-receptor type 1 involved_in ISO (PMID:21216966)
(MGI:5619464|PMID:21216966)		 ParkinsonsUK-UCL PMID:21216966 MGI:5619464 NCBI chrNW_004955445:7,754,313...7,819,229
Ensembl chrNW_004955445:7,754,319...7,819,275 		JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISO (MGI:3798818|PMID:12667446)
(MGI:3722921|PMID:14729979)		 UniProt
ParkinsonsUK-UCL		 PMID:12667446 PMID:14729979 MGI:3722921 MGI:3798818 NCBI chrNW_004955413:25,406,589...25,408,727
Ensembl chrNW_004955413:25,406,589...25,412,218 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:3722921|PMID:14729979), (MGI:6467680|PMID:17707796) UniProt PMID:14729979 PMID:17707796 MGI:3722921 MGI:6467680 NCBI chrNW_004955424:210,867...279,267
Ensembl chrNW_004955424:226,038...280,593 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISO (PMID:33384352) UniProt PMID:33384352 NCBI chrNW_004955466:2,838,785...2,855,443
Ensembl chrNW_004955466:2,838,785...2,855,172 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO (MGI:2677605|PMID:14517290) ParkinsonsUK-UCL PMID:14517290 MGI:2677605 NCBI chrNW_004955403:19,510,122...19,536,428
Ensembl chrNW_004955403:19,532,103...19,535,944 		JBrowse link
G Qrich1 glutamine rich 1 involved_in ISO (PMID:33384352) UniProt PMID:33384352 NCBI chrNW_004955532:1,052,174...1,092,211
Ensembl chrNW_004955532:1,052,174...1,091,449 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO (MGI:5914333|PMID:28797121) MGI PMID:28797121 MGI:5914333 NCBI chrNW_004955482:5,404,739...5,415,243
Ensembl chrNW_004955482:5,404,739...5,415,243 		JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 involved_in ISO (PMID:9837962) UniProt PMID:9837962 NCBI chrNW_004955462:14,352,956...14,553,299
Ensembl chrNW_004955462:14,357,945...14,548,543 		JBrowse link
positive regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2 antagonist/killer 1 involved_in ISO (PMID:16645094) UniProt PMID:16645094 NCBI chrNW_004955437:2,036,415...2,041,997
Ensembl chrNW_004955437:2,036,415...2,041,997 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in ISO (PMID:16645094) UniProt PMID:16645094 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO (PMID:16645094), (PMID:28128204) UniProt PMID:16645094 PMID:28128204 NCBI chrNW_004955478:7,720,664...7,803,662
Ensembl chrNW_004955478:7,751,830...7,799,460 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO (PMID:20348923) UniProt PMID:20348923 NCBI chrNW_004955446:1,020,707...1,098,327
Ensembl chrNW_004955446:1,020,043...1,098,820 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:16645094) UniProt PMID:16645094 NCBI chrNW_004955455:3,037,885...3,041,827 JBrowse link
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) UniProt PMID:23220234 NCBI chrNW_004955410:19,984,768...19,995,446
Ensembl chrNW_004955410:19,984,768...19,995,733 		JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO (PMID:26268696) UniProt PMID:26268696 NCBI chrNW_004955443:5,747,681...5,773,759
Ensembl chrNW_004955443:5,747,699...5,773,773 		JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) UniProt PMID:23220234 NCBI chrNW_004955410:19,984,768...19,995,446
Ensembl chrNW_004955410:19,984,768...19,995,733 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5648772|PMID:26015568) UniProt PMID:26015568 MGI:5648772 NCBI chrNW_004955542:224,471...232,401
Ensembl chrNW_004955542:224,471...232,428 		JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 involved_in ISO (MGI:5619464|PMID:21216966) ParkinsonsUK-UCL PMID:21216966 MGI:5619464 NCBI chrNW_004955402:771,410...846,671 JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO (PMID:26268696) UniProt PMID:26268696 NCBI chrNW_004955443:5,747,681...5,773,759
Ensembl chrNW_004955443:5,747,699...5,773,773 		JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein NOT|involved_in ISO (PMID:21803450) ARUK-UCL PMID:21803450 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268 		JBrowse link
G Creb3 cAMP responsive element binding protein 3 involved_in ISO (PMID:16940180), (PMID:18391022) ParkinsonsUK-UCL PMID:16940180 PMID:18391022 NCBI chrNW_004955472:564,227...568,708
Ensembl chrNW_004955472:564,493...568,491 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (MGI:5607229|PMID:20955178) UniProt PMID:20955178 MGI:5607229 NCBI chrNW_004955413:26,647,553...26,727,875
Ensembl chrNW_004955413:26,648,339...26,727,933 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:25239945)
(MGI:5607229|PMID:20955178), (MGI:5607243|PMID:16332684)
(MGI:5605954|PMID:14559994)		 UniProt
GO_Central
ParkinsonsUK-UCL		 PMID:14559994 PMID:16332684 PMID:20955178 PMID:25239945 MGI:5605954 MGI:5607229 MGI:5607243 NCBI chrNW_004955455:3,037,885...3,041,827 JBrowse link
regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 involved_in ISO (PMID:15234121) ParkinsonsUK-UCL PMID:15234121 NCBI chrNW_004955444:12,217,337...12,233,570
Ensembl chrNW_004955444:12,217,337...12,234,193 		JBrowse link
G Ficd FIC domain protein adenylyltransferase involved_in ISO (PMID:25601083) UniProt PMID:25601083 NCBI chrNW_004955455:9,794,919...9,799,006
Ensembl chrNW_004955455:9,795,116...9,799,006 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11981
    response to stimulus 6456
      response to stress 3069
        response to topologically incorrect protein 93
          response to unfolded protein 76
            cellular response to unfolded protein 70
              endoplasmic reticulum unfolded protein response + 59
              mitochondrial unfolded protein response + 1
Path 2
Term Annotations click to browse term
  biological_process 11981
    cellular process 11217
      cellular response to stimulus 5192
        cellular response to chemical stimulus 2745
          cellular response to organic substance 2251
            cellular response to topologically incorrect protein 85
              cellular response to unfolded protein 70
                endoplasmic reticulum unfolded protein response + 59
                mitochondrial unfolded protein response + 1
paths to the root