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ONTOLOGY REPORT - ANNOTATIONS


Term:cellular response to unfolded protein
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Accession:GO:0034620 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
Comment:Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to the signaling pathways that respond to the presence of unfolded proteins in the ER.
Synonyms:related_synonym: heat shock protein activity


show annotations for term's descendants           Sort by:
 
cellular response to unfolded protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07011951.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 2:177,651,241...177,653,288 JBrowse link
G AABR07033324.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr11:17,336,444...17,340,373 JBrowse link
G AABR07048992.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 5:99,031,013...99,033,107 JBrowse link
G Bag3 BAG cochaperone 3 involved_in ISO (PMID:18006506) RGD PMID:18006506 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Daxx death-domain associated protein involved_in ISO
IEA
ISS
(PMID:15016915)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:15016915 GO_REF:0000024 GO_REF:0000107 NCBI chr20:5,480,103...5,485,962
Ensembl chr20:5,480,103...5,485,926
JBrowse link
G Derl1 derlin 1 acts_upstream_of_or_within ISO (MGI:4361100|PMID:19509052) RGD PMID:19509052 MGI:4361100 NCBI chr 7:97,737,176...97,759,852
Ensembl chr 7:97,737,178...97,759,852
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO (PMID:19328063), (PMID:20625543) RGD PMID:19328063 PMID:20625543 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Hsc70-ps1 heat shock cognate protein 70, pseudogene 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:177,651,231...177,653,349 JBrowse link
G Hsf1 heat shock transcription factor 1 involved_in ISO (PMID:15016915) RGD PMID:15016915 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hspa13 heat shock protein family A (Hsp70) member 13 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:14,146,515...14,160,697
Ensembl chr11:14,144,130...14,160,892
JBrowse link
G Hspa14 heat shock protein family A (Hsp70) member 14 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:78,735,630...78,756,412
Ensembl chr17:78,735,598...78,756,399
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in IBA
ISO
PMID:21873635
(PMID:20625543)
RGD PMID:20625543, PMID:21873635 RGD:13792537 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in IBA
ISO
PMID:21873635
(PMID:20625543)
RGD PMID:20625543, PMID:21873635 RGD:13792537 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 involved_in IBA
ISO
PMID:21873635
(PMID:18006506)
RGD PMID:18006506, PMID:21873635 RGD:13792537 NCBI chr12:45,905,371...45,920,014
Ensembl chr12:45,905,371...45,920,013
JBrowse link
G LOC100363133 heat shock cognate 71 kDa protein-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:99,030,998...99,033,110 JBrowse link
G LOC108348108 heat shock 70 kDa protein 1A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:2,699,707...2,701,856
Ensembl chr20:4,877,324...4,879,779
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G LOC680121 similar to heat shock protein 8 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:13,499,168...13,501,271
Ensembl chr11:13,499,164...13,501,263
JBrowse link
G Optn optineurin involved_in ISO
IEA
ISS
(PMID:27534431)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:27534431 GO_REF:0000024 GO_REF:0000107 NCBI chr17:77,167,700...77,218,374
Ensembl chr17:77,167,740...77,218,389
JBrowse link
G Pmp22 peripheral myelin protein 22 acts_upstream_of_or_within ISO GO:0034620 (MGI:5517729|PMID:23847051) RGD PMID:23847051 MGI:5517729 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
JBrowse link
G Rhbdd1 rhomboid domain containing 1 involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:5437551|PMID:22795130)
PMID:21873635
(PMID:22795130)
UniProt
RGD
PMID:22795130, PMID:21873635 GO_REF:0000024 MGI:5437551, RGD:13792537 NCBI chr 9:88,110,731...88,229,462
Ensembl chr 9:88,110,731...88,229,479
JBrowse link
G Tm7sf3 transmembrane 7 superfamily member 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:5909200|PMID:27740623)
(PMID:27740623)
UniProt
RGD
PMID:27740623 GO_REF:0000024 MGI:5909200 NCBI chr 4:180,913,703...180,951,564
Ensembl chr 4:180,913,706...180,951,564
JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 involved_in ISO (PMID:19328063)
(MGI:3840374|PMID:19328063)
RGD PMID:19328063 MGI:3840374 NCBI chr 7:141,039,433...141,070,269
Ensembl chr 7:141,034,982...141,069,989
JBrowse link
G Umod uromodulin involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:5916257|PMID:28437467)
Ensembl
RGD
PMID:28437467 GO_REF:0000107 MGI:5916257 NCBI chr 1:189,186,027...189,199,939
Ensembl chr 1:189,186,026...189,199,376
JBrowse link
endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor involved_in ISO
IBA
(PMID:17157811)
PMID:21873635
RGD PMID:17157811, PMID:21873635 RGD:13792537 NCBI chr19:11,473,538...11,509,500
Ensembl chr19:11,473,541...11,508,102
JBrowse link
G Atf3 activating transcription factor 3 involved_in ISO (MGI:3722921|PMID:14729979) RGD PMID:14729979 MGI:3722921 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 involved_in ISS
ISO
GO_REF:0000024
(MGI:5496937|PMID:23624402)
UniProt
RGD
PMID:23624402 GO_REF:0000024 MGI:5496937 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atf6b activating transcription factor 6 beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:4,414,283...4,422,283
Ensembl chr20:4,414,276...4,422,283
JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 involved_in ISS
ISO
GO_REF:0000024
(MGI:5607242|PMID:17612490)
UniProt
RGD
PMID:17612490 GO_REF:0000024 MGI:5607242 NCBI chr12:12,403,385...12,409,103
Ensembl chr12:12,403,385...12,407,561
JBrowse link
G Casp12 caspase 12 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:1858648|PMID:10882126)
Ensembl
RGD
PMID:10882126 GO_REF:0000107 MGI:1858648 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Ccnd1 cyclin D1 acts_upstream_of_or_within ISO (MGI:3620306|PMID:16176978) RGD PMID:16176978 MGI:3620306 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISO
IEA
ISS
(PMID:23152784)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:23152784 GO_REF:0000024 GO_REF:0000107 NCBI chr10:84,780,644...84,789,800
Ensembl chr10:84,780,608...84,789,832
JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4438316|PMID:19767743)
UniProt
RGD
PMID:19767743 GO_REF:0000024 MGI:4438316 NCBI chr 3:80,892,433...80,933,283
Ensembl chr 3:80,892,435...80,933,283
JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:64,869,285...64,981,519
Ensembl chr 4:64,869,026...64,981,384
JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:11,490,852...11,499,287
Ensembl chr 7:11,490,852...11,499,282
JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:189,596,657...189,602,243
Ensembl chr 2:189,595,415...189,602,143
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
GO_REF:0000024
MGI:2654034|MGI:5441015 (MGI:3525819|PMID:15601821), (MGI:6270315|PMID:30188326)
(MGI:5496937|PMID:23624402)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:15601821 PMID:23624402 PMID:30188326 GO_REF:0000024 GO_REF:0000107 MGI:3525819 MGI:5496937 MGI:6270315 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Derl1 derlin 1 involved_in ISO
IBA
(PMID:15215856)
PMID:21873635
RGD PMID:15215856, PMID:21873635 RGD:13792537 NCBI chr 7:97,737,176...97,759,852
Ensembl chr 7:97,737,178...97,759,852
JBrowse link
G Derl2 derlin 2 involved_in IBA
ISO
PMID:21873635
(PMID:16449189)
RGD PMID:16449189, PMID:21873635 RGD:13792537 NCBI chr10:57,641,682...57,653,554
Ensembl chr10:57,644,207...57,653,359
JBrowse link
G Derl3 derlin 3 involved_in ISO
IBA
(PMID:16449189)
PMID:21873635
RGD PMID:16449189, PMID:21873635 RGD:13792537 NCBI chr20:13,692,102...13,707,645
Ensembl chr20:13,704,314...13,706,205
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 acts_upstream_of_or_within ISO (MGI:3511630|PMID:15542627) RGD PMID:15542627 MGI:3511630 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:2177666 (MGI:1333015|PMID:9930704), (MGI:1858648|PMID:10882126), (MGI:2136067|PMID:11430819), (MGI:2677605|PMID:14517290), (MGI:3511630|PMID:15542627), (MGI:3583403|PMID:15911877), (MGI:3620306|PMID:16176978)
(PMID:10677345), (PMID:11907036), (PMID:22169477)
UniProt
RGD
PMID:9930704 PMID:10677345 PMID:10882126 PMID:11430819 PMID:11907036 PMID:14517290 PMID:15542627 PMID:15911877 PMID:16176978 PMID:22169477 GO_REF:0000024 MGI:1333015 MGI:1858648 MGI:2136067 MGI:2677605 MGI:3511630 MGI:3583403 MGI:3620306 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 acts_upstream_of_or_within ISO MGI:2387965 (MGI:3620306|PMID:16176978) RGD PMID:16176978 MGI:3620306 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
G Erlec1 endoplasmic reticulum lectin 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:115,314,890...115,352,871
Ensembl chr14:115,314,890...115,352,562
JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:27566589)
GO_REF:0000107
RGD
Ensembl
PMID:27566589 GO_REF:0000107 NCBI chr 1:247,784,830...247,821,771
Ensembl chr 1:247,787,582...247,821,728
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 acts_upstream_of_or_within ISO (MGI:1858648|PMID:10882126), (MGI:2136067|PMID:11430819), (MGI:3525819|PMID:15601821) RGD PMID:10882126 PMID:11430819 PMID:15601821 MGI:1858648 MGI:2136067 MGI:3525819 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha acts_upstream_of_or_within ISO (MGI:3525819|PMID:15601821) RGD PMID:15601821 MGI:3525819 NCBI chr15:19,619,947...19,655,381
Ensembl chr15:19,619,973...19,655,381
JBrowse link
G Fgf21 fibroblast growth factor 21 IEP RGD PMID:23123503 RGD:10401883 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
(MGI:1913176|PMID:10922362)
PMID:21873635
RGD PMID:10922362, PMID:15102845, PMID:21873635 MGI:1913176, RGD:1304324, RGD:13792537 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Herpud2 HERPUD family member 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:26,266,571...26,311,528
Ensembl chr 8:26,266,760...26,311,350
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in IBA
ISO
PMID:21873635
(MGI:4437543|PMID:19816510)
RGD PMID:19816510, PMID:21873635 MGI:4437543, RGD:13792537 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (MGI:3583403|PMID:15911877) RGD PMID:15911877 MGI:3583403 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 acts_upstream_of_or_within ISO (MGI:2677605|PMID:14517290) RGD PMID:14517290 MGI:2677605 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Os9 OS9, endoplasmic reticulum lectin involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:70,378,625...70,407,135
Ensembl chr 7:70,380,311...70,407,177
JBrowse link
G Parp16 poly (ADP-ribose) polymerase family, member 16 involved_in ISO
IBA
(PMID:23103912)
PMID:21873635
RGD PMID:23103912, PMID:21873635 RGD:13792537 NCBI chr 8:70,712,393...70,731,212
Ensembl chr 8:70,708,873...70,729,985
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A acts_upstream_of_or_within IEP
ISO
MGI:2652765 (MGI:3525819|PMID:15601821) RGD PMID:15601821, PMID:22154936, PMID:18266951 MGI:3525819, RGD:9999171, RGD:9999413 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO
ISS
(PMID:22169477)
GO_REF:0000024
RGD
UniProt
PMID:22169477 GO_REF:0000024 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO (PMID:33384352) RGD PMID:33384352 NCBI chr 8:117,305,803...117,346,738
Ensembl chr 8:117,307,339...117,346,736
JBrowse link
G Selenos selenoprotein S involved_in ISO
IEA
IBA
(PMID:15215856)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:15215856, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:126,979,579...126,989,344
Ensembl chr 1:126,979,575...126,989,344
JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3652355 (MGI:3619104|PMID:16415102)
RGD PMID:16415102, PMID:21873635 MGI:3619104, RGD:13792537 NCBI chr 2:148,718,279...148,722,263
Ensembl chr 2:148,718,280...148,722,263
JBrowse link
G Serp2 stress-associated endoplasmic reticulum protein family member 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:58,687,784...58,712,023
Ensembl chr15:58,687,786...58,711,872
JBrowse link
G Stc2 stanniocalcin 2 acts_upstream_of_or_within ISO (MGI:3511371|PMID:15485913) RGD PMID:15485913 MGI:3511371 NCBI chr10:16,542,909...16,552,675
Ensembl chr10:16,542,882...16,553,295
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO (MGI:5582182|PMID:12150907) RGD PMID:12150907 MGI:5582182 NCBI chr10:15,197,754...15,200,035
Ensembl chr10:15,197,803...15,200,117
JBrowse link
G Tbl2 transducin (beta)-like 2 involved_in ISO (PMID:25393282) RGD PMID:25393282 NCBI chr12:24,565,843...24,578,855
Ensembl chr12:24,565,849...24,578,786
JBrowse link
G Tmtc4 transmembrane O-mannosyltransferase targeting cadherins 4 acts_upstream_of_or_within ISO MGI:5008116 (MGI:6270315|PMID:30188326) RGD PMID:30188326 MGI:6270315 NCBI chr15:109,338,762...109,394,905
Ensembl chr15:109,339,564...109,394,927
JBrowse link
G Vapb VAMP associated protein B and C involved_in ISO
ISS
(PMID:16891305)
GO_REF:0000024
RGD
UniProt
PMID:16891305 GO_REF:0000024 NCBI chr 3:171,832,558...171,871,042
Ensembl chr 3:171,832,500...171,868,647
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in IBA
ISO
PMID:21873635
(MGI:3629256|PMID:16571599), (MGI:4999711|PMID:19911006)
RGD PMID:16571599 PMID:19911006, PMID:21873635 MGI:3629256 MGI:4999711, RGD:13792537 NCBI chr14:78,640,707...78,665,224
Ensembl chr14:78,640,620...78,665,966
JBrowse link
G Xbp1 X-box binding protein 1 involved_in IDA
ISO
(MGI:5573106|PMID:24753614), (MGI:5607242|PMID:17612490) RGD PMID:17612490 PMID:24753614, PMID:15171721 MGI:5573106 MGI:5607242, RGD:1304536 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Yod1 YOD1 deubiquitinase involved_in ISO
IBA
ISS
(PMID:19818707)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:19818707, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:47,441,296...47,443,013
Ensembl chr13:47,440,803...47,443,188
JBrowse link
IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO
IBA
(PMID:11779465), (PMID:19328063), (PMID:28128204), (PMID:29198525), (PMID:9637683)
PMID:21873635
(MGI:5571560|PMID:24508390), (MGI:6114871|PMID:25164867)
RGD PMID:9637683 PMID:11779465 PMID:19328063 PMID:24508390 PMID:25164867 PMID:28128204 PMID:29198525, PMID:21873635 MGI:5571560 MGI:6114871, RGD:13792537 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Ern2 endoplasmic reticulum to nucleus signaling 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:192,126,023...192,142,865
Ensembl chr 1:192,126,023...192,142,854
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISO (MGI:5571560|PMID:24508390) RGD PMID:24508390 MGI:5571560 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Parp16 poly (ADP-ribose) polymerase family, member 16 involved_in ISO
IEA
(PMID:23103912)
GO_REF:0000107
RGD
Ensembl
PMID:23103912 GO_REF:0000107 NCBI chr 8:70,712,393...70,731,212
Ensembl chr 8:70,708,873...70,729,985
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO (MGI:5616322|PMID:15465829) RGD PMID:15465829 MGI:5616322 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Vapb VAMP associated protein B and C involved_in ISO
ISS
(PMID:20940299)
GO_REF:0000024
RGD
UniProt
PMID:20940299 GO_REF:0000024 NCBI chr 3:171,832,558...171,871,042
Ensembl chr 3:171,832,500...171,868,647
JBrowse link
mitochondrial unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07014739.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr14:29,232,295...29,232,537 JBrowse link
G Abcb10 ATP binding cassette subfamily B member 10 involved_in ISO (PMID:28315685) RGD PMID:28315685 NCBI chr19:56,742,809...56,772,904
Ensembl chr19:56,742,835...56,772,904
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6b activating transcription factor 6 beta involved_in ISO (PMID:9837962) RGD PMID:9837962 NCBI chr20:4,414,283...4,422,283
Ensembl chr20:4,414,276...4,422,283
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in IGI
ISO
PMID:20160352
(PMID:20160352)
RGD PMID:20160352, PMID:20160352 RGD:10047363 NCBI chr14:78,640,707...78,665,224
Ensembl chr14:78,640,620...78,665,966
JBrowse link
negative regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crebrf CREB3 regulatory factor involved_in ISO (PMID:18391022) RGD PMID:18391022 NCBI chr10:16,693,846...16,753,162
Ensembl chr10:16,694,792...16,752,205
JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:25239945) RGD PMID:25239945 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bfar bifunctional apoptosis regulator involved_in ISO (PMID:21068390) RGD PMID:21068390 NCBI chr10:1,464,783...1,497,653
Ensembl chr10:1,464,765...1,497,653
JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in ISO (PMID:28128204), (PMID:32160526)
(MGI:5912977|PMID:28128204)
RGD PMID:28128204 PMID:32160526 MGI:5912977 NCBI chr 3:123,195,580...123,206,828
Ensembl chr 3:123,195,580...123,206,828
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 involved_in ISO (MGI:5571560|PMID:24508390) RGD PMID:24508390 MGI:5571560 NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652
JBrowse link
G Ufl1 Ufm1-specific ligase 1 involved_in ISO
ISS
(PMID:32160526)
GO_REF:0000024
RGD
UniProt
PMID:32160526 GO_REF:0000024 NCBI chr 5:39,616,479...39,650,894
Ensembl chr 5:39,615,956...39,650,895
JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) RGD PMID:27030769 MGI:5774886 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO
IBA
(PMID:14676213)
PMID:21873635
UniProtKB:O55033 (MGI:5613478|PMID:14676213)
RGD PMID:14676213, PMID:21873635 MGI:5613478, RGD:13792537 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779
JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO
IBA
UniProtKB:Q99M51 (MGI:5613478|PMID:14676213)
PMID:21873635
RGD PMID:14676213, PMID:21873635 MGI:5613478, RGD:13792537 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO (PMID:21216966)
(MGI:5619464|PMID:21216966)
RGD PMID:21216966 MGI:5619464 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISS
ISO
GO_REF:0000024
(MGI:3722921|PMID:14729979), (MGI:3798818|PMID:12667446)
UniProt
RGD
PMID:12667446 PMID:14729979 GO_REF:0000024 MGI:3722921 MGI:3798818 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:3722921|PMID:14729979), (MGI:6467680|PMID:17707796) RGD PMID:14729979 PMID:17707796 MGI:3722921 MGI:6467680 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISO
ISS
(PMID:33384352)
GO_REF:0000024
RGD
UniProt
PMID:33384352 GO_REF:0000024 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 involved_in ISO (MGI:2677605|PMID:14517290) RGD PMID:14517290 MGI:2677605 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO (PMID:33384352) RGD PMID:33384352 NCBI chr 8:117,305,803...117,346,738
Ensembl chr 8:117,307,339...117,346,736
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO MGI:4456438 (MGI:5914333|PMID:28797121) RGD PMID:28797121 MGI:5914333 NCBI chr12:37,471,259...37,480,344
Ensembl chr12:37,471,260...37,480,297
JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 involved_in ISO (PMID:9837962) RGD PMID:9837962 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
positive regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 involved_in ISO (PMID:16645094) RGD PMID:16645094 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in ISO
IEA
ISS
(PMID:16645094)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:16645094 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO (PMID:16645094), (PMID:28128204) RGD PMID:16645094 PMID:28128204 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO
IEA
ISS
(PMID:20348923)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:20348923 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
IEA
(PMID:16645094)
GO_REF:0000107
RGD
Ensembl
PMID:16645094 GO_REF:0000107 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) RGD PMID:23220234 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO
IEA
ISS
(PMID:26268696)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:26268696 GO_REF:0000024 GO_REF:0000107 NCBI chr14:42,537,352...42,559,580
Ensembl chr14:42,535,701...42,560,174
JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) RGD PMID:23220234 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO
GO_REF:0000024
(MGI:5648772|PMID:26015568)
UniProt
RGD
PMID:26015568 GO_REF:0000024 MGI:5648772 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO (MGI:5619464|PMID:21216966) RGD PMID:21216966 MGI:5619464 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Tmem33 transmembrane protein 33 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:26268696)
Ensembl
UniProt
RGD
PMID:26268696 GO_REF:0000024 GO_REF:0000107 NCBI chr14:42,537,352...42,559,580
Ensembl chr14:42,535,701...42,560,174
JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein NOT|involved_in ISO (PMID:21803450) RGD PMID:21803450 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Creb3 cAMP responsive element binding protein 3 involved_in ISO (PMID:16940180)
(PMID:16940180), (PMID:18391022)
RGD PMID:16940180 PMID:18391022 NCBI chr 5:59,063,532...59,068,196
Ensembl chr 5:59,063,531...59,068,188
JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (MGI:5607229|PMID:20955178) RGD PMID:20955178 MGI:5607229 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Xbp1 X-box binding protein 1 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:5605954|PMID:14559994), (MGI:5607229|PMID:20955178), (MGI:5607243|PMID:16332684)
(PMID:25239945)
GO_REF:0000024
RGD
UniProt
PMID:14559994 PMID:16332684 PMID:20955178 PMID:25239945, PMID:21873635 GO_REF:0000024 MGI:5605954 MGI:5607229 MGI:5607243, RGD:13792537 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pigbos1 PIGB opposite strand 1 involved_in ISO
ISS
(PMID:31653868)
GO_REF:0000024
RGD
UniProt
PMID:31653868 GO_REF:0000024 NCBI chr 8:79,715,337...79,719,706 JBrowse link
regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 involved_in ISO (PMID:15234121) RGD PMID:15234121 NCBI chr 5:8,876,090...8,894,345
Ensembl chr 5:8,876,044...8,894,339
JBrowse link
G Ficd FIC domain protein adenylyltransferase involved_in ISO
ISS
(PMID:25601083)
GO_REF:0000024
RGD
UniProt
PMID:25601083 GO_REF:0000024 NCBI chr12:48,658,283...48,663,175
Ensembl chr12:48,658,283...48,663,143
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    response to stimulus 10357
      response to stress 4032
        response to topologically incorrect protein 142
          response to unfolded protein 120
            cellular response to unfolded protein 99
              endoplasmic reticulum unfolded protein response + 71
              mitochondrial unfolded protein response + 3
Path 2
Term Annotations click to browse term
  biological_process 19491
    cellular process 18343
      cellular response to stimulus 8742
        cellular response to chemical stimulus 3542
          cellular response to organic substance 2867
            cellular response to topologically incorrect protein 119
              cellular response to unfolded protein 99
                endoplasmic reticulum unfolded protein response + 71
                mitochondrial unfolded protein response + 3
paths to the root