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ONTOLOGY REPORT - ANNOTATIONS


Term:cholesterol esterification
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Accession:GO:0034435 term browser browse the term
Definition:A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.


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cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcat lecithin-cholesterol acyltransferase involved_in ISO (PMID:24620755), (PMID:26195816), (PMID:3458198), (PMID:4335615) UniProt PMID:3458198 PMID:4335615 PMID:24620755 PMID:26195816 NCBI chrNW_004936475:18,294,013...18,297,433 JBrowse link
G Soat1 sterol O-acyltransferase 1 involved_in ISO (PMID:16647063), (PMID:32433613), (PMID:32433614)
(PMID:8407899)
UniProt
BHF-UCL
PMID:8407899 PMID:16647063 PMID:32433613 PMID:32433614 NCBI chrNW_004936481:9,614,605...9,669,705 JBrowse link
G Soat2 sterol O-acyltransferase 2 involved_in ISO (PMID:11294643), (PMID:16647063) UniProt PMID:11294643 PMID:16647063 NCBI chrNW_004936512:10,420,847...10,430,813 JBrowse link
G Stard4 StAR related lipid transfer domain containing 4 involved_in ISO (MGI:5295922|PMID:21767660) CACAO PMID:21767660 MGI:5295922 NCBI chrNW_004936531:5,865,840...5,877,591 JBrowse link
negative regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484)
PMID:24201375
ARUK-UCL PMID:21810484 PMID:24201375 RGD:14697729 NCBI chrNW_004936669:922,978...941,996 JBrowse link
positive regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO (PMID:18971559) BHF-UCL PMID:18971559 NCBI chrNW_004936484:19,713,299...19,721,144 JBrowse link
G Agtr1 angiotensin II receptor type 1 involved_in ISO (PMID:18971559) BHF-UCL PMID:18971559 NCBI chrNW_004936519:6,831,096...6,873,977 JBrowse link
G Apoa1 apolipoprotein A1 involved_in ISO (PMID:4335615) BHF-UCL PMID:4335615 NCBI chrNW_004936542:2,111,055...2,112,626 JBrowse link
G Apoa2 apolipoprotein A2 involved_in ISO (PMID:14967812) BHF-UCL PMID:14967812 NCBI chrNW_004936903:520,420...521,726 JBrowse link
G Apoa4 apolipoprotein A4 involved_in ISO (PMID:1935934) BHF-UCL PMID:1935934 NCBI chrNW_004936542:2,098,683...2,101,127 JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:15654758)
(MGI:3850619|PMID:15654758)
BHF-UCL PMID:15654758 MGI:3850619 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Stard4 StAR related lipid transfer domain containing 4 involved_in ISO (PMID:18403318) BHF-UCL PMID:18403318 NCBI chrNW_004936531:5,865,840...5,877,591 JBrowse link
regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:24201375)
(PMID:15238223)
ARUK-UCL
UniProt
PMID:15238223 PMID:24201375 NCBI chrNW_004936669:922,978...941,996 JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (MGI:3852307|PMID:16556852) BHF-UCL PMID:16556852 MGI:3852307 NCBI chrNW_004936500:1,620,763...1,678,561 JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in ISO (PMID:20544018) UniProt PMID:20544018 NCBI chrNW_004936498:1,446,794...1,459,590 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12168
    metabolic process 7642
      cellular metabolic process 7020
        cellular lipid metabolic process 721
          lipid modification 153
            steroid esterification 13
              sterol esterification 13
                cholesterol esterification 13
                  negative regulation of cholesterol esterification 1
                  positive regulation of cholesterol esterification 7
                  regulation of cholesterol esterification + 10
Path 2
Term Annotations click to browse term
  biological_process 12168
    metabolic process 7642
      primary metabolic process 6754
        lipid metabolic process 958
          cellular lipid metabolic process 721
            lipid modification 153
              steroid esterification 13
                sterol esterification 13
                  cholesterol esterification 13
                    negative regulation of cholesterol esterification 1
                    positive regulation of cholesterol esterification 7
                    regulation of cholesterol esterification + 10
paths to the root