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ONTOLOGY REPORT - ANNOTATIONS


Term:cholesterol esterification
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Accession:GO:0034435 term browser browse the term
Definition:A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.


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cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAT1 acetyl-CoA acetyltransferase 1 involved_in TAS (PMID:24608080) ARUK-UCL PMID:24608080 NCBI chr11:108,116,705...108,148,822
Ensembl chr11:108,116,695...108,147,603
JBrowse link
G LCAT lecithin-cholesterol acyltransferase involved_in IDA (PMID:24620755), (PMID:26195816), (PMID:3458198), (PMID:4335615) UniProt PMID:3458198 PMID:4335615 PMID:24620755 PMID:26195816 NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131
JBrowse link
G SOAT1 sterol O-acyltransferase 1 involved_in IDA
IBA
IMP
(PMID:16647063), (PMID:32433613), (PMID:32433614)
(PMID:21873635)
(PMID:8407899)
UniProt
GO_Central
BHF-UCL
PMID:8407899 PMID:16647063 PMID:21873635 PMID:32433613 PMID:32433614 NCBI chr 1:179,293,719...179,358,680
Ensembl chr 1:179,293,714...179,358,680
JBrowse link
G SOAT2 sterol O-acyltransferase 2 involved_in IDA
IBA
(PMID:11294643), (PMID:16647063)
(PMID:21873635)
UniProt
GO_Central
PMID:11294643 PMID:16647063 PMID:21873635 NCBI chr12:53,103,486...53,124,535
Ensembl chr12:53,103,486...53,124,535
JBrowse link
G STARD4 StAR related lipid transfer domain containing 4 involved_in ISO (MGI:5295922|PMID:21767660) CACAO PMID:21767660 MGI:5295922 NCBI chr 5:111,491,422...111,512,567
Ensembl chr 5:111,496,033...111,512,590
JBrowse link
negative regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISS
IDA
(PMID:24201375)
(PMID:21810484)
ARUK-UCL PMID:21810484 PMID:24201375 NCBI chr 9:137,007,234...137,028,922
Ensembl chr 9:137,007,234...137,028,922
JBrowse link
positive regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen involved_in IDA (PMID:18971559) BHF-UCL PMID:18971559 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G AGTR1 angiotensin II receptor type 1 involved_in IMP (PMID:18971559) BHF-UCL PMID:18971559 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G APOA1 apolipoprotein A1 involved_in IBA
IDA
(PMID:21873635)
(PMID:4335615)
GO_Central
BHF-UCL
PMID:4335615 PMID:21873635 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G APOA2 apolipoprotein A2 involved_in IDA (PMID:14967812) BHF-UCL PMID:14967812 NCBI chr 1:161,222,292...161,223,628
Ensembl chr 1:161,222,292...161,223,631
JBrowse link
G APOA4 apolipoprotein A4 involved_in IDA
IBA
(PMID:1935934)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:1935934 PMID:21873635 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304
JBrowse link
G APOA5 apolipoprotein A5 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:116,789,367...116,792,420
Ensembl chr11:116,789,367...116,792,420
JBrowse link
G APOC1 apolipoprotein C1 involved_in TAS (PMID:18992221) BHF-UCL PMID:18992221 NCBI chr19:44,914,325...44,919,346
Ensembl chr19:44,914,247...44,919,349
JBrowse link
G APOE apolipoprotein E involved_in IDA (PMID:15654758) BHF-UCL PMID:15654758 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G STARD4 StAR related lipid transfer domain containing 4 involved_in IDA (PMID:18403318) BHF-UCL PMID:18403318 NCBI chr 5:111,491,422...111,512,567
Ensembl chr 5:111,496,033...111,512,590
JBrowse link
regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of IDA
IMP
(PMID:24201375)
(PMID:15238223)
ARUK-UCL
UniProt
PMID:15238223 PMID:24201375 NCBI chr 9:137,007,234...137,028,922
Ensembl chr 9:137,007,234...137,028,922
JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 involved_in ISS (PMID:16556852) BHF-UCL PMID:16556852 NCBI chr21:42,199,689...42,304,387
Ensembl chr21:42,199,689...42,297,244
JBrowse link
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in IMP (PMID:20544018) UniProt PMID:20544018 NCBI chr11:72,097,292...72,103,297
Ensembl chr11:72,085,895...72,103,297
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18536
    metabolic process 11863
      cellular metabolic process 10840
        cellular lipid metabolic process 1058
          lipid modification 227
            steroid esterification 16
              sterol esterification 16
                cholesterol esterification 16
                  negative regulation of cholesterol esterification 1
                  positive regulation of cholesterol esterification 9
                  regulation of cholesterol esterification + 12
Path 2
Term Annotations click to browse term
  biological_process 18536
    metabolic process 11863
      primary metabolic process 10571
        lipid metabolic process 1430
          cellular lipid metabolic process 1058
            lipid modification 227
              steroid esterification 16
                sterol esterification 16
                  cholesterol esterification 16
                    negative regulation of cholesterol esterification 1
                    positive regulation of cholesterol esterification 9
                    regulation of cholesterol esterification + 12
paths to the root