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ONTOLOGY REPORT - ANNOTATIONS


Term:cholesterol esterification
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Accession:GO:0034435 term browser browse the term
Definition:A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.


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cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LCAT lecithin-cholesterol acyltransferase involved_in ISO (PMID:24620755), (PMID:26195816), (PMID:3458198), (PMID:4335615) UniProt PMID:3458198 PMID:4335615 PMID:24620755 PMID:26195816 NCBI chr 5:81,556,047...81,559,313 JBrowse link
G SOAT1 sterol O-acyltransferase 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:20,481,386...20,556,706
Ensembl chr 7:20,486,069...20,546,055
JBrowse link
G SOAT2 sterol O-acyltransferase 2 involved_in ISO (PMID:11294643), (PMID:16647063) UniProt PMID:11294643 PMID:16647063 NCBI chr27:2,053,063...2,062,773
Ensembl chr27:2,053,067...2,062,329
JBrowse link
G STARD4 StAR related lipid transfer domain containing 4 involved_in ISO (MGI:5295922|PMID:21767660) CACAO PMID:21767660 MGI:5295922 NCBI chr 3:1,154,358...1,171,248
Ensembl chr 3:1,154,358...1,170,469
JBrowse link
negative regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484)
PMID:24201375
ARUK-UCL PMID:21810484 PMID:24201375 RGD:14697729 NCBI chr 9:48,610,906...48,630,932
Ensembl chr 9:48,613,996...48,629,857
JBrowse link
positive regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
G AGTR1 angiotensin II receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:43,569,658...43,617,113
Ensembl chr23:43,614,035...43,616,238
JBrowse link
G APOA1 apolipoprotein A1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:16,740,071...16,742,081
Ensembl chr 5:16,740,130...16,741,943
JBrowse link
G APOA2 apolipoprotein A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:21,263,641...21,265,887
Ensembl chr38:21,262,789...21,265,887
JBrowse link
G APOA4 apolipoprotein A4 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:16,751,588...16,754,215
Ensembl chr 5:16,751,799...16,754,837
JBrowse link
G APOE apolipoprotein E involved_in ISO (MGI:3850619|PMID:15654758)
(PMID:15654758)
BHF-UCL PMID:15654758 MGI:3850619 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440
JBrowse link
G STARD4 StAR related lipid transfer domain containing 4 involved_in ISO (PMID:18403318) BHF-UCL PMID:18403318 NCBI chr 3:1,154,358...1,171,248
Ensembl chr 3:1,154,358...1,170,469
JBrowse link
regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:15238223)
(PMID:24201375)
UniProt
ARUK-UCL
PMID:15238223 PMID:24201375 NCBI chr 9:48,610,906...48,630,932
Ensembl chr 9:48,613,996...48,629,857
JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 involved_in ISO (MGI:3852307|PMID:16556852) BHF-UCL PMID:16556852 MGI:3852307 NCBI chr31:36,574,406...36,627,598
Ensembl chr31:36,553,380...36,620,043
JBrowse link
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:25,981,170...25,986,942
Ensembl chr21:25,981,254...25,996,432
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13863
    metabolic process 8965
      cellular metabolic process 8179
        cellular lipid metabolic process 818
          lipid modification 183
            steroid esterification 13
              sterol esterification 13
                cholesterol esterification 13
                  negative regulation of cholesterol esterification 1
                  positive regulation of cholesterol esterification 7
                  regulation of cholesterol esterification + 10
Path 2
Term Annotations click to browse term
  biological_process 13863
    metabolic process 8965
      primary metabolic process 7905
        lipid metabolic process 1093
          cellular lipid metabolic process 818
            lipid modification 183
              steroid esterification 13
                sterol esterification 13
                  cholesterol esterification 13
                    negative regulation of cholesterol esterification 1
                    positive regulation of cholesterol esterification 7
                    regulation of cholesterol esterification + 10
paths to the root