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ONTOLOGY REPORT - ANNOTATIONS


Term:cholesterol esterification
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Accession:GO:0034435 term browser browse the term
Definition:A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.


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cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LCAT lecithin-cholesterol acyltransferase involved_in ISO (PMID:24620755), (PMID:26195816), (PMID:3458198), (PMID:4335615) UniProt PMID:3458198 PMID:4335615 PMID:24620755 PMID:26195816 NCBI chr16:48,278,137...48,285,305
Ensembl chr16:67,668,646...67,673,127
JBrowse link
G SOAT1 sterol O-acyltransferase 1 involved_in ISO (PMID:8407899)
(PMID:16647063), (PMID:32433613), (PMID:32433614)
BHF-UCL
UniProt
PMID:8407899 PMID:16647063 PMID:32433613 PMID:32433614 NCBI chr 1:154,776,305...154,840,594
Ensembl chr 1:158,464,886...158,524,909
JBrowse link
G SOAT2 sterol O-acyltransferase 2 involved_in ISO (PMID:11294643), (PMID:16647063) UniProt PMID:11294643 PMID:16647063 NCBI chr12:35,632,018...35,653,227
Ensembl chr12:36,413,954...36,434,074
JBrowse link
G STARD4 StAR related lipid transfer domain containing 4 involved_in ISO (MGI:5295922|PMID:21767660) CACAO PMID:21767660 MGI:5295922 NCBI chr 5:106,855,990...106,873,384
Ensembl chr 5:112,657,516...112,675,165
JBrowse link
negative regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484)
PMID:24201375
ARUK-UCL PMID:21810484 PMID:24201375 RGD:14697729 NCBI chr 9:108,067,633...108,089,742
Ensembl chr 9:137,036,696...137,057,776
JBrowse link
positive regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen involved_in ISO (PMID:18971559) BHF-UCL PMID:18971559 NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044
JBrowse link
G AGTR1 angiotensin II receptor type 1 involved_in ISO (PMID:18971559) BHF-UCL PMID:18971559 NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380
JBrowse link
G APOA1 apolipoprotein A1 involved_in ISO (PMID:4335615) BHF-UCL PMID:4335615 NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122
JBrowse link
G APOA2 apolipoprotein A2 involved_in ISO (PMID:14967812) BHF-UCL PMID:14967812 NCBI chr 1:136,634,754...136,636,122
Ensembl chr 1:140,546,591...140,547,959
JBrowse link
G APOA4 apolipoprotein A4 involved_in ISO (PMID:1935934) BHF-UCL PMID:1935934 NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382
JBrowse link
G APOE apolipoprotein E involved_in ISO (PMID:15654758)
(MGI:3850619|PMID:15654758)
BHF-UCL PMID:15654758 MGI:3850619 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490
JBrowse link
G STARD4 StAR related lipid transfer domain containing 4 involved_in ISO (PMID:18403318) BHF-UCL PMID:18403318 NCBI chr 5:106,855,990...106,873,384
Ensembl chr 5:112,657,516...112,675,165
JBrowse link
regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:24201375)
(PMID:15238223)
ARUK-UCL
UniProt
PMID:15238223 PMID:24201375 NCBI chr 9:108,067,633...108,089,742
Ensembl chr 9:137,036,696...137,057,776
JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 involved_in ISO (MGI:3852307|PMID:16556852) BHF-UCL PMID:16556852 MGI:3852307 NCBI chr21:28,534,697...28,619,590
Ensembl chr21:41,839,115...41,933,050
JBrowse link
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in ISO (PMID:20544018) UniProt PMID:20544018 NCBI chr11:67,177,580...67,183,631
Ensembl chr11:70,390,141...70,407,246
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12654
    metabolic process 7926
      cellular metabolic process 7262
        cellular lipid metabolic process 754
          lipid modification 163
            steroid esterification 13
              sterol esterification 13
                cholesterol esterification 13
                  negative regulation of cholesterol esterification 1
                  positive regulation of cholesterol esterification 7
                  regulation of cholesterol esterification + 10
Path 2
Term Annotations click to browse term
  biological_process 12654
    metabolic process 7926
      primary metabolic process 6987
        lipid metabolic process 1010
          cellular lipid metabolic process 754
            lipid modification 163
              steroid esterification 13
                sterol esterification 13
                  cholesterol esterification 13
                    negative regulation of cholesterol esterification 1
                    positive regulation of cholesterol esterification 7
                    regulation of cholesterol esterification + 10
paths to the root