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ONTOLOGY REPORT - ANNOTATIONS


Term:cholesterol esterification
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Accession:GO:0034435 term browser browse the term
Definition:A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.



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cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcat lecithin cholesterol acyltransferase involved_in ISS
ISO
GO_REF:0000024
(PMID:24620755), (PMID:26195816), (PMID:3458198), (PMID:4335615)
UniProt
RGD
PMID:3458198 PMID:4335615 PMID:24620755 PMID:26195816 GO_REF:0000024 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
JBrowse link
G Scd stearoyl-CoA desaturase involved_in ISO (MGI:1889921|PMID:10899171) RGD PMID:10899171 MGI:1889921 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Soat1 sterol O-acyltransferase 1 involved_in ISO
IBA
ISS
IEA
(PMID:16647063), (PMID:32433613), (PMID:32433614), (PMID:8407899)
(PMID:32433613), (PMID:32433614)
PMID:21873635
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:8407899 PMID:16647063 PMID:32433613 PMID:32433614 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494
JBrowse link
G Soat2 sterol O-acyltransferase 2 involved_in ISS
ISO
IBA
IEA
GO_REF:0000024
(PMID:11294643)
PMID:21873635
GO_REF:0000107
(PMID:11294643), (PMID:16647063)
UniProt
RGD
Ensembl
PMID:11294643 PMID:16647063 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 7:133,281,818...133,294,915
Ensembl chr 7:133,281,818...133,294,915
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 involved_in ISO (MGI:5295922|PMID:21767660) RGD PMID:21767660 MGI:5295922 NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024
JBrowse link
negative regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:21810484) RGD PMID:21810484 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
positive regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO (PMID:18971559) RGD PMID:18971559 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a involved_in ISO (PMID:18971559) RGD PMID:18971559 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Apoa1 apolipoprotein A1 involved_in IBA
ISO
PMID:21873635
(PMID:4335615)
RGD PMID:4335615 PMID:21873635 RGD:13792537 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apoa2 apolipoprotein A2 involved_in ISO (PMID:14967812) RGD PMID:14967812 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
JBrowse link
G Apoa4 apolipoprotein A4 involved_in ISO
IBA
(PMID:1935934)
PMID:21873635
RGD PMID:1935934 PMID:21873635 RGD:13792537 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Apoa5 apolipoprotein A5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:15654758)
(MGI:3850619|PMID:15654758)
RGD PMID:15654758 MGI:3850619 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 involved_in ISO (PMID:18403318) RGD PMID:18403318 NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024
JBrowse link
regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in
ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:15238223)
(PMID:15238223), (PMID:24201375)
UniProt
Ensembl
RGD
PMID:15238223 PMID:24201375 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (MGI:3852307|PMID:16556852) RGD PMID:16556852 MGI:3852307 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:20544018)
UniProt
RGD
PMID:20544018 GO_REF:0000024 NCBI chr 1:156,272,116...156,277,687
Ensembl chr 1:156,272,064...156,291,179
JBrowse link
G LOC100361543 RhoA activator C11orf59-like involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:34,637,461...34,638,516
Ensembl chr  X:34,637,459...34,638,516
JBrowse link
G Mir27a microRNA 27a involved_in ISO (PMID:24608080) RGD PMID:24608080 NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917
JBrowse link
G Mir27b microRNA 27b involved_in ISO (PMID:24608080) RGD PMID:24608080 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18872
    metabolic process 11588
      cellular metabolic process 9824
        cellular lipid metabolic process 1050
          lipid modification 233
            steroid esterification 18
              sterol esterification 18
                cholesterol esterification 18
                  negative regulation of cholesterol esterification 1
                  positive regulation of cholesterol esterification 8
                  regulation of cholesterol esterification + 14
Path 2
Term Annotations click to browse term
  biological_process 18872
    metabolic process 11588
      primary metabolic process 10391
        lipid metabolic process 1430
          cellular lipid metabolic process 1050
            lipid modification 233
              steroid esterification 18
                sterol esterification 18
                  cholesterol esterification 18
                    negative regulation of cholesterol esterification 1
                    positive regulation of cholesterol esterification 8
                    regulation of cholesterol esterification + 14
paths to the root