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ONTOLOGY REPORT - ANNOTATIONS

Term:cholesterol esterification
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Accession:GO:0034435 term browser browse the term
Definition:A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.

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cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcat lecithin cholesterol acyltransferase involved_in ISS
ISO		 GO_REF:0000024
(PMID:24620755), (PMID:26195816), (PMID:3458198), (PMID:4335615)		 UniProt
RGD		 PMID:3458198 PMID:4335615 PMID:24620755 PMID:26195816 GO_REF:0000024 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813 		JBrowse link
G Scd stearoyl-CoA desaturase involved_in ISO (MGI:1889921|PMID:10899171) RGD PMID:10899171 MGI:1889921 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Soat1 sterol O-acyltransferase 1 involved_in IBA
ISS
IEA
ISO		 PMID:21873635
GO_REF:0000024
GO_REF:0000107
(PMID:16647063), (PMID:32433613), (PMID:32433614), (PMID:8407899)		 UniProt
Ensembl
RGD		 PMID:8407899 PMID:16647063 PMID:32433613 PMID:32433614, PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr13:74,035,258...74,077,759
Ensembl chr13:74,035,080...74,077,783 		JBrowse link
G Soat2 sterol O-acyltransferase 2 involved_in IBA
IEA
ISO
ISS		 PMID:21873635
GO_REF:0000107
(PMID:11294643), (PMID:16647063)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:11294643 PMID:16647063, PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 7:143,754,892...143,767,989
Ensembl chr 7:143,754,892...143,767,989 		JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 involved_in ISO (MGI:5295922|PMID:21767660) RGD PMID:21767660 MGI:5295922 NCBI chr18:25,982,210...25,997,555
Ensembl chr18:25,984,638...25,997,555 		JBrowse link
negative regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in		 ISO
IMP
IEA		 (PMID:21810484)
PMID:24201375
GO_REF:0000107		 RGD
Ensembl		 PMID:21810484, PMID:24201375 GO_REF:0000107, RGD:14697729 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809 		JBrowse link
positive regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO (PMID:18971559) RGD PMID:18971559 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a involved_in ISO (PMID:18971559) RGD PMID:18971559 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077 		JBrowse link
G Apoa1 apolipoprotein A1 involved_in IBA
ISO		 PMID:21873635
(PMID:4335615)		 RGD PMID:4335615, PMID:21873635 RGD:13792537 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apoa2 apolipoprotein A2 involved_in ISO (PMID:14967812) RGD PMID:14967812 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802 		JBrowse link
G Apoa4 apolipoprotein A4 involved_in ISO
IEA
IBA		 (PMID:1935934)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:1935934, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376 		JBrowse link
G Apoa5 apolipoprotein A5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:50,559,079...50,561,720
Ensembl chr 8:50,559,126...50,561,736 		JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA		 (PMID:15654758)
(MGI:3850619|PMID:15654758)
GO_REF:0000107		 RGD
Ensembl		 PMID:15654758 GO_REF:0000107 MGI:3850619 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 involved_in ISO (PMID:18403318) RGD PMID:18403318 NCBI chr18:25,982,210...25,997,555
Ensembl chr18:25,984,638...25,997,555 		JBrowse link
regulation of cholesterol esterification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISS
ISO		 GO_REF:0000024
(PMID:15238223), (PMID:24201375)		 UniProt
RGD		 PMID:15238223 PMID:24201375 GO_REF:0000024 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (MGI:3852307|PMID:16556852) RGD PMID:16556852 MGI:3852307 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489 		JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:20544018)		 UniProt
RGD		 PMID:20544018 GO_REF:0000024 NCBI chr 1:166,991,474...166,997,045
Ensembl chr 1:166,991,474...166,997,045 		JBrowse link
G LOC100361543 RhoA activator C11orf59-like involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:37,261,428...37,262,470
Ensembl chr 1:166,991,474...166,997,045 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19599
    metabolic process 11860
      cellular metabolic process 10814
        cellular lipid metabolic process 1018
          lipid modification 220
            steroid esterification 16
              sterol esterification 16
                cholesterol esterification 16
                  negative regulation of cholesterol esterification 1
                  positive regulation of cholesterol esterification 8
                  regulation of cholesterol esterification + 12
Path 2
Term Annotations click to browse term
  biological_process 19599
    metabolic process 11860
      primary metabolic process 10619
        lipid metabolic process 1361
          cellular lipid metabolic process 1018
            lipid modification 220
              steroid esterification 16
                sterol esterification 16
                  cholesterol esterification 16
                    negative regulation of cholesterol esterification 1
                    positive regulation of cholesterol esterification 8
                    regulation of cholesterol esterification + 12
paths to the root