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ONTOLOGY REPORT - ANNOTATIONS

Term:response to fluid shear stress
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Accession:GO:0034405 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.


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response to fluid shear stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in ISO
IEA 		(PMID:10376603)
GO_REF:0000107 		RGD
Ensembl		 PMID:10376603 GO_REF:0000107 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 involved_in ISO (PMID:12960175) RGD PMID:12960175 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Csf2 colony stimulating factor 2 IEP RGD PMID:15010288 RGD:10450246 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G F3 coagulation factor III, tissue factor IEP RGD PMID:9974408 RGD:2313772 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Gja1 gap junction protein, alpha 1 IEP RGD PMID:15558296 RGD:7207817 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Ift88 intraflagellar transport 88 acts_upstream_of_or_within ISO MGI:2157527 (PMID:18285569) RGD PMID:18285569 NCBI chr15:31,573,325...31,666,068
Ensembl chr15:31,573,376...31,672,147 		JBrowse link
G Nos3 nitric oxide synthase 3 involved_in ISO
IEA 		(PMID:10376603)
GO_REF:0000107 		RGD
Ensembl		 PMID:10376603 GO_REF:0000107 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G P2rx4 purinergic receptor P2X 4 involved_in ISO (PMID:10969036) RGD PMID:10969036 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:2386080 (PMID:16269410) RGD PMID:16269410 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IEP RGD PMID:12738619 RGD:2292209 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting acts_upstream_of_or_within ISO
IEA 		MGI:2182840 (PMID:18285569)
GO_REF:0000107 		RGD
Ensembl		 PMID:18285569 GO_REF:0000107 NCBI chr10:13,573,779...13,621,138
Ensembl chr10:13,573,021...13,621,128 		JBrowse link
cellular response to fluid shear stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car2 carbonic anhydrase 2 IEP RGD PMID:16777439 RGD:1600700 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Has2 hyaluronan synthase 2 involved_in ISO
IEA 		(PMID:21551265)
GO_REF:0000107 		RGD
Ensembl		 PMID:21551265 GO_REF:0000107 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933 		JBrowse link
G Hdac3 histone deacetylase 3 involved_in ISO
IEA
ISS 		(PMID:25190803)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:25190803 GO_REF:0000024 GO_REF:0000107 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hdac5 histone deacetylase 5 involved_in ISO (PMID:20181743) RGD PMID:20181743 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Klf2 KLF transcription factor 2 involved_in ISO
IEA 		(PMID:22327366)
GO_REF:0000107 		RGD
Ensembl		 PMID:22327366 GO_REF:0000107 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISS
ISO 		GO_REF:0000024
(PMID:20181743) 		UniProt
RGD		 PMID:20181743 GO_REF:0000024 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Mmp1 matrix metallopeptidase 1 IEP RGD PMID:19880665 RGD:7207384 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp13 matrix metallopeptidase 13 IEP RGD PMID:21246051 RGD:10043175 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp2 matrix metallopeptidase 2 IEP RGD PMID:21637818 RGD:7207287 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:20181743) 		UniProt
RGD		 PMID:20181743 GO_REF:0000024 NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO
IEA
ISS 		(PMID:25190803)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:25190803 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel involved_in ISO (PMID:19265036) RGD PMID:19265036 NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825 		JBrowse link
G Plau plasminogen activator, urokinase IEP RGD PMID:19166201 RGD:7241210 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plec plectin involved_in ISO
IEA 		(PMID:9808630)
GO_REF:0000107 		RGD
Ensembl		 PMID:9808630 GO_REF:0000107 NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 acts_upstream_of_or_within ISO (PMID:24841674) RGD PMID:24841674 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta acts_upstream_of_or_within ISO (PMID:24841674) RGD PMID:24841674 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Spp1 secreted phosphoprotein 1 acts_upstream_of_or_within ISO (PMID:24841674) RGD PMID:24841674 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:24841674) RGD PMID:24841674 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 IEP RGD PMID:20537494 RGD:11060271 NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:25190803), (PMID:25280941) 		UniProt
RGD		 PMID:25190803 PMID:25280941 GO_REF:0000024 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
cellular response to laminar fluid shear stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ass1 argininosuccinate synthase 1 involved_in ISO
IEA 		(PMID:21106532)
GO_REF:0000107 		RGD
Ensembl		 PMID:21106532 GO_REF:0000107 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Klf2 KLF transcription factor 2 involved_in ISO
IEA 		(PMID:23043106)
GO_REF:0000107 		RGD
Ensembl		 PMID:23043106 GO_REF:0000107 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944 		JBrowse link
G Klf4 KLF transcription factor 4 involved_in ISO
IEA 		(PMID:22430140)
GO_REF:0000107 		RGD
Ensembl		 PMID:22430140 GO_REF:0000107 NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 involved_in ISO
IEA 		(PMID:23043106)
GO_REF:0000107 		RGD
Ensembl		 PMID:23043106 GO_REF:0000107 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO
IEA 		(PMID:23043106)
GO_REF:0000107 		RGD
Ensembl		 PMID:23043106 GO_REF:0000107 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:25280941) 		UniProt
RGD		 PMID:25280941 GO_REF:0000024 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
response to laminar fluid shear stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 involved_in ISO
IEA 		(PMID:15358760)
GO_REF:0000107 		RGD
Ensembl		 PMID:15358760 GO_REF:0000107 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Ace angiotensin I converting enzyme IEP RGD PMID:9048650 RGD:8142369 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 IEP RGD PMID:11156854 RGD:2325252 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor IEP RGD PMID:18636553 RGD:2313727 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010 		JBrowse link
G Klf2 KLF transcription factor 2 IEP RGD PMID:16466697 RGD:2316544 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 IEP RGD PMID:19353375 RGD:2314427 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Serpine1 serpin family E member 1 IEP RGD PMID:16500919 RGD:8547920 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Smad6 SMAD family member 6 involved_in ISO
IEA 		(PMID:9256479)
GO_REF:0000107 		RGD
Ensembl		 PMID:9256479 GO_REF:0000107 NCBI chr 8:64,450,114...64,519,673
Ensembl chr 8:64,450,114...64,519,763 		JBrowse link
G Smad7 SMAD family member 7 involved_in IEA
ISO 		GO_REF:0000107
(PMID:9256479) 		Ensembl
RGD		 PMID:9256479 GO_REF:0000107 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 IEP RGD PMID:16217485 RGD:2302098 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 IEP RGD PMID:16217485 RGD:2302098 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 IEP RGD PMID:16217485 RGD:2302098 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
vascular endothelial cell response to fluid shear stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir92a1 microRNA 92a-1 involved_in ISO (PMID:24255059) RGD PMID:24255059 NCBI chr15:92,181,336...92,181,413
Ensembl chr15:92,181,336...92,181,413 		JBrowse link
G Mir92a2 microRNA 92a-2 involved_in ISO (PMID:24255059) RGD PMID:24255059 NCBI chr  X:132,421,942...132,422,033
Ensembl chr  X:132,421,942...132,422,033 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:24255059) RGD PMID:24255059 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    response to stimulus 11082
      response to stress 4353
        response to fluid shear stress 48
          cellular response to fluid shear stress + 26
          response to laminar fluid shear stress + 17
          response to oscillatory fluid shear stress + 0
          response to pulsatile fluid shear stress + 0
paths to the root