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ONTOLOGY REPORT - ANNOTATIONS


Term:response to fluid shear stress
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Accession:GO:0034405 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.


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response to fluid shear stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO (PMID:10376603) RGD PMID:10376603 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 ISO (PMID:12960175) RGD PMID:12960175 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Csf2 colony stimulating factor 2 IEP RGD PMID:15010288 RGD:10450246 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G F3 coagulation factor III, tissue factor IEP RGD PMID:9974408 RGD:2313772 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Gja1 gap junction protein, alpha 1 IEP RGD PMID:15558296 RGD:7207817 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Ift88 intraflagellar transport 88 ISO MGI:MGI:2157527 (MGI:MGI:3844802|PMID:18285569) RGD PMID:18285569 MGI:MGI:3844802 NCBI chr15:37,690,417...37,786,855
Ensembl chr15:37,691,345...37,784,924
JBrowse link
G Nos3 nitric oxide synthase 3 ISO
IEA
(PMID:10376603)
GO_REF:0000107
RGD
Ensembl
PMID:10376603 GO_REF:0000107 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G P2rx4 purinergic receptor P2X 4 ISO (PMID:10969036) RGD PMID:10969036 NCBI chr12:39,308,022...39,325,673
Ensembl chr12:39,308,025...39,325,673
JBrowse link
G P2rx7 purinergic receptor P2X 7 ISO MGI:MGI:2386080 (MGI:MGI:3616954|PMID:16269410) RGD PMID:16269410 MGI:MGI:3616954 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IEP RGD PMID:12738619 RGD:2292209 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting ISO MGI:MGI:2182840 (MGI:MGI:3844802|PMID:18285569) RGD PMID:18285569 MGI:MGI:3844802 NCBI chr10:13,914,057...13,962,008
Ensembl chr10:13,915,214...13,962,008
JBrowse link
cellular response to fluid shear stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car2 carbonic anhydrase 2 IEP RGD PMID:16777439 RGD:1600700 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Has2 hyaluronan synthase 2 ISO (PMID:21551265) RGD PMID:21551265 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Hdac3 histone deacetylase 3 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:25190803)
Ensembl
UniProt
RGD
PMID:25190803 GO_REF:0000024, GO_REF:0000107 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Hdac5 histone deacetylase 5 ISO (MGI:MGI:4440396|PMID:20181743) RGD PMID:20181743 MGI:MGI:4440396 NCBI chr10:90,140,183...90,169,853
Ensembl chr10:90,140,183...90,151,042
JBrowse link
G Klf2 Kruppel-like factor 2 ISO (PMID:22327366) RGD PMID:22327366 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
JBrowse link
G Mef2c myocyte enhancer factor 2C IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:4440396|PMID:20181743)
Ensembl
UniProt
RGD
PMID:20181743 GO_REF:0000024, GO_REF:0000107, MGI:MGI:4440396 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Mmp1 matrix metallopeptidase 1 IEP RGD PMID:19880665 RGD:7207384 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp13 matrix metallopeptidase 13 IEP RGD PMID:21246051 RGD:10043175 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 IEP RGD PMID:21637818 RGD:7207287 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 ISO
ISS
(MGI:MGI:4440396|PMID:20181743)
GO_REF:0000024
RGD
UniProt
PMID:20181743 GO_REF:0000024, MGI:MGI:4440396 NCBI chr 7:98,820,799...98,960,878
Ensembl chr 7:98,820,812...98,960,837
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 ISO
ISS
(PMID:25190803)
GO_REF:0000024
RGD
UniProt
PMID:25190803 GO_REF:0000024 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel ISO (PMID:19265036)
(MGI:MGI:5315687|PMID:19265036)
RGD PMID:19265036 MGI:MGI:5315687 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257
JBrowse link
G Plau plasminogen activator, urokinase IEP RGD PMID:19166201 RGD:7241210 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO (MGI:MGI:5608648|PMID:24841674) RGD PMID:24841674 MGI:MGI:5608648 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO (MGI:MGI:5608648|PMID:24841674) RGD PMID:24841674 MGI:MGI:5608648 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Spp1 secreted phosphoprotein 1 ISO (MGI:MGI:5608648|PMID:24841674) RGD PMID:24841674 MGI:MGI:5608648 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO (MGI:MGI:5608648|PMID:24841674) RGD PMID:24841674 MGI:MGI:5608648 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 IEP RGD PMID:20537494 RGD:11060271 NCBI chr 4:28,947,951...28,953,261
Ensembl chr 4:28,947,965...28,953,067
JBrowse link
G Xbp1 X-box binding protein 1 ISS
ISO
GO_REF:0000024
(PMID:25190803), (PMID:25280941)
UniProt
RGD
PMID:25190803, PMID:25280941 GO_REF:0000024 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
cellular response to laminar fluid shear stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ass1 argininosuccinate synthase 1 ISO (PMID:21106532) RGD PMID:21106532 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Klf2 Kruppel-like factor 2 ISO (PMID:23043106) RGD PMID:23043106 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
JBrowse link
G Klf4 Kruppel like factor 4 ISO (PMID:22430140) RGD PMID:22430140 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO (PMID:23043106) RGD PMID:23043106 NCBI chr10:47,768,592...47,775,130
Ensembl chr10:47,766,680...47,775,055
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 ISO (PMID:23043106) RGD PMID:23043106 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Xbp1 X-box binding protein 1 ISO
ISS
(PMID:25280941)
GO_REF:0000024
RGD
UniProt
PMID:25280941 GO_REF:0000024 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
response to laminar fluid shear stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 ISO (PMID:15358760) RGD PMID:15358760 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Ace angiotensin I converting enzyme IEP RGD PMID:9048650 RGD:8142369 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 IEP RGD PMID:11156854 RGD:2325252 NCBI chr16:71,810,377...71,887,926
Ensembl chr16:71,810,377...71,887,926
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor IEP RGD PMID:18636553 RGD:2313727 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625
JBrowse link
G Klf2 Kruppel-like factor 2 IEP RGD PMID:16466697 RGD:2316544 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 IEP RGD PMID:19353375 RGD:2314427 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
JBrowse link
G Serpine1 serpin family E member 1 IEP RGD PMID:16500919 RGD:8547920 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Smad6 SMAD family member 6 ISO (PMID:9256479) RGD PMID:9256479 NCBI chr 8:68,897,746...68,967,221
Ensembl chr 8:68,898,296...68,966,108
JBrowse link
G Smad7 SMAD family member 7 ISO
IEA
(PMID:9256479)
GO_REF:0000107
RGD
Ensembl
PMID:9256479 GO_REF:0000107 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Tgfb1 transforming growth factor, beta 1 IEP RGD PMID:16217485 RGD:2302098 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 IEP RGD PMID:16217485 RGD:2302098 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfb3 transforming growth factor, beta 3 IEP RGD PMID:16217485 RGD:2302098 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
vascular endothelial cell response to fluid shear stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Socs5 suppressor of cytokine signaling 5 ISO (MGI:MGI:5659826|PMID:24255059) RGD PMID:24255059 MGI:MGI:5659826 NCBI chr 6:10,671,311...10,705,610
Ensembl chr 6:10,674,371...10,704,977
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to stress 4061
        response to fluid shear stress 45
          cellular response to fluid shear stress + 23
          response to laminar fluid shear stress + 17
          response to oscillatory fluid shear stress + 0
          response to pulsatile fluid shear stress + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.