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ONTOLOGY REPORT - ANNOTATIONS


Term:plasma lipoprotein particle clearance
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Accession:GO:0034381 term browser browse the term
Definition:The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
Synonyms:exact_synonym: lipoprotein particle clearance


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plasma lipoprotein particle clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD36 CD36 molecule ISS (PMID:12376530) BHF-UCL PMID:12376530 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G LDLR low density lipoprotein receptor TAS
ISS
(PMID:20005821) ARUK-UCL PMID:20005821 GO_REF:0000024 NCBI chr19:11,089,432...11,133,820
Ensembl chr19:11,089,462...11,133,820
Ensembl chr19:11,089,462...11,133,820
JBrowse link
G MSR1 macrophage scavenger receptor 1 ISS
IBA
IEA
(PMID:12376530)
(PMID:21873635)
BHF-UCL
GO_Central
Ensembl
PMID:12376530 PMID:21873635 GO_REF:0000107 NCBI chr 8:16,107,881...16,192,651
Ensembl chr 8:16,107,878...16,567,490
JBrowse link
G SCARB1 scavenger receptor class B member 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668
JBrowse link
chylomicron remnant clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOB apolipoprotein B TAS Reactome Reactome:R-HSA-8964026 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073
JBrowse link
G APOC1 apolipoprotein C1 IDA (PMID:4020294) BHF-UCL PMID:4020294 NCBI chr19:44,914,325...44,919,346
Ensembl chr19:44,914,247...44,919,349
JBrowse link
G APOC2 apolipoprotein C2 IDA
IBA
(PMID:4020294)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:4020294 PMID:21873635 NCBI chr19:44,946,051...44,949,565
Ensembl chr19:44,945,971...44,949,566
Ensembl chr19:44,945,971...44,949,566
JBrowse link
G APOC3 apolipoprotein C3 IDA (PMID:4020294) BHF-UCL PMID:4020294 NCBI chr11:116,829,907...116,833,072
Ensembl chr11:116,829,706...116,833,072
JBrowse link
G APOE apolipoprotein E IMP
IDA
TAS
(PMID:7175379)
(PMID:1911868)
BHF-UCL
UniProt
Reactome
PMID:1911868 PMID:7175379 Reactome:R-HSA-8964026 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G LDLR low density lipoprotein receptor TAS Reactome Reactome:R-HSA-8964026 NCBI chr19:11,089,432...11,133,820
Ensembl chr19:11,089,462...11,133,820
Ensembl chr19:11,089,462...11,133,820
JBrowse link
G LIPC lipase C, hepatic type TAS (PMID:9685400) BHF-UCL PMID:9685400 NCBI chr15:58,410,457...58,569,844
Ensembl chr15:58,410,569...58,569,844
JBrowse link
G LMF1 lipase maturation factor 1 ISO (MGI:55554|PMID:6857276) MGI PMID:6857276 MGI:55554 NCBI chr16:853,634...981,613
Ensembl chr16:975,761...981,596
Ensembl chr16:975,761...981,596
JBrowse link
high-density lipoprotein particle clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMN amnion associated transmembrane protein TAS Reactome Reactome:R-HSA-8964011 NCBI chr14:102,922,430...102,933,597
Ensembl chr14:102,922,656...102,933,596
Ensembl chr14:102,922,656...102,933,596
JBrowse link
G APOA1 apolipoprotein A1 IC
TAS
(PMID:12651854) BHF-UCL
Reactome
PMID:12651854 Reactome:R-HSA-8964011 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G APOA2 apolipoprotein A2 IDA (PMID:10764676) BHF-UCL PMID:10764676 NCBI chr 1:161,222,292...161,223,628
Ensembl chr 1:161,222,292...161,223,631
JBrowse link
G APOC2 apolipoprotein C2 IMP
IBA
(PMID:15778093)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:15778093 PMID:21873635 NCBI chr19:44,946,051...44,949,565
Ensembl chr19:44,945,971...44,949,566
Ensembl chr19:44,945,971...44,949,566
JBrowse link
G APOE apolipoprotein E IDA (PMID:210175) BHF-UCL PMID:210175 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G APOM apolipoprotein M ISS
IBA
(PMID:15793583)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:15793583 PMID:21873635 NCBI chr 6:31,652,404...31,658,210
Ensembl chr 6:31,652,416...31,658,210
JBrowse link
G CUBN cubilin TAS Reactome Reactome:R-HSA-8964011 NCBI chr10:16,823,966...17,130,492
Ensembl chr10:16,823,966...17,129,811
Ensembl chr10:16,823,966...17,129,811
JBrowse link
G HDLBP high density lipoprotein binding protein TAS Reactome Reactome:R-HSA-8964011 NCBI chr 2:241,227,291...241,315,815
Ensembl chr 2:241,227,264...241,317,061
JBrowse link
G LDLR low density lipoprotein receptor IEA Ensembl GO_REF:0000107 NCBI chr19:11,089,432...11,133,820
Ensembl chr19:11,089,462...11,133,820
Ensembl chr19:11,089,462...11,133,820
JBrowse link
G SCARB1 scavenger receptor class B member 1 IDA
TAS
(PMID:9211901) BHF-UCL
Reactome
PMID:9211901 Reactome:R-HSA-8964011 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668
JBrowse link
intermediate-density lipoprotein particle clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E IDA (PMID:1917954) UniProt PMID:1917954 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
low-density lipoprotein particle clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing IDA (PMID:11222466) BHF-UCL PMID:11222466 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AP2A1 adaptor related protein complex 2 subunit alpha 1 TAS Reactome Reactome:R-HSA-8964038 NCBI chr19:49,767,001...49,807,114
Ensembl chr19:49,767,001...49,807,114
Ensembl chr19:49,767,001...49,807,114
JBrowse link
G AP2A2 adaptor related protein complex 2 subunit alpha 2 TAS Reactome Reactome:R-HSA-8964038 NCBI chr11:925,850...1,012,240
Ensembl chr11:924,894...1,012,245
JBrowse link
G AP2B1 adaptor related protein complex 2 subunit beta 1 TAS Reactome Reactome:R-HSA-8964038 NCBI chr17:35,587,265...35,726,413
Ensembl chr17:35,578,046...35,726,413
JBrowse link
G AP2M1 adaptor related protein complex 2 subunit mu 1 TAS Reactome Reactome:R-HSA-8964038 NCBI chr 3:184,174,855...184,184,091
Ensembl chr 3:184,174,689...184,184,091
JBrowse link
G AP2S1 adaptor related protein complex 2 subunit sigma 1 TAS Reactome Reactome:R-HSA-8964038 NCBI chr19:46,838,167...46,850,846
Ensembl chr19:46,838,136...46,850,992
Ensembl chr19:46,838,136...46,850,992
JBrowse link
G APOB apolipoprotein B TAS
IMP
(PMID:15797858), (PMID:2563166) Reactome
BHF-UCL
PMID:2563166 PMID:15797858 Reactome:R-HSA-8964038 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073
JBrowse link
G CD36 CD36 molecule IMP
IBA
(PMID:10772654)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:10772654 PMID:21873635 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CES3 carboxylesterase 3 TAS Reactome Reactome:R-HSA-8964038 NCBI chr16:66,961,266...66,975,149
Ensembl chr16:66,961,245...66,975,149
JBrowse link
G CLTA clathrin light chain A TAS Reactome Reactome:R-HSA-8964038 NCBI chr 9:36,190,855...36,212,059
Ensembl chr 9:36,190,856...36,304,781
JBrowse link
G CLTC clathrin heavy chain TAS Reactome Reactome:R-HSA-8964038 NCBI chr17:59,619,895...59,696,956
Ensembl chr17:59,619,689...59,696,956
JBrowse link
G COMMD1 copper metabolism domain containing 1 ISO (MGI:5806548|PMID:26965651) MGI PMID:26965651 MGI:5806548 NCBI chr 2:61,888,391...62,141,186
Ensembl chr 2:61,888,724...62,147,247
JBrowse link
G DGAT2 diacylglycerol O-acyltransferase 2 ISS BHF-UCL GO_REF:0000024 NCBI chr11:75,768,778...75,801,534
Ensembl chr11:75,759,512...75,801,535
JBrowse link
G EHD1 EH domain containing 1 IEA
ISS
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr11:64,851,642...64,879,693
Ensembl chr11:64,851,642...64,888,296
JBrowse link
G HMOX1 heme oxygenase 1 TAS (PMID:9884342) BHF-UCL PMID:9884342 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G LDLR low density lipoprotein receptor TAS
IEA
IMP
(PMID:17142622), (PMID:6299582) Reactome
Ensembl
BHF-UCL
PMID:6299582 PMID:17142622 GO_REF:0000107 Reactome:R-HSA-8964038 NCBI chr19:11,089,432...11,133,820
Ensembl chr19:11,089,462...11,133,820
Ensembl chr19:11,089,462...11,133,820
JBrowse link
G LDLRAP1 low density lipoprotein receptor adaptor protein 1 IMP (PMID:12417523), (PMID:12464675), (PMID:15166224) BHF-UCL PMID:12417523 PMID:12464675 PMID:15166224 NCBI chr 1:25,543,588...25,590,400
Ensembl chr 1:25,543,606...25,568,886
Ensembl chr 1:25,543,606...25,568,886
JBrowse link
G LIPA lipase A, lysosomal acid type TAS Reactome Reactome:R-HSA-8964038 NCBI chr10:89,213,571...89,251,926
Ensembl chr10:89,213,569...89,414,557
JBrowse link
G LIPC lipase C, hepatic type ISO RGD PMID:8071607 RGD:2308769 NCBI chr15:58,410,457...58,569,844
Ensembl chr15:58,410,569...58,569,844
JBrowse link
G NCEH1 neutral cholesterol ester hydrolase 1 TAS Reactome Reactome:R-HSA-8964038 NCBI chr 3:172,630,249...172,711,067
Ensembl chr 3:172,630,249...172,711,218
JBrowse link
G NPC1 NPC intracellular cholesterol transporter 1 TAS Reactome Reactome:R-HSA-8964038 NCBI chr18:23,506,184...23,586,506
Ensembl chr18:23,506,184...23,586,506
JBrowse link
G NPC2 NPC intracellular cholesterol transporter 2 TAS Reactome Reactome:R-HSA-8964038 NCBI chr14:74,479,935...74,493,512
Ensembl chr14:74,476,192...74,494,177
JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 TAS Reactome Reactome:R-HSA-8964038 NCBI chr 1:55,039,548...55,064,852
Ensembl chr 1:55,039,447...55,064,852
Ensembl chr 1:55,039,447...55,064,852
JBrowse link
G SCARB1 scavenger receptor class B member 1 ISS BHF-UCL GO_REF:0000024 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668
JBrowse link
G SOAT1 sterol O-acyltransferase 1 TAS Reactome Reactome:R-HSA-8964038 NCBI chr 1:179,293,719...179,358,680
Ensembl chr 1:179,293,714...179,358,680
JBrowse link
G SOAT2 sterol O-acyltransferase 2 TAS Reactome Reactome:R-HSA-8964038 NCBI chr12:53,103,486...53,124,535
Ensembl chr12:53,103,486...53,124,535
JBrowse link
G WASHC1 WASH complex subunit 1 ISO (MGI:5806548|PMID:26965651) MGI PMID:26965651 MGI:5806548 NCBI chr 9:14,475...30,487
Ensembl chr 9:14,475...73,865
JBrowse link
negative regulation of high-density lipoprotein particle clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOC3 apolipoprotein C3 IMP
IBA
(PMID:15778093)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:15778093 PMID:21873635 NCBI chr11:116,829,907...116,833,072
Ensembl chr11:116,829,706...116,833,072
JBrowse link
negative regulation of low-density lipoprotein particle clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 IEA Ensembl GO_REF:0000107 NCBI chr11:17,392,498...17,476,849
Ensembl chr11:17,392,498...17,476,879
JBrowse link
G APOC3 apolipoprotein C3 IMP
IBA
(PMID:15778093)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:15778093 PMID:21873635 NCBI chr11:116,829,907...116,833,072
Ensembl chr11:116,829,706...116,833,072
JBrowse link
G CSK C-terminal Src kinase IEA Ensembl GO_REF:0000107 NCBI chr15:74,782,080...74,803,197
Ensembl chr15:74,782,057...74,803,198
JBrowse link
G IL19 interleukin 19 IEA Ensembl GO_REF:0000107 NCBI chr 1:206,770,773...206,842,981
Ensembl chr 1:206,770,764...206,842,981
Ensembl chr 1:206,770,764...206,842,981
JBrowse link
G KHSRP KH-type splicing regulatory protein IGI (PMID:26523989) BHF-UCL PMID:26523989 NCBI chr19:6,413,102...6,424,811
Ensembl chr19:6,413,348...6,424,794
JBrowse link
G MYLIP myosin regulatory light chain interacting protein IEA Ensembl GO_REF:0000107 NCBI chr 6:16,129,086...16,151,015
Ensembl chr 6:16,129,086...16,148,248
JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 IDA (PMID:17328821), (PMID:22848640) BHF-UCL PMID:17328821 PMID:22848640 NCBI chr 1:55,039,548...55,064,852
Ensembl chr 1:55,039,447...55,064,852
Ensembl chr 1:55,039,447...55,064,852
JBrowse link
negative regulation of very-low-density lipoprotein particle clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOC1 apolipoprotein C1 IDA
IBA
(PMID:1917954)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:1917954 PMID:21873635 NCBI chr19:44,914,325...44,919,346
Ensembl chr19:44,914,247...44,919,349
JBrowse link
G APOC2 apolipoprotein C2 IDA
IBA
(PMID:1917954)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:1917954 PMID:21873635 NCBI chr19:44,946,051...44,949,565
Ensembl chr19:44,945,971...44,949,566
Ensembl chr19:44,945,971...44,949,566
JBrowse link
G APOC3 apolipoprotein C3 IDA
IBA
(PMID:1917954)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:1917954 PMID:21873635 NCBI chr11:116,829,907...116,833,072
Ensembl chr11:116,829,706...116,833,072
JBrowse link
G LRPAP1 LDL receptor related protein associated protein 1 IDA
IBA
(PMID:8083232)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:8083232 PMID:21873635 NCBI chr 4:3,503,612...3,532,497
Ensembl chr 4:3,503,612...3,532,446
JBrowse link
oxidised low-density lipoprotein particle clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD36 CD36 molecule IMP (PMID:27607416) ARUK-UCL PMID:27607416 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
positive regulation of chylomicron remnant clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 ISS BHF-UCL GO_REF:0000024 NCBI chr 8:143,213,218...143,217,170
Ensembl chr 8:143,213,218...143,217,170
JBrowse link
positive regulation of high-density lipoprotein particle clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPLD1 glycosylphosphatidylinositol specific phospholipase D1 ISS UniProtKB GO_REF:0000024 NCBI chr 6:24,423,969...24,495,232
Ensembl chr 6:24,424,565...24,495,205
JBrowse link
G LIPG lipase G, endothelial type IMP (PMID:19136670) BHF-UCL PMID:19136670 NCBI chr18:49,560,699...49,599,185
Ensembl chr18:49,560,699...49,599,185
JBrowse link
positive regulation of low-density lipoprotein particle clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA2 annexin A2 IDA
IEA
(PMID:22848640) BHF-UCL
Ensembl
PMID:22848640 GO_REF:0000107 NCBI chr15:60,347,151...60,398,025
Ensembl chr15:60,347,134...60,402,883
JBrowse link
G LDLRAP1 low density lipoprotein receptor adaptor protein 1 IMP (PMID:28257760) BHF-UCL PMID:28257760 NCBI chr 1:25,543,588...25,590,400
Ensembl chr 1:25,543,606...25,568,886
Ensembl chr 1:25,543,606...25,568,886
JBrowse link
regulation of low-density lipoprotein particle clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNPY2 canopy FGF signaling regulator 2 ISS (PMID:22378787) BHF-UCL PMID:22378787 NCBI chr12:56,309,844...56,316,346
Ensembl chr12:56,309,842...56,316,119
JBrowse link
G CRP C-reactive protein ISO RGD PMID:8305421 RGD:9586002 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G FGF21 fibroblast growth factor 21 NAS (PMID:22378787) BHF-UCL PMID:22378787 NCBI chr19:48,755,524...48,758,330
Ensembl chr19:48,755,524...48,758,333
JBrowse link
G HNRNPK heterogeneous nuclear ribonucleoprotein K IMP (PMID:20371611) BHF-UCL PMID:20371611 NCBI chr 9:83,968,083...83,980,630
Ensembl chr 9:83,968,083...83,980,616
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 IDA (PMID:12660231) UniProtKB PMID:12660231 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
triglyceride-rich lipoprotein particle clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E IMP (PMID:23676495) UniProt PMID:23676495 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
very-low-density lipoprotein particle clearance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOB apolipoprotein B TAS Reactome Reactome:R-HSA-8964046 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073
JBrowse link
G APOBR apolipoprotein B receptor TAS Reactome Reactome:R-HSA-8964046 NCBI chr16:28,494,643...28,498,964
Ensembl chr16:28,494,643...28,498,970
JBrowse link
G APOC1 apolipoprotein C1 IGI
IBA
TAS
(PMID:15576844)
(PMID:21873635)
BHF-UCL
GO_Central
Reactome
PMID:15576844 PMID:21873635 Reactome:R-HSA-8964046 NCBI chr19:44,914,325...44,919,346
Ensembl chr19:44,914,247...44,919,349
JBrowse link
G APOC4 apolipoprotein C4 TAS Reactome Reactome:R-HSA-8964046 NCBI chr19:44,942,237...44,945,496
Ensembl chr19:44,942,237...44,945,496
JBrowse link
G APOE apolipoprotein E IMP
IDA
(PMID:9649566)
(PMID:1917954), (PMID:2762297)
BHF-UCL
UniProt
PMID:1917954 PMID:2762297 PMID:9649566 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G VLDLR very low density lipoprotein receptor IDA
TAS
(PMID:8083232) BHF-UCL
Reactome
PMID:8083232 Reactome:R-HSA-8964046 NCBI chr 9:2,621,786...2,660,056
Ensembl chr 9:2,621,787...2,660,056
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18677
    multicellular organismal process 8790
      plasma lipoprotein particle clearance 57
        high-density lipoprotein particle clearance + 13
        low-density lipoprotein particle clearance + 39
        negative regulation of lipoprotein particle clearance + 10
        oxidised low-density lipoprotein particle clearance 1
        positive regulation of lipoprotein particle clearance + 5
        regulation of lipoprotein particle clearance + 20
        triglyceride-rich lipoprotein particle clearance + 9
        very-low-density lipoprotein particle clearance + 9
Path 2
Term Annotations click to browse term
  biological_process 18677
    biological regulation 13365
      regulation of biological process 12663
        regulation of plasma lipoprotein particle levels 96
          plasma lipoprotein particle clearance 57
            high-density lipoprotein particle clearance + 13
            low-density lipoprotein particle clearance + 39
            negative regulation of lipoprotein particle clearance + 10
            oxidised low-density lipoprotein particle clearance 1
            positive regulation of lipoprotein particle clearance + 5
            regulation of lipoprotein particle clearance + 20
            triglyceride-rich lipoprotein particle clearance + 9
            very-low-density lipoprotein particle clearance + 9
paths to the root