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Term:low-density lipoprotein particle remodeling
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Accession:GO:0034374 term browser browse the term
Definition:The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL.
Synonyms:exact_synonym: LDL remodeling
 related_synonym: small dense LDL formation;   small dense low-density lipoprotein particle formation

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low-density lipoprotein particle remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (MGI:3852307|PMID:16556852) RGD PMID:16556852 MGI:3852307 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Apoa2 apolipoprotein A2 involved_in ISO
RGD PMID:8106353 PMID:21873635 RGD:13792537 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
JBrowse link
G Apob apolipoprotein B involved_in ISO (PMID:15797858) RGD PMID:15797858 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoe apolipoprotein E involved_in ISO (MGI:3850619|PMID:15654758) RGD PMID:15654758 MGI:3850619 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Lipc lipase C, hepatic type involved_in IDA
PMID:3244012 PMID:8071607 PMID:9685400 GO_REF:0000107, RGD:2308769, RGD:2308763 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G Mpo myeloperoxidase involved_in ISO (PMID:10772654) RGD PMID:10772654 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mttp microsomal triglyceride transfer protein acts_upstream_of_or_within ISO (MGI:6095248|PMID:27471003) RGD PMID:27471003 MGI:6095248 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Pla2g10 phospholipase A2, group X involved_in ISO (PMID:12021277) RGD PMID:12021277 NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000
JBrowse link
G Pla2g12b phospholipase A2, group XIIB acts_upstream_of_or_within ISO (MGI:6095248|PMID:27471003) RGD PMID:27471003 MGI:6095248 NCBI chr20:27,369,196...27,389,517
Ensembl chr20:27,370,266...27,388,743
JBrowse link
G Pla2g2e phospholipase A2, group IIE acts_upstream_of_or_within ISO MGI:5660236 (MGI:5605113|PMID:24910243) RGD PMID:24910243 MGI:5605113 NCBI chr 5:151,121,392...151,127,157
Ensembl chr 5:151,121,439...151,126,821
JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (PMID:18801741) RGD PMID:18801741 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913
JBrowse link
G Pla2g5 phospholipase A2, group V involved_in
MGI:3042209 (MGI:5605113|PMID:24910243)
PMID:14962950 PMID:24910243 GO_REF:0000024 MGI:5605113 MGI:6393145 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658
JBrowse link
G Pla2g7 phospholipase A2 group VII involved_in ISO (PMID:8624782) RGD PMID:8624782 NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    multicellular organismal process 8936
      plasma lipoprotein particle organization 41
        plasma lipoprotein particle remodeling 27
          low-density lipoprotein particle remodeling 13
Path 2
Term Annotations click to browse term
  biological_process 20099
    cellular process 18695
      cellular component organization or biogenesis 6763
        cellular component organization 6510
          protein-containing complex organization 1827
            protein-containing complex remodeling 29
              protein-lipid complex remodeling 27
                plasma lipoprotein particle remodeling 27
                  low-density lipoprotein particle remodeling 13
paths to the root