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ONTOLOGY REPORT - ANNOTATIONS

Term:plasma lipoprotein particle remodeling
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Accession:GO:0034369 term browser browse the term
Definition:The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT).
Synonyms:exact_synonym: plasma lipoprotein particle remodelling

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chylomicron remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LIPC lipase C, hepatic type ISO RGD PMID:7897313 RGD:2308767 NCBI chr26:24,946,843...25,109,338
Ensembl chr26:24,946,673...25,087,921 		JBrowse link
G LPL lipoprotein lipase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:18,009,049...18,038,315
Ensembl chr 8:18,009,093...18,038,598 		JBrowse link
high-density lipoprotein particle remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA5 ATP binding cassette subfamily A member 5 involved_in ISO (MGI:4454250|PMID:20382126) BHF-UCL PMID:20382126 MGI:4454250 NCBI chr16:52,278,563...52,373,218
Ensembl chr16:52,278,573...52,362,273 		JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 involved_in ISO (MGI:3852307|PMID:16556852), (MGI:5634884|PMID:21481393) BHF-UCL PMID:16556852 PMID:21481393 MGI:3852307 MGI:5634884 NCBI chr 2:86,098,818...86,176,101
Ensembl chr 2:86,099,414...86,179,949 		JBrowse link
G APOA1 apolipoprotein A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:108,201,967...108,203,902
Ensembl chr 1:108,201,439...108,203,609 		JBrowse link
G APOA2 apolipoprotein A2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:2,757,939...2,760,356
Ensembl chr20:2,759,237...2,760,686 		JBrowse link
G APOA4 apolipoprotein A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:108,186,627...108,190,508
Ensembl chr 1:108,186,921...108,189,698 		JBrowse link
G APOC3 apolipoprotein C3 involved_in ISO (PMID:17438339) BHF-UCL PMID:17438339 NCBI chr 1:108,196,283...108,199,274
Ensembl chr 1:108,196,939...108,199,342 		JBrowse link
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:38,377,154...38,381,219
Ensembl chr 6:38,376,887...38,381,438 		JBrowse link
G APOM apolipoprotein M involved_in ISO (MGI:3575626|PMID:15793583)
(PMID:15793583)
(PMID:18006500)		 BHF-UCL PMID:15793583 PMID:18006500 MGI:3575626
G CETP cholesteryl ester transfer protein involved_in IEA UniProt
TreeGrafter
Ensembl		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:42,909,994...42,936,277
Ensembl chr 5:42,910,226...42,936,277 		JBrowse link
G LCAT lecithin-cholesterol acyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:59,495,936...59,500,530
Ensembl chr 5:59,497,115...59,500,448 		JBrowse link
G LIPC lipase C, hepatic type involved_in ISO (PMID:3244012) RGD
BHF-UCL		 PMID:3244012 PMID:8157689 RGD:2308770 NCBI chr26:24,946,843...25,109,338
Ensembl chr26:24,946,673...25,087,921 		JBrowse link
G LIPG lipase G, endothelial type involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:31,368,189...31,395,103
Ensembl chr18:31,368,857...31,394,278 		JBrowse link
G PLA2G3 phospholipase A2 group III involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:14,025,373...14,033,214
Ensembl chr19:14,025,742...14,030,643 		JBrowse link
G PLTP phospholipid transfer protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:17,972,054...17,986,100
Ensembl chr 2:17,972,215...17,988,701 		JBrowse link
G SCARB1 scavenger receptor class B member 1 involved_in ISO (MGI:3056693|PMID:15210842), (MGI:5634884|PMID:21481393) BHF-UCL PMID:15210842 PMID:21481393 MGI:3056693 MGI:5634884 NCBI chr11:120,134,485...120,223,512
Ensembl chr11:120,134,874...120,216,904 		JBrowse link
low-density lipoprotein particle remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCG1 ATP binding cassette subfamily G member 1 involved_in ISO (MGI:3852307|PMID:16556852)
(PMID:16556852)		 BHF-UCL PMID:16556852 MGI:3852307 NCBI chr 2:86,098,818...86,176,101
Ensembl chr 2:86,099,414...86,179,949 		JBrowse link
G APOA2 apolipoprotein A2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:2,757,939...2,760,356
Ensembl chr20:2,759,237...2,760,686 		JBrowse link
G APOB apolipoprotein B involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:86,624,209...86,669,175
Ensembl chr14:86,624,332...86,668,704 		JBrowse link
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:38,377,154...38,381,219
Ensembl chr 6:38,376,887...38,381,438 		JBrowse link
G CETP cholesteryl ester transfer protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:42,909,994...42,936,277
Ensembl chr 5:42,910,226...42,936,277 		JBrowse link
G LIPC lipase C, hepatic type involved_in ISO PMID:9685400
(PMID:3244012)		 RGD
BHF-UCL		 PMID:3244012 PMID:8071607 PMID:9685400 RGD:2308763 RGD:2308769 NCBI chr26:24,946,843...25,109,338
Ensembl chr26:24,946,673...25,087,921 		JBrowse link
G LOC103228738 group 10 secretory phospholipase A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:14,135,279...14,160,346
Ensembl chr 5:14,135,338...14,159,885 		JBrowse link
G MPO myeloperoxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:35,120,194...35,130,851
Ensembl chr16:35,120,581...35,130,671 		JBrowse link
G MTTP microsomal triglyceride transfer protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27471003) Ensembl
MGI		 PMID:27471003 GO_REF:0000107 NCBI chr 7:47,706,591...47,765,154
Ensembl chr 7:47,717,089...47,765,149 		JBrowse link
G PLA2G12B phospholipase A2 group XIIB acts_upstream_of_or_within ISO (PMID:27471003) MGI PMID:27471003 NCBI chr 9:58,311,609...58,335,286
Ensembl chr 9:58,312,500...58,336,930 		JBrowse link
G PLA2G2E phospholipase A2 group IIE involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24910243) Ensembl
MGI		 PMID:24910243 GO_REF:0000107 NCBI chr20:112,632,404...112,636,571
Ensembl chr20:112,632,759...112,635,992 		JBrowse link
G PLA2G3 phospholipase A2 group III involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:14,025,373...14,033,214
Ensembl chr19:14,025,742...14,030,643 		JBrowse link
G PLA2G5 phospholipase A2 group V involved_in
acts_upstream_of_or_within		 ISO (MGI:6393145|PMID:14962950)
(PMID:14962950)
(PMID:24910243)		 UniProt
MGI		 PMID:14962950 PMID:24910243 MGI:6393145 NCBI chr20:112,465,341...112,487,082
Ensembl chr20:112,464,033...112,487,089 		JBrowse link
G PLA2G7 phospholipase A2 group VII involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:25,538,645...25,571,230
Ensembl chr17:25,538,438...25,574,269 		JBrowse link
negative regulation of plasma lipoprotein oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA4 apolipoprotein A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:108,186,627...108,190,508
Ensembl chr 1:108,186,921...108,189,698 		JBrowse link
G APOM apolipoprotein M involved_in ISO (MGI:5427066|PMID:22204862)
(PMID:16682745), (PMID:22204862)		 BHF-UCL PMID:16682745 PMID:22204862 MGI:5427066
G PON1 paraoxonase 1 NOT|involved_in ISO (PMID:15342686) BHF-UCL PMID:15342686 NCBI chr21:53,713,434...53,739,658
Ensembl chr21:53,714,012...53,739,875 		JBrowse link
negative regulation of very-low-density lipoprotein particle remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA1 apolipoprotein A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:108,201,967...108,203,902
Ensembl chr 1:108,201,439...108,203,609 		JBrowse link
G APOA2 apolipoprotein A2 involved_in ISO (PMID:14967812) BHF-UCL PMID:14967812 NCBI chr20:2,757,939...2,760,356
Ensembl chr20:2,759,237...2,760,686 		JBrowse link
G APOC3 apolipoprotein C3 involved_in ISO (PMID:3973011) BHF-UCL PMID:3973011 NCBI chr 1:108,196,283...108,199,274
Ensembl chr 1:108,196,939...108,199,342 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:27471003) MGI
Ensembl		 PMID:27471003 GO_REF:0000107 NCBI chr11:95,792,428...95,877,989
Ensembl chr11:95,792,996...95,878,293 		JBrowse link
plasma lipoprotein particle oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLA2G7 phospholipase A2 group VII involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:25,538,645...25,571,230
Ensembl chr17:25,538,438...25,574,269 		JBrowse link
positive regulation of very-low-density lipoprotein particle remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA5 apolipoprotein A5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:108,154,880...108,158,998
Ensembl chr 1:108,155,641...108,157,375 		JBrowse link
triglyceride-rich lipoprotein particle remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA2 apolipoprotein A2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:2,757,939...2,760,356
Ensembl chr20:2,759,237...2,760,686 		JBrowse link
G APOA5 apolipoprotein A5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16166565) Ensembl
MGI		 PMID:16166565 GO_REF:0000107 NCBI chr 1:108,154,880...108,158,998
Ensembl chr 1:108,155,641...108,157,375 		JBrowse link
very-low-density lipoprotein particle remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA4 apolipoprotein A4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:108,186,627...108,190,508
Ensembl chr 1:108,186,921...108,189,698 		JBrowse link
G APOA5 apolipoprotein A5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:108,154,880...108,158,998
Ensembl chr 1:108,155,641...108,157,375 		JBrowse link
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:38,377,154...38,381,219
Ensembl chr 6:38,376,887...38,381,438 		JBrowse link
G CETP cholesteryl ester transfer protein involved_in IEA UniProt
TreeGrafter
Ensembl		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:42,909,994...42,936,277
Ensembl chr 5:42,910,226...42,936,277 		JBrowse link
G LCAT lecithin-cholesterol acyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:59,495,936...59,500,530
Ensembl chr 5:59,497,115...59,500,448 		JBrowse link
G LIPC lipase C, hepatic type involved_in ISO (PMID:8640403) RGD
BHF-UCL		 PMID:6791934 PMID:8640403 RGD:2308780 NCBI chr26:24,946,843...25,109,338
Ensembl chr26:24,946,673...25,087,921 		JBrowse link
G LPL lipoprotein lipase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:18,009,049...18,038,315
Ensembl chr 8:18,009,093...18,038,598 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17098
    multicellular organismal process 7317
      plasma lipoprotein particle organization 41
        plasma lipoprotein particle remodeling 27
          high-density lipoprotein particle remodeling + 15
          low-density lipoprotein particle remodeling 14
          plasma lipoprotein particle oxidation + 4
          triglyceride-rich lipoprotein particle remodeling + 11
Path 2
Term Annotations click to browse term
  biological_process 17098
    cellular process 16624
      cellular component organization or biogenesis 6830
        cellular component organization 6605
          protein-containing complex organization 1804
            protein-containing complex remodeling 32
              protein-lipid complex remodeling 27
                plasma lipoprotein particle remodeling 27
                  high-density lipoprotein particle remodeling + 15
                  low-density lipoprotein particle remodeling 14
                  plasma lipoprotein particle oxidation + 4
                  triglyceride-rich lipoprotein particle remodeling + 11
paths to the root