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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA negative supercoiling activity
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Accession:GO:0034335 term browser browse the term
Definition:Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.
Comment:Note that this term was reinstated from obsolete.
Synonyms:related_synonym: DNA gyrase activity


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DNA negative supercoiling activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPO11 SPO11 initiator of meiotic double strand breaks enables IEA UniProt GO_REF:0000003 NCBI chr20:57,329,803...57,343,993
Ensembl chr20:57,329,803...57,343,994 		JBrowse link
G TOP2A DNA topoisomerase II alpha enables IEA UniProt GO_REF:0000003 NCBI chr17:40,388,525...40,417,896
Ensembl chr17:40,388,525...40,417,896 		JBrowse link
G TOP2B DNA topoisomerase II beta enables IEA UniProt GO_REF:0000003 NCBI chr 3:25,597,905...25,664,907
Ensembl chr 3:25,597,978...25,664,909 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19524
    ATP-dependent activity 618
      ATP-dependent activity, acting on DNA 217
        DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity 3
          DNA negative supercoiling activity 3
Path 2
Term Annotations click to browse term
  molecular_function 19524
    catalytic activity 6003
      catalytic activity, acting on a nucleic acid 683
        catalytic activity, acting on DNA 354
          DNA topoisomerase activity 7
            DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity 3
              DNA negative supercoiling activity 3
paths to the root