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Pathways

ONTOLOGY REPORT - ANNOTATIONS


Term:adherens junction organization
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Accession:GO:0034332 term browser browse the term
Definition:A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
Synonyms:exact_synonym: adherens junction organisation
 xref: Reactome:R-HSA-418990 "Adherens junctions interactions"
 never_in_taxon: NCBITaxon:4751 ! Fungi



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adherens junction organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 involved_in IEA
ISO
GO_REF:0000107
(PMID:30639848)
Ensembl
RGD
PMID:30639848 GO_REF:0000107 NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:80,226,674...80,361,600
JBrowse link
G Cdc42 cell division cycle 42 acts_upstream_of_or_within ISO MGI:3619134 (PMID:16892058) RGD PMID:16892058 NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:154,839,631...154,876,627
JBrowse link
G Cdh1 cadherin 1 involved_in ISO
IEA
IBA
(PMID:21724833)
GO_REF:0000107
GO_REF:0000033
RGD
Ensembl
GO_Central
PMID:21724833 GO_REF:0000033 GO_REF:0000107 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565
JBrowse link
G Cdh10 cadherin 10 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:70,355,521...70,577,880
Ensembl chr 2:70,357,217...70,578,332
JBrowse link
G Cdh11 cadherin 11 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:2,152,961...2,312,140
Ensembl chr19:2,154,840...2,312,140
JBrowse link
G Cdh12 cadherin 12 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:72,201,859...73,436,039
Ensembl chr 2:72,886,532...73,436,039
JBrowse link
G Cdh13 cadherin 13 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:63,258,251...64,296,122
Ensembl chr19:63,258,122...64,296,119
JBrowse link
G Cdh15 cadherin 15 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:67,812,169...67,834,986
Ensembl chr19:67,812,164...67,834,985
JBrowse link
G Cdh17 cadherin 17 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:30,024,544...30,112,226
Ensembl chr 5:30,060,090...30,112,226
JBrowse link
G Cdh18 cadherin 18 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:74,548,681...75,550,720
Ensembl chr 2:75,075,595...75,550,720
JBrowse link
G Cdh19 cadherin 19 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:28,450,361...28,561,932
Ensembl chr13:28,451,283...28,533,753
JBrowse link
G Cdh2 cadherin 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288
JBrowse link
G Cdh20 cadherin 20 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:21,252,272...21,583,526
Ensembl chr13:21,515,123...21,584,349
JBrowse link
G Cdh22 cadherin 22 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:174,264,869...174,389,940
Ensembl chr 3:174,264,869...174,390,142
JBrowse link
G Cdh24 cadherin 24 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:32,061,588...32,071,323
Ensembl chr15:32,061,588...32,071,283
JBrowse link
G Cdh26 cadherin 26 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:185,898,185...185,950,892
Ensembl chr 3:185,898,431...185,950,892
JBrowse link
G Cdh3 cadherin 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:51,303,414...51,353,900
Ensembl chr19:51,300,083...51,354,257
JBrowse link
G Cdh5 cadherin 5 involved_in ISO
IEA
(PMID:26598555)
GO_REF:0000107
RGD
Ensembl
PMID:26598555 GO_REF:0000107 NCBI chr19:821,875...860,931
Ensembl chr19:822,464...860,822
JBrowse link
G Cdh6 cadherin 6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:63,801,630...63,952,309
Ensembl chr 2:63,806,135...63,952,287
JBrowse link
G Cdh7 cadherin 7 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:27,186,223...27,336,076
Ensembl chr13:27,187,257...27,336,023
JBrowse link
G Cdh8 cadherin 8 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:5,494,552...5,901,950
Ensembl chr19:5,500,221...5,902,627
JBrowse link
G Cdh9 cadherin 9 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:67,954,708...68,094,371
Ensembl chr 2:67,955,166...68,094,365
JBrowse link
G Csk C-terminal Src kinase involved_in IEP
IBA
GO_REF:0000033 GO_Central
RGD
PMID:15389520 GO_REF:0000033, RGD:5134367 NCBI chr 8:66,925,650...66,944,861
Ensembl chr 8:66,925,651...66,930,274
JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within IEA
ISO
GO_REF:0000107
(PMID:19129494)
Ensembl
RGD
PMID:19129494 GO_REF:0000107 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
JBrowse link
G Dsp desmoplakin acts_upstream_of_or_within IEA
ISO
GO_REF:0000107
MGI:1926500|MGI:2156542 (PMID:11781569)
Ensembl
RGD
PMID:11781569 GO_REF:0000107 NCBI chr17:26,829,153...26,877,419
Ensembl chr17:26,829,153...26,877,121
JBrowse link
G Efnb2 ephrin B2 involved_in IEA
ISO
GO_REF:0000107
(PMID:30639848)
Ensembl
RGD
PMID:30639848 GO_REF:0000107 NCBI chr16:87,485,215...87,529,224
Ensembl chr16:87,485,198...87,529,208
JBrowse link
G Epha4 Eph receptor A4 involved_in IEA
ISO
GO_REF:0000107
(PMID:30639848)
Ensembl
RGD
PMID:30639848 GO_REF:0000107 NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:86,263,982...86,406,755
JBrowse link
G Flot1 flotillin 1 involved_in ISO
IEA
(PMID:24046456)
GO_REF:0000107
RGD
Ensembl
PMID:24046456 GO_REF:0000107 NCBI chr20:2,922,662...2,932,906
Ensembl chr20:2,922,655...2,932,771
JBrowse link
G Numb NUMB, endocytic adaptor protein acts_upstream_of_or_within IEA
ISO
GO_REF:0000107
MGI:894702 (PMID:17589506)
Ensembl
RGD
PMID:17589506 GO_REF:0000107 NCBI chr 6:109,162,499...109,284,527
Ensembl chr 6:109,162,499...109,284,463
JBrowse link
G Numbl NUMB-like, endocytic adaptor protein acts_upstream_of_or_within IEA
ISO
GO_REF:0000107
MGI:107423 (PMID:17589506)
Ensembl
RGD
PMID:17589506 GO_REF:0000107 NCBI chr 1:91,677,437...91,701,415
Ensembl chr 1:91,677,242...91,701,424
JBrowse link
G Plec plectin involved_in IEA
ISO
GO_REF:0000107
MGI:3721885 (PMID:26519478)
Ensembl
RGD
PMID:26519478 GO_REF:0000107 NCBI chr 7:109,768,447...109,829,798
Ensembl chr 7:109,768,447...109,828,089
JBrowse link
G Specc1l sperm antigen with calponin homology and coiled-coil domains 1-like acts_upstream_of_or_within IEA
ISO
GO_REF:0000107
MGI:4124253 (PMID:26787558)
Ensembl
RGD
PMID:26787558 GO_REF:0000107 NCBI chr20:13,337,399...13,443,080
Ensembl chr20:13,339,108...13,443,079
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IEP RGD PMID:15389520 RGD:5134367 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462
JBrowse link
adherens junction assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta involved_in ISO
IEA
(PMID:22855531)
GO_REF:0000107
RGD
Ensembl
PMID:22855531 GO_REF:0000107 NCBI chr12:16,776,664...16,779,634
Ensembl chr12:16,776,661...16,780,242
JBrowse link
G Clmp CXADR-like membrane protein acts_upstream_of_or_within ISO (PMID:26956488) RGD PMID:26956488 NCBI chr 8:49,957,639...50,065,959
Ensembl chr 8:49,957,720...50,065,959
JBrowse link
G Ctnnb1 catenin beta 1 involved_in ISO
IEA
ISS
(PMID:20086044), (PMID:20123964)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:20086044 PMID:20123964 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
JBrowse link
G Dsg3 desmoglein 3 involved_in ISO
IEA
(PMID:31835537)
GO_REF:0000107
RGD
Ensembl
PMID:31835537 GO_REF:0000107 NCBI chr18:12,074,321...12,105,954
Ensembl chr18:12,074,321...12,111,766
JBrowse link
G Fer FER tyrosine kinase IEP RGD PMID:12700184 RGD:2291909 NCBI chr 9:110,967,317...111,274,315
Ensembl chr 9:110,967,390...111,274,315
JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:23565059)
Ensembl
RGD
PMID:23565059 GO_REF:0000107 NCBI chr 2:193,937,261...193,988,247
Ensembl chr 2:193,937,261...193,975,164
JBrowse link
G Jam3 junctional adhesion molecule 3 involved_in ISO
IEA
(PMID:19060272)
GO_REF:0000107
RGD
Ensembl
PMID:19060272 GO_REF:0000107 NCBI chr 8:33,767,606...33,828,451
Ensembl chr 8:33,767,607...33,828,623
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 involved_in ISO
IEA
(PMID:25753039)
GO_REF:0000107
RGD
Ensembl
PMID:25753039 GO_REF:0000107 NCBI chr11:82,212,896...82,273,803
Ensembl chr11:82,212,951...82,273,803
JBrowse link
G Ramp2 receptor activity modifying protein 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:18097473)
UniProt
RGD
PMID:18097473 GO_REF:0000024 NCBI chr10:86,689,148...86,690,956
Ensembl chr10:86,688,703...86,691,231
JBrowse link
G Smad7 SMAD family member 7 involved_in ISO
IEA
(PMID:18593713)
GO_REF:0000107
RGD
Ensembl
PMID:18593713 GO_REF:0000107 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849
JBrowse link
G Tbcd tubulin folding cofactor D involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:107,215,626...107,372,398
Ensembl chr10:107,215,633...107,372,402
JBrowse link
G Vcl vinculin involved_in IEA
ISO
GO_REF:0000107
(PMID:20086044)
Ensembl
RGD
PMID:20086044 GO_REF:0000107 NCBI chr15:3,315,069...3,404,891
Ensembl chr15:3,315,069...3,405,163
JBrowse link
G Zfp703 zinc finger protein 703 involved_in IEA
ISO
GO_REF:0000107
(PMID:21317240)
Ensembl
RGD
PMID:21317240 GO_REF:0000107 NCBI chr16:71,779,340...71,783,510
Ensembl chr16:71,779,340...71,783,510
JBrowse link
adherens junction disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fer FER tyrosine kinase IEP RGD PMID:12700184 RGD:2291909 NCBI chr 9:110,967,317...111,274,315
Ensembl chr 9:110,967,390...111,274,315
JBrowse link
adherens junction maintenance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afdn afadin, adherens junction formation factor acts_upstream_of_or_within ISO (PMID:25100583) RGD PMID:25100583 NCBI chr 1:58,041,065...58,170,505
Ensembl chr 1:58,041,641...58,170,505
JBrowse link
G Fermt2 FERM domain containing kindlin 2 involved_in ISO
IEA
(PMID:28799653)
GO_REF:0000107
RGD
Ensembl
PMID:28799653 GO_REF:0000107 NCBI chr15:21,162,603...21,257,995
Ensembl chr15:21,162,605...21,258,115
JBrowse link
G Inava innate immunity activator involved_in ISO
IEA
IBA
(PMID:29420262)
GO_REF:0000107
GO_REF:0000033
RGD
Ensembl
GO_Central
PMID:29420262 GO_REF:0000033 GO_REF:0000107 NCBI chr13:50,218,149...50,238,430
Ensembl chr13:50,218,150...50,238,454
JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:5319219 (PMID:21406566)
GO_Central
RGD
PMID:21406566 GO_REF:0000033 NCBI chr 7:92,378,228...92,517,444
Ensembl chr 7:92,378,238...92,517,303
JBrowse link
G Pkp2 plakophilin 2 IMP RGD PMID:18261826 RGD:6784508 NCBI chr11:98,165,974...98,231,916
Ensembl chr11:98,165,974...98,231,916
JBrowse link
G Tjp1 tight junction protein 1 involved_in ISO (PMID:25753039) RGD PMID:25753039 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
JBrowse link
negative regulation of adherens junction organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 involved_in ISO
IEA
(PMID:26598555)
GO_REF:0000107
RGD
Ensembl
PMID:26598555 GO_REF:0000107 NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261
JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO
IEA
(PMID:26598555)
GO_REF:0000107
RGD
Ensembl
PMID:26598555 GO_REF:0000107 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
positive regulation of adherens junction organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Add1 adducin 1 involved_in ISO
IEA
IBA
(PMID:25978380)
GO_REF:0000107
GO_REF:0000033
RGD
Ensembl
GO_Central
PMID:25978380 GO_REF:0000033 GO_REF:0000107 NCBI chr14:80,333,242...80,401,641
Ensembl chr14:80,333,244...80,391,732
JBrowse link
G Ptpn23 protein tyrosine phosphatase, non-receptor type 23 involved_in IEA
ISO
GO_REF:0000107
(PMID:21724833)
Ensembl
RGD
PMID:21724833 GO_REF:0000107 NCBI chr 8:119,239,213...119,261,675
Ensembl chr 8:119,239,213...119,261,675
JBrowse link
regulation of adherens junction organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rdx radixin involved_in ISO
IEA
(PMID:22467863)
GO_REF:0000107
RGD
Ensembl
PMID:22467863 GO_REF:0000107 NCBI chr 8:61,275,792...61,348,260
Ensembl chr 8:61,274,460...61,333,967
JBrowse link
zonula adherens assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 involved_in ISO (PMID:15572692) RGD PMID:15572692 NCBI chr 9:69,321,072...69,490,630
Ensembl chr 9:69,321,150...69,490,597
JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 acts_upstream_of_or_within IEA
ISO
GO_REF:0000107
MGI:3757646 (PMID:17765678)
Ensembl
RGD
PMID:17765678 GO_REF:0000107 NCBI chr15:125,287...237,334
Ensembl chr15:125,290...237,332
JBrowse link
zonula adherens maintenance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camsap3 calmodulin regulated spectrin-associated protein family, member 3 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:19041755)
UniProt
Ensembl
RGD
PMID:19041755 GO_REF:0000024 GO_REF:0000107 NCBI chr12:6,440,959...6,464,582
Ensembl chr12:6,441,152...6,464,582
JBrowse link
G Kifc3 kinesin family member C3 involved_in ISO
IEA
(PMID:19041755)
GO_REF:0000107
RGD
Ensembl
PMID:19041755 GO_REF:0000107 NCBI chr19:9,831,159...9,926,405
Ensembl chr19:9,831,159...9,926,405
JBrowse link
G Plekha7 pleckstrin homology domain containing A7 involved_in ISO (PMID:19041755) RGD PMID:19041755 NCBI chr 1:179,798,856...179,982,155
Ensembl chr 1:179,799,040...179,982,281
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      cellular component organization or biogenesis 7050
        cellular component organization 6802
          cell junction organization 1011
            cell-cell junction organization 237
              adherens junction organization 61
                adherens junction assembly + 15
                adherens junction disassembly 1
                adherens junction maintenance + 9
                negative regulation of adherens junction organization 2
                positive regulation of adherens junction organization 2
                regulation of adherens junction organization + 5
paths to the root