Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:Arp2/3 complex-mediated actin nucleation
go back to main search page
Accession:GO:0034314 term browser browse the term
Definition:The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins.
Synonyms:exact_synonym: actin filament branch nucleation;   branched actin filament nucleation


show annotations for term's descendants           Sort by:
 
Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:11741539), (PMID:17220302), (PMID:29925947)
PMID:21873635
UniProt
RGD
PMID:11741539 PMID:17220302 PMID:29925947, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr14:94,296,443...94,333,735 JBrowse link
G Actr3 actin related protein 3 involved_in IBA
IEA
ISO
ISS
PMID:21873635
GO_REF:0000107
(PMID:11741539), (PMID:17220302)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:11741539 PMID:17220302, PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr13:36,800,739...36,843,837 JBrowse link
G Arpc1a actin related protein 2/3 complex, subunit 1A involved_in IEA
IBA
GO_REF:0000002
PMID:21873635
InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr12:9,502,496...9,525,304 JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B involved_in IBA
ISO
PMID:21873635
(PMID:11741539)
RGD PMID:11741539, PMID:21873635 RGD:13792537 NCBI chr12:9,482,176...9,495,772 JBrowse link
G Arpc2 actin related protein 2/3 complex, subunit 2 involved_in IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
GO_REF:0000002
(PMID:11741539)
Ensembl
InterPro
RGD
PMID:11741539, PMID:21873635 GO_REF:0000002 GO_REF:0000107, RGD:13792537 NCBI chr 9:75,820,782...75,851,471 JBrowse link
G Arpc3 actin related protein 2/3 complex, subunit 3 involved_in ISO
IBA
(PMID:11741539)
PMID:21873635
RGD PMID:11741539, PMID:21873635 RGD:13792537 NCBI chr12:34,172,780...34,186,651 JBrowse link
G Arpc4 actin related protein 2/3 complex, subunit 4 involved_in ISO (PMID:11741539) RGD PMID:11741539 NCBI chr 4:146,522,255...146,532,784 JBrowse link
G Arpc5 actin related protein 2/3 complex, subunit 5 involved_in IBA
IEA
ISO
PMID:21873635
GO_REF:0000002
(PMID:11741539)
InterPro
RGD
PMID:11741539, PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr13:64,904,504...64,913,413 JBrowse link
G Arpc5l actin related protein 2/3 complex, subunit 5-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:22,758,710...22,767,520 JBrowse link
G Arpc5l-ps1 actin related protein 2/3 complex, subunit 5-like, pseudogene 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:45,263,352...45,264,349 JBrowse link
G Iqgap2 IQ motif containing GTPase activating protein 2 involved_in ISO (PMID:12515716) RGD PMID:12515716 NCBI chr 2:26,894,836...27,170,270 JBrowse link
G Jmy junction mediating and regulatory protein, p53 cofactor involved_in IBA
ISO
PMID:21873635
(MGI:4418600|PMID:19287377)
RGD PMID:19287377, PMID:21873635 MGI:4418600, RGD:13792537 NCBI chr 2:24,662,104...24,730,955 JBrowse link
G Magel2 MAGE family member L2 involved_in ISO (PMID:23452853) RGD PMID:23452853 NCBI chr 1:115,880,137...115,884,680 JBrowse link
G Trim27 tripartite motif-containing 27 involved_in ISO (PMID:23452853) RGD PMID:23452853 NCBI chr17:43,538,282...43,550,633 JBrowse link
G Washc1 WASH complex subunit 1 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
GO_REF:0000024
(MGI:5603599|PMID:23452853)
(MGI:4415646|PMID:19922875)
GO_REF:0000107
(PMID:23452853)
UniProt
RGD
Ensembl
PMID:19922875 PMID:23452853 GO_REF:0000024 GO_REF:0000107 MGI:4415646 MGI:5603599 NCBI chr 9:105,722,779...105,830,836 JBrowse link
G Whamm WASP homolog associated with actin, golgi membranes and microtubules involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:135,526,363...135,557,091 JBrowse link
negative regulation of Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coro1b coronin 1B involved_in IEA
ISO
GO_REF:0000107
(PMID:17350576), (PMID:18775315)
Ensembl
RGD
PMID:17350576 PMID:18775315 GO_REF:0000107 NCBI chr 1:201,442,977...201,448,416 JBrowse link
G Ctnna2 catenin alpha 2 involved_in ISO (PMID:30013181) RGD PMID:30013181 NCBI chr 4:109,293,978...110,443,413 JBrowse link
G Dnai3 dynein axonemal intermediate chain 3 involved_in ISO (PMID:32128961) RGD PMID:32128961 NCBI chr 2:234,947,910...235,006,173 JBrowse link
G Gmfb glia maturation factor, beta involved_in IBA
IEA
PMID:21873635
GO_REF:0000002
InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr15:20,069,923...20,081,005 JBrowse link
G Gmfg glia maturation factor, gamma involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
(MGI:5505367|PMID:23727094)
PMID:21873635
Ensembl
RGD
PMID:23727094, PMID:21873635 GO_REF:0000107 MGI:5505367, RGD:13792537 NCBI chr 1:83,728,797...83,739,189 JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO (MGI:5805366|PMID:17318189) RGD PMID:17318189 MGI:5805366 NCBI chr12:32,590,164...32,618,841 JBrowse link
G Pick1 protein interacting with PRKCA 1 involved_in IDA PMID:18297063 UniProt PMID:18297063 RGD:8554748 NCBI chr 7:110,796,623...110,816,850 JBrowse link
positive regulation of Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 involved_in ISO (PMID:21107423) RGD PMID:21107423 NCBI chr 9:61,856,379...61,904,029 JBrowse link
G Brk1 BRICK1 subunit of SCAR/WAVE actin nucleating complex involved_in ISO (PMID:21107423) RGD PMID:21107423 NCBI chr 4:146,750,821...146,766,050 JBrowse link
G Cyfip1 cytoplasmic FMR1 interacting protein 1 involved_in ISO (PMID:21107423) RGD PMID:21107423 NCBI chr 1:106,710,924...106,799,393 JBrowse link
G Fchsd2 FCH and double SH3 domains 2 involved_in ISO (PMID:29887380) RGD PMID:29887380 NCBI chr 1:155,444,471...155,685,539 JBrowse link
G Nckap1 NCK-associated protein 1 involved_in ISO
IEA
(PMID:21107423)
GO_REF:0000107
RGD
Ensembl
PMID:21107423 GO_REF:0000107 NCBI chr 3:65,417,450...65,491,769 JBrowse link
G RGD1561552 similar to WASP family 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:73,040,984...73,043,716 JBrowse link
G Was WASP actin nucleation promoting factor involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:14,405,096...14,413,850 JBrowse link
G Wasf1 WASP family member 1 involved_in ISO
IBA
(PMID:21107423)
PMID:21873635
RGD PMID:21107423, PMID:21873635 RGD:13792537 NCBI chr20:44,325,815...44,372,999 JBrowse link
G Wasf2 WASP family member 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:145,336,816...145,402,041 JBrowse link
G Wasf3 WASP family member 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:8,563,805...8,660,799 JBrowse link
G Wasl WASP like actin nucleation promoting factor involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:53,083,536...53,132,061 JBrowse link
regulation of Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1ar adaptor-related protein complex 1 associated regulatory protein acts_upstream_of_or_within ISO MGI:1923959 (MGI:5429457|PMID:22689987) RGD PMID:22689987 MGI:5429457 NCBI chr 2:216,276,631...216,309,020 JBrowse link
G Arf1 ADP-ribosylation factor 1 involved_in IDA PMID:23889934 UniProt PMID:23889934 RGD:8553918 NCBI chr10:43,997,983...44,014,543 JBrowse link
G Arfip1 ADP-ribosylation factor interacting protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:169,843,804...169,924,136 JBrowse link
G Arfip2 ADP-ribosylation factor interacting protein 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:159,974,255...159,980,398 JBrowse link
G Coro1b coronin 1B involved_in IC PMID:22619279 UniProt PMID:22619279 RGD:10047170 NCBI chr 1:201,442,977...201,448,416 JBrowse link
G Pick1 protein interacting with PRKCA 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:110,796,623...110,816,850 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18342
      actin filament-based process 833
        actin cytoskeleton organization 746
          actin filament organization 467
            actin nucleation 51
              Arp2/3 complex-mediated actin nucleation 38
                negative regulation of Arp2/3 complex-mediated actin nucleation 7
                positive regulation of Arp2/3 complex-mediated actin nucleation 11
                regulation of Arp2/3 complex-mediated actin nucleation + 22
Path 2
Term Annotations click to browse term
  biological_process 19492
    cellular process 18342
      cellular component organization or biogenesis 6723
        cellular component organization 6483
          organelle organization 4060
            cytoskeleton organization 1453
              actin cytoskeleton organization 746
                actin filament organization 467
                  actin polymerization or depolymerization 232
                    regulation of actin polymerization or depolymerization 200
                      regulation of actin filament polymerization 181
                        positive regulation of actin filament polymerization 99
                          actin nucleation 51
                            Arp2/3 complex-mediated actin nucleation 38
                              negative regulation of Arp2/3 complex-mediated actin nucleation 7
                              positive regulation of Arp2/3 complex-mediated actin nucleation 11
                              regulation of Arp2/3 complex-mediated actin nucleation + 22
paths to the root