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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of GTPase activity
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Accession:GO:0034260 term browser browse the term
Definition:Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
Comment:An example of this is P2xA in Dictyostelium (UniProt symbol Q86JM7) in PMID:24335649.
Synonyms:exact_synonym: down regulation of GTPase activity;   downregulation of GTPase activity;   negative regulation of guanosinetriphosphatase activity
 narrow_synonym: down regulation of Rab GTPase activity;   down regulation of Ras GTPase activity;   down regulation of Rho GTPase activity;   down regulation of regulation of Ran GTPase activity;   downregulation of Rab GTPase activity;   downregulation of Ras GTPase activity;   downregulation of Rho GTPase activity;   downregulation of regulation of Ran GTPase activity;   inhibition of GTPase activity;   inhibition of Rab GTPase activity;   inhibition of Ras GTPase activity;   inhibition of Rho GTPase activity;   inhibition of regulation of Ran GTPase activity;   negative regulation of Rab GTPase activity;   negative regulation of Ran GTPase activity;   negative regulation of Ras GTPase activity;   negative regulation of Rho GTPase activity
 alt_id: GO:0034259;   GO:0034261;   GO:1902264;   GO:1902881


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negative regulation of GTPase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 IDA RGD PMID:15870074 RGD:2325307 NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716
JBrowse link
G Amot angiomotin acts_upstream_of_or_within ISO MGI:2656627 (MGI:3719955|PMID:17699752) RGD PMID:17699752 MGI:3719955 NCBI chr  X:116,751,231...116,810,238
Ensembl chr  X:116,751,230...116,792,864
JBrowse link
G Arfgef1 ADP ribosylation factor guanine nucleotide exchange factor 1 involved_in ISO
ISS
(PMID:15644318)
GO_REF:0000024
RGD
UniProt
PMID:15644318 GO_REF:0000024 NCBI chr 5:8,666,046...8,760,458
Ensembl chr 5:8,666,200...8,760,458
JBrowse link
G Arl2 ADP-ribosylation factor like GTPase 2 involved_in ISO
ISS
IEA
(PMID:10831612)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:10831612 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:221,504,150...221,516,191
Ensembl chr 1:221,504,170...221,516,110
JBrowse link
G Arrb1 arrestin, beta 1 IDA RGD PMID:1517224 RGD:631708 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Arrb2 arrestin, beta 2 IDA RGD PMID:1517224 RGD:631708 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 acts_upstream_of_or_within ISO MGI:3055492 (MGI:5510934|PMID:23716571) RGD PMID:23716571 MGI:5510934 NCBI chr 8:64,115,005...64,154,432
Ensembl chr 8:64,121,392...64,154,396
JBrowse link
G Bcas3 BCAS3, microtubule associated cell migration factor involved_in ISO (MGI:5582152|PMID:22300583) RGD PMID:22300583 MGI:5582152 NCBI chr10:72,756,548...73,271,851
NCBI chr10:72,951,303...73,015,309
JBrowse link
G Cpeb2 cytoplasmic polyadenylation element binding protein 2 involved_in IDA PMID:22157746 UniProt PMID:22157746 RGD:8553654 NCBI chr14:72,327,929...72,382,519
Ensembl chr14:72,331,705...72,380,330
JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:4453088|PMID:19948740)
GO_REF:0000107
(PMID:20154697)
UniProt
RGD
Ensembl
PMID:19948740 PMID:20154697 GO_REF:0000024 GO_REF:0000107 MGI:4453088 NCBI chr 3:14,889,263...15,060,286
Ensembl chr 3:14,889,510...15,060,286
JBrowse link
G Dgki diacylglycerol kinase, iota involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:64,365,115...64,831,473
Ensembl chr 4:64,374,342...64,831,473
JBrowse link
G F11r F11 receptor involved_in ISO (PMID:23885123) RGD PMID:23885123 NCBI chr13:89,826,272...89,850,151
Ensembl chr13:89,826,254...89,850,612
JBrowse link
G Fzd10 frizzled class receptor 10 involved_in ISO (PMID:19137009) RGD PMID:19137009 NCBI chr12:31,757,407...31,760,604
Ensembl chr12:31,757,407...31,760,604
JBrowse link
G Gmip Gem-interacting protein involved_in IBA
ISO
PMID:21873635
(PMID:12093360)
RGD PMID:12093360, PMID:21873635 RGD:13792537 NCBI chr16:21,349,652...21,363,412
Ensembl chr16:21,349,652...21,362,955
JBrowse link
G Gpsm1 G-protein signaling modulator 1 involved_in ISO (PMID:11024022) RGD PMID:11024022 NCBI chr 3:3,767,394...3,794,360
Ensembl chr 3:3,767,394...3,794,359
JBrowse link
G Hras HRas proto-oncogene, GTPase involved_in ISO (PMID:23027131) RGD PMID:23027131 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Klre1 killer cell lectin-like receptor, family E, member 1 involved_in ISO (PMID:22585739) RGD PMID:22585739 NCBI chr 4:163,346,684...163,355,050
Ensembl chr 4:163,349,125...163,354,976
JBrowse link
G Klrk1 killer cell lectin like receptor K1 involved_in ISO
IEA
(PMID:22585739)
GO_REF:0000107
RGD
Ensembl
PMID:22585739 GO_REF:0000107 NCBI chr 4:163,392,652...163,403,735
Ensembl chr 4:163,393,217...163,403,653
JBrowse link
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like involved_in ISO (PMID:19188362) RGD PMID:19188362 NCBI chr 1:169,720,247...169,721,788
Ensembl chr 1:169,720,253...169,721,758
JBrowse link
G Lrch1 leucine rich repeats and calponin homology domain containing 1 involved_in ISO (PMID:28028151)
(MGI:5824146|PMID:28028151)
RGD PMID:28028151 MGI:5824146 NCBI chr15:56,778,738...56,970,439
Ensembl chr15:56,785,162...56,970,365
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (PMID:22423108) RGD PMID:22423108 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link
G Mkks MKKS centrosomal shuttling protein acts_upstream_of_or_within ISO MGI:3608879 (MGI:5510934|PMID:23716571) RGD PMID:23716571 MGI:5510934 NCBI chr 3:129,866,542...129,885,213
Ensembl chr 3:129,866,545...129,884,810
JBrowse link
G Pde6d phosphodiesterase 6D involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 9:93,562,099...93,607,061
Ensembl chr 9:93,562,095...93,607,087
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 IDA RGD PMID:17662049 RGD:7240703 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Plxnb3 plexin B3 involved_in ISS
ISO
GO_REF:0000024
(PMID:20696765)
UniProt
RGD
PMID:20696765 GO_REF:0000024 NCBI chr  X:157,015,297...157,030,147
Ensembl chr  X:157,015,305...157,028,434
JBrowse link
G Ptprn2 protein tyrosine phosphatase, receptor type N2 IDA RGD PMID:16413169 RGD:1625628 NCBI chr 6:144,384,773...145,133,042
Ensembl chr 6:144,384,773...145,133,042
JBrowse link
G Rcc2 regulator of chromosome condensation 2 involved_in ISO (PMID:25074804)
(MGI:5551375|PMID:19738201), (MGI:5621257|PMID:25074804)
RGD PMID:19738201 PMID:25074804 MGI:5551375 MGI:5621257 NCBI chr 5:159,220,531...159,236,313
Ensembl chr 5:159,220,979...159,234,320
JBrowse link
G Rdx radixin involved_in ISO (PMID:22467863) RGD PMID:22467863 NCBI chr 8:56,570,728...56,612,851
Ensembl chr 8:56,585,396...56,610,612
JBrowse link
G Rgn regucalcin IMP RGD PMID:11510494 RGD:9590205 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904
JBrowse link
G Rrp1b ribosomal RNA processing 1B involved_in ISO (MGI:5914084|PMID:18081427) RGD PMID:18081427 MGI:5914084 NCBI chr20:10,844,234...10,869,830
Ensembl chr20:10,844,266...10,869,821
JBrowse link
G Rtkn rhotekin involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:114,833,453...114,850,705
Ensembl chr 4:114,835,064...114,850,701
Ensembl chr 4:114,835,064...114,850,701
JBrowse link
G Sh3bp4 SH3-domain binding protein 4 involved_in ISO
IEA
ISS
(PMID:22575674)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:22575674 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:96,210,750...96,288,903
Ensembl chr 9:96,210,750...96,288,903
JBrowse link
G Slit2 slit guidance ligand 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:66,831,848...67,171,491
Ensembl chr14:66,831,848...67,170,361
JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 acts_upstream_of_or_within ISO (MGI:2154590|PMID:11585837) RGD PMID:11585837 MGI:2154590 NCBI chr 2:124,400,689...124,405,331
Ensembl chr 2:124,400,679...124,405,331
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 acts_upstream_of_or_within ISO (MGI:2154590|PMID:11585837) RGD PMID:11585837 MGI:2154590 NCBI chr15:90,172,769...90,177,823
Ensembl chr15:90,172,975...90,175,802
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:10761932)
UniProt
RGD
PMID:10761932 GO_REF:0000024 NCBI chr12:37,471,259...37,480,344
Ensembl chr12:37,471,260...37,480,297
JBrowse link
G Tsc1 TSC complex subunit 1 IMP RGD PMID:15611338 RGD:1601406 NCBI chr 3:7,219,955...7,269,063
Ensembl chr 3:7,237,192...7,265,145
JBrowse link
G Ttc8 tetratricopeptide repeat domain 8 acts_upstream_of_or_within ISO (MGI:5510934|PMID:23716571) RGD PMID:23716571 MGI:5510934 NCBI chr 6:122,920,308...122,974,525
Ensembl chr 6:122,920,317...122,974,522
JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 acts_upstream_of_or_within ISO (PMID:27400149)
(MGI:6141968|PMID:27400149)
RGD PMID:27400149 MGI:6141968 NCBI chr 4:152,452,211...152,578,469
Ensembl chr 4:152,452,848...152,578,446
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19634
    negative regulation of biological process 5637
      negative regulation of GTPase activity 39
Path 2
Term Annotations click to browse term
  biological_process 19634
    biological regulation 13612
      regulation of molecular function 3154
        regulation of catalytic activity 2408
          regulation of hydrolase activity 1225
            regulation of GTPase activity 442
              negative regulation of GTPase activity 39
paths to the root