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ONTOLOGY REPORT - ANNOTATIONS


Term:cellular response to amino acid starvation
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Accession:GO:0034198 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
Synonyms:narrow_synonym: GAAC response;   general amino acid control response


show annotations for term's descendants           Sort by:
 
cellular response to amino acid starvation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 ISO (MGI:MGI:3722921|PMID:14729979) RGD PMID:14729979 MGI:MGI:3722921 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 ISS
ISO
GO_REF:0000024
(MGI:MGI:3582244|PMID:11106749), (MGI:MGI:3722921|PMID:14729979), (MGI:MGI:3798818|PMID:12667446)
UniProt
RGD
PMID:11106749, PMID:12667446, PMID:14729979 GO_REF:0000024, MGI:MGI:3582244, MGI:MGI:3722921, MGI:MGI:3798818 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Becn1 beclin 1 IEP RGD PMID:22835012 RGD:11561942 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bmt2 base methyltransferase of 25S rRNA 2 homolog ISO (PMID:29123071) RGD PMID:29123071 NCBI chr 4:40,064,131...40,136,074
Ensembl chr 4:40,063,932...40,136,061
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO (PMID:26102367)
(MGI:MGI:5700278|PMID:26102367)
RGD PMID:26102367 MGI:MGI:5700278 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Dap death-associated protein ISO
IBA
(PMID:20537536)
PMID:21873635
RGD PMID:20537536, PMID:21873635 RGD:13792537 NCBI chr 2:84,275,884...84,328,998
Ensembl chr 2:84,275,884...84,328,998
JBrowse link
G Dapl1 death associated protein-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:45,538,408...45,559,281
Ensembl chr 3:45,538,797...45,559,331
JBrowse link
G Depdc5 DEP domain containing 5, GATOR1 subcomplex subunit ISO
IBA
(PMID:23723238)
PMID:21873635
RGD PMID:23723238, PMID:21873635 RGD:13792537 NCBI chr14:83,089,000...83,219,576
Ensembl chr14:83,089,000...83,219,464
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 IEA
ISO
GO_REF:0000107
(PMID:25329545)
Ensembl
RGD
PMID:25329545 GO_REF:0000107 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO
ISS
(PMID:25329545)
GO_REF:0000024
RGD
UniProt
PMID:25329545 GO_REF:0000024 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO (PMID:25329545)
(MGI:MGI:3722921|PMID:14729979), (MGI:MGI:5576818|PMID:24333428)
RGD PMID:14729979, PMID:24333428, PMID:25329545 MGI:MGI:3722921, MGI:MGI:5576818 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha ISO
ISS
(MGI:MGI:3582244|PMID:11106749)
GO_REF:0000024
RGD
UniProt
PMID:11106749 GO_REF:0000024, MGI:MGI:3582244 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Fas Fas cell surface death receptor ISO (PMID:11096076) RGD PMID:11096076 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Flcn folliculin ISO
ISS
(PMID:24095279), (PMID:27113757), (PMID:31672913)
GO_REF:0000024
RGD
UniProt
PMID:24095279, PMID:27113757, PMID:31672913 GO_REF:0000024 NCBI chr10:46,153,185...46,172,331
Ensembl chr10:46,153,188...46,172,309
JBrowse link
G Gcn1 GCN1 activator of EIF2AK4 ISO (MGI:MGI:5576818|PMID:24333428) RGD PMID:24333428 MGI:MGI:5576818 NCBI chr12:46,728,684...46,789,696
Ensembl chr12:46,728,699...46,789,726
JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L IDA RGD PMID:19273590 RGD:9999430 NCBI chr 1:86,994,090...87,006,776
Ensembl chr 1:86,996,093...87,006,776
JBrowse link
G Impact impact RWD domain protein ISO
ISS
(MGI:MGI:5576818|PMID:24333428)
GO_REF:0000024
RGD
UniProt
PMID:24333428 GO_REF:0000024, MGI:MGI:5576818 NCBI chr18:4,325,872...4,346,734
Ensembl chr18:4,325,875...4,346,769
JBrowse link
G Itfg2 integrin alpha FG-GAP repeat containing 2 ISO (PMID:28199306) RGD PMID:28199306 NCBI chr 4:161,730,643...161,744,281
Ensembl chr 4:161,730,641...161,743,896
JBrowse link
G Kptn kaptin (actin binding protein) ISO
IBA
(PMID:28199306)
PMID:21873635
RGD PMID:28199306, PMID:21873635 RGD:13792537 NCBI chr 1:78,015,714...78,016,508
Ensembl chr 1:78,015,722...78,023,676
JBrowse link
G Lars1 leucyl-tRNA synthetase 1 ISO (PMID:22424946) RGD PMID:22424946 NCBI chr18:36,524,013...36,579,471
Ensembl chr18:36,524,007...36,579,403
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha IEP RGD PMID:22835012 RGD:11561942 NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO (PMID:11096076) RGD PMID:11096076 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO (PMID:11096076) RGD PMID:11096076 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO (PMID:11096076) RGD PMID:11096076 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEA
ISO
GO_REF:0000107
(PMID:11096076)
Ensembl
RGD
PMID:11096076 GO_REF:0000107 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mios meiosis regulator for oocyte development ISO
IBA
(PMID:23723238)
PMID:21873635
RGD PMID:23723238, PMID:21873635 RGD:13792537 NCBI chr 4:34,238,370...34,264,015
Ensembl chr 4:34,237,762...34,264,015
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO
ISS
(PMID:22343943), (PMID:22424946), (PMID:22576015), (PMID:22692423)
GO_REF:0000024
RGD
UniProt
PMID:22343943, PMID:22424946, PMID:22576015, PMID:22692423 GO_REF:0000024 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nprl2 NPR2-like, GATOR1 complex subunit ISO
IBA
(PMID:23723238)
PMID:21873635
RGD PMID:23723238, PMID:21873635 RGD:13792537 NCBI chr 8:116,297,950...116,301,123
Ensembl chr 8:116,297,950...116,301,122
JBrowse link
G Nprl3 NPR3-like, GATOR1 complex subunit ISO
IBA
(PMID:23723238)
PMID:21873635
RGD PMID:23723238, PMID:21873635 RGD:13792537 NCBI chr10:15,620,824...15,661,332
Ensembl chr10:15,620,871...15,661,331
JBrowse link
G Prkd1 protein kinase D1 ISO (PMID:22095288) RGD PMID:22095288 NCBI chr 6:71,035,017...71,349,531
Ensembl chr 6:71,035,332...71,349,249
JBrowse link
G RGD1565498 similar to Hypothetical protein LOC270802 ISO
IBA
(PMID:28199306)
PMID:21873635
RGD PMID:28199306, PMID:21873635 RGD:13792537 NCBI chr 7:63,922,871...63,937,721
Ensembl chr 7:63,922,879...63,936,385
JBrowse link
G Rnf152 ring finger protein 152 ISO
IBA
ISS
(PMID:25936802)
PMID:21873635
GO_REF:0000024
(MGI:MGI:5644195|PMID:25936802)
RGD
UniProt
PMID:25936802, PMID:21873635 GO_REF:0000024, MGI:MGI:5644195, RGD:13792537 NCBI chr13:25,183,295...25,262,785
Ensembl chr13:25,186,106...25,262,469
JBrowse link
G Rpl17 ribosomal protein L17 IEP RGD PMID:8144559 RGD:1304507 NCBI chr18:70,969,733...70,972,839
Ensembl chr18:70,970,596...70,975,494
JBrowse link
G Rps25 ribosomal protein s25 IEP RGD PMID:8144559 RGD:1304507 NCBI chr 8:48,727,346...48,729,722
Ensembl chr 8:48,727,618...48,729,580
JBrowse link
G Rraga Ras-related GTP binding A ISO
ISS
(PMID:25936802)
GO_REF:0000024
RGD
UniProt
PMID:25936802 GO_REF:0000024 NCBI chr 5:104,941,067...104,942,662
Ensembl chr 5:104,941,066...104,942,662
JBrowse link
G RragB Ras-related GTP binding B ISO UniProtKB:Q9HB90 (PMID:23723238) RGD PMID:23723238 NCBI chr  X:19,085,913...19,135,049
Ensembl chr  X:19,336,372...19,369,746
Ensembl chr  X:19,336,372...19,369,746
JBrowse link
G Rragc Ras-related GTP binding C ISO UniProtKB:Q5VZM2 (PMID:23723238) RGD PMID:23723238 NCBI chr 5:141,572,536...141,590,784
Ensembl chr 5:141,572,536...141,590,781
JBrowse link
G Seh1l SEH1-like nucleoporin ISO (PMID:23723238) RGD PMID:23723238 NCBI chr18:63,545,150...63,568,101 JBrowse link
G Sesn1 sestrin 1 ISO (PMID:25263562) RGD PMID:25263562 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Sesn2 sestrin 2 ISO (PMID:25263562) RGD PMID:25263562 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Sesn3 sestrin 3 ISO (PMID:25263562) RGD PMID:25263562 NCBI chr 8:12,823,060...12,878,749
Ensembl chr 8:12,823,155...12,872,705
JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 ISO (PMID:21068542) RGD PMID:21068542 NCBI chr 2:250,709,812...250,744,216
Ensembl chr 2:250,709,439...250,744,196
JBrowse link
G Slc38a2 solute carrier family 38, member 2 IEP RGD PMID:11311116 RGD:68721 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
JBrowse link
G Szt2 SZT2 subunit of KICSTOR complex ISO (PMID:28199306), (PMID:28199315) RGD PMID:28199306, PMID:28199315 NCBI chr 5:137,192,120...137,238,384
Ensembl chr 5:137,190,875...137,238,354
JBrowse link
G Tfeb transcription factor EB ISO (PMID:22343943), (PMID:22576015), (PMID:22692423) RGD PMID:22343943, PMID:22576015, PMID:22692423 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596
JBrowse link
G Ucp2 uncoupling protein 2 IEP glutamine RGD PMID:18692019 RGD:7240714 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 ISO UniProtKB:O70405 (MGI:MGI:5607224|PMID:21855797) RGD PMID:21855797 MGI:MGI:5607224 NCBI chr12:51,908,105...51,934,704
Ensembl chr12:51,908,448...51,934,702
JBrowse link
G Wdr24 WD repeat domain 24 ISO (PMID:23723238) RGD PMID:23723238 NCBI chr10:15,191,078...15,195,860
Ensembl chr10:15,191,078...15,195,860
JBrowse link
G Wdr59 WD repeat domain 59 ISO (PMID:23723238) RGD PMID:23723238 NCBI chr19:43,651,686...43,714,391
Ensembl chr19:43,651,148...43,714,418
JBrowse link
cellular response to leucine starvation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO (MGI:MGI:5494763|PMID:23447528) RGD PMID:23447528 MGI:MGI:5494763 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
G Gcn1 GCN1 activator of EIF2AK4 ISO (MGI:MGI:5494763|PMID:23447528) RGD PMID:23447528 MGI:MGI:5494763 NCBI chr12:46,728,684...46,789,696
Ensembl chr12:46,728,699...46,789,726
JBrowse link
G Impact impact RWD domain protein ISO
ISS
(MGI:MGI:5494763|PMID:23447528)
GO_REF:0000024
RGD
UniProt
PMID:23447528 GO_REF:0000024, MGI:MGI:5494763 NCBI chr18:4,325,872...4,346,734
Ensembl chr18:4,325,875...4,346,769
JBrowse link
G Lars1 leucyl-tRNA synthetase 1 ISO (PMID:22424946) RGD PMID:22424946 NCBI chr18:36,524,013...36,579,471
Ensembl chr18:36,524,007...36,579,403
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO (PMID:22424946) RGD PMID:22424946 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G RragB Ras-related GTP binding B ISO (PMID:22424946) RGD PMID:22424946 NCBI chr  X:19,085,913...19,135,049
Ensembl chr  X:19,336,372...19,369,746
Ensembl chr  X:19,336,372...19,369,746
JBrowse link
G Rragd Ras-related GTP binding D ISO (PMID:22424946) RGD PMID:22424946 NCBI chr 5:48,224,994...48,260,691
Ensembl chr 5:48,224,994...48,260,685
JBrowse link
G Sesn1 sestrin 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Sesn2 sestrin 2 ISO
IBA
(PMID:26449471)
PMID:21873635
RGD PMID:26449471, PMID:21873635 RGD:13792537 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Sesn3 sestrin 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:12,823,060...12,878,749
Ensembl chr 8:12,823,155...12,872,705
JBrowse link
regulation of eIF2 alpha phosphorylation by amino acid starvation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO
ISS
(PMID:26102367)
(MGI:MGI:2149467|PMID:10655230), (MGI:MGI:3582244|PMID:11106749), (MGI:MGI:3589053|PMID:16121183), (MGI:MGI:3770235|PMID:16054071), (MGI:MGI:5700278|PMID:26102367)
GO_REF:0000024
RGD
UniProt
PMID:10655230, PMID:11106749, PMID:16054071, PMID:16121183, PMID:26102367 GO_REF:0000024, MGI:MGI:2149467, MGI:MGI:3582244, MGI:MGI:3589053, MGI:MGI:3770235, MGI:MGI:5700278 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
G Impact impact RWD domain protein ISO
IBA
ISS
(MGI:MGI:5494763|PMID:23447528)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:23447528, PMID:21873635 GO_REF:0000024, MGI:MGI:5494763, RGD:13792537 NCBI chr18:4,325,872...4,346,734
Ensembl chr18:4,325,875...4,346,769
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to stress 4061
        cellular response to stress 1982
          cellular response to starvation 181
            cellular response to amino acid starvation 50
              GCN2-mediated signaling 0
              cellular response to leucine starvation 10
              negative regulation of cellular response to amino acid starvation 0
              positive regulation of cellular response to amino acid starvation 0
              positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation 0
              regulation of cellular response to amino acid starvation + 0
              regulation of eIF2 alpha phosphorylation by amino acid starvation 2
Path 2
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to external stimulus 3202
        response to extracellular stimulus 763
          response to nutrient levels 732
            response to starvation 244
              cellular response to starvation 181
                cellular response to amino acid starvation 50
                  GCN2-mediated signaling 0
                  cellular response to leucine starvation 10
                  negative regulation of cellular response to amino acid starvation 0
                  positive regulation of cellular response to amino acid starvation 0
                  positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation 0
                  regulation of cellular response to amino acid starvation + 0
                  regulation of eIF2 alpha phosphorylation by amino acid starvation 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.